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Aggregations of Frankliniella schultzei males were observed on the corollas of Hibiscus rosasinensis and Gossypium hirsutum flowers in southeast Queensland. Aggregations were seen only on the upper surfaces of corollas but may have occurred on other flower parts, which were hidden from view. Conspecific females entered aggregations and a small proportion of them mated [18% (n = 163), H. rosasinensis; 30% (n = 181 ), G. hirsutum]. Most females (87 and 72%, respectively) that did not mate in aggregations walked to other flower parts. Behavior was difficult to observe on these parts, but mating was sometimes observed there. The number of females that landed within aggregations on the upper surfaces of both H. rosasinensis and G. hirsutum corollas was highly correlated with the number of males (r = 0.88, r = 0.93, respectively; P < 0.001 ). Significantly more mating pairs were observed in high-density aggregations (mean ± SE, 1.10 ± 0.22 and 4.44 ± 0.48, respectively ) than in low-density aggregations (0.37 ± 0.11 and 1.67 ± 0.29, respectively ) (P < 0.05 ) on flowers of both species. More F. schultzei females were attracted to sticky traps baited with live conspecific males set among flowering Ipomoea indica (mean ± SE, 8.83 ± 0.32 ) and G. hirsutum (10.90 ± 0.79) plants than to control traps (0.10 ± 0.05 and 0.70 ± 0.25, respectively) (P < 0.05), presumably in response to male-produced pheromones. Significantly more females were attracted to traps with high male densities than to traps with low densities. We found no statistical evidence that aggregation size influenced mating success (proportion males that mated). Mating success, however, should be evaluated with respect to mating on all flower parts and not just the upper surfaces of corollas. The results of this study constitute the first behavioral evidence for an attractant sex pheromone in thrips. [ABSTRACT FROM AUTHOR]

Nasal medications hold significant importance and are widely utilized due to their numerous advantageous properties, offering a compelling route for both local and systemic therapeutic effects. Nowadays, the development of nasal particles under 1 micrometer is in the focus of much scientific research. In our experiments, the use of innovative nanotechnology to increase the effectiveness of the active substance was of paramount importance. Our aim was to create solid nanoparticles that enable targeted and effective delivery of the active ingredient into the body. The innovation of this experimental series lies not only in highlighting the importance of amphiphilic compounds in enhancing penetration, but also in the fact that while most nasally administered formulations are in liquid form, our formulation is solid. Liquid formulations frequently suffer from the disadvantage of possible leakage during administration, which can reduce the bioavailability of the active ingredient. In our experiments we created novel drug delivery systems of finely divided powders, which, thanks to the penetration enhancers, can be successfully administered. These enhancers facilitate the swift disintegration and penetration of the particles through the membrane. This represents a new direction in nasal drug delivery methods. The results of our trials are promising in the development of innovative pharmaceutical products and outline the role of amphiphilic compounds in more efficient utilization and targeted application of active substances. According to our results it can be concluded that this innovative approach not only addresses the common issues associated with liquid nasal formulations but also paves the way for more stable and effective delivery methods. The use of finely divided powders for nasal delivery, enabled by penetration enhancers, represents a major breakthrough in the field, providing a dependable alternative to conventional liquid formulations and ensuring improved therapeutic results. [ABSTRACT FROM AUTHOR]

Ketoconazole (K) is a poorly water-soluble drug that faces significant challenges in achieving therapeutic efficacy. This study aimed to enhance the dissolution rate of ketoconazole by depositing spray-dried ketoconazole (SK) onto the surface of ground trehalose dihydrate (T) using spray drying. Ketoconazole-trehalose surface solid dispersions (SKTs) were prepared in ratios of 1:1 (SK1T1), 1:4 (SK1T4), and 1:10 (SK1T10), and characterized them using particle size analysis, scanning electron microscopy, powder X-ray diffraction, and in vitro dissolution studies. Results showed that the dissolution rates of the dispersions were significantly higher than those of pure ketoconazole, with the 1:10 ratio showing the highest dissolution rate. The improved dissolution was attributed to the formation of a new crystalline phase and better dispersion of ketoconazole particles. These findings suggest that the surface solid dispersion approach could be a valuable method for enhancing the bioavailability of poorly water-soluble drugs. [ABSTRACT FROM AUTHOR]

In this research, 3D-printed antifungal buccal films (BFs) were manufactured as a potential alternative to commercially available antifungal oral gels addressing key considerations such as ease of manufacturing, convenience of administration, enhanced drug efficacy and suitability of paediatric patients. The fabrication process involved the use of a semi-solid extrusion method to create BFs from zein-Poly-Vinyl-Pyrrolidone (zein-PVP) polymer blend, which served as a carrier for drug (miconazole) and taste enhancers. After manufacturing, it was determined that the disintegration time for all films was less than 10 min. However, these films are designed to adhere to buccal tissue, ensuring sustained drug release. Approximately 80% of the miconazole was released gradually over 2 h from the zein/PVP matrix of the 3D printed films. Moreover, a detailed physicochemical characterization including spectroscopic and thermal methods was conducted to assess solid state and thermal stability of film constituents. Mucoadhesive properties and mechanical evaluation were also studied, while permeability studies revealed the extent to which film-loaded miconazole permeates through buccal tissue compared to commercially available oral gel formulation. Histological evaluation of the treated tissues was followed. Furthermore, in vitro antifungal activity was assessed for the developed films and the commercial oral gel. Finally, films underwent a two-month drug stability test to ascertain the suitability of the BFs for clinical application. The results demonstrate that 3D-printed films are a promising alternative for local administration of miconazole in the oral cavity. [ABSTRACT FROM AUTHOR]

Acute metabolic acidosis alters 1,25 dihydroxyvitamin D metabolism in experimental animals. We have used the NH4Cl-treated rachitic rat as a model to investigate the effect of acidosis on hepatic 25 hydroxyvitamin D (25 OHD) production. NH4Cl ingestion for 4 days was associated with a significant decrease in blood pH (7.44 +/- 0.03 vs 7.17 +/- 0.03, P less than 0.001) and bicarbonate (22.2 +/- 0.9 vs 10.5 +/- 1.6 mEq/liter, P less than 0.001). Acute metabolic acidosis stimulated 3H-25 hydroxyvitamin D production in liver homogenates. Acidosis resulted in a 52% decrease in Km (50.9 nM vs 24.5 nM) and an 11% decrease in the Vmax (554 picomoles/g liver protein/3 h vs 491 picomoles/g liver protein/3 h). The data collectively suggest that an acid load in vivo increases hepatic 25 OHD production and apparently enhances enzyme affinity for substrate. [ABSTRACT FROM AUTHOR]

We report the discovery of a peculiar X-ray transient, EP240408a, by Einstein Probe (EP) and follow-up studies made with EP, Swift, NICER, GROND, ATCA and other ground-based multiwavelength telescopes. The new transient was first detected with Wide-field X-ray Telescope (WXT) on board EP on April 8th, 2024, manifested in an intense yet brief X-ray flare lasting for 12 s. The flare reached a peak flux of 3.9 × 10−9 erg cm−2 s−1 in 0.5–4 keV, ∼300 times brighter than the underlying X-ray emission detected throughout the observation. Rapid and more precise follow-up observations by EP/FXT, Swift and NICER confirmed the finding of this new transient. Its X-ray spectrum is non-thermal in 0.5–10 keV, with apower-law photon index varying within 1.8–2.5. The X-ray light curve shows a plateau lasting for ∼4 d, followed by a steep decay till becoming undetectable ∼10 d after the initial detection. Based on its temporal property and constraints from previous EP observations, an unusual timescale in the range of 7–23 d is found for EP240408a, which is intermediate between the commonly found fast and long-term transients. No counterparts have been found in optical and near-infrared, with the earliest observation at 17 h after the initial X-ray detection, suggestive of intrinsically weak emission in these bands. We demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far, by comparison with, in particular, jetted tidal disruption events, gamma-ray bursts, X-ray binaries and fast blue optical transients. The nature of EP240408a thus remains an enigma. We suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of ∼10 d. The detection and follow-ups of more of such objects are essential for revealing their origin. [ABSTRACT FROM AUTHOR]

Hyperpolarization has become a powerful tool to enhance the sensitivity of magnetic resonance. A universal tool to hyperpolarize small molecules in solution, however, has not yet emerged. Transferring hyperpolarized, labile protons between molecules is a promising approach towards this end. Therefore, hydrogenative parahydrogen-induced polarization (PHIP) was recently proposed as a source to polarize exchanging protons (PHIP-X). Here, we identified four key components that govern PHIP-X: adding the spin order, polarizing the labile proton, proton exchange, and polarization of the target nucleus. We investigated the last two steps experimentally and using simulations. We found optimal exchange rates and field cycling methods to polarize the target molecules. We also investigated the influence of spin relaxation of exchanging protons on the target polarization. It was found experimentally that transferring the polarization from protons directly bound to the target X-nucleus (here 13C) of lactate and methanol using a pulse sequence was more efficient than applying a corresponding sequence to the labile proton. Furthermore, varying the concentrations of the transfer and target molecules yielded a distinct maximum 13C polarization. We believe this work will further help to understand and optimize PHIP-X towards a broadly applicable hyperpolarization method. Hyperpolarization has become a powerful tool to enhance the sensitivity of NMR analyses, whereby hydrogenative parahydrogen-induced polarization with exchanging protons could broaden its applicability. Here, the authors identify four key components that govern the polarization of exchanging protons, and propose optimal exchange rates and field cycling methods to polarize target molecules. [ABSTRACT FROM AUTHOR]

Habitat management have received considerable attention in agricultural systems for the promotion of successful pest management. The intercropping of aromatic plants in plantation crops can result in reduced pest abundance as a repellent directly and/or increasing natural enemy abundance thereby reducing pest abundance indirectly. To promote the management of pests in tea plantations, we intercropped three aromatic plants, Tagetes patula (L.) (Asteraceae), Tagetes erecta (L.) (Asteraceae), and Perilla frutescens (L.) Britton (Lamiaceae) to assess their impact on the dynamics of species abundance, richness, and diversity of arthropod pests and their natural enemies over 2 years. Results showed that aromatic plants decreased the abundance of pest, with concomitant increases in predator (especially spiders and ladybirds) and parasitoid (Ichneumonidae spp.) abundance, creating a stable low abundance of pests in tea plantations. The ratio of natural enemies to pests in fields intercropped with T. erecta was fourfold to sevenfold higher than observed in naturally tilled plots. Aromatic plants also had a significant positive effect on species richness and evenness of natural enemies. The T. patula and T. erecta intercropped treatments showed significantly higher pest evenness and higher natural enemy diversity than that in clean tillage. Our study indicated that biocontrol via habitat management with intercropping aromatic plants could become a recommended practice for pest management in tea plantations. [ABSTRACT FROM AUTHOR]

Using a novel hybrid-fusion neural network technique and cloud computing environment, this paper examines the relationship between individual flexibility, workplace interpersonal problems, and construction worker safety. The population is made up of construction firms based in Mashhad, Iran. This is an applied study, and the data collection approach used is a descriptive survey. The data was obtained using cloud-based storage, data analysis techniques, and data processing tools. The primary objective is to investigate the critical nature of personal safety on construction sites and techniques for minimizing construction accidents. The statistical population consisted of Mashhad, Iran-based construction firms. Due to the impossibility of studying the entire research population, a sample of n = 200 participants was chosen for this study. Following questionnaire distribution, 151 valid questionnaires were gathered. The primary study instrument was a 28-item questionnaire devised by the researcher based on the Questionnaire on the Experience and Evaluation of Work and occupational health. On a Likert scale, the things were rated. Cronbach's alpha coefficient was also used to determine the questionnaire's validity. SPSS-26 software was used to analyze the data in a MATLAB environment. The findings indicate that interpersonal conflict, workplace stress, supervisor involvement, physical injuries, dangerous incidents, and coworker participation are all connected with worker safety at a significant level of p 0.05. One of the research's advances is the use of new hybrid-fusion neural networks. Cloud computing has performed admirably in this study, taking into account the massive volume of data for speedy analysis and the development of a mechanism as an appropriate application. Additionally, the study was motivated by a dearth of comprehensive research on individual flexibility and interpersonal conflicts among construction workers. [ABSTRACT FROM AUTHOR]

Background: In the current study, estimation of lamivudine (LMU) by UV spectroscopy, reverse-phase HPLC (RP-HPLC) and HPTLC methods in tablet formulation was developed, and comparative studies between the methods were investigated by analytical results and statistical test analysis of variance (ANOVA) to find out best method. In the UV spectral method, LMU was quantified at 271 nm absorption maxima using methanol as the solvent. In the RP-HPLC method, the Shimadzu C18 column (250 mm × 4.6 mm i.d., 5 µm particle size) was employed for chromatographic separation. The mobile phase used consists of methanol: water (70:30 v/v) in an isocratic mode with a 1.0 mL/min flow rate. In the HPTLC method, the chromatogram was developed on a pre-coated plate of silica gel 60 F254 with a mobile phase composition of chloroform: methanol (8:2 v/v). The quantification was performed at an absorbance mode of 271 nm by densitometry. The methods were validated according to the International Conference on Harmonization (ICH) guideline Q2 (R1). The degradation conditions were employed as per ICH guidelines Q1A(R2) and Q1B which include acid, alkaline, neutral, thermal and photostability to determine the intrinsic stability of the drug in varied environmental conditions. Results: LMU absorption maxima was found to be 271 nm. The retention time of LMU was 3.125 min, and the total analysis time was 5 min. The Rf value of LMU was 0.49–0.62. The methods were linear within 2–12 μg/mL range. The correlation coefficient (r2) for UV, HPLC and HPTLC was 0.9980, 0.9993 and 0.9988, and percent recoveries were calculated as 98.40–100.52%, 99.27–101.18% and 98.01–100.30%, respectively, with percentage relative standard deviation (RSD) less than 2% showing that methods were precise and accurate. Conclusion: Developed UV, RP-HPLC and HPTLC methods are free from intervention caused by excipients present in tablets and thus can be used for regular quantitative analysis of LMU in tablet formulation. Based on analytical results and statistical tests, ANOVA, it is inferred that the HPLC method is best for LMU quantification tablet formulation due to its high reproducibility, good retention time and sensitivity; it has a higher percent recovery and has less analysis time, i.e., 5 min. The degradation peaks were well separated from the LMU peak indicating stability of the HPLC method. [ABSTRACT FROM AUTHOR]

Payment for Ecosystem Services (PES) can promote different types of governance arrangements to address the triple challenge of biodiversity loss, climate change and air pollution. These institutional arrangements, however, do not explicitly incorporate climate change into the ecosystem's capacity to provide services. In this study, we explore why and how to incorporate climate uncertainties using as example the Altos de Cantillana Nature Reserve, a unique biodiversity hotspot in Central Chile. First, prioritized ecosystem services (ES) were grouped in bundles and linked to measured and modeled impacts of climate change on key water-related processes. Second, institutional barriers to PES were identified from case studies and analyzed considering challenges in a changing climate. Finally, bundles with different levels of risk were matched to six recommendations that better incorporate levels of risks to the uncertainty of climate change into Payment for Ecosystem Services in Chile. [ABSTRACT FROM AUTHOR]

Biodiversity faces unprecedented threats from rapid global change1. Signals of biodiversity change come from time-series abundance datasets for thousands of species over large geographic and temporal scales. Analyses of these biodiversity datasets have pointed to varied trends in abundance, including increases and decreases. However, these analyses have not fully accounted for spatial, temporal and phylogenetic structures in the data. Here, using a new statistical framework, we show across ten high-profile biodiversity datasets2–11 that increases and decreases under existing approaches vanish once spatial, temporal and phylogenetic structures are accounted for. This is a consequence of existing approaches severely underestimating trend uncertainty and sometimes misestimating the trend direction. Under our revised average abundance trends that appropriately recognize uncertainty, we failed to observe a single increasing or decreasing trend at 95% credible intervals in our ten datasets. This emphasizes how little is known about biodiversity change across vast spatial and taxonomic scales. Despite this uncertainty at vast scales, we reveal improved local-scale prediction accuracy by accounting for spatial, temporal and phylogenetic structures. Improved prediction offers hope of estimating biodiversity change at policy-relevant scales, guiding adaptive conservation responses.This study presents an approach to deal with spatial, temporal and phylogenetic non-independence in large-scale analyses of biodiversity change, improving trend estimation and inference across scales. [ABSTRACT FROM AUTHOR]

I wish to thank Professor M. D. Milne for helpful criticism in preparation of the manuscript. [ABSTRACT FROM AUTHOR]

Tandem bicycles are used for all para-cycling events for visually impaired athletes. Tandems are structurally more challenging to design than solo bicycles: they must resist higher loading over a longer wheelbase, yet must still fit between the legs of the riders. Despite this, there is limited published work on tandem design. This paper presents a method for determining maximal loading of a tandem bicycle frame in racing scenarios. The only inputs required are the dimensions of the frame and the torques exerted by the riders. Outputs are the forces acting on the frame. The method is used to provide loads for structural analyses of tandem frames of different topologies. Twisting of the frame under a starting effort is shown to be the worst load case. The "double diamond" is shown to be the most efficient tubular frame design, on a stiffness per weight basis, but is only 2% superior to an "open" topology. [ABSTRACT FROM AUTHOR]

There have been growing ethical concerns about the widespread use of HIV-related molecular epidemiological public health surveillance and research-or what has come to be known as molecular HIV surveillance. The varied concerns of the practice originate due to lack of informed consent, lack of demonstrated benefit for communities, potential for eroded patient care relationships leading to poor health outcomes, and potential implications for information sharing and findings which could increase stigmatization and other negative impacts in contexts where HIV, drug use, sex work, migration, and poverty are criminalized. As people living with HIV, lawyers, clinicians, and social scientists, we are part of the growing movement calling for critical and ethical attention to the practice of molecular HIV surveillance and the public health logic which underwrites the practice. We urge Canadian public health actors and researchers working with molecular surveillance data to heed global guidance and recommendations for culturally informed ethical practices, to engage community members in HIV surveillance programs, and to ensure that people living with HIV are provided appropriate consent processes for uses of secondary data analysis. Furthermore, we urge researchers and Research Ethics Boards to interrogate assumptions of impracticality in seeking subsequent consent to use persons' health information held in data repositories and explore new methods of informed consent., (© 2024. The Author(s) under exclusive license to The Canadian Public Health Association.)

Triatomines (Hemiptera: Heteroptera: Reduviidae), commonly known as conenose or kissing bugs, includes species of outstanding medical importance given their role as vectors of the protozoan parasite Trypanosoma cruzi Chagas (Kinetoplastida: Trypanosomatidae), the aetiological agent of Chagas disease. Herein, we present an updated review of the chemical ecology of triatomines, with special reference to molecules involved in the communication of these insects. Infochemicals, including hormones and semiochemicals (pheromones and allelochemicals), have a pivotal role in mediating information and shaping interactions within and between triatomines, during distinct behavioural contexts. We analyse the new findings about the chemical composition of alarm, aggregation and sex pheromones, as well as on cuticular hydrocarbons, host attractants and repellents. We also discuss how triatomine hormones may serve as communication signals and highlight the importance of the reverse chemical ecology approach in studying the complex chemoecology of these arthropod vectors. In the final section, we outline how knowledge about triatomine chemical ecology can be used for implementing real-world control operations with proven epidemiological impact. [ABSTRACT FROM AUTHOR]

Climate-responsive building design holds immense potential for enhancing comfort, energy efficiency, and environmental sustainability. However, many social, cultural, and economic obstacles might prevent the wide adoption of designing climate-adapted buildings. One of these obstacles can be removed by enabling practitioners to easily access, visualize and analyze local climate data. The CBE Clima Tool (Clima) is a free and open-source web application that offers easy access to publicly available weather files and has been created for building energy simulation and design. It provides a series of interactive visualizations of the variables contained in the EnergyPlus Weather Files and several derived ones like the UTCI or the adaptive comfort indices. It is aimed at students, educators, and practitioners in the architecture and engineering fields. Since its inception, Clima's user base has exhibited robust growth, attracting over 25,000 unique users annually from across 70 countries. Our tool is poised to revolutionize climate-adaptive building design, transcending geographical boundaries and fostering innovation in the architecture and engineering fields. [ABSTRACT FROM AUTHOR]

Governments and international organizations are increasingly determined to create more sustainable food value chains (SFVCs). However, only little empirical evidence is available on how SFVCs are understood. Enquiring African food value chain actors allows gathering valuable insights into their perception of sustainability, which characteristics of sustainable food value chains they prioritize, and which obstacles to a sustainable transformation they identify. By means of a Q-methodology involving interviews with 33 Kenyan respondents, four perspectives were distinguished. The first perspective, "economic productivity and growth," prioritizes economic growth and has only limited attention to the social dimension of sustainability. The second perspective, "food security and food availability," believes that ensuring food security should be the key goal of SFVCs. The third perspective, "environment first," is dedicated to the environmental dimension of sustainability; the perspective implies that protecting natural resources is the primary way to sustain this level of production. The fourth perspective, "transformative knowledge," entails that by innovating and sharing knowledge, food value chains can become more sustainable in different areas. Overall, this study provides reliable insights into how Kenyan food value chain actors perceive sustainability in their sector and which elements they believe should be prioritized when rethinking food systems. The study results are valuable for policy-making to further define an SFVC in Kenya and to pave the way for a sustainable transformation of the food sector in developing countries. [ABSTRACT FROM AUTHOR]

Background: The inverse log-linear relationship between Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) is well established and reliably used for evaluation of hypothalamus-pituitary-thyroid (HPT) axis function. However, there are limited data regarding oncologic states in the TSH-FT4 relationship. The purpose of this study was to evaluate thyroid pituitary hypothalamic feedback regulation by the inverse log TSH and FT4 relationship in the cancer patient population at the Ohio State University Comprehensive Cancer Center (OSUCCC-James). Methods: This retrospective study analyzed the correlation between TSH and FT4 results from 18846 outpatient subjects collected in August 2019-November 2021 at the Department of Family Medicine (OSU Wexner Medical Center), Department of Oncology (OSUCCC-James). Patients with diagnoses related to cancers were included in the oncology group. Patients with diagnoses not related to cancers were included in the non-oncology group. Patients of the Department of Endocrinology, Department of Cardiology, Department of Obstetrics & Gynecology and Department of Hematology were excluded from this study. Time of collection for TSH and FT4 was from 7am to 7 pm. Data were analyzed by morning (7am–12pm) and afternoon (12pm–7pm). Spearman correlation and non-linear fit were used for data analysis. Sex differences were analyzed as well in each group. Results: Overall, an inverse correlation was observed between TSH and FT4 in both groups (non-oncology and oncology) regardless of sample collection time and sex differences. Further analysis by linear model in log TSH and FT4 showed a significant inverse fit in males compared with females in the group of oncology, both in the afternoon (p < 0.05). Data were further analyzed by ranges of FT4, as lower or higher (pathophysiology) or within (physiology) the reference interval of FT4. There was no statistical significance between the non-oncology and oncology groups, but relatively good correlation in non-oncology group in either physiologic or pathophysiologic FT4 levels and sample collection time. Interestingly, the best correlation between TSH and FT4 was found in the non-oncology group at pathophysiologic FT4 concentrations (abnormally high). In addition, at pathophysiologic FT4 concentrations (abnormally low), the oncology group demonstrated a significant TSH response in the morning than in the afternoon (p < 0.05). Conclusions: Though overall the TSH-FT4 curves showed an inverse relationship, there are variations of TSH-FT4 relationship for collection times when considering FT4 in physiologic or pathophysiologic states. The results advance understanding of TSH response, which is beneficial for the interpretation of thyroid disease. We recommend re-evaluation for interpretation of pituitary hypothalamic axis by TSH results when FT4 is abnormally high in oncology patients or low in non-oncology patients, due to poor predictability and the potential for misdiagnosis. A better understanding of the complex nature of the TSH-FT4 relationship may need further study with better defining subclinical states of cancer patients. [ABSTRACT FROM AUTHOR]

Cyperus rotundus L. has been widely used in the treatment and prevention of numerous diseases in traditional systems of medicine around the world, such as nervous, gastrointestinal systems diseases and inflammation. In traditional Chinese medicine (TCM), its rhizomes are frequently used to treat liver disease, stomach pain, breast tenderness, dysmenorrheal and menstrual irregularities. The review is conducted to summarize comprehensively the plant's vernacular names, distribution, phytochemistry, pharmacology, toxicology and analytical methods, along with the data mining for TCM prescriptions containing C. rotundus. Herein, 552 compounds isolated or identified from C. rotundus were systematically collated and classified, concerning monoterpenoids, sesquiterpenoids, flavonoids, phenylpropanoids, phenolics and phenolic glycosides, triterpenoids and steroids, diterpenoids, quinonoids, alkaloids, saccharides and others. Their pharmacological effects on the digestive system, nervous system, gynecological diseases, and other bioactivities like antioxidant, anti-inflammatory, anti-cancer, insect repellent, anti-microbial activity, etc. were summarized accordingly. Moreover, except for the data mining on the compatibility of C. rotundus in TCM, the separation, identification and analytical methods of C. rotundus compositions were also systematically summarized, and constituents of the essential oils from different regions were re-analyzed using multivariate statistical analysis. In addition, the toxicological study progresses on C. rotundus revealed the safety property of this herb. This review is designed to serve as a scientific basis and theoretical reference for further exploration into the clinical use and scientific research of C. rotundus. [ABSTRACT FROM AUTHOR]

This descriptive qualitative research examined the views of people caring for an elderly family member on ageism, spirituality, and death. A total of 12 people who lived in the same house as the elderly person they cared for made up the study sample. Data were collected via face-to-face, in-depth interviews using a structured interview format. The content analysis method was used for the data analysis. The analysis of the study data yielded three themes: the definition of ageism, the meaning of spirituality and its effects on care, and the position of death in life. The results indicated that living with and caring for an elderly individual made the lives of the family members providing care meaningful, spirituality was important in the care of elderly individuals, and caregivers could be considered at risk in terms of the burden of care. It is recommended that health professionals support caregivers sharing the same house with an elderly family member through training programs on the burden of care, spiritual care, and death. [ABSTRACT FROM AUTHOR]

The A3 adenosine receptor (A3AR) is over-expressed in human hepatocellular carcinoma (HCC) cells. Namodenoson, an A3AR agonist, induces de-regulation of the Wnt and NF-kB signaling pathways resulting in apoptosis of HCC cells. In a phase I healthy volunteer study and in a phase I/II study in patients with advanced HCC, namodenoson was safe and well tolerated. Preliminary evidence of antitumor activity was observed in the phase I/II trial in a subset of patients with advanced disease, namely patients with Child–Pugh B (CPB) hepatic dysfunction, whose median overall survival (OS) on namodenoson was 8.1 months. A phase II blinded, randomized, placebo-controlled trial was subsequently conducted in patients with advanced HCC and CPB cirrhosis. The primary endpoint of OS superiority over placebo was not met. However, subgroup analysis of CPB7 patients (34 namodenoson-treated, 22 placebo-treated) showed nonsignificant differences in OS/progression-free survival and a significant difference in 12-month OS (44% vs 18%, p = 0.028). Partial response was achieved in 9% of namodenoson-treated patients vs 0% in placebo-treated patients. Based on the positive efficacy signal in HCC CPB7 patients and the favorable safety profile of namodenoson, a phase III study is underway. [ABSTRACT FROM AUTHOR]

Artificial Intelligence (AI) is undergoing rapid development, meaning that potential risks in application are not able to be fully understood. Multiple international principles and guidance documents have been published to guide the implementation of AI tools in various industries, including healthcare practice. In Aotearoa New Zealand (NZ) we recognised that the challenge went beyond simply adapting existing risk frameworks and governance guidance to our specific health service context and population. We also deemed prioritising the voice of Māori (the indigenous people of Aotearoa NZ) a necessary aspect of honouring Te Tiriti (the Treaty of Waitangi), as well as prioritising the needs of healthcare service users and their families. Here we report on the development and establishment of comprehensive and effective governance over the development and implementation of AI tools within a health service in Aotearoa NZ. The implementation of the framework in practice includes testing with real-world proposals and ongoing iteration and refinement of our processes. [ABSTRACT FROM AUTHOR]

The next years will see the completion of the radioactive ion beam facility SPES (Selective Production of Exotic Species) and the upgrade of the accelerators complex at Istituto Nazionale di Fisica Nucleare – Legnaro National Laboratories (LNL) opening up new possibilities in the fields of nuclear structure, nuclear dynamics, nuclear astrophysics, and applications. The nuclear physics community has organised a workshop to discuss the new physics opportunities that will be possible in the near future by employing state-of-the-art detection systems. A detailed discussion of the outcome from the workshop is presented in this report. [ABSTRACT FROM AUTHOR]

Nowadays, technology plays a fundamental role in the development of daily life activities. In this regard, there is an increase in disciplines that have used technologies, with educational fields standing out above all. Within education, there are a series of emerging technologies that are increasingly implemented in the classroom. Emerging technologies are also well aligned to autistic students and their specific learning and cognitive preferences. Therefore, the aim of this review is to carry out a systematic and thematic review on the application of Virtual reality (VR) in teaching and learning environments for autistic students during the period 1996–2021. Our analysis located a sample of 38 documents obtained from the WEB of Science and Scopus based on following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidance. Our results highlight that much of the research was focused on areas of emotional recognition and social skills development. In addition, we found that when activities were interactive and realistic within the VR environments, the acceptance of this tool was improved for this specific population. [ABSTRACT FROM AUTHOR]

For many neuroscience applications, brain extraction in MRI images is the first pre-processing step of a quantification pipeline. Once the brain is extracted, further post-processing calculations become faster, more specific and easier to implement and interpret. It is the case, for example, of functional MRI brain studies, or relaxation time mappings and brain tissues classifications to characterise brain pathologies. Existing brain extraction tools are mostly adapted to work on the human anatomy, this gives poor results when applied to animal brain images. We have developed an atlas-based Veterinary Images Brain Extraction (VIBE) algorithm that encompasses a pre-processing step to adapt the atlas to the patient's image, and a subsequent registration step. We show that the brain extraction is achieved with excellent results in terms of Dice and Jaccard metrics. The algorithm is automatic, with no need to adapt the parameters in a broad range of situations: we successfully tested multiple MRI contrasts (T1-weighted, T2-weighted, T2-weighted FLAIR), all the acquisition planes (sagittal, dorsal, transverse), different animal species (dogs and cats) and canine cranial conformations (brachycephalic, mesocephalic, dolichocephalic). VIBE can be successfully extended to other animal species, provided that an atlas for that specific species exists. We show also how brain extraction, as a preliminary step, can help to segment brain tissues with a K-Means clustering algorithm. [ABSTRACT FROM AUTHOR]

Thrips (Thysanoptera: Thripidae) feed on leaf and flower tissue and some of them can be facultative predators. Caliothrips phaseoli Hood causes severe damage to different species of the Fabaceae family, mainly to Phaseolus vulgaris L. crops. The purpose of this research is to assess the change in feeding damage due to predation on Tetranychus merganser (Acari: Tetranychidae) eggs by the first and second larval stages of C. phaseoli on bean leaf discs, under laboratory conditions. Predation and damage were assessed through functional response and ordinal scale, respectively. The first and second larval stages of C. phaseoli exhibited a type II functional response. The second larval stage of C. phaseoli displayed shorter handling time and higher attack rate in comparison to the first instar. The first and second larval stages of C. phaseoli consumed 3.8 and 4.9 eggs of T. merganser per day, respectively. The second larval stage caused the highest damage (median = 3). The feeding damage of C. phaseoli was negatively associated to the number of eggs offered. The C. phaseoli larvae became more predatory than herbivorous when the number of eggs offered increased; therefore, C. phaseoli can be considered a facultative predator. [ABSTRACT FROM AUTHOR]

Being the first to discover a resource can provide a competitive advantage (priority effect), even for an animal that is inferior in aggressive contests. Nicrophorus spp. (burying beetles) are known for caching a small vertebrate carcass as provision for their young, reducing volatile cues available to rivals by burying the carcass (vertical movement) and by altering the microbial community. A decomposing carcass, however, can leave cues (residues of decay) on soil and leaf litter that a burying beetle has less opportunity to neutralize. I investigated whether horizontal movement of the carcass by burying beetles, separating the carcass from soil at the site of death, might reduce competition from congeners. When fresh carcasses were placed in the field on top of soil with residues of decay, akin to no horizontal displacement, carcasses were discovered within 24 h by free-flying competitors more frequently (58.2%) than when the carcass was placed 1 m from treated soil (8.3%). In a second experiment, carcasses were more likely to be discovered by burying beetles when a chemical attractant (methyl thiocyanate) was placed near a carcass (0.03 and 0.25 m) than when it was placed more distant (1 and 5 m) or for controls (no attractant). The results suggest that horizontal displacement of a carcass after discovery serves not only to locate a suitable spot for burial but also to reduce information available to rivals searching for the resource. [ABSTRACT FROM AUTHOR]

Autism is characterized by peculiar sensory processing. The sensory features of a place may have a crucial impact on the decision a person with autism makes when choosing what to visit in a tourist experience. We present a map-based mobile app, conceived for people with mid to high-functioning autism, which exploits sensory features of places to filter the information displayed and suggest locations that may be suitable for their idiosyncratic needs. The mobile app also exploits the crowdmapping paradigm in order to gather these features from the community of users, since they are not publicly available. We describe the results of a composite user evaluation of the app, made up of a task experiment, a field study, and an online questionnaire, which aims to understand (i) whether the explicit presentation of sensory information impacts the decision of going to a specific place, (ii) if the crowdmapping functionality is used and how and (iii) how people with autism navigate the mobile app. The results confirm the importance of the sensory features for people with autism in the decision to go to a specific place. Moreover, they show that crowdmapping may be a good solution to collect such features, but should be integrated with other methods. Finally, the results show that the preferred modality of exploring information about places is by using the map. [ABSTRACT FROM AUTHOR]

Normative transitions between educational settings can be important life events for young people, having the potential to influence mental health trajectories across the life course. Interventions to target transitions have been used to support children and young people as they transition between school settings, but there is limited synthesis of their effects. Seven databases were searched to identify studies of universal interventions focused on supporting mental health and wellbeing across three main types of educational transition: preschool to elementary school; school to school (including elementary to middle; middle to high and other combinations depending on country); and high school to post-compulsory education. Effect directions for behavioural, psychological/emotional and social measures of mental health were extracted for each study and synthesized using effect direction plot methodology. Searches identified 6494 records for screening. This resulted in 34 papers being included in the review, consisting of 24 different interventions. Social outcomes appeared more amenable to intervention than behavioural outcomes, with mixed findings for psychological measures of mental health. Intervention characteristics shifted based on the age of young person involved in the transition, with greater focus on parenting and school environment during the early transitions, and more focus on social support for the transition to post-compulsory education. A broad range of interventions were identified for supporting mental health and wellbeing across the three types of educational transition with mixed impact and diverse methodologies. More research is needed to identify transferable intervention mechanisms that may hold across different contexts and settings. PROSPERO registration number: CRD42020176336. [ABSTRACT FROM AUTHOR]

This study aimed to determine if self-complete at-home recordings could produce audio samples of sufficient quality for use in voice analysis software, and if audio samples of similar or sufficient quality could be extracted from audio-recorded naturalistic phone interviews. Data were obtained from 31 adults aged 18 years and over who smoked. The /a/ sound segment was manually isolated, and analysis functions were used to produce the following values: fundamental frequency, jitter, shimmer, noise ratio, formant 3, and formant 4. The /a/ sound segment was then manually isolated from audio recordings of naturalistic interviews previously conducted by phone. These were analysed in the same way and compared for quality against Evistr-recorded audio samples from the same participants. A third audio sample consisted of an Evistr or phone-recorded sustained phonation of the /a/ sound. Means and standard deviations were calculated for the target vocal parameters. Statistical comparisons for quality of sound segment were conducted for readings, interviews, and vowel phonation and for sound signals extracted via both recording methods. Self-recording by adults who smoked provided audio samples of sufficient quality for analysis of vocal features that have been associated with a clinical outcome. The values obtained for sustained phonation audio samples displayed the least perturbation and noise for the vocal parameters surveyed. Sound signals recorded with smartphones appeared to be affected by electronic interference but have potential for use in diagnostic tools for measuring vocal parameters. [ABSTRACT FROM AUTHOR]

We predicted that chronic pain patients have a more negative stress mindset and a lower level of social identification than people without chronic pain and that this, in turn, influences well-being through less adaptive coping. 1240 participants (465 chronic pain patients; 775 people in the control group) completed a cross-sectional online-survey. Chronic pain patients had a more negative stress mindset and a lower level of social identification than people without chronic pain. However, a positive stress mindset was linked to better well-being and fewer depressive symptoms, through the use of the adaptive coping behaviors positive reframing and active coping. A higher level of social identification did not impact well-being or depression through the use of instrumental and emotional support coping, but through the more frequent use of positive reframing and active coping. For chronic pain therapy, we propose including modules that foster social identification and a positive stress mindset. [ABSTRACT FROM AUTHOR]

The accurate and rapid detection for the nucleoside reverse transcriptase inhibitor lamivudine (LAM, 3TC) in cellular systems is always a challenge in the clinic application. Here, a sensitive Cu and Ni nano cluster sensor for LAM is generated under hydrothermal conditions.The Cu and Ni atoms are highly dispersed and aggregated in the nanosized opening pore windows of the synthesized LTA zeolite, through the diatomic synergistic contribution of Cu and Ni and the enrichment of zeolitic channel pores. Using differential pulse voltammetry (DPV), the detection limit (LOD) of LAM at the potential (− 0.15 V) can reach 0.001 pM and the linear range is 0.002 pM–0.002 μM. Since the nano cluster is separated and restricted by the nanosized windows of the zeolite framework, the sensor provides high stability, good recovery (92.5–109%) and RSD (0.8–3.2%) in the analysis of tap water, RPMI 1640 medium, and rabbit serum. The Cu/Ni/LTA zeolite-modified glassy carbon electrode (Cu/Ni/LTA/GCE) exhibits excellent catalytic performance for LAM with high selectivity over potentially interfering agents. [ABSTRACT FROM AUTHOR]

This article evaluates the influence of Corporate Social Responsibility practices on organizational results. Although this relationship has been widely studied, there are no previous studies that analyze the role played by the characteristics of different company cultures. Although there are many publications on this topic, it is still not clear if and how such cultural characteristics influence the practice within the scope of operations management. The purpose of this study is to investigate the relation between Corporate Social Responsibility (CSR), organizational results and these cultural characteristics in Brazilian cosmetic companies. A survey was used to gather responses from 102 companies in the Brazilian cosmetic sector, and the data were examined using Correspondence Analysis, analyzing the patterns of associations. The results indicate an association between the most flexible internal cultural practices and a positive perception of the returns from the CSR and organizational results. Therefore, companies interested in enhancing their results should promote the internalization of flexible cultural principles, such as: privileging gender equality; providing employees direct access to their managers; fostering collective practices and interests; creating a free environment to question superiors and creating spaces to listen to employees. [ABSTRACT FROM AUTHOR]

Purpose: The study of energy balance [i.e., energy intake (EI) and energy expenditure (EE)] is a powerful tool for understanding body weight regulation and may contribute to our understanding of rapid weight gain risk in certain cancer survivors post-diagnosis. The purpose of this review was to summarize studies that assessed longitudinal, prospective changes in components of energy balance from diagnosis/start of treatment to any duration of follow-up in cancer survivors with prior evidence of weight gain (breast, prostate, thyroid, gynecologic, testicular, and acute lymphoblastic leukemia) Results: The available literature suggests that energy balance components may be altered in cancer survivors who have a heightened risk of weight gain post-diagnosis. The evidence for EI was overall inconsistent. Conversely, decreases in resting and physical activity EE during the active phases of treatment (e.g., chemotherapy, hypothyroid state) were commonly noted, which then slowly rebounded towards baseline levels at the end of treatment and during follow-up assessments. Much of this evidence is based on data collected from breast cancer survivors, which highlights a paucity of data currently available on other cancer types. Conclusions: While there is growing acknowledgement that weight management interventions in cancer survivors are needed, it is important to recognize that changes in both behavioral (EI, physical activity EE) and passive (resting EE, thermic effect of food) components of energy balance may occur post-diagnosis. This information can help to inform weight management interventions which often entail modifications in diet and/or physical activity. [ABSTRACT FROM AUTHOR]

Trichocolletes orientalis is an Australian solitary, ground-nesting bee, reported to have some unusual aspects to its nesting biology. Prime among these, and a focus for the present study, is the production of copious amounts of oil by post-feeding pre-defaecating larvae. To better understand the mechanism of oil production, we examined the bee’s floral resources and larval provisions and compared the fatty acid profiles of the provision and larval oil exudate using gas chromatography. The study population was monolectic on the legume Hardenbergia comptoniana. Unusually for Neopasiphaeinae, larval provisions were liquid but contained no obvious free oil. Differences in the fatty acid composition of the provision and larval oil lead us to conclude that larvae must secrete the oil. Fully fed larvae prevented from curling produced a yellowish, non-oily liquid from the anus. The Malpighian tubules are implicated in the production of this liquid and perhaps the oil (which has not been reported for any other bee species). While likely preventing water loss from resting larvae, the oil contains some fatty acids with known antimicrobial and antifungal properties and might protect the larvae from pathogens. Additionally, we provide a complete life cycle calendar for the bee. [ABSTRACT FROM AUTHOR]

In the last decade, there has been an increase in publications on technology-based interventions for autism spectrum disorder (ASD). Virtual reality based assessments and intervention tools are promising and have shown to be acceptable amongst individuals with ASD. This scoping review reports on 49 studies utilizing virtual reality and augmented reality technology in social skills interventions for individuals with ASD. The included studies mostly targeted children and adolescents, but few targeted very young children or adults. Our findings show that the mode number of participants with ASD is low, and that female participants are underrepresented. Our review suggests that there is need for studies that apply virtual and augmented realty with more rigorous designs involving established and evidenced-based intervention strategies. [ABSTRACT FROM AUTHOR]

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by progressive loss of pulmonary function. Drug-induced interstitial lung disease has been reported as a severe adverse effect of some drugs, such as bleomycin, amiodarone, and methotrexate. Based on good characteristics, drug-induced pulmonary fibrosis (PF) animal model has played a key role in our understanding of the molecular mechanisms of PF pathogenesis and recapitulates the specific pathology in patients and helps develop therapeutic strategies. Here, we summarize the mechanisms and characteristics of given fibrotic drug-induced animal models for PFs. Together with the key publications describing these models, this brief but detailed overview would be helpful for the pharmacological research with animal models of PFs. Potential mechanisms underlying drug induced lung toxicity. Highlights: Bleomycin mainly causes lung injuries via inducing DNA damage and bleomycin-ANXA2-YWHA-TFEB complex induces dysfunction of autophagy in AECs. Amiodarone mainly induces intracellular phospholipid accumulation (phospholipidosis) in AEC2s and alveolar macrophages. Methotrexate significantly promotes the epithelial-mesenchymal transition (EMT) process of AEC2s. Nitrogen mustard facilitates the activation and recruitment of macrophages. [ABSTRACT FROM AUTHOR]

In this research, we develop a reporting framework based on an ethical account of the Australian live sheep export (LSE) industry's current operations. We demonstrate that LSE operates within a legitimacy vacuum constituted by a repeated cycle of events that we characterize as scandal-response-obduracy with a constant factor being animal cruelty on an industrial scale. The lack of legitimacy is facilitated by an obdurate regulatory context, an absence of consumer awareness of industry practices, jurisdictional impediments to enforcement of animal cruelty laws and foundational epistemic vices upon which the industry calculates an unethical cost benefit analysis of current practice. While legitimacy theory would expect demise of the LSE industry, its prolonged continuation is more than a curiosity. It presents an opportunity to understand how focus on vice epistemics and reporting of animal welfare may contribute to emancipatory change in the form of improved animal welfare in agricultural industries. [ABSTRACT FROM AUTHOR]

Companies in the Water Industry present digital Corporate Social Responsibility (CSR) agenda and, also, the social and environmental commitment to their stakeholders through the websites. The purpose of this research is to assess the digital CSR in Portuguese companies of the Water Industry. Furthermore, the research examines factors that impacts on the digital status of the online disclosure. The authors analyze the CSR information published on their websites of the Portuguese companies, operating in bottle water industry using empirical analysis. The data was collected based on the Global Reporting Initiative (GRI 2021a) standards that details the level of disclosure in this industry and highlight areas of underreporting. The results point to factors that need to improve to companies' digital CSR report good practices and weak points based on the companies' size, number of employees and turnover as factors that influence this level of disclosure. [ABSTRACT FROM AUTHOR]

The SIMP (Solid Isotropic Material with Penalization) is one of the topology optimization methods. Its purpose is to eliminate material from those elements belonging to the design area for which the substitute material created during this process has a relatively low density. The article presents a method of designing and manufacturing a vehicle frame aimed for a student competition, which is comparable to practices used in large manufacturing companies. Topology optimization was applied in the design of the suspension and the frame of the three-wheeled vehicle. Optimization method SIMP was used, including "multiple load cases", where three load cases were analysed. Commercial Altair software: HyperWorks was used for structure optimization. The weight of the manufactured frame has been reduced by 57% while maintaining the appropriate rigidity of the vehicle structure. The resulting shape was the basis to develop a vehicle that took part in student competitions organized in Germany. The applied optimization was appreciated and the vehicle took, among others, second place in the category of "construction". [ABSTRACT FROM AUTHOR]

Objective: To explore the safety, and efficacy of a proprietary hydrolyzed oil extract from seeds of Biota orientalis (hBO/Epiitalis®, Interpath Pty Ltd) in patients with knee pain due to osteoarthritis (OA). Methods: Patients aged 40–65 with X-ray diagnosed knee OA and knee pain ≥ 60 on a 100-point VAS (visual analog scale) were enrolled and randomized into four groups to receive daily hBO for 56 days as high (hBO-HD, 640 mg), mid (hBO-MD, 320 mg) or low (hBO-LD, 160 mg) doses, or a matched placebo oil. The primary outcome was change in VAS knee pain from baseline to 56 days in the mITT (modified intention to treat) population. Exploratory outcomes were the mWOMAC (modified Western Ontario and McMaster Universities Arthritis Index), and the SF-36 QoL (quality of life) questionnaire. The OMERACT-OARSI (Outcome Measures in Arthritis Clinical Trials–Osteoarthritis Research Society International) responder index was also calculated. Results: 223 patients were included in the mITT population. Reductions in VAS scores between baseline and day 56 [Least square mean (LS mean) and 95% confidence interval (CI) of LS mean] were 36.4 (31.7–41.0), 37.9 (33.2–42.7), 35.7 (31.2–40.1) and 9.8 (14.5–15.2) for the hBO-HD, hBO-MD, hBO-LD, and placebo groups respectively. The VAS changes in all hBO groups were significantly different (p < 0.0001) vs. changes in the placebo group. hBO treatment led to similar quantitative beneficial changes in mWOMAC, SF-36 and OMERACT-OARSI responder index. There were no SAEs and no adverse events ascribed to the intervention. Conclusion: In a 56-day trial, hBO was safe, and was efficacious at reducing symptoms in patients with knee OA. Registration: NCT04117490; Oct 7, 2019. [ABSTRACT FROM AUTHOR]

Forest carbon offset (FCO) projects play an increasingly important role in mitigating climate change through market mechanisms in both compliance and voluntary markets. However, there are challenges and barriers to developing an FCO project, such as carbon leakage and cost-effectiveness. There have been few attempts to summarize and synthesize all types and aspects of existing challenges and possible solutions for FCO projects. This paper systematically reviews and discusses the current challenges involved in developing FCO projects, and then draws on the experience and lessons of existing projects to show how those challenges were addressed in world-leading voluntary carbon standards, namely the Verified Carbon Standard, the American Carbon Registry, the Climate Action Reserve, and Plan Vivo. These voluntary markets have rich experience in FCO projects and are responsible for a significant share of the market. From the 53 publications used in this analysis, three broad thematic categories of challenges emerged. These were related to methodology, socio-economic implications, and implementation. Methodological challenges, particularly additionality, permanence, and leakage, were the focus of 46% of the selected research papers, while socio-economic challenges, including transaction, social, and opportunity costs, were addressed by 35%. The remaining 19% of the research articles focused on implementational challenges related to monitoring, reporting, and verification. Major voluntary standards adequately addressed most of the methodological and implementational barriers by adopting various approaches. However, the standards did not adequately address socio-economic issues, despite these being the second most frequently discussed theme in the papers analyzed. More research is clearly needed on the socio-economic challenges involved in the development of FCO projects. For the development of high-quality forestry carbon offset projects, there are many challenges and no simple, universal recipe for addressing them. However, it is crucial to build upon the current science and move forward with carbon projects which ensure effective, long-term carbon sinks and maximize benefits for biodiversity and people; this is particularly important with a growing public and private interest in this field. [ABSTRACT FROM AUTHOR]

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The present theoretical study models a vertically aligned carbon nanotube (VACNT) array in plasma and structures its growth based on the variation of plasma operating conditions and process parameters. We investigate the consequence of plasma concentration, power, pressure and substrate temperature on the aspects of the VACNT array. Furthermore, the amorphous carbon deposition between the CNTs of the array is also examined. As field emission is one of the most outstanding applications of the VACNT array, the field enhancement factor for the array is also deliberated and optimized. The results are modelled, considering the balance of plasma species, plasma and CNT energy exchange, hydrocarbon and hydrogen generation over the catalyst nanoparticle, CNT array growth, and carbon deposition over the substrate between CNTs in VACNT array growth using plasma-enhanced chemical vapour deposition. The model is numerically solved by deliberating the experimental literature's initial conditions and plasma parameters. The aspects of an array, i.e. its length and average CNT diameter, can be optimized as desired by altering the operating conditions and glow discharge parameters. Additionally, the influence of array aspects on the field emission properties is observed. The results of the study are validated by the available experimental data. This theoretical study can be effectively used to grow the VACNT array and its optimization to obtain better field emitters. [ABSTRACT FROM AUTHOR]

Previous studies on the relationship between environmental performance and environmental disclosure have found mixed results. This exploratory qualitative study investigates the possible reasons for the environmental disclosures of nine companies listed in the top 200 Australian Securities Exchange (ASX) companies. This study reveals that the companies were more likely to disclose environmental information if their stakeholders, particularly from the financial markets (investors) and/or customers, demanded that they do so. Disclosure can then be seen as a function of stakeholders' demand or pressure, and in the absence of such a demand, firms may disclose little or remain silent. The good and poor environmental performers in this study, as rated by the Corporate Monitor ratings of environmental performance, tend to exhibit the same disclosure behaviour, which may indicate that the environmental disclosure may not necessarily reflect the actual performance. [ABSTRACT FROM AUTHOR]

In plotting the course for the discipline of sociology, sociologists over the past two decades have called for the practice of "public sociology" (Burawoy in American Sociological Review, 70(1), 4–28, 2005), for disciplinary convergence around a critical methodology (Carroll in Canadian Review of Sociology, 50(1), 1–26, 2013) and the devotion of our scholarly efforts to issues of social justice (Romero in American Sociological Review,85(1), 1–30, 2020). While public, critical, and social justice-oriented work is important, these disciplinary mandates can serve to marginalize other types of sociological work that are valuable as well. In this climate, work coming from perspectives that are not as left leaning politically, or that does not seek to advance any political agenda may be seen as less valued or legitimate, and scholars who choose to separate their political agendas from their research may experience marginalization (McLaughlin in Canadian Journal of Sociology, 30(1), 1–40, 2005; Pawluch in The American Sociologist,50, 204–219, 2019). Inspired by the work and doctoral mentorship of Dorothy Pawluch, this paper seeks to both understand the historical development of the field of Canadian sociology and consider the value and place of the interpretive tradition within it. Through reflecting on the research of others and my own experiences as a graduate student, I argue that the "chilly" climate Dorothy (Pawluch in The American Sociologist,50, 204–219, 2019) alludes to for scholars who operate outside of a politically informed "social-justice agenda" does exist, but that mentorship can help mediate this chill for interpretive leaning students. Finally, I suggest that the branch of the interpretive tradition which asks researchers to suspend their own perspectives and privilege the position of others still has value for Canadian sociology. It can both produce deep, meaningful research contributions and provide students with tools for engaging in productive intellectual debate and transformative encounters with difference. [ABSTRACT FROM AUTHOR]

China's Tibet autonomous region has abundant solar energy resources, cold winters, and cool summers. These are ideal conditions for the application of passive solar heating methods. However, differences in climatic conditions and building types can significantly affect passive solar technology's feasibility, which makes it challenging to promote passive solar buildings in Tibet. In this study, the suitability zone for passive solar technology is categorized based on the sub-zoning indicators for Tibet. By modeling between direct gain windows, Trombe walls, and attached sunspaces, the effect of indoor thermal environments and the capacity for heating load reduction is compared for different passive solar technologies. The climate-difference impact analysis shows that the I-B-1 zone is better suited for passive solar technology than other climate zones. More specifically, this zone has an average energy-saving rate difference of up to 28.61% compared to the II-A-1 zone. The analysis of the impact of building type differences indicates that residential buildings have higher Trombe wall-to-wall ratio limits and more significant potential for energy savings than office buildings. The study also clarifies the implications of Tibet's climate conditions and building type differences on the effectiveness of passive solar technology. Moreover, it recommends appropriate passive solar technology adoption methods for every climate zone. This study can be used as a reference and engineering guide to improving the indoor thermal environment of Tibetan buildings, tailored to the highly variable local conditions. [ABSTRACT FROM AUTHOR]