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For over 60 years, scientists and engineers have been trying to crack a seemingly intractable problem: how to build practical devices that exploit nuclear fusion. Access to electricity has facilitated a standard of living that was previously unimaginable, but as the world's population grows and developing nations increasingly reap the benefits of electrification, we face a serious global problem: burning fossil fuels currently produces about eighty percent of the world's energy, but it produces a greenhouse effect that traps outgoing infrared radiation and warms the planet, risking dire environmental consequences unless we reduce our fossil fuel consumption to near zero in the coming decades. Nuclear fusion, the energy-producing process in the sun and stars, could provide the answer: if it can be successfully harnessed here on Earth, it will produce electricity with near-zero CO2 byproduct by using the nuclei in water as its main fuel. The principles behind fusion are understood, but the technology is far from being fully realized, and governments, universities, and venture capitalists are pumping vast amounts of money into many ideas, some highly speculative, that could lead to functioning fusion reactors. This book puts all of these attempts together in one place, providing clear explanations for readers who are interested in new energy technologies, including those with no formal training in science or engineering. For each of the many approaches to fusion, the reader will learn who pioneered the approach, how the concept works in plain English, how experimental tests were engineered, the future prospects, and comparison with other approaches. From long-established fusion technologies to emerging and exotic methods, the reader will learn all about the idea that could eventually constitute the single greatest engineering advance in human history.

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.