Search

Aquaculture sector is considered an important economic activity both at global and European levels. It contributes in food security, employment, and social cohesion especially in coastal areas. Furthermore, it provides high nutritional value products and plays a significant role in constant supply of fish products in the market. However, major marketing challenges are observed within the sector. Particularly, product communication is considered a major marketing issue as it has been indicated by a plethora of studies. Notably, it has been observed that there is a higher consumer preference of captured fish versus farmed fish, especially in coastal areas. This is due to the fact that there is a substantial consumer knowledge gap regarding aquaculture production process. Interestingly, this is also being observed in organic aquaculture sector, indicating a substantial consumer knowledge gap and consequently consumer confusion unable to identify the added value of organic aquaculture products. Therefore, the present study aims to review the literature regarding consumer knowledge and confusion in aquaculture production. Thus, a scoping review of research was conducted based on systematic search from relevant research, review articles, and online documents. Policy and marketing strategy recommendations are provided on how to improve consumers' knowledge and consequently how to tackle consumers' confusion regarding sustainability production practices. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic's early stages severely impacted global fisheries, particularly areas heavily reliant on imported food and tourism like the Galapagos Islands, Ecuador. To contain the spread of the virus, a full lockdown was implemented. However, the collapse of the tourism industry precipitated the worst economic crisis in the history of this multiple-use marine protected area. This paper examines the impact of the pandemic's early stages on consumption patterns and seafood security in the Galapagos from consumers' perspective, drawing on online surveys conducted during the lockdown. Our findings revealed pre-existing seafood insecurity across the archipelago, further exacerbated by the pandemic on the least-populated island. Nevertheless, the seafood system displayed moderated resilience to the pandemic's socioeconomic disruptions. A variety of adaptive responses were adopted by Galapagos residents to cope with the lockdown. Consumers modified their seafood consumption habits, while fishers adapted their harvesting and marketing strategies. Such adaptive responses were shaped by the unique socioeconomic characteristics of each inhabited island and the ability of seafood suppliers to shift from a tourism- and export-oriented to a resident- and domestic-oriented market. This transition has created novel opportunities to foster a systemic transformation of the Galapagos seafood system to enhance its resilience against future crises caused by new pandemics, climate change, or other natural and anthropogenic drivers of change. [ABSTRACT FROM AUTHOR]

Vesical Imaging Reporting and Data System (VI-RADS) shows good potential in determining muscle-invasive bladder cancer (MIBC) patients. However, whether VI-RADS could predict the prognosis of radical cystectomy (RC) patients has not been reported. Our purpose is to determine whether VI-RADS contributed to predict oncologic outcomes. In this retrospective study, we analysed the information of bladder cancer patients who admitted to our centre from June 2012 to June 2022. All patients who underwent multiparametric magnetic resonance imaging (mpMRI) and underwent RC were included. VI-RADS scoring was performed by two radiologists blinded to the clinical data. Patients' clinical features, pathology data, and imaging information were recorded. Kaplan–Meier method was used to estimate patients' overall survival (OS) and progression-free survival (PFS). Log-rank test was used to assess statistical differences. COX regression analysis was used to estimate risk factors. Ultimately, we included 219 patients, with 188 males and 31 females. The median age was 66 (IQR = 61–74.5) years. The VI-RADS scores were as follows: VI-RADS 1, 4 (1.8%); VI-RADS 2, 68 (31.1%); VI-RADS 3, 40 (18.3%); VI-RADS 4, 69 (31.5%); and VI-RADS 5, 38 (17.4%). Patients with VI-RADS ≥ 3 had poorer OS and PFS than those with VI-RADS < 3. The AUC of VI-RADS predicting 3-year OS was 0.804, with sensitivity of 0.824 and negative predictive value of 0.942. Multivariate COX analysis showed that VI-RADS ≥ 3 was risk factors for OS (HR = 3.517, P = 0.003) and PFS (HR = 4.175, P < 0.001). In the MIBC subgroup, patients with VI-RADS ≥ 4 had poorer OS and PFS. In the non-muscle invasive bladder cancer (NMIBC) subgroup, the prognosis of patients with VI-RADS ≥ 3 remained poorer. VI-RADS scores could effectively predict the survival of patients after RC. [ABSTRACT FROM AUTHOR]

Introduction: The Scalp Eschar and Neck Lymph Adenopathy After a Tick Bite (SENLAT) syndrome is frequently caused by Rickettsia slovaca and Rickettsia raoultii. Only six microbiologically confirmed SENLAT cases have been reported in Italy between 1996 and 2021. We report ten cases of SENLAT seen between 2015 and 2022 in a tertiary care center in Tuscany, Italy. Cases presentation: All patients were women; most common symptoms were scalp eschar on the site of tick bite (100%) and cervical lymphadenopathy (90%). No microbiological identification was obtained. Persistent alopecia, for several months to years, was observed in four patients. The known difficulty of microbiological diagnosis in SENLAT was worsened, in our cases, by factors as the absence of ticks available for identification and microbiological study, and antibiotic treatment administration previous to microbiological tests. Conclusion: The report highlights the presence of SENLAT in Italy, aiming to raise the awareness toward the emergence of this clinical entity. [ABSTRACT FROM AUTHOR]

Objectives : The aim of this study was to evaluate the clinical outcomes of diode laser as an adjunct to nonsurgical periodontal therapy (NSPT) for residual periodontal pockets in mandibular second molars. Materials and methods : Sixty-seven mandibular second molars (154 residual periodontal pockets) were recruited into the study and randomly assigned to the Laser + NSPT group and the NSPT group. The Laser + NSPT group underwent NSPT adjunct with diode laser radiation (wavelength: 810 nm, power: 1.5 W, 40 s maximum), while the NSPT group underwent nonsurgical periodontal therapy alone. Clinical parameters were measured at baseline (T0) and 4(T1), 12(T2), and 24(T3), weeks after treatment. Results: Periodontal pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) in both groups showed significant improvements at the end of study compared to baseline. The reductions of PPD, CAL, and BOP in the Laser + NSPT group were significantly greater than NSPT group. At T3, the Laser + NSPT group had a mean PPD of 3.06 ± 0.86 mm, CAL of 2.58 ± 0.94 mm and BOP of 15.49%, while the NSPT group had a mean PPD of 4.46 ± 1.57 mm, CAL of 3.03 ± 1.25 mm and BOP of 64.29%. Conclusions: The diode laser as an adjunct to nonsurgical periodontal therapy may contribute to clinical outcomes for residual periodontal pockets. However, the approach may cause reduction of keratinized tissue width. Trial registration number: This study was registered in the Chinese Clinical Trial Registry ChiCTR2200061194. Clinical relevance: Diode laser as an adjunct to nonsurgical periodontal therapy may contribute to the clinical outcomes for residual periodontal pockets in mandibular second molars. [ABSTRACT FROM AUTHOR]

In this study, an exact solution using the Generalized Integral Transform Technique (GITT), for the laminar forced convection problem of non-Newtonian fluid flow in elliptical duct by considering the viscous dissipation effects is provided. The proposed solution has been validated by comparison with the numerical solution based on the Dynamic Alternating Direction Implicit (DADI) method developed in this study and with the results available in literature. Results of the analysis showed that the temperature distribution is highly influenced by the Brinkman number as well as the aspect ratio. The use of elliptical duct enhances the viscous heating and the heat transfer coefficient compared to the circular duct. The analytical solution was used to investigate the polyalkylene–glycol–TiO2 non-Newtonian nanofluids flow in microchannels. The results showed that the addition of nanoparticles reduces viscous dissipation effect due to the shear-thinning behavior and the increase in thermal conductivity. In addition, the elliptical microchannel showed a significant enhancement in the heat transfer rate and reduction by half of the thermal length compared to the circular microchannel. These two advantages are with high importance in development of micro-electro-mechanical system (MEMS). [ABSTRACT FROM AUTHOR]

Objectives: To evaluate AI biases and errors in estimating bone age (BA) by comparing AI and radiologists' clinical determinations of BA. Methods: We established three deep learning models from a Chinese private dataset (CHNm), an American public dataset (USAm), and a joint dataset combining the above two datasets (JOIm). The test data CHNt (n = 1246) were labeled by ten senior pediatric radiologists. The effects of data site differences, interpretation bias, and interobserver variability on BA assessment were evaluated. The differences between the AI models' and radiologists' clinical determinations of BA (normal, advanced, and delayed BA groups by using the Brush data) were evaluated by the chi-square test and Kappa values. The heatmaps of CHNm-CHNt were generated by using Grad-CAM. Results: We obtained an MAD value of 0.42 years on CHNm-CHNt; this result indicated an appropriate accuracy for the whole group but did not indicate an accurate estimation of individual BA because with a kappa value of 0.714, the agreement between AI and human clinical determinations of BA was significantly different. The features of the heatmaps were not fully consistent with the human vision on the X-ray films. Variable performance in BA estimation by different AI models and the disagreement between AI and radiologists' clinical determinations of BA may be caused by data biases, including patients' sex and age, institutions, and radiologists. Conclusions: The deep learning models outperform external validation in predicting BA on both internal and joint datasets. However, the biases and errors in the models' clinical determinations of child development should be carefully considered. Key Points: • With a kappa value of 0.714, clinical determinations of bone age by using AI did not accord well with clinical determinations by radiologists. • Several biases, including patients' sex and age, institutions, and radiologists, may cause variable performance by AI bone age models and disagreement between AI and radiologists' clinical determinations of bone age. • AI heatmaps of bone age were not fully consistent with human vision on X-ray films. [ABSTRACT FROM AUTHOR]

Children with elevated liver enzymes are occasionally discovered through laboratory work-up from different clinical scenarios. Although the majority will have transient and/or benign conditions, a subgroup will have underlying liver disorders. The differential diagnosis is broad and therefore, a systematic approach is of utmost importance. In this article, we reviewed the most recent and relevant literature to provide a comprehensive overview of the main disease processes that cause hypertransaminasemia in children. Ultimately, we propose a practical stepwise approach to guide primary care physicians in the evaluation of abnormal liver enzymes in asymptomatic children. The first step is to obtain a complete history along with a thorough physical examination to exclude red flags, which should dictate urgent consultation with a paediatric gastroenterologist or hepatologist. Conclusion: Hypertransaminasemia is a challenging scenario in the primary care setting. The aetiology can be broad, ranging from hepatic and extrahepatic to transient versus chronic liver disease. Timely referral to a specialised centre is of paramount importance for conducting targeted research and to not miss the chance of identifying a progressive, but still asymptomatic, treatable liver disease. What is Known: • Elevated liver enzyme is a challenging scenario in the primary care setting. • There are few studies guiding the evaluation of asymptomatic hypertransaminasemia in the paediatric population and a standardised approach is lacking. What is New: • We propose a practical stepwise approach to guide primary care physicians in the evaluation of abnormal liver enzymes. [ABSTRACT FROM AUTHOR]

Base flood elevation (BFE) and design flood elevation (DFE) are essential references for building floodproofing. Previous BFE and DFE mapping methods were mainly applied to inland rivers and coastal areas, and few studies mentioned the mapping method of densely populated cities. This study proposes a high-resolution BFE and DFE mapping in the densely populated city of Tainan in Taiwan using the SOBEK model and hydraulic digital elevation model. DEM 1 was a 20-m resolution DEM without the building block (BB) method. DEMs 2 and 3 were 1-m resolution DEMs without and with the BB method, respectively. Compared to the observed flooding depths from the water level gauge, the simulation results with DEMs 1 and 2 were closer to the actual situation than that with DEM 3, as DEMs 1 and 2 could represent the water storage effect in buildings. Because buildings in a high building density area (HBDA) had adopted dry floodproofing, the water level rose when the subcritical flow flowed by the buildings. From a risk management perspective, BFE and DFE mapping should adopt DEM 3. The water levels rise effect on buildings was less pronounced in a low building density area (LBDA). DEM 1 could be used for BFE and DFE mapping to save computing power. Generally, a city can be divided into different areas according to building densities. The high-resolution DEM with BB method should be used for HBDA. LBDA should use a low-resolution DEM without the BB method, which can account for model computation efficiency and flood risk management. [ABSTRACT FROM AUTHOR]

Previous research (Ophir et al. in Proc Natl Acad Sci 106(37):15583–15587, 10.1073/pnas.0903620106, 2009; Uncapher and Wagner in Proc Natl Acad Sci 115(40):9889-9896, 10.1073/pnas.1611612115, 2018; Wiradhany and Koerts in Media Psychol 24(2):276–303, 10.1080/15213269.2019.1685393, 2021) suggested that different groups (high, low, and moderate) of habitual media multitaskers process information differently. Most of these studies focused on comprehending the cognitive differences among them. But there is considerably less information on their differences in processing emotional stimuli. In this article, using self-referential emotional stimuli ('positive/likeable' and 'negative/dislikeable' words), we aim to examine whether there is any difference in the self-referential emotional memory among different groups of media multitaskers (HMM, MMM, and LMM) using a recall and recognition paradigm. We also investigate whether HMM, MMM, and LMM vary in an emotional categorization task. A total of 120 students (mean age = 20.9 years; males = 84) voluntarily participated and self-reported their preferences for media multitasking using a questionnaire (Ophir et al. 2009). A total of 50 self-referenced words (positive/likeable and negative/dislikeable) were presented to them on a computerized screen for an emotional categorization task. Afterward, they performed a surprise free recall and a recognition task of the same words. Results suggested that HMM were faster in liking 'positive/likeable' words over 'negative/dislikeable' words in emotional categorization tasks in comparison with LMM and MMM. HMM and MMM performed poorly in both the recall and recognition of 'positive/likeable' emotional words compared to LMM. No significant difference was observed in recall and recognition between HMM and MMM. The three groups did not differ significantly in the recall and recognition tasks related to 'negative/dislikeable' emotional words. These findings help understand the differences in processing self-related emotional stimuli among different groups of media multitaskers. [ABSTRACT FROM AUTHOR]

Climate change impacts are one of the global challenges that change the intensity and frequency of rainfall. The Dodola town has previously experienced rainfall-induced flooding effects, and future floods may be more frequent and severe due to possible variations in rainfall intensity due to climate change. In this study, the rainfall intensity–duration–frequency (IDF) curves are updated for the design of urban stormwater drainage infrastructures under climate change to reduce flooding risks. To assess the variations in the rainfall intensity, the future IDF curves for the periods (2020–2100) and two GCMs (CanESM2 and HadGEM2-ES) were derived and compared to the current IDF curves. It was found that rainfall intensities for future climate conditions will differ from the current period for all durations and return periods. The comparison results show that the relative change between future rainfall intensities and historic rainfall ranges from 1.5 to 30.6%, 2.48 to 42.6%, and 3.7 to 23.24% for 2020–2040, 2041–2070, and 2071–2100, respectively. The IDF relationships revealed that as a result of climate change, urban flooding will increase in the future. This study will help to better understand the impacts of climate change on rainfall IDF relationships, as well as have implications for the design of current and future stormwater management systems in Dodola, Ethiopia. [ABSTRACT FROM AUTHOR]

Purpose of Review: This review serves to explore minimally invasive BPH therapies, with a focus on the sexual side effects of each given modality. The article seeks to give the reader a better understanding of the risk of erectile and ejaculatory dysfunction following various bladder outlet procedures and surgeries. Recent Findings: Multiple urologic treatment technologies are entering the market and gaining FDA approval. UroLift®, Rezūm™, and Aquablation are now supported by the American Urological Association guidelines for the treatment of BPH-related LUTS. Each modality has a relatively low risk of erectile or ejaculatory dysfunction when compared to traditional transurethral resection of the prostate (TURP). Other treatment options, such as prostatic arterial embolization and the Temporarily Implanted Nitinol Device (iTind), may edge their way toward standard of care as new evidence regarding safety and efficacy becomes available. Summary: Various treatment modalities have been proven to be safe when considering a bladder outlet procedure. Depending on the patient's prostatic size, anatomy, and his goals of care, clinicians should be able to offer a BPH treatment option with a favorable prognosis as well as an acceptable risk profile. [ABSTRACT FROM AUTHOR]

Multimodal Electroencephalography techniques were used to determine whether the name of famous people undergoes self-relevant processing due to a shared surname with participants. During a three-stimulus oddball task, brain activity was recorded when participants suddenly saw their own names (self-name [SN]), a famous name with the same surname (FNS), or a famous name with a different surname (FND). While familiarity ratings were kept similar across the three kinds of name, behavioral analysis showed a higher rating on self-relevance for SN than for FNS, which, in turn, received a higher rating than FND. P2 amplitudes demonstrated a similar enhancement in response to SN and FNS compared to FND while P3 amplitudes and power of theta band (3.5–6 Hz) oscillation were more pronounced in response to SN than to FNS, which in turn elicited larger P3 and theta activities than FND. These findings, excluding the influence of familiarity, revealed that famous people sharing same surname with us could elicit a reliable self-relevant effect, despite lack of real social connection. This self-relevant processing may be embodied by the P3 amplitude and theta band neural oscillation in EEG. [ABSTRACT FROM AUTHOR]

Enzymes are powerful and effective biological catalysts demanded in various areas of human activity, especially in medicinal area and as modem diagnostic tools. Enzymes-based electrode sensors (2D format) and nanopore sensors (3D format) represent modern, high-tech areas of bionanotechnology and bionanoscience. A comparative analysis of the catalytic activity of enzymes on flat electrode as a 2D sensor, on an electrode functionalized with a nanoporous material based on indium tin oxide as a transition from 2 to 3D model, and in a biological nanopore as a 3D sensor was carried out. Analysis of electrochemical properties of substrate or product/metabolite for the assessment of catalytic activity of enzymes was described. Comparative kinetic parameters of enzymes immobilized on an electrode and in a nanopore as sensors are given. The authors present the prospects of both electrochemical studies of enzymes using electrode sensor and studies of enzymes or substrates confined in a nanopore sensor. Highlights: Enzyme-based electrodes (2D format) for analysis of ensemble of proteins were discussed. A novel method was developed for analysis of cytochrome P450 confined in nanopores on electrode. Nanopore sensors as 3D systems for analysis of single molecule catalytic activity were analyzed. Comparative kinetic parameters of enzyme systems on an electrode and in a nanopore were augmented. [ABSTRACT FROM AUTHOR]

Sleep is needed for maintenance of normal homeostasis and memory consolidation processes and the deep third stage of sleep plays a particularly important role. However, a significant proportion of the population suffers from poor sleep quality, insomnia, and problems with going to sleep. Pharmacological treatment of these problems is not always possible or appropriate, and in recent years we have seen increasing interest in nonpharmacological methods of influencing falling asleep and sleep. This review addresses various approaches to improving sleep quality and accelerating going to sleep: sensory actions of different modalities, approaches using transcranial stimulation, and normalization of daily sleep–waking rhythms. This article considers their main possible mechanisms of action. Nonpharmacological treatments most commonly produce increases in slow-wave activity in the third stage of sleep. The areas of application of different approaches are assessed: from exclusively research purposes to application in clinical practice and use in consumer devices. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the safety and efficacy of prostatic artery embolization (PAE) using polyethylene glycol microspheres (PEGM) in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). Materials and methods: This multicentric prospective study enrolled 81 patients who underwent PAE with 400 ± 75 µm PEGM (HydroPearl®, Terumo, Japan). Results from baseline and 1-, 3-, 6-, and 12-month follow-ups were assessed for subjective outcomes including International Prostate Symptoms Score (IPSS), Quality of life (QoL), and International Index of Erectile Function, and objective outcomes such as peak urinary flow (Qmax) and post-void residual volume (PVR). The visual analogue scale, satisfaction questionnaire, prostatic volume, and prostatic specific antigen levels were also evaluated. Complications were documented using the modified Clavien–Dindo classification. Results: Technical success was obtained in all patients. Clinical success was achieved in 78.5% of patients. Before PAE, 54.3% of patients had an indwelling catheter which was removed in 75% of them after procedure. A statistically significant decrease was observed in IPSS and QoL from baseline to 12 months (20.14 vs 5.89; 4.8 vs 0.63, P <.01), respectively. Objective outcomes also showed a statistically significant improvement in Qmax (+ 114.9%; P <.01), achieving a maximum urinary flow of 14.2 mL/sec, and PVR (decrease 58%; P <.05) at 12 months. Minor complications (Clavien–Dindo grades I–II) occurred in 13.6% of patients, without major complications observed. Conclusion: PAE with PEGM is safe and effective treatment in patients with symptomatic BPH, with a significant improvement in both subjective and objective outcomes. [ABSTRACT FROM AUTHOR]

Lipoxygenase (LOX) activity is closely related to wheat processing and storage quality. In the present research, ten wheat cultivars were used to compare the effects of genotype, location, year, and their interactions on the LOX activity. Furthermore, 123 wheat cultivars were evaluated for LOX activity with 192 simple sequence repeat (SSR) markers and to identify elite alleles related to LOX activity. The results indicated that LOX activity was highly affected by genotype (variety) than that by the location. A total of 22 SSR molecular marker loci with a significant or very significant correlation with LOX activity were identified on performing association analysis. In 3 years, only one molecular marker locus associated with LOX activity was detected (WMC488); in 2 years, seven molecular marker loci were detected, while in only 1 year, the other 14 molecular marker loci were detected. A total of 7 and 6 marker loci significantly related to LOX activity accounting for 31.2% and 27.2%, respectively, were located in homologous groups 4 and 5, and group 7. This research provided the theoretical basis and the markers for molecular-assisted wheat breeding that facilitate the breeding process in the processing and storage quality of grains. [ABSTRACT FROM AUTHOR]

Ataxia telangiectasia (AT) is a rare neurodegenerative genetic disorder due to bi-allelic mutations in the Ataxia Telangiectasia Mutated (ATM) gene. The aim of this paper is to better define the immunological profile over time, the clinical immune-related manifestations at diagnosis and during follow-up, and to attempt a genotype–phenotype correlation of an Italian cohort of AT patients. Retrospective data of 69 AT patients diagnosed between December 1984 and November 2019 were collected from the database of the Italian Primary Immunodeficiency Network. Patients were classified at diagnosis as lymphopenic (Group A) or non-lymphopenic (Group B). Fifty eight out of 69 AT patients (84%) were genetically characterized and distinguished according to the type of mutations in truncating/truncating (TT; 27 patients), non-truncating (NT)/T (28 patients), and NT/NT (5 patients). In 3 patients, only one mutation was detected. Data on age at onset and at diagnosis, cellular and humoral compartment at diagnosis and follow-up, infectious diseases, signs of immune dysregulation, cancer, and survival were analyzed and compared to the genotype. Lymphopenia at diagnosis was related per se to earlier age at onset. Progressive reduction of cellular compartment occurred during the follow-up with a gradual reduction of T and B cell number. Most patients of Group A carried bi-allelic truncating mutations, had a more severe B cell lymphopenia, and a reduced life expectancy. A trend to higher frequency of interstitial lung disease, immune dysregulation, and malignancy was noted in Group B patients. Lymphopenia at the onset and the T/T genotype are associated with a worst clinical course. Several mechanisms may underlie the premature and progressive immune decline in AT subjects. [ABSTRACT FROM AUTHOR]

90° is the limitation of lyophilicity and lyophobicity for ideal surface for centuries, but it has been proved to be contradictory on some occasions. The symmetrical surfaces with different surface tensions can attract or repel each other in water. Therefore, at the molecular level, the lyophilicity or lyophobicity is the results of interactions between the liquids and substrates. Here, using atomic force microscope (AFM) to measure interaction forces between symmetrical self-assembled monolayers (SAMs) in different liquids, we found that the SAMs repel each other when the surfaces are hydrophilic whereas attract when hydrophobic in water. The contact angle corresponding to the transition of attraction to repulsion is approximate to 65°, defined as the intrinsic wetting threshold (IWT) of water. For ethylene glycol (EG), dimethyl sulfoxide (DMSO), N,N-dimethyl formamide (DMF), the IWTs could be determined by changes of adhesion forces between SAMs. This research redefined the IWTs for liquids, which is the essential guide to both basic theory and applications of wettability. [ABSTRACT FROM AUTHOR]

Purpose: Diabetes is associated with poorer cancer outcomes. Screening for breast and cervical cancer is recommended by clinical guidelines; however, utilization of these tests in people with diabetes has been unclear due to methodological limitations in the evidence base. We used administrative data to determine the association between diabetes and the rates of becoming up-to-date with periodic breast and cervical cancer screening over a 20-year period.Methods: Healthcare databases from Ontario, Canada, were linked to assemble two population-based cohorts of 50-70 and 21-70 year-olds between 1994 and 2011, eligible for breast and cervical cancer screening, respectively. Using age as the time scale, multivariable recurrent events models were implemented to examine the association between the presence of diabetes and the rates of becoming up-to-date with the recommended cancer screenings.Results: In each of the breast and cervical cancer screening cohorts, there were, respectively, 1,516,302 (16% had diabetes at baseline) and 4,751,220 (9.5% had diabetes at baseline) screen-eligible women. In multivariable models, prevalent diabetes (duration ≥ 2 years) was associated with lower rates of becoming up-to-date with cervical (hazard ratio, HR 0.85, 95% confidence interval, CI 0.84-0.85) and breast (HR 0.94, CI 0.93-0.94) cancer screening, compared to no diabetes.Conclusions: Having diabetes is associated with decreased rates of becoming up-to-date with two recommended periodic cancer screenings, with a bigger reduction in the rates of becoming up-to-date with cervical cancer screening. Greater attention to cervical cancer preventive services is needed in women with diabetes. [ABSTRACT FROM AUTHOR]

Main conclusion: Australian native species of sorghum contain negligible amounts of dhurrin in their leaves and the cyanogenesis process is regulated differently under water-stress in comparison to domesticated sorghum species. Cyanogenesis in forage sorghum is a major concern in agriculture as the leaves of domesticated sorghum are potentially toxic to livestock, especially at times of drought which induces increased production of the cyanogenic glucoside dhurrin. The wild sorghum species endemic to Australia have a negligible content of dhurrin in the above ground tissues and thus represent a potential resource for key agricultural traits like low toxicity. In this study we investigated the differential expression of cyanogenesis related genes in the leaf tissue of the domesticated species Sorghum bicolor and the Australian native wild species Sorghum macrospermum grown in glasshouse-controlled water-stress conditions using RNA-Seq analysis to analyse gene expression. The study identified genes, including those in the cyanogenesis pathway, that were differentially regulated in response to water-stress in domesticated and wild sorghum. In the domesticated sorghum, dhurrin content was significantly higher compared to that in the wild sorghum and increased with stress and decreased with age whereas in wild sorghum the dhurrin content remained negligible. The key genes in dhurrin biosynthesis, CYP79A1, CYP71E1 and UGT85B1, were shown to be highly expressed in S. bicolor. DHR and HNL encoding the dhurrinase and α-hydroxynitrilase catalysing bio-activation of dhurrin were also highly expressed in S. bicolor. Analysis of the differences in expression of cyanogenesis related genes between domesticated and wild sorghum species may allow the use of these genetic resources to produce more acyanogenic varieties in the future. [ABSTRACT FROM AUTHOR]

Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health Assembly resolutions, including human filarial diseases. The end of NTDs is embedded within the Sustainable Development Goals for 2030, under target 3.3. Onchocerciasis afflicts approximately 20.9 million people worldwide with > 90% of those infected residing in Africa. Control programs have made tremendous efforts in the management of onchocerciasis by mass drug administration and aerial larviciding; however, disease elimination is not yet achieved. In the new WHO roadmap, it is recognized that new drugs or drug regimens that kill or permanently sterilize adult filarial worms would significantly improve elimination timelines and accelerate the achievement of the program goal of disease elimination. Drug development is, however, handicapped by high attrition rates, and many promising molecules fail in preclinical development or in subsequent toxicological, safety and efficacy testing; thus, research and development (R&D) costs are, in aggregate, very high. Drug discovery and development for NTDs is largely driven by unmet medical needs put forward by the global health community; the area is underfunded and since no high return on investment is possible, there is no dedicated drug development pipeline for human filariasis. Repurposing existing drugs is one approach to filling the drug development pipeline for human filariasis. The high cost and slow pace of discovery and development of new drugs has led to the repurposing of "old" drugs, as this is more cost-effective and allows development timelines to be shortened. However, even if a drug is marketed for a human or veterinary indication, the safety margin and dosing regimen will need to be re-evaluated to determine the risk in humans. Drug repurposing is a promising approach to enlarging the pool of active molecules in the drug development pipeline. Another consideration when providing new treatment options is the use of combinations, which is not addressed in this review. We here summarize recent advances in the late preclinical or early clinical stage in the search for a potent macrofilaricide, including drugs against the nematode and against its endosymbiont, Wolbachia pipientis. [ABSTRACT FROM AUTHOR]

Background: The increasing demand for food production has led to a tenfold increase in nitrogen (N) fertilizer use since the Green Revolution. Nowadays, agricultural soils have been turned into high-nitrifying environments that increase N pollution. To decrease N losses, synthetic nitrification inhibitors (SNIs) such as 3,4-dimethylpyrazole phosphate (DMPP) have been developed. However, SNIs are not widely adopted by farmers due to their biologically limited stability and soil mobility. On the other hand, allelopathic substances from root exudates from crops such as sorghum are known for their activity as biological nitrification inhibitors (BNIs). These substances are released directly into the rhizosphere. Nevertheless, BNI exudation could be modified or even suppressed if crop development is affected. In this work, we compare the performance of biological (sorghum crop) and synthetic (DMPP) nitrification inhibitors in field conditions. Results: Sorghum crop BNIs and DMPP prevented an increase in the abundance of ammonia-oxidizing bacteria (AOB) without affecting the total bacterial abundance. Both nitrification inhibitors maintained similar soil NH4+ content, but at 30 days post-fertilization (DPF), the sorghum BNIs resulted in higher soil NO3− content than DMPP. Even so, these inhibitors managed to reduce 64% and 96%, respectively, of the NO3−-N/NH4+-N ratio compared to the control treatment. Similar to soil mineral N, there were no differences in leaf δ15N values between the two nitrification inhibitors, yet at 30 DPF, δ15N values from sorghum BNI were more positive than those of DMPP. N2O emissions from DMPP-treated soil were low throughout the experiment. Nevertheless, while sorghum BNIs also maintained low N2O emissions, they were associated with a substantial N2O emission peak at 3 DPF that lasted until 7 DPF. Conclusions: Our results indicate that while sorghum root exudates can reduce nitrification in field soil, even at the same efficiency as DMPP for a certain amount of time, they are not able to prevent the N pollution derived from N fertilization as DMPP does during the entire experiment. [ABSTRACT FROM AUTHOR]

Familiar self-associated stimuli such as one's own name and face are more efficient in guiding attention than other-associated stimuli. Remarkably, a short association of geometric shapes to the self versus others is sufficient to induce prioritization of the self- (vs. other-) associated shape in a matching task. Replications with other tasks measuring different stages of information processing, however, produced mixed results. It thus remains unclear whether the effect can be attributed to the newly associated stimulus alone. Therefore, in Study 1 (N = 28), we implemented the matching task and additionally compared the effectiveness of familiar versus newly self-associated stimuli with that of stranger-related stimuli to hold attention as cues in a dot-probe task. The self and the stranger were either represented by familiar labels ("I" vs. "stranger"), newly associated shapes, or shape–label pairs. In Study 2 (N = 31), participants associated nonwords to themselves and a stranger to compare the attentional impact of familiar and new self-associated letter combinations. Thus, we addressed the potential limitation due to modality present in former studies—which used mostly pictorial stimuli as new representations and letter combinations as familiar representations. Across both studies, in the dot-probe task, responses were faster towards targets following the self-associated stimuli compared with stranger-associated stimuli but only when familiar representations were used. Responses in the matching task were faster when confirming the correct self-associated pair. The results suggest that, under conditions of attentional competition, the prioritization of self-associated compared with other-associated cues does not generalize to newly associated stimuli. [ABSTRACT FROM AUTHOR]

The purpose of this study was to evaluate the possible benefits (in terms of periodontal status improvement and periodontal bacteria count reduction) of using 980 nm diode laser in the treatment of periodontitis in patients after myocardial infarction. Thirty-six patients under 65 years of age (mean: 56.3 ± 7.9) with periodontitis, 6 weeks to 6 months after myocardial infarction, were recruited for the study. The control group (n = 18) received SRP (scaling, root planing and polishing) while the test group (n = 18) received SRP followed by laser therapy of the periodontal pockets with 980 nm diode laser, 1 W, continuous wave mode, 20 s per tooth side. Procedures were repeated twice at 5–7 day intervals. Microbiological and periodontal examination, including periodontal pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP) and plaque control record (PCR), were performed before treatment, 2 weeks and 3 months after treatment. The study was registered on ClinicalTrials.gov with Identifier: NCT04145557, 29.10.2019 "retrospectively registered". Additional use of laser resulted in a significant reduction in pockets with PPD ≥ 7 mm (p = 0.0151). The diode laser reduced total bacteria count (p = 0.0154) and delayed recolonisation during a 3-month observation period. A significant increase in the number of Capnocytophaga gingivalis was observed in the control group (p = 0.048). Additional use of the diode laser after SRP had no significant effect on BOP, CAL and PCR. Within the limitations of our study, we can conclude that 980 nm diode laser can be a useful tool in the treatment of periodontitis in patients after myocardial infarction. [ABSTRACT FROM AUTHOR]

Purpose: To describe the proteomic profiles in semen samples and define the differences in sperm proteomic profiles among samples that ultimately achieved pregnancy (P) via intracytoplasmic sperm injection (ICSI) in an oocyte donation program and those that were unsuccessful (NP). Methods: Prospective, analytical, observational nested case and control study evaluating the proteomic profile of spermatozoa from patients' ejaculates where pregnancies were (group pregnant (P), n= 4) or were not (group non-pregnant (NP), n=4) achieved after ICSI in an oocyte donation program aiming to standardize female factor. Proteins were separated and analyzed by means of SWATH-MS) and compared between P/NP groups to identify sperm biomarkers of fertility/infertility. Proteins are available via ProteomeXchange. Results: We identified and quantified 2228 proteins, with 37 significantly higher in the P group and 16 higher in NP. Enrichment analysis revealed that the increased proteins in P group sperm were related to motility, anaerobic metabolism, and protein biosynthesis functions, while the increased proteins in the NP group were involved in protein biosynthesis, protein folding, aerobic metabolism, and signal transduction, all of which are functions not previously described as influencing sperm success. Some proteins identified (e.g., SLC2A3, or CD81) are located in the cell membrane and thus may be employed to select spermatozoa by magnetic-activated cell sorting (MACS). Conclusion(s): This work revealed differences in the proteomic profiles of sperm samples successful in achieving pregnancy and those that were not, expanding our understanding of sperm function and infertility-related molecular markers, and enabling the future development of male fertility diagnostic tools and therapies. [ABSTRACT FROM AUTHOR]

Coffee husk, eucalyptus, and pine residues were torrefied at 290 °C in a screw reactor, during 5, 10, 15 or 20 min. The effects of feedstock type and torrefaction process parameters (holding time) on their energy characteristics were investigated. Raw and torrefied biomasses were then submitted successively to leaching and to white and brown rot fungi, to mimic storage conditions. Mass loss after leaching step, water content and weight loss due to fungal deterioration after 2, 4, 8, 12, 16 weeks were recorded. The chemical composition and high heating value (HHV) of the torrefied samples were measured to determine the alterations compared to raw biomass during their storage. Increasing torrefaction residence time improves the decay resistance of the biomasses. Variation of carbon content (%wt., dry basis) and HHV (kJ/kg, dry basis) were observed during native and torrefied biomasses fungal degradations. Carbon contents and HHV values of raw and torrefied biomasses decreased during Trametes versicolor exposure [49.65% > C > 44.07% and 19.71 kJ/kg > HHV > 17.19 kJ/kg, results from results from all tests combined.], whereas they increased during exposure to Coniophora puteana [46.15% < C < 52.70% and 17.43 kJ/kg < HHV < 20.74 kJ/kg]. Severe torrefaction is therefore a good way to improve coffee husk, eucalyptus, and pine energy properties while limiting loss of their energy properties during storage. [ABSTRACT FROM AUTHOR]

Aim: To prospectively evaluate the feasibility and reproducibility of the semiquantitative measurement of the unenhanced area of the prostate by trans-abdominal contrast-enhanced ultrasound (CEUS) performed immediately after prostate artery embolization (PAE) as a prognostic factor of success.Methods: Thirty-nine patients with PAE were prospectively included. They all underwent pre- and post-PAE trans-abdominal prostate CEUS. Two readers independently evaluated the pre- and post-PAE unenhanced area using a semiquantitative method: unenhanced areas were measured on 3 different slices (basis, middle, and apex) and reported to the whole prostate area. The mean of the three measures was reported semiquantitatively in classes of ten percent and quartiles. We evaluated correlation with clinical success, at 3 months after PAE, defined as a > 25% reduction in the International Prostatic Symptoms Score and a Quality of life < 3.Results: Twenty-three patients who had bilateral PAE were analyzed. Pre-PAE trans-abdominal prostate CEUS showed visible early and marked enhancement of the entire prostate in all patients. After PAE, all patients had a semiquantitatively measured unenhanced area > 25%. The semiquantitative measurement was found to be highly reproducible, with an interclass correlation > 0.8. No correlation was found between the area of unenhanced tissue and clinical success evaluated at 3 months.Conclusion: Trans-abdominal prostate CEUS performed early after PAE provides reproducible results and is a valuable tool to evaluate unenhanced areas of the prostate.Level Of Evidence: 3, local non random sample. [ABSTRACT FROM AUTHOR]

Purpose: "Omics" techniques have been used to understand and to identify biomarkers of male infertility. We report on the first metabonomics models created to diagnose varicocele and infertility among men with varicocele. Methods: We recruited 35 infertile men with varicocele (VI group), 21 fertile men with varicocele (VF group) and 24 fertile men without varicocele (C group). All men underwent standard semen analysis, scrotal duplex ultrasonography, and sexual hormone level measurement. Hydrogen-1 nuclear magnetic resonance (1H NMR) spectra of seminal plasma were used to create metabonomics models to discriminate between men with and without varicocele, and between fertile and infertile men with varicocele. Results: Using the statistical formalisms partial least square discriminants analysis and genetic algorithm–based linear discriminant analysis (GA-LDA), we created two models that discriminated the three groups from each other with accuracy of 92.17%. We also created metabonomics models using orthogonal partial least square discriminants analysis and GA-LDA that discriminated VF group from VI group, with an accuracy of 94.64% and 100% respectively. We identified 19 metabolites that were important in group segregation: caprate, 2-hydroxy-3-methylvalerate, leucine, valine, 3-hydroxybutyrate, lactate, alanine, 4-aminobutyrate, isoleucine, citrate, methanol, glucose, glycosides, glycerol-3-phosphocoline, n-acetyltyrosine, glutamine, tyrosine, arginine, and uridine. Conclusions: 1HNMR-based metabonomics of seminal plasma can be used to create metabonomics models to discriminate between men with varicocele from those without varicocele, and between fertile men with varicocele from those infertile with varicocele. Furthermore, the most important metabolites for group segregation are involved in the oxidative stress caused by varicocele. [ABSTRACT FROM AUTHOR]

The aim of the study was to investigate the possible association of hypnotizability and deep sleep (N3) duration, and whether the interoceptive sensibility influences this association. This was motivated by the proneness of highly hypnotizable individuals to easily change their psychophysiological state, i.e., from wakefulness to hypnosis and sleep, and by the positive association observed between hypnotizability and interoceptive sensibility. Forty-seven healthy participants previously enrolled in a polysomnographic night sleep study completed the questionnaire for Multidimensional Assessment of Interoceptive Awareness (MAIA) and underwent hypnotic assessment through the Stanford Hypnotic Susceptibility Scale, form A (SHSS,A). Results showed that N3 duration is not linearly correlated with hypnotizability. Controlling for a few MAIA scales did not modify the relation between hypnotizability and deep sleep. A polynomial relation indicates that N3 duration and N3 percentage of the total sleep time increase with hypnotizability in the low-to-medium range of hypnotizability and decrease in the medium-to-high range. In conclusion, hypnotic assessment predicts N3 duration and their association is not modified by interoceptive awareness/sensitivity. [ABSTRACT FROM AUTHOR]

To assess the HIV -1subtypes distribution in HIV-1 positive migrants living in Milan we studied 77 HIV-1 patients followed at the San Raffaele Hospital of Milan. Twenty subjects were born in Europe, 43 in the Americas, 10 in Africa and 4 in Asia. Unsafe heterosexual activity prevailed in migrants born in Africa and male homosexuality in those born in European, American and Asian countries (p = 0.05). The phylogeny showed that 38/77 (49.3%) subjects carried HIV-B subtype while the remaining strains were classified as not pure HIV-1 B subtypes 13/77 (16.9%) or recombinant forms 26/77 (33.8%). Female gender more frequently showed HIV-1 non-B strains and rarely HIV-1 B subtypes (12/39, 30.8% vs. 3/38, 7.9%, p = 0.02). Transmitted drug resistance was identified in 10/77 (13%) patients predominately with B subtype. Our data underscore a large heterogeneity in HIV-1 subtypes and a large proportion of recombinant forms. [ABSTRACT FROM AUTHOR]

Objectives: To compare safety and clinical outcomes of embolization of the superior rectal arteries in patients with hemorrhoidal bleeding using particles and coils versus coils only.Methods: We retrospectively reviewed data for patients undergoing embolization for chronic hemorrhoidal bleeding from January 2014 to April 2017. Embolization was performed with coils alone or with particles and coils. Clinical scores (Paris bleeding severity score, Goligher classification and quality of life score) were obtained, and embolization was performed with microparticles (300-500 μm) followed by fibered pushable coils. Clinical success was defined as an improvement of > 2 points in the Paris bleeding severity score, without complications. Outcomes were compared between the two groups in a matched-pairs analysis (1:1 scenario), with patients embolized with particles and coils as the study group and patients embolized with coils alone as the control.Results: We treated 45 consecutive patients. After matched-pairs analysis, the final study population was 38 patients (19 study group and 19 controls). Clinical success did not differ significantly between the two populations: 63% for control group and 68% for the study group (p = 0.790). The median change in clinical score was - 3 [- 6; - 1] for the control group and - 3 [- 4; - 1] for the study group (p = 0.187). Grade 1 complications were reported in 15% of patients, with no major complications.Conclusions: Embolization was feasible, with a technical success of 100% and no major complications. Clinical success was obtained in 66% in patients with no difference when using combined embolization with particles and coils versus coils only. [ABSTRACT FROM AUTHOR]

This study attempts to answer the question: "Is hearing the last to go?" We present evidence of hearing among unresponsive actively dying hospice patients. Individual ERP (MMN, P3a, and P3b) responses to deviations in auditory patterns are reported for conscious young, healthy control participants, as well as for hospice patients, both when the latter were conscious, and again when they became unresponsive to their environment. Whereas the MMN (and perhaps too the P3a) is considered an automatic response to auditory irregularities, the P3b is associated with conscious detection of oddball targets. All control participants, and most responsive hospice patients, evidenced a "local" effect (either a MMN, a P3a, or both) and some a "global" effect (P3b) to deviations in tone, or deviations in auditory pattern. Importantly, most unresponsive patients showed evidence of MMN responses to tone changes, and some showed a P3a or P3b response to either tone or pattern changes. Thus, their auditory systems were responding similarly to those of young, healthy controls just hours from end of life. Hearing may indeed be one of the last senses to lose function as humans die. [ABSTRACT FROM AUTHOR]

Purpose: Dirofilariasis caused by the filarial nematode Dirofilaria repens is mainly a disease of dogs and other carnivores. Also, humans can be accidentally infected with this parasite. The infective third-stage filariform larvae are transmitted by various species of mosquitoes. Until this day, a total of 17 human cases caused by D. repens have been diagnosed in Slovakia, 11 subcutaneous, 4 ocular, 1 pulmonary and 1 in the epididymis. The aim of this report was to describe an unusual clinical case of dirofilariasis of the scrotum. Methods: Extirpated worm was subjected to the molecular and histological identification. PCR for the amplification of cytochrome oxidase subunit 1 (CO1) was performed using specific D. repens primer pair. Results: Here we document the 13th case of human dirofilariasis in a 46-year-old man from southwestern Slovakia. Very rare in humans, genital involvement manifests itself as pseudotumor nodule affecting the epididymis. The patient consulted a general practitioner due to a palpable subcutaneous lump in the scrotum. Routine laboratory analysis revealed blood eosinophilia (16.6%). The ultrasound examination was indicated, and subsequently, surgical excision of the right epididymal nodule was performed. On the basis of histological microscopic examination and PCR-based detection, the helminth was identified as Dirofilaria repens. This represents the ninth case of autochthonous dirofilariasis in Slovakia. Conclusions: The majority of D. repens infections were recorded in southwestern regions of Slovak Republic, which are considered to be endemic areas for canine dirofilariasis. Our described patient also comes from southwestern part of Slovakia (Topoľníky, Dunajská Streda region). [ABSTRACT FROM AUTHOR]

The heat transfer characteristics of laminar single-phase forced convective water flow through a micro-tube heat exchanger are numerically investigated in this paper. Two-dimensional simulations are performed to find the effects of variable fluid properties on heat transfer for hydrodynamically and thermally developed flow. The effects of variable fluid properties on convective heat transfer coefficient (h) and Nusselt number (Nu) are significant for micro-convective flow. It is noted that the variation in temperature-dependent thermal conductivity [k(T)] greatly enhances the h as compared to the variation in temperature-dependent viscosity [µ(T)], although water viscosity–temperature sensitivity (SμT) is greater than that of thermal conductivity–temperature sensitivity (SkT). The effects of variation in wall heat flux ( q w ″ ) and inlet temperature on heat transfer are investigated for variable fluid properties. It is noted that the Nu declines with an augment in q w ″ for temperature-dependent density variation [ρ(T)]. The Nu increases with an increase in q w ″ for µ(T) and k(T) variations. The results show that the Nu decreases with an increase in inlet temperature for variable fluid properties. The undevelopment and redevelopment of the flow are observed due to µ(T) variation. Additionally, the effects of wall heat flux, inlet temperature and inlet velocity on the variation of Nu/Pr1/3 with Re are examined for µ(T) variation. [ABSTRACT FROM AUTHOR]

In this study, a choice experiment was performed to investigate consumer preferences and willingness to pay for a set of eco-labels on extra-virgin olive oil. Specifically, we tested three types of eco-labels indicating that the olive oil was (i) obtained from ancient trees, (ii) produced in mountainous areas, and (iii) obtained with sustainable water use. These three different eco-labels were analyzed in combination with the well-known organic label and other relevant attributes of extra-virgin olive oil. The choice experiment was based on a consumer survey carried out in Italy, the largest olive oil consuming country in the world, in January–February 2017. A market research agency recruited a nationally-representative total sample of 1061 participants who were involved in a web-based interview. Consumer choices were analyzed using a Random Parameter Logit model. The main result of the study is that, on average, Italian consumers are willing to pay a significant premium price for all the tested eco-labels on extra-virgin olive oil with the organic label being the most preferred eco-label. However, high heterogeneity in consumer preferences was also detected. [ABSTRACT FROM AUTHOR]

Theory of mind (ToM) is defined as the ability to attribute mental states to oneself and others and is often said to be one of the cornerstones of efficient social interaction. In recent years, a number of authors have suggested that one particular ToM process occurs spontaneously in that it is rapid and outside of conscious control. This work has argued that humans efficiently compute the visual perspective of other individuals. In this article, we present a critique of this notion both on empirical and theoretical grounds. We argue that the experiments and paradigms that purportedly demonstrate spontaneous perspective-taking have not as yet convincingly demonstrated the existence of such a phenomenon. We also suggest that it is not possible to represent the percept of another person, spontaneous or otherwise. Indeed, the perspective-taking field has suggested that humans can represent the visual experience of others. That is, going beyond assuming that we can represent another's viewpoint in anything other than symbolic form. In this sense, the field suffers from the same problem that afflicted the "pictorial" theory in the mental imagery debate. In the last section we present a number of experiments designed to provide a more thorough assessment of whether humans can indeed represent the visual experience of others. [ABSTRACT FROM AUTHOR]

Peeling skin syndrome is a heterogeneous group of rare disorders. Peeling skin, leukonychia, acral punctate keratoses, cheilitis and knuckle pads (PLACK syndrome, OMIM616295) is a newly described form of PSS with an autosomal recessive mode of inheritance. We report a 5.5-year-old boy with features of PLACK syndrome. Additionally, he had mild cerebral atrophy and mild muscle involvements. Whole exome sequencing was performed in genomic DNA of this individual and subsequent analysis revealed a homozygous c.544G > T (p.Glu182*) nonsense mutation in the CAST gene encoding calpastatin. Sanger sequencing confirmed this variant and demonstrated that his affected aunt was also homozygous. Real-time qRT-PCR and immunoblot analysis showed reduced calpastatin expression in skin fibroblasts derived from both affected individuals compared to heterozygous family members. In vitro calpastatin activity assays also showed decreased activity in affected individuals. This study further supports a key role for calpastatin in the tight regulation of proteolytic pathways within the skin. [ABSTRACT FROM AUTHOR]

Contemporary brain reading technologies promise to provide the possibility to decode and interpret mental states and processes. Brain reading could have numerous societally relevant implications. In particular, the private character of mind might be affected, generating ethical and legal concerns. This paper aims at equipping ethicists and policy makers with conceptual tools to support an evaluation of the potential applicability and the implications of current and near future brain reading technology. We start with clarifying the concepts of mind reading and brain reading, and the different kinds of mental states that could in principle be read. Subsequently, we devise an evaluative framework that is composed of five criteria-accuracy, reliability, informativity, concealability and enforceability-aimed at enabling a clearer estimation of the degree to which brain reading might be realistically deployed in contexts where mental privacy could be at stake. While accuracy and reliability capture how well a certain method can access mental content, informativity indicates the relevance the obtainable data have for practical purposes. Concealability and enforceability are particularly important for the evaluation of concerns about potential violations of mental privacy and civil rights. The former concerns the degree with which a brain reading method can be concealed from an individual's perception or awareness. The latter regards the extent to which a method can be used against somebody's will. With the help of these criteria, stakeholders can orient themselves in the rapidly developing field of brain reading. [ABSTRACT FROM AUTHOR]

In the present paper, a novel method is provided to detect significant daily consumption patterns and to obtain scaling laws to predict consumption patterns for groups of homogeneous users. The first issue relies on the use of Self-Organizing Map to gain insights about the initial assumption of distinct homogeneous consumption groups and to find additional clusters based on calendar dates. Non-dimensional pattern detection is performed on both residential and non-residential connections, with data provided by one-year measurements of a large-size smart water network placed in Naples (Italy). The second issue relies on the use of the variance function to explain the dependence of aggregated variance on the mean and on the number of aggregated users. Equations and related parameters' values are provided to predict mean dimensional daily patterns and variation bands describing water consumption of a generic set of aggregated users. [ABSTRACT FROM AUTHOR]

The fifth author's name was incorrectly published as "M. Messas". The correct name is "E. Messas". The original article has been corrected. [ABSTRACT FROM AUTHOR]

Purpose: To report our initial experience of fully percutaneous deep venous arterialization (pDVA) for the treatment of chronic critical limb ischemia (cCLI) after failed distal angioplasty.Materials and Methods: pDVA was performed in five consecutive patients by creating an arteriovenous fistula (AVF) between a below the knee artery and its satellite deep vein. In this early experience, only patients with failed prior interventional attempts at establishing flow with no distal targets for an arterial bypass were selected. Early technical success was defined as successful AVF creation and retrograde venous perfusion of the wound site. Patient demographics, procedural details, morbidity/mortality and wound healing outcomes were assessed prospectively. Patients were followed up in wound care centers, and graft patency was documented on duplex ultrasound.Results: All five consecutive patients (mean age 58 years) underwent successful pDVA without any procedural complications. There were neither 30-day major adverse limb events nor major cardiovascular complications. Three out of the five patients (60%) had clinical improvement as observed by resolution of rest pain and complete wound healing. At the 1-month FU, one patient died and one patient received a major amputation. The median wound healing time was 39 weeks.Conclusion: pDVA is a safe and feasible vascularization alternative in patients with end-stage/no-option CLI. The early experience highlights the need for a multidisciplinary approach including a dedicated wound care service. [ABSTRACT FROM AUTHOR]

In the present paper a procedure is introduced to detect water consumption patterns within water distribution systems. The analysis is based on hourly consumption data referred to single-household flow meters, connected to the Smart Water Network of Soccavo (Naples, Italy). The procedure is structured in two consecutive phases, namely clustering and classification. Clustering is performed on a selection of standardized monthly time series, randomly chosen within the database; different clustering models are tested, basing on K-means, dendrogram and Self-Organizing Map, and the most performant is identified comparing a selection of Clustering Validity Indices. Supervised classification is performed on the remaining time series to associate unlabeled patterns to the previously defined clusters. Final results show that the proposed procedure is able to detect annual patterns describing significant customers behaviors, along with patterns related to instrumental errors and to abnormal consumptions. [ABSTRACT FROM AUTHOR]

Dirofilariasis is a parasitic disease of dogs and other carnivores transmitted mainly by the mosquitoes of the genera Culex, Aedes, Anopheles. Full life cycle of the Dirofilaria nematodes in humans is extremely rarely observed, usually lacking species determination at the molecular level. We report fully documented unusual clinical manifestation of subcutaneous dirofilariasis with intensive microfilariemia in peripheral blood revealed by the Knott's concentration technique. The identification of the Dirofilaria repens nematode was based on typical morphological findings for adult gravid female nematode found in the histopathological preparations. The morphology of microfilariae obtained from patient's peripheral blood was also typical for D. repens. The final identification was confirmed by the molecular analysis of microfilariae collected from the blood. [ABSTRACT FROM AUTHOR]

Varicocele, the leading cause of male infertility, can impair sperm quality and fertility via various oxidative stress mechanisms. An imbalance between excessive reactive oxygen species production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thus rendering a subset of varicocele men less fertile. In particular, sperm DNA fragmentation is usually elevated in men with clinical varicocele in both abnormal and normal semen parameters by the current World Health Organization criteria. In this review, we discuss the evidence concerning the association between varicocele, oxidative stress, and SDF, and the possible mechanisms involved in infertility. Furthermore, we summarize the role of varicocele repair as a means of alleviating SDF and improving fertility. Lastly, we critically appraise the evidencebased algorithm recently issued by the Society for Translational Medicine aimed at guiding urologists on the use of SDF testing in men with varicocele seeking fertility. Current evidence based on careful review of published studies confirms the effectiveness of varicocelectomy as a means of both reducing oxidatively induced sperm DNA damage and potentially improving fertility. Varicocele repair should be offered as part of treatment option for male partners of infertile couples presenting with palpable varicoceles. [ABSTRACT FROM AUTHOR]