Author: "Yamidanov RS" / Publisher: springer - Searchworks@Jio Institute Digital Library Search Results

Author: Salimgareeva MKh, Yamidanov RS, Vakhitova YV, and Seredenin SB
Subjects: Adamantane administration & dosage, Adamantane pharmacology, Animals, Brain-Derived Neurotrophic Factor metabolism, Corpus Striatum metabolism, Densitometry, Gene Expression Regulation physiology, Hippocampus metabolism, Hypothalamus metabolism, Immunoblotting, Male, Rats, Adamantane analogs & derivatives, Extracellular Signal-Regulated MAP Kinases metabolism, Gene Expression Regulation drug effects, Nerve Growth Factors metabolism, Signal Transduction drug effects
Abstract: We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats.
Published: 2012
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Author: Salimgareeva MKh, Sadovnikov SV, Yamidanov RS, Vakhitova YV, and Seredenin SB
Subjects: Acetylation, Adamantane administration & dosage, Adamantane pharmacology, Animals, Brain drug effects, Chromatin drug effects, Chromatin metabolism, Corpus Striatum drug effects, Corpus Striatum metabolism, Gene Expression Regulation drug effects, Hippocampus drug effects, Hippocampus metabolism, Hypothalamus drug effects, Hypothalamus metabolism, Male, Protein Processing, Post-Translational, Rats, Adamantane analogs & derivatives, Brain metabolism, Histone Deacetylase 1 metabolism, Histones metabolism
Abstract: We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus. Ladasten reduced HDAC1 level in rat striatum and hippocampus and modified H3acK9 and H4acK8 levels in various structures of rat brain.
Published: 2011
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Author: Yamidanov RS, Salimgareeva MKh, Sadovnikov SV, Vakhitova YV, Govorun VM, and Seredenin SB
Subjects: Adamantane pharmacology, Animals, Brain metabolism, Electrophoresis, Gel, Two-Dimensional, Rats, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Adamantane analogs & derivatives, Brain drug effects, Nerve Tissue Proteins metabolism, Proteomics
Abstract: Two-dimensional electrophoresis and mass spectrometry detection were used to evaluate the range of proteins in rat brain after single treatment with ladasten (50 mg/kg). We identified 13 proteins with various levels of expression.
Published: 2010
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Author: Salimgareeva MKh, Vakhitova YV, Yamidanov RS, Sadovnikov SV, and Seredenin SB
Subjects: Adamantane toxicity, Animals, Hippocampus drug effects, Hippocampus metabolism, Hypothalamus drug effects, Hypothalamus metabolism, Male, Protein Binding drug effects, Rats, Adamantane analogs & derivatives, Brain drug effects, Brain metabolism, Cyclic AMP Response Element-Binding Protein metabolism, DNA metabolism
Abstract: We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.
Published: 2009
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