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Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans.
- Source :
- Nature Medicine; Aug2009, Vol. 15 Issue 8, p873-875, 3p, 2 Graphs
- Publication Year :
- 2009
-
Abstract
- The immunologic basis for the potential enhanced HIV-1 acquisition in adenovirus serotype 5 (Ad5)-seropositive individuals who received the Merck recombinant Ad5 HIV-1 vaccine in the STEP study remains unclear. Here we show that baseline Ad5-specific neutralizing antibodies are not correlated with Ad5-specific T lymphocyte responses and that Ad5-seropositive subjects do not develop higher vector-specific cellular immune responses as compared with Ad5-seronegative subjects after vaccination. These findings challenge the hypothesis that activated Ad5-specific T lymphocytes were the cause of the potential enhanced HIV-1 susceptibility in the STEP study. [ABSTRACT FROM AUTHOR]
- Subjects :
- ADENOVIRUS diseases
ADENOVIRUSES
AIDS vaccines
IMMUNITY
IMMUNIZATION
VACCINATION
Subjects
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 15
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 43579434
- Full Text :
- https://doi.org/10.1038/nm.1991