Search

Purpose of Review: Advances in computing have led to an explosion in digital health. This review discusses potential applications of digital technologies, their implications for patient care, and future directions at the intersection between nutrition and gastrointestinal (GI) conditions. Recent Findings: We present an array of digital technologies, including mobile applications, wearable devices, biosensors, artificial intelligence (AI), and telehealth, that have uses for GI nutrition. While having practical value, many are still limited to the early phases of development or have not yet been proven to provide clinical benefit. Summary: Digital health technologies offer unprecedented insight into the individual's health and lifestyle. AI technologies, coupled with the wealth of data collected, offer a path toward precision nutrition. Balanced against the incredible potential and promise of digital health, we should also recognize its limitations, particularly risks involving patient privacy and AI bias, when implementing these tools. Much more research is needed for creating, refining, and validating these technologies for GI nutrition before they can be more widely adopted in clinical practice. [ABSTRACT FROM AUTHOR]

The effect of pretreatment and simultaneous treatment with thiamine on therapeutic efficacy of calcium disodium edetate (CaNaEDTA) in lead intoxication was investigated in rats. The animals exposed to Pb as Pb (CHCOO)·3 HO through drinking water (0.1%) for 8 wk were treated with either saline, thiamine-HCl (sc), CaNaEDTA (ip), or thiamine-HCl plus CaNaEDTA, for 3 d or thiamine-HCl for 3 d followed by thiamine, then HCl plus CaNaEDTA for a further 3 d. The Pb exposure caused significant accumulation of Pb in liver, kideny, and brain, inhibition in the activity of blood δ-amino-levulinic acid dehydratase (δ-ALAD), and increase in levels of urinary δ-aminolevulinic acid, homovanillic acid (HVA), vanillyl mandelic acid (VMA), brain HVA and VMA. The brain δ-ALAD and lipomide dehydrogenase remained unaffected by Pb. Thiamine significantly enhanced the urinary excretion of Pb by CaNaEDTA, but only marginally influenced the efficacy of CaNaEDTA to either mobilize tissue Pb or reverse the biochemical alterations. [ABSTRACT FROM AUTHOR]

The influence of dietary iron deficiency, lead exposure or their combination on certain enzymes, and the accumulation of Pb and essential metal levels in vital organs of rats was investigated. Iron deficiency caused alterations in the activity of muscle, hepatic and renal succinate dehydrogenase, and hepatic mitochondrial succinate cytochrome c reductase, whereas Pb exposure had no influence on these enzymes. There was no synergistic effect of the two factors on the activity of the enzymes. However, feeding of a Fe-deficient diet during Pb exposure enhanced the accumulation of Pb in soft tissues and flat bones. The hepatic copper and zinc levels were lowered upon either feeding a Fe-deficient diet or Pb exposure. However, the synergistic effect of the two factors was evident in hepatic Cu, but not in hepatic Zn. The feeding of a Fe-deficient diet decreased liver, kidney, and spleen levels of Fe, whereas Pb exposure decreased kidney and spleen Fe. The synergistic influence of the two factors could be observed only in liver and kidney. [ABSTRACT FROM AUTHOR]

The influence of lead exposure, iron deficiency, or their combination on certain biochemical parameters in blood, plasma, and urine of rats was investigated in an attempt to identify the specific diagnostic tests of the two conditions and to draw a possible interrelationship between the two factors. The decrease in blood-glutathione peroxidase activity,-packed cell volume, plasma-ceruloplasmin, and-Fe levels and increase in urinary excretion of δ-aminolevulinic acid, plasma-cholesterol, and-total Fe binding capacity occur under Fe deficiency as well as Pb intoxication. However, increase in the activity of blood δ-aminolevulinic acid dehydratase (ALAD) without any change in blood zinc protoporphyrin (ZPP) level appears to be a specific effect of Fe deficiency that could be distinguished from Pb intoxication, a condition characterized by the inhibition in blood ALAD activity accompanied by an increase in blood ZPP level. The linear regression analysis of the data showed that the blood Pb and plasma free cholesterol levels increase with the decrease in plasma Fe level. [ABSTRACT FROM AUTHOR]

The influence of the administration of thiamin (vitamin B), ascorbic acid (vitamin C) or their combination on the efficacy of two thiol metal chelators, viz. α-mercapto-β-(2-furyl) acrylic acid (MFA) and 2,3-dimercaptosuccinic acid (DMS), in counteracting lead (Pb) toxicity was investigated in rats. Ascorbic acid or its combination with thiamine enhanced the urinary elimination of Pb, reduced the hepatic and renal burden of Pb, and reversed the Pb-induced inhibition of the activity of blood 5-aminolevulinic acid dehydratase (δ-ALA-D). All these effects were more evident in DMS- than in MFA-treated rats. The combination of MFA and DMS treatments further improved the performance of the animals in enhancing urinary Pb excretion and in reducing Pb hepatic levels. [ABSTRACT FROM AUTHOR]

We consider the quiver Yangians associated to general affine Dynkin diagrams. Although the quivers are generically not toric, the algebras have some similar structures. The odd reflections of the affine Dynkin diagrams should correspond to Seiberg duality of the quivers, and we investigate the relations of the dual quiver Yangians. We also mention the construction of the twisted quiver Yangians. It is conjectured that the truncations of the (twisted) quiver Yangians can give rise to certain 풲-algebras. Incidentally, we give the screening currents of the 풲-algebras in terms of the free field realization in the case of generalized conifolds. Moreover, we discuss the toroidal and elliptic algebras for any general quivers. [ABSTRACT FROM AUTHOR]

We study global anomalies of discrete gauge symmetries in six-dimensional supergravities and their realizations in F-theory. We explicitly construct a discrete Green-Schwarz mechanism that depends on the choice of a coupling constant and on a certain quadratic refinement in differential cohomology. By geometrically engineering theories with G = ℤ3 gauge symmetry and no tensor multiplets, we observe that a particular choice of the quadratic refinement is singled out in F-theory. This implies new Swampland constraints on the discrete charge spectra of 6d supergravities. On the other hand, the discrete Green-Schwarz coupling depends on the geometry of the Calabi-Yau. We use anomaly inflow to relate this to a 't Hooft anomaly of the induced global symmetry in the worldsheet theories of non-critical strings. Using topological symmetry lines, we further relate this anomaly to the modular properties of twisted-twined elliptic genera. We then argue that the latter are encoded in the A-model topological string partition functions on different torus fibrations that are equipped with a flat torsional B-field. This allows us to derive a geometric expression for the global discrete anomaly in terms of the height-pairing of a multi-section on a genus one fibered Calabi-Yau. [ABSTRACT FROM AUTHOR]

We study global anomalies of discrete gauge symmetries in six-dimensional supergravities and their realizations in F-theory. We explicitly construct a discrete Green-Schwarz mechanism that depends on the choice of a coupling constant and on a certain quadratic refinement in differential cohomology. By geometrically engineering theories with G = ℤ3 gauge symmetry and no tensor multiplets, we observe that a particular choice of the quadratic refinement is singled out in F-theory. This implies new Swampland constraints on the discrete charge spectra of 6d supergravities. On the other hand, the discrete Green-Schwarz coupling depends on the geometry of the Calabi-Yau. We use anomaly inflow to relate this to a 't Hooft anomaly of the induced global symmetry in the worldsheet theories of non-critical strings. Using topological symmetry lines, we further relate this anomaly to the modular properties of twisted-twined elliptic genera. We then argue that the latter are encoded in the A-model topological string partition functions on different torus fibrations that are equipped with a flat torsional B-field. This allows us to derive a geometric expression for the global discrete anomaly in terms of the height-pairing of a multi-section on a genus one fibered Calabi-Yau. [ABSTRACT FROM AUTHOR]

We study the massless charged spectrum of U(1) gauge fields in F-theory that arise from flux breaking of a nonabelian group. The U(1) charges that arise in this way can be very large. In particular, using vertical flux breaking, we construct an explicit 4D F-theory model with a U(1) decoupled from other gauge sectors, in which the massless/light fields have charges as large as 657. This result greatly exceeds prior results in the literature. We argue heuristically that this result may provide an upper bound on charges for light fields under decoupled U(1) factors in the F-theory landscape. We also show that the charges can be even larger when the U(1) is coupled to other gauge groups. [ABSTRACT FROM AUTHOR]

We study the massless charged spectrum of U(1) gauge fields in F-theory that arise from flux breaking of a nonabelian group. The U(1) charges that arise in this way can be very large. In particular, using vertical flux breaking, we construct an explicit 4D F-theory model with a U(1) decoupled from other gauge sectors, in which the massless/light fields have charges as large as 657. This result greatly exceeds prior results in the literature. We argue heuristically that this result may provide an upper bound on charges for light fields under decoupled U(1) factors in the F-theory landscape. We also show that the charges can be even larger when the U(1) is coupled to other gauge groups. [ABSTRACT FROM AUTHOR]

We give a general description of gauge symmetry breaking using vertical and remainder fluxes in 4D F-theory models. The fluxes can break a geometric gauge group to a smaller group and induce chiral matter, even when the larger group admits no chiral matter representations. We focus specifically on applications to realizations of the Standard Model gauge group and chiral matter spectrum through breaking of rigid exceptional gauge groups E7, E6, which are ubiquitous in the 4D F-theory landscape. Supplemented by an intermediate SU(5) group, these large classes of models give natural constructions of Standard Model-like theories with small numbers of generations of matter in F-theory. [ABSTRACT FROM AUTHOR]

In F-theory, if a fiber type of an elliptic fibration involves a condition that requires an exceptional curve to split into two irreducible components, it is called “split” or “non-split” type depending on whether it is globally possible or not. In the latter case, the gauge symmetry is reduced to a non-simply-laced Lie algebra due to monodromy. We show that this split/non-split transition is, except for a special class of models, a conifold transition from the resolved to the deformed side, associated with the conifold singularities emerging where the codimension-one singularity is enhanced to D2k+2 (k ≥ 1) or E7. We also examine how the previous proposal for the origin of non-local matter can be actually implemented in our blow-up analysis. [ABSTRACT FROM AUTHOR]

With the development of 16S rRNA technology, gut microbiome evaluation has been performed in many diseases, including gastrointestinal tumors. Among these cancers, gastric cancer (GC) exhibits high morbidity and mortality and has been extensively studied in its pathogenesis and diagnosis techniques. The current researches have proved that the gut microbiome may have the potential to distinguish GC patients from healthy patients. However, the change of the gut microbiome according to tumor node metastasis classification (TNM) has not been clarified. Besides, the characteristics of gut microbiome in GC patients and their ages of onset are also ambiguous. To address the above shortcomings, we investigated 226 fecal samples and divided them according to their tumor stage and onset age. The findings revealed that surgery and tumor stage can change the characteristic of GC patients' gut microbiota. In specific, the effect of surgery on early gastric cancer (EGC) was greater than that on advanced gastric cancer (AGC), and the comparison of postoperative microflora with healthy people indicated that EGC has more differential bacteria than AGC. Besides, we found that Collinsella, Blautia, Anaerostipes, Dorea, and Lachnospiraceae_ND3007_group expressed differently between EGC and AGC. More importantly, it is the first time revealed that the composition of gut microbiota in GC is different between different onset ages. Key points: •Gut microbiota of gastric cancer (GC) patients are either highly associated with TNM stage and surgery or not. It shows surgery has more significant changes in early gastric cancer (EGC) than advanced gastric cancer (AGC). •There existed specific gut microbiota between EGC and AGC which may have potential to distinguish the early or advanced GC. •Onset age of GC may influence the gut microbiota: the composition of gut microbiota of early-onset gastric cancer (EOGC) and late-onset gastric cancer (LOGC) is significantly different. [ABSTRACT FROM AUTHOR]

We investigate infinite distance limits in the complex structure moduli space of F-theory compactified on K3 to eight dimensions. While this is among the simplest possible arenas to test ideas about the Swampland Distance Conjecture, it is nevertheless non-trivial enough to improve our understanding of the physics for these limiting geometries, including phenomena of emergence. It also provides a perspective on infinite distance limits from the viewpoint of open strings. The paper has two quite independent themes. In the main part we show that all degenerations of elliptic K3 surfaces at infinite distance as analysed in the companion paper [1] can be interpreted as (partial) decompactification or emergent string limits in F-theory, in agreement with the Emergent String Conjecture. We present a unified geometric picture of the possible towers of states that can become light and illustrate our general claims via the connection between Kulikov models of degenerating K3 surfaces and the dual heterotic string. As an application we classify the possible maximal non-abelian Lie algebras and their Kac-Moody and loop extensions that can arise in the infinite distance limits. In the second part we discuss the infinite distance behaviour of certain exact quartic gauge couplings. We encounter a tension with the hypothesis that effective couplings should be fully generated by integrating out massive states. We show that by appropriately renormalizing the string coupling, at least partial emergence can be achieved. [ABSTRACT FROM AUTHOR]

We extend the investigation in [1] of special toroidal compactifications of heterotic string theory for which the half-BPS states provide representations of subgroups of the Conway group. We also explore dual descriptions of these theories and find that they are all linked to either F-theory or type IIA string theory on K3 surfaces with symplectic automorphism groups that are the same Conway subgroups as those of the heterotic dual. The matching with type IIA K3 dual theories includes both the matching of symmetry groups and a comparison between the Narain lattice on the heterotic side and the cohomology lattice on the type IIA side. We present twelve examples where we can identify a type IIA dual K3 orbifold theory as the dual description of the heterotic theory. In addition, we include a supplementary Mathematica package that performs most of the computations required for these comparisons. [ABSTRACT FROM AUTHOR]

Many interesting questions about F-theory models, including several concerning the F-theory swampland, involve massless matter charged under U(1) gauge symmetries. It is therefore important to better understand the geometric properties of F-theory models realizing various U(1) charges. We propose that, for F-theory models described by elliptic fibrations in Weierstrass form, the U(1) charge of light matter is encoded in the orders of vanishing of the section components corresponding to the U(1) gauge symmetry. We give specific equations relating the U(1) charges to the orders of vanishing that seem to hold for both U(1)-charged singlets and for matter additionally charged under a simply-laced nonabelian gauge algebra. Our formulas correctly describe properties of F-theory models in the prior literature, and we give an argument that they should describe the orders of vanishing for arbitrarily high U(1) charges. They also resemble formulas for the p-adic valuations of elliptic divisibility sequences developed by Stange [1]. These proposals could serve as a U(1) analogue of the Katz-Vafa method, allowing one to determine U(1) charges without resolution. Additionally, they predict geometric information about F-theory models with general U(1) charges, which may be useful for exploring the F-theory landscape and swampland. [ABSTRACT FROM AUTHOR]

We study the phase transition between G-instantons and D3-branes quantitatively. A G-instanton is a classical solution to the self-dual equation of the M/F-theory three-form tensor field C in the complex fourfold. This phase transition is dual to that between 'vertical' small instantons and 5-branes in the heterotic string. Using G as a background gauge flux, we may dynamically control the gauge symmetry breaking and connect between different vacua of F-theory. We may understand the amount of flux undergoing the phase transition and the resulting number of D3-branes in terms of group-theoretical quantities. We also discuss the resulting chirality change and preservation of anomaly freedom. [ABSTRACT FROM AUTHOR]

We analyze the de Sitter construction of [1] using ten-dimensional supergravity, finding exact agreement with the four-dimensional effective theory. Starting from the fermionic couplings in the D7-brane action, we derive the ten-dimensional stress-energy due to gaugino condensation on D7-branes. We demonstrate that upon including this stress-energy, as well as that due to anti-D3-branes, the ten-dimensional equations of motion require the four-dimensional curvature to take precisely the value determined by the four-dimensional effective theory of [1]. [ABSTRACT FROM AUTHOR]

We prove that, for every 6D supergravity theory that has an F-theory description, the property of charge completeness for the connected component of the gauge group (meaning that all charges in the corresponding charge lattice are realized by massive or massless states in the theory) is equivalent to a standard assumption made in F-theory for how geometry encodes the global gauge theory by means of the Mordell-Weil group of the elliptic fibration. This result also holds in 4D F-theory constructions for the parts of the gauge group that come from sections and from 7-branes. We find that in many 6D F-theory models the full charge lattice of the theory is generated by massless charged states; this occurs for each gauge factor where the associated anomaly coefficient satisfies a simple positivity condition. We describe many of the cases where this massless charge sufficiency condition holds, as well as exceptions where the positivity condition fails, and analyze the related global structure of the gauge group and associated Mordell-Weil torsion in explicit F-theory models. [ABSTRACT FROM AUTHOR]

We construct novel web diagrams with a trivalent or quadrivalent gluing for various 6d/5d theories from certain Higgsings of 6d conformal matter theories on a circle. The theories realized on the web diagrams include 5d Kaluza-Klein theories from circle compactifications of the 6d G2 gauge theory with 4 flavors, the 6d F4 gauge theory with 3 flavors, the 6d E6 gauge theory with 4 flavors and the 6d E7 gauge theory with 3 flavors. The Higgsings also give rise to 5d Kaluza-Klein theories from twisted compactifications of 6d theories including the 5d pure SU(3) gauge theory with the Chern-Simons level 9 and the 5d pure SU(4) gauge theory with the Chern-Simons level 8. We also compute the Nekrasov partition functions of the theories by applying the topological vertex formalism to the newly obtained web diagrams. [ABSTRACT FROM AUTHOR]

We observe that in many F-theory models, tuning a specific gauge group G and matter content M under certain circumstances leads to an automatic enhancement to a larger gauge group G′ ⊃ G and matter content M′ ⊃ M. We propose that this is true for any theory G, M whenever there exists a containing theory G′, M′ that cannot be Higgsed down to G, M. We give a number of examples including non-Higgsable gauge factors, nonabelian gauge factors, abelian gauge factors, and exotic matter. In each of these cases, tuning an F-theory model with the desired features produces either an enhancement or an inconsistency, often when the associated anomaly coefficient becomes too large. This principle applies to a variety of models in the apparent 6D supergravity swampland, including some of the simplest cases with U(1) and SU(N) gauge groups and generic matter, as well as infinite families of U(1) models with higher charges presented in the prior literature, potentially ruling out all these apparent swampland theories. [ABSTRACT FROM AUTHOR]

We extend the dictionary between the BPS spectrum of Heterotic strings and the one of F-/M-theory compactifications on K3 fibered Calabi-Yau 3-folds to cases with higher rank non-Abelian gauge groups and in particular to dual pairs between Heterotic CHL orbifolds and compactifications on Calabi-Yau 3-folds with a compatible genus one fibration. We show how to obtain the new supersymmetric index purely from the Calabi-Yau geometry by reconstructing the Noether-Lefschetz generators, which are vector-valued modular forms. There is an isomorphism between the latter objects and vector-valued lattice Jacobi forms, which relates them to the elliptic genera and twisted-twined elliptic genera of six- and five-dimensional Heterotic strings. The meromorphic Jacobi forms generate the dimensions of the refined cohomology of the Hilbert schemes of symmetric products of the fiber and allow us to refine the BPS indices in the fiber and therefore to obtain, conjecturally, actual state counts. Using the properties of the vector-valued lattice Jacobi forms we also provide a mathematical proof of the non-Abelian weak gravity conjecture for F-/M-theory compactified on this general class of fibered Calabi-Yau 3-folds. [ABSTRACT FROM AUTHOR]

Using topological string techniques, we compute BPS counting functions of 5d gauge theories which descend from 6d superconformal field theories upon circle compactification. Such theories are naturally organized in terms of nodes of Higgsing trees. We demonstrate that the specialization of the partition function as we move from the crown to the root of a tree is determined by homomorphisms between rings of Weyl invariant Jacobi forms. Our computations are made feasible by the fact that symmetry enhancements of the gauge theory which are manifest on the massless spectrum are inherited by the entire tower of BPS particles. In some cases, these symmetry enhancements have a nice relation to the 1-form symmetry of the associated gauge theory. [ABSTRACT FROM AUTHOR]

In this paper, we initiate the study of the 2d F-theory landscape based on compact elliptic Calabi-Yau fivefolds. In particular, we determine the boundary models of the landscape using Calabi-Yau fivefolds with the largest known Hodge numbers h1,1 and h4,1. The former gives rise to the largest geometric gauge group in the currently known 2d (0,2) supergravity landscape, which is E 8 482 632 421 × F 4 3 224 195 728 × G 2 11 927 989 964 × SU 2 25 625 222 180 . Besides that, we systematically study the hypersurfaces in weighted projective spaces with small degrees, and check the gravitational anomaly cancellation. Moreover, we also initiate the study of singular bases in 2d F-theory. We find that orbifold singularities on the base fourfold have non-zero contributions to the gravitational anomaly. [ABSTRACT FROM AUTHOR]

Five- and four-dimensional superconformal field theories with eight supercharges arise from canonical threefold singularities in M-theory and Type IIB string theory, respectively. We study their Coulomb and Higgs branches using crepant resolutions and deformations of the singularities. We propose a relation between the resulting moduli spaces, by compactifying the theories to 3d, followed by 3d N = 4 mirror symmetry and an S-type gauging of an abelian flavor symmetry. In particular, we use this correspondence to determine the Higgs branch of some 5d SCFTs and their magnetic quivers from the geometry. As an application of the general framework, we observe that singularities that engineer Argyres-Douglas theories in Type IIB also give rise to rank-0 5d SCFTs in M-theory. We also compute the higher-form symmetries of the 4d and 5d SCFTs, including the one-form symmetries of generalized Argyres-Douglas theories of type (G, G′). [ABSTRACT FROM AUTHOR]

Glauber-Sudarshan states, sometimes simply referred to as Glauber states, or alternatively as coherent and squeezed-coherent states, are interesting states in the configuration spaces of any quantum field theories, that closely resemble classical trajectories in space-time. In this paper, we identify four-dimensional de Sitter space as a coherent state over a supersymmetric Minkowski vacuum. Although such an identification is not new, what is new however is the claim that this is realizable in full string theory, but only in conjunction with temporally varying degrees of freedom and quantum corrections resulting from them. Furthermore, fluctuations over the de Sitter space is governed by a generalized graviton (and flux)-added coherent state, also known as the Agarwal-Tara state. The realization of de Sitter space as a state, and not as a vacuum, resolves many issues associated with its entropy, zero-point energy and trans-Planckian censorship, amongst other things. [ABSTRACT FROM AUTHOR]

We determine 5d N = 1 SCFTs originating from 6d (En, Em) conformal matter theories with n ≠ m by circle reduction and mass deformations. The marginal geometries are constructed and we derive their combined fiber diagrams (CFDs). The CFDs allow for an enumeration of descendant SCFTs obtained by decoupling matter hypermultiplets and a description of candidate weakly coupled quivers. [ABSTRACT FROM AUTHOR]

Interaction between L-methionine (Met) and nicotinic acid (NA) in an aqueous buffer solution (pH 7.4) is studied via dissolution calorimetry and densimetry. The thermodynamic characteristics of the formation of a 1 : 1 molecular complex between Met and L at Т = 298.15 K are determined. The experimental density of the Met–L–buffer system is measured at T = 288.15, 298.15, 303.15, 308.15, and 313.15 K in the 0.0036 to 0.0367 mol/kg range of NA concentrations at a constant Met concentration (0.01249 mol/kg). It is shown that the extreme character of apparent molar volume–concentration dependences suggests the structure-strengthening effect NA has on solutions containing the amino acid (Met) with a slight shift of maxima with increasing temperature. The results are discussed in the context of the Gurney model. [ABSTRACT FROM AUTHOR]

We focus on 4D N = 2 string vacua described both by perturbative Heterotic theory and by Type IIA theory; a Calabi-Yau three-fold XIIA in the Type IIA language is further assumed to have a regular K3-fibration. It is well-known that one can assign a modular form Φ to such a vacuum by counting perturbative BPS states in Heterotic theory or collecting Noether-Lefschetz numbers associated with the K3-fibration of XIIA. In this article, we expand the observations and ideas (using gauge threshold correction) in the literature and formulate a modular form Ψ with full generality for the class of vacua above, which can be used along with Φ for the purpose of classification of those vacua. Topological invariants of XIIA can be extracted from Φ and Ψ, and even a pair of diffeomorphic Calabi-Yau's with different Kähler cones may be distinguished by introducing the notion of "the set of Ψ's for Higgs cascades/for curve classes". We illustrated these ideas by simple examples. [ABSTRACT FROM AUTHOR]

We construct a general form for an F-theory Weierstrass model over a general base giving a 6D or 4D supergravity theory with gauge group (SU(3) × SU(2) × U(1))/ℤ6 and generic associated matter, which includes the matter content of the standard model. The Weierstrass model is identified by unHiggsing a model with U(1) gauge symmetry and charges q ≤ 4 previously found by the first author. This model includes two distinct branches that were identified in earlier work, and includes as a special case the class of models recently studied by Cvetič, Halverson, Lin, Liu, and Tian, for which we demonstrate explicitly the possibility of unification through an SU(5) unHiggsing. We develop a systematic methodology for checking that a parameterized class of F-theory Weierstrass models with a given gauge group G and fixed matter content is generic (contains all allowed moduli) and confirm that this holds for the models constructed here. [ABSTRACT FROM AUTHOR]

We examine the proposal in the previous paper to resolve the puzzle in transitions in discrete gauge groups. We focus on a four-section geometry to test the proposal. We observed that a discrete ℤ2 gauge group enlarges and U(1) also forms in F-theory along any bisection geometries locus in the four-section geometry built as the complete intersections of two quadrics in ℙ3 fibered over any base. Furthermore, we demonstrate that giving vacuum expectation values to hypermultiplets breaks the enlarged U(1) × ℤ2 gauge group down to a discrete ℤ4 gauge group via Higgsing. We thus confirmed that the proposal in the previous paper is consistent when a four-section splits into a pair of bisections in the four-section geometry. This analysis may be useful for understanding the Higgsing processes occurring in the transitions in discrete gauge groups in six-dimensional F-theory models. We also discuss the construction of a family of six-dimensional F-theory models in which U(1) × ℤ4 forms. [ABSTRACT FROM AUTHOR]

In this study, we introduce a new class of rational elliptic 3-folds, which we refer to as “1/2 Calabi-Yau 3-folds”. We construct elliptically fibered Calabi-Yau 3-folds by utilizing these rational elliptic 3-folds. The construction yields a novel approach to build elliptically fibered Calabi-Yau 3-folds of various Mordell-Weil ranks. Our construction of Calabi-Yau 3-folds can be considered as a three-dimensional generalization of the operation of gluing pairs of 1/2 K3 surfaces to yield elliptic K3 surfaces. From one to seven U(1)s form in six-dimensional N = 1 F-theory on the constructed Calabi-Yau 3-folds. Seven tensor multiplets arise in these models. [ABSTRACT FROM AUTHOR]

We argue that global F-theory compactifications to four dimensions gener- ally exhibit higher rank Yukawa matrices from multiple geometric contributions known as Yukawa points. The holomorphic couplings furthermore have large hierarchies for generic complex structure moduli. Unlike local considerations, the compact setup realizes these features all through geometry, and requires no instanton corrections. As an example, we consider a concrete toy model with SU(5) × U(1) gauge symmetry. From the geometry, we find two Yukawa points for the 1 0 − 2 5 ¯ 6 5 ¯ − 4 coupling, producing a rank two Yukawa matrix. Our methods allow us to track all complex structure dependencies of the holomorphic couplings and study the ratio numerically. This reveals hierarchies of O (105) and larger on a full-dimensional subspace of the moduli space. [ABSTRACT FROM AUTHOR]

We apply machine learning techniques to solve a specific classification problem in 4D F-theory. For a divisor D on a given complex threefold base, we want to read out the non-Higgsable gauge group on it using local geometric information near D. The input features are the triple intersection numbers among divisors near D and the output label is the non-Higgsable gauge group. We use decision tree to solve this problem and achieved 85%-98% out-of-sample accuracies for different classes of divisors, where the data sets are generated from toric threefold bases without (4,6) curves. We have explicitly generated a large number of analytic rules directly from the decision tree and proved a small number of them. As a crosscheck, we applied these decision trees on bases with (4,6) curves as well and achieved high accuracies. Additionally, we have trained a decision tree to distinguish toric (4,6) curves as well. Finally, we present an application of these analytic rules to construct local base configurations with interesting gauge groups such as SU(3). [ABSTRACT FROM AUTHOR]

Using a one-way Monte Carlo algorithm from several different starting points, we get an approximation to the distribution of toric threefold bases that can be used in four-dimensional F-theory compactification. We separate the threefold bases into 'resolvable' ones where the Weierstrass polynomials ( f, g) can vanish to order (4 , 6) or higher on codimension-two loci and the 'good' bases where these (4 , 6) loci are not allowed. A simple estimate suggests that the number of distinct resolvable base geometries exceeds 10, with over 10 'good' bases, though the actual numbers are likely much larger. We find that the good bases are concentrated at specific 'end points' with special isolated values of h that are bigger than 1,000. These end point bases give Calabi-Yau fourfolds with specific Hodge numbers mirror to elliptic fibrations over simple threefolds. The non-Higgsable gauge groups on the end point bases are almost entirely made of products of E, F, G and SU(2). Nonetheless, we find a large class of good bases with a single non-Higgsable SU(3). Moreover, by randomly contracting the end point bases, we find many resolvable bases with h( B) ∼ 50-200 that cannot be contracted to another smooth threefold base. [ABSTRACT FROM AUTHOR]

We show that F-theory compactifications with abelian gauge factors generally exhibit a non-trivial global gauge group structure. The geometric origin of this structure lies with the Shioda map of the Mordell-Weil generators. This results in constraints on the $$ \mathfrak{u}(1) $$ charges of non-abelian matter consistent with observations made throughout the literature. In particular, we find that F-theory models featuring the Standard Model algebra actually realise the precise gauge group [SU(3) × SU(2) × U(1)]/ ℤ . Furthermore, we explore the relationship between the gauge group structure and geometric (un-)higgsing. In an explicit class of models, we show that, depending on the global group structure, an $$ \mathfrak{s}\mathfrak{u}(2)\oplus \mathfrak{u}(1) $$ gauge theory can either unhiggs into an SU(2) × SU(2) or an SU(3) × SU(2) theory. We also study implications of the charge constraints as a criterion for the F-theory 'swampland'. [ABSTRACT FROM AUTHOR]

Supergravity theories in more than four dimensions with grand unified gauge symmetries are an important intermediate step towards the ultraviolet completion of the Standard Model in string theory. Using toric geometry, we classify and analyze six-dimensional F-theory vacua with gauge group SO(10) taking into account Mordell-Weil U(1) and discrete gauge factors. We determine the full matter spectrum of these models, including charged and neutral SO(10) singlets. Based solely on the geometry, we compute all matter multiplicities and confirm the cancellation of gauge and gravitational anomalies independent of the base space. Particular emphasis is put on symmetry enhancements at the loci of matter fields and to the frequent appearance of superconformal points. They are linked to non-toric Kähler deformations which contribute to the counting of degrees of freedom. We compute the anomaly coefficients for these theories as well by using a base-independent blow-up procedure and superconformal matter transitions. Finally, we identify six-dimensional supergravity models which can yield the Standard Model with high-scale supersymmetry by further compactification to four dimensions in an Abelian flux background. [ABSTRACT FROM AUTHOR]

Using E-strings, we can analyze not only six-dimensional superconformal field theories but also probe vacua of non-perturabative heterotic string. We study strings made of D3-branes wrapped on various two-cycles in the global F-theory setup. We claim that E-strings are elementary in the sense that various combinations of E-strings can form M-strings as well as heterotic strings and new kind of strings, called G-strings. Using them, we show that emissions and combinations of heterotic small instantons generate most of known six-dimensional superconformal theories, their affinizations and little string theories. Taking account of global structure of compact internal geometry, we also show that special combinations of E-strings play an important role in constructing six-dimensional theories of D- and E-types. We check global consistency conditions from anomaly cancellation conditions, both from five-branes and strings, and show that they are given in terms of elementary E-string combinations. [ABSTRACT FROM AUTHOR]

According to a recent classification of 6d (1 , 0) theories within F-theory there are only six 'pure' 6d gauge theories which have a UV superconformal fixed point. The corresponding gauge groups are SU(3) , SO(8) , F , E , E , and E . These exceptional models have BPS strings which are also instantons for the corresponding gauge groups. For G simply-laced, we determine the 2d $$ \mathcal{N}=\left(0,4\right) $$ worldsheet theories of such BPS instanton strings by a simple geometric engineering argument. These are given by a twisted S compactification of the 4d $$ \mathcal{N}=2 $$ theories of type H , D , E , E and E (and their higher rank generalizations), where the 6d instanton number is mapped to the rank of the corresponding 4d SCFT. This determines their anomaly polynomials and, via topological strings, establishes an interesting relation among the corresponding T × S partition functions and the Hilbert series for moduli spaces of G instantons. Such relations allow to bootstrap the corresponding elliptic genera by modularity. As an example of such procedure, the elliptic genera for a single instanton string are determined. The same method also fixes the elliptic genus for case of one F instanton. These results unveil a rather surprising relation with the Schur index of the corresponding 4d $$ \mathcal{N}=2 $$ models. [ABSTRACT FROM AUTHOR]

Starting from 6D superconformal field theories (SCFTs) realized via F-theory, we show how reduction on a circle leads to a uniform perspective on the phase structure of the resulting 5D theories, and their possible conformal fixed points. Using the correspon-dence between F-theory reduced on a circle and M-theory on the corresponding elliptically fibered Calabi-Yau threefold, we show that each 6D SCFT with minimal supersymmetry directly reduces to a collection of between one and four 5D SCFTs. Additionally, we find that in most cases, reduction of the tensor branch of a 6D SCFT yields a 5D generalization of a quiver gauge theory. These two reductions of the theory often correspond to different phases in the 5D theory which are in general connected by a sequence of flop transitions in the extended Kähler cone of the Calabi-Yau threefold. We also elaborate on the structure of the resulting conformal fixed points, and emergent flavor symmetries, as realized by M-theory on a canonical singularity. [ABSTRACT FROM AUTHOR]

We determine the discrete gauge symmetries that arise in F-theory compactifications on examples of genus-one fibered Calabi-Yau 4-folds without a section. We construct genus-one fibered Calabi-Yau 4-folds using Fano manifolds, cyclic 3-fold covers of Fano 4-folds, and Segre embeddings of products of projective spaces. Discrete ℤ , ℤ , ℤ and ℤ symmetries arise in these constructions. We introduce a general method to obtain multisections for several constructions of genus-one fibered Calabi-Yau manifolds. The pullbacks of hyperplane classes under certain projections represent multisections to these genus-one fibrations. We determine the degrees of these multisections by computing the intersection numbers with fiber classes. As a result, we deduce the discrete gauge symmetries that arise in F-theory compactifications. This method applies to various Calabi-Yau genus-one fibrations. [ABSTRACT FROM AUTHOR]

Warped higher-dimensional compactifications with "bulk" standard model, or their AdS/CFT dual as the purely 4D scenario of Higgs compositeness and partial compositeness, offer an elegant approach to resolving the electroweak hierarchy problem as well as the origins of avor structure. However, low-energy electroweak/avor/CP constraints and the absence of non-standard physics at LHC Run 1 suggest that a "little hierarchy problem" remains, and that the new physics underlying naturalness may lie out of LHC reach. Assuming this to be the case, we show that there is a simple and natural extension of the minimal warped model in the Randall-Sundrum framework, in which matter, gauge and gravitational fields propagate modestly different degrees into the IR of the warped dimension, resulting in rich and striking consequences for the LHC (and beyond). The LHC-accessible part of the new physics is AdS/CFT dual to the mechanism of "vectorlike confinement", with TeV-scale Kaluza-Klein excitations of the gauge and gravitational fields dual to spin-0,1,2 composites. Unlike the minimal warped model, these low-lying excitations have predominantly avor-blind and avor/CP-safe interactions with the standard model. Remarkably, this scenario also predicts small deviations from avor-blindness originating from virtual effects of Higgs/top compositeness at ~ O(10) TeV, with subdominant resonance decays into Higgs/top-rich final states, giving the LHC an early "preview" of the nature of the resolution of the hierarchy problem. Discoveries of this type at LHC Run 2 would thereby anticipate (and set a target for) even more explicit explorations of Higgs compositeness at a 100TeV collider, or for next-generation avor tests. [ABSTRACT FROM AUTHOR]

We study global symmetry groups of six-dimensional superconformal field theories (SCFTs). In the Coulomb branch we use field theoretical arguments to predict an upper bound for the global symmetry of the SCFT. We then analyze global symmetry groups of F-theory constructions of SCFTs with a one-dimensional Coulomb branch. While in the vast majority of cases, all of the global symmetries allowed by our Coulomb branch analysis can be realized in F-theory, in a handful of cases we find that F-theory models fail to realize the full symmetry of the theory on the Coulomb branch. In one particularly mysterious case, F-theory models realize several distinct maximal subgroups of the predicted group, but not the predicted group itself. [ABSTRACT FROM AUTHOR]