Changes in CREB (SER133) content and DNA-binding activity of transcriptional factors in rat brain cells against the background of ladasten exposure.

Authors :: Salimgareeva MKh
Vakhitova YV
Yamidanov RS
Sadovnikov SV
Seredenin SB
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2009 May; Vol. 147 (5), pp. 599-602.
Publication Year :: 2009
Abstract: We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.

Subjects :: Adamantane toxicity
Animals
Hippocampus drug effects
Hippocampus metabolism
Hypothalamus drug effects
Hypothalamus metabolism
Male
Protein Binding drug effects
Rats
Adamantane analogs & derivatives
Brain drug effects
Brain metabolism
Cyclic AMP Response Element-Binding Protein metabolism
DNA metabolism

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