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The article highlights a study which investigated the use of ligandbased design strategy targeting a G protein-coupled receptor (GPCR) on platelets to identify a novel antiplatelet agent that does not prolong bleeding and can be used for more effective antiplatelet therapy. The authors compared the in vivo effects of the DG-041 compound on platelet function and bleeding time with clopidogrel. DG-041 was found to inhibit platelet aggregation with no concurrent increase in bleeding time.

The article focuses on the research on neuroprotective effects of brain-derived neurotrophic factor (BDNF) in different Alzheimer's disease models. It references a study by A.H. Nagahara et al published in the 2009 issue of "Nature Medicine." It is hypothesizes that gene therapy which involves BDNF delivery to the entorhinal region might improve Alzheimer's disease by reducing neurodegeneration. The research study uses both a transgenic mouse and aged rats in order to test the hypothesis.