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Your search keyword '"Betts, Michael"' showing total 2 results
Start Over Author "Betts, Michael" Topic aids vaccines Publisher springer nature
2 results on '"Betts, Michael"'

1. Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans.

Author

O'Brien, Kara L., Liu, Jinyan, King, Sharon L., Sun, Ying-Hua, Schmitz, Joern E., Lifton, Michelle A., Hutnick, Natalie A., Betts, Michael R., Dubey, Sheri A., Goudsmit, Jaap, Shiver, John W., Robertson, Michael N., Casimiro, Danilo R., and Barouch, Dan H.

Subjects
ADENOVIRUS diseases, ADENOVIRUSES, AIDS vaccines, IMMUNITY, IMMUNIZATION, VACCINATION
Abstract

The immunologic basis for the potential enhanced HIV-1 acquisition in adenovirus serotype 5 (Ad5)-seropositive individuals who received the Merck recombinant Ad5 HIV-1 vaccine in the STEP study remains unclear. Here we show that baseline Ad5-specific neutralizing antibodies are not correlated with Ad5-specific T lymphocyte responses and that Ad5-seropositive subjects do not develop higher vector-specific cellular immune responses as compared with Ad5-seronegative subjects after vaccination. These findings challenge the hypothesis that activated Ad5-specific T lymphocytes were the cause of the potential enhanced HIV-1 susceptibility in the STEP study. [ABSTRACT FROM AUTHOR]

Published
2009
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2. Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells.

Author

Hutnick, Natalie A., Carnathan, Diane G., Dubey, Sheri A., Cox, Kara S., Kierstead, Lisa, Ratcliffe, Sarah J., Robertson, Michael N., Casimiro, Danilo R., Ertl, Hildegund C. J., and Betts, Michael R.

Subjects
AIDS vaccines, T cells, ADENOVIRUS diseases, VACCINATION
Abstract

The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5–HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4+ T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4+ T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4+ T cells in increasing HIV-1 susceptibility in the STEP trial. [ABSTRACT FROM AUTHOR]

Published
2009
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