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The book offers a comprehensive overview of all the fundamental aspects of ENT surgical procedures using a step-by-step approach. It covers the main ENT subspecialties, including Head and Neck, Laryngology, Otology, Rhinology, Facial Plastics, Pediatrics, and Emergencies. Each chapter concludes with a set of key questions and answers related to the surgical procedure. This structure is specifically designed to facilitate rapid revision and foster the practical understanding required in the day-to-day management of ENT patients. Authored by practicing ENT specialists with diverse experiences, the book provides expert insights and practical tips that extend beyond textbook learning. It primarily targets junior doctors, from FY1 to ENT registrar level, and serves as a valuable resource for medical students and more experienced professionals seeking a refresher.

Major surgical societies have been publishing perioperative recommendations for over half a century, based on committees conducting reviews of the literature. Surgical books fundamentally target the intraoperative period when anesthesia is going on. Fatalities are often embedded in a larger context of systemic failures, in which initial problems are sidestepped or mishandled till they become overwhelming and irreversible. There must be a guiding principle and a truly integrated approach for each condition and treatment, of course based on the strongest available evidence. This unique book provides the reader standardized instructions and recommendations on the management of all high-risk surgical candidates in different specialties and contexts, encompassing a continuum of care, and not just in selected phases or groups.Written by worldwide experts, it is divided in 11 sections and 41 chapters which discuss: Preoperative evaluation, Lifestyle interventions, Surgical specialties, Protocols of special relevance, Fluids, electrolytes and shock, Perioperative surgical challenges, Bedside and adjunct procedures, Wound care, Innovative Approaches (including artificial intelligence and machine learning), End of life care and other ethical challenges. It also includes an additional section with supplementary material.Residents, fellows, practitioners in training and seasoned professionals seeking society recertification, primarily in surgery, anesthesiology, intensive care medicine, internal medicine, emergency services, trauma, vascular surgery, nursing, and physical therapy will find this book valuable. Professionals in the industry (especially those related to surgery, critical care monitoring devices, imaging diagnosis and interventional radiology), policy makers and government agencies will also benefit from this work.

In this book the most recent technical and technological advancements in the treatment of intracranial tumours will be described, and a wide and updated review of the literature on neurosurgical pathologies with high clinical impact will be offered to the readers. Technical nuances and surgical pearls, as well as tricks suggested by the most renowned experts in the field will be explained and illustrated in the light of the most modern approach to oncological neurosurgical pathologies. Each surgical technique will be contextualized in a multi-modal approach to the pathology, defining specific aims and goals of surgery, and a comparative analysis of surgical and clinical results deriving from the different approaches will be systematically discussed, analyzing the specific drawbacks and advantages in approaching the different pathologies, and emphasizing the preservation of patient's functioning and quality of life as well as the neurological status. Through this book, the editors aim to provide an effective educational support to already trained and experienced neurosurgeons, who want to approach the multi-modal management of intracranial tumors according to the principles of Evidence Based Medicine, highlighting classes of evidence, by using schemes and therapeutic algorithms based on most updated data available in the literature.

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

The new edition of this outstanding reference textbook, in two volumes, offers comprehensive and authoritative coverage of the contemporary specialty of oral and maxillofacial surgery. The aim is to provide an all-encompassing, user-friendly source of information that will meet the needs of residents and experienced surgeons in clinical practice and will also serve as an ideal companion during preparation for board certification or recertification examinations. All of the authors, numbering some 100, are distinguished experts in the areas that they address. The new edition takes full account of the significant changes in clinical practice and guidelines that have occurred during recent years. Readers will find clear explanations of the practical application of surgical principles, with a wealth of supporting illustrative material, including atlas-type illustrations to complement the descriptions of specific procedures. The fourth edition of Peterson's Principles of Oral and Maxillofacial Surgery is a truly exceptional resource for clinicians and students alike.

This fully revised and expanded second edition provides a comprehensive, up-to-date overview of the fundamentals of contemporary larynx and trachea surgery, presenting the state of the art in European laryngology. The book includes the most recent developments in surgery, such as robotic surgery, as well as novel materials such as the CO2 waveguide, and describes the technical aspects of the various procedures in detail to allow readers to implement them. It particularly focuses on issues like the treatment of papilloma, the transoral surgery of T3-T4 larynx cancer and scarring of the vocal fold. The contributors are experts in the field, mainly from the European Laryngological Society and European Head & Neck Society, but also from America and Asia.This textbook is a valuable resource for ENT trainees and those superspecializing in laryngology, as well as for experienced laryngologists and head & neck surgeons.

This atlas describes an array of tumors and diseases that affect the orbit and associated cranial nerves. Often lacking in radiology residency and fellowship training is teaching of the anatomy of the orbit and cranial nerves, as well as the imaging appearance of orbital tumors and diseases that affect these regions. This atlas fills this gap of knowledge with tumors and diseases encountered and treated at MD Anderson Cancer Center, providing a review of the imaging anatomy and the appearance of the tumors and diseases that should aid in formatting a differential diagnosis. The text consists of ten chapters divided into separate anatomic sections followed by an eleventh chapter describing the treated orbit and tumor recurrence. Each of the first ten chapters begins with a description of the relevant anatomy, labeled CT and MRI images and drawings to highlight important anatomic considerations. This is an ideal guide for practicing general radiologists, neuroradiologists and trainees, as well as ophthalmologists, head and neck surgeons, neurosurgeons, medical and radiation oncologists, and pathologists who interpret or review orbital images as part of their daily practice.

This book provides clinicians, clinicians-in-training and researchers with a unique rapid-access educational resource on the spectrum of issues at the intersection of skin and malignancy. In it, there is clinical detail provided on how the skin reveals systemic malignancy via cutaneous metastases, genodermatoses or paraneoplastic dermatoses. At the same time, it reviews pharmacologic treatment of internal malignancy and how this can result in cutaneous adverse reactions; conversely, therapeutics for skin conditions can increase risk for internal malignancy. As arguably the most significant cutaneous malignancy, melanoma receives specific attention for its metastatic potential, current diagnostic advances, and recent therapeutic breakthroughs. Dermato-Oncology Study Guide: Essential Text and Review serves a critical educational need for clinicians caring for patients with systemic malignancy by creating an easy-to-use resource that provides practical tools to recognize skin signs of internal malignancy. Furthermore it helps in anticipating and managing adverse reactions of therapeutics for systemic malignancy, and gives the reader the opportunity to weigh the risks of malignancy of pharmacologic agents for skin disease.

Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. Volume I begins with a general overview, including the industry landscape, of HNC detection, diagnosis, and treatment. Next, it covers the applications of innovative technologies such as microfluidics, nanotechnology, and deep learning to early detect as well as study HNC. For example, studying the cellular features at a single-cell level became possible with the advancement of technologies such as mass cytometry or specifically, Cytometry by Time Of Flight Mass Spectrometry (CyTOF), which has revolutionized the way we can study complex human diseases such as HNC. Finally,the last few chapters are dedicated to describing the standard of care of HNC.The first volume of Early Detection and Treatment of Head & Neck Cancers is highly pertinent to the next generation of interdisciplinary clinicians, scientists, residents, and students who are particularly interested in HNC and in the translation of early detection methods, technologies, and research to clinical practice.

This book is a comprehensive, focused resource on intraoperative neurophysiological monitoring (IOM). This rapidly evolving field has created a demand for an up-to-date book such as this that builds on foundational concepts necessary to the practice of IOM in the context of anatomy and physiology. Each chapter is designed to not only inform the reader, but to also test the reader on the information presented - therefore promoting practical, problem-based learning. Surpassing the quality of its successful predecessor, Principles of Neurophysiological Assessment, Mapping, and Monitoring, Second Edition, is positioned to suit the needs of residents and fellows studying for the IOM certificate programs, physicians and anesthesiologists practicing IOM, and neurotechnologists both experienced and in training.

This book is a comprehensive guide to skull base imaging. Skull base is often a “no man's land” that requires treatment using a team approach between neurosurgeons, head and neck surgeons, vascular interventionalists, radiotherapists, chemotherapists, and other professionals. Imaging of the skull base can be challenging because of its intricate anatomy and the broad breadth of presenting pathology. Although considerably complex, the anatomy is comparatively constant, while presenting pathologic entities may be encountered at myriad stages. Many of the pathologic processes that involve the skull base are rare, causing the average clinician to require help with their diagnosis and treatment. But, before any treatment can begin, these patients must come to imaging and receive the best test to establish the correct diagnosis and make important decisions regarding management and treatment. This book provides a guide to neuoradiologists performing that imaging and as a reference for relatedphysicians and surgeons. The book is divided into nine sections: Pituitary Region, Cerebellopontine Angle, Anterior Cranial Fossa, Middle Cranial Fossa, Craniovertebral Junction, Posterior Cranial Fossa, Inflammatory, Sarcomas, and Anatomy. Within each section, either common findings in those skull areas or different types of sarcomas or inflammatory conditions and their imaging are detailed. The anatomy section gives examples of normal anatomy from which to compare findings against. All current imaging techniques are covered, including: CT, MRI, US, angiography, CT cisternography, nuclear medicine and plain film radiography. Each chapter additionally includes key points, classic clues, incidence, differential diagnosis, recommended treatment, and prognosis. Skull Base Imaging provides a clear and concise reference for all physicians who encounter patients with these complex and relatively rare maladies.

This clinically oriented book provides a comprehensive update on the biology, diagnosis, and treatment of salivary gland cancer. Detailed information is presented on molecular characterization and radiological staging, and a series of treatment-related chapters describe the different surgical approaches to major and minor salivary gland cancer, including reconstructive surgery techniques, and the roles of radiotherapy and heavy ion therapy. Rehabilitation, follow-up, and the management of metastatic disease are also fully discussed. The aim is to equip the reader with the knowledge required to deliver appropriate tailored treatment in each patient, based on tumor characteristics and other pertinent factors. An additional feature is the inclusion of information on advocacy groups and their perspectives. All of the chapters are written by leading specialists in the field. In presenting the most recent advances and innovations in diagnosis and therapy and relating them to individualized treatment, this book will appeal to a wide audience including otorhinolaryngologists, head and neck surgeons, maxillofacial surgeons, radiation oncologists, and other clinicians.

Surgical pathologists play a central role in patient surveillance and treatment by surgeons, radiation oncologists, and medical oncologists. Although salivary gland tumors are uncommon overall, their histopathologic diversity and challenge command the attention of practicing surgical pathologists. Atlas of Salivary Gland Pathology focuses on the diagnostic approach to salivary gland neoplasia—one of the more challenging fields within surgical pathology—emphasizing the need to understand downstream implications with respect to patient surveillance and treatment. The presence of formidable histologic mimicry in salivary gland neoplasia is well-documented in the pathology literature and has also been observed in the consultation practice of the volume editor. This textbook is designed with the needs of practicing surgical pathologists and pathologists-in-training in mind, providing a comprehensive overview of both common and rare salivary gland neoplasms. The primary educational objectives for readers include the following: 1) distinguish benign from low-grade malignant salivary gland neoplasms, 2) effectively use histochemical, immunohistochemical, and cytogenetic studies in challenging cases, 3) understand which diagnoses merit additional surgery and/or adjuvant therapy (radiation, chemotherapy), and 4) enhance pathologist-to-clinician communication in the setting of salivary gland disease.

Melanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease, as well as the biological and scientific understanding of its pathogenesis and treatment. Key topics highlighted include recent breakthroughs in molecular diagnostics, breakthroughs in targeted therapeutic approaches, overviews of signaling and transcriptional pathways, and important controversies such as screening, early diagnosis, sentinel node biopsy, and prevention strategies. In all, the volume provides a cutting edge and comprehensive presentation of the field of melanoma, written by a team of internationally renowned thought-leaders.

This book provides a practical guide to decision making in head and neck oncologic surgery. As new technology is introduced, there is increasing knowledge regarding the efficacy of traditional head and neck surgical therapies and how to select among these varied and complex approaches is becoming increasingly difficult. Concise easy to follow chapters are devoted to one or two specific questions or decisions in head and neck oncologic surgery, aiding the reader to develop their decision making skills. Difficult Decisions in Head and Neck Oncologic Surgery is a timely reference source for practicing surgeons, surgeons in training, and educators on the recommended ideal approaches in selected clinical situations.

This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

This book, now in a revised and updated second edition, remains a unique reference on postoperative neuroimaging. It is designed as a guide that will familiarize the reader with the radiological features of various types of surgical procedures, implanted hardware, and potential complications. Specific topics covered include imaging after facial cosmetic surgery; orbital and oculoplastic surgery; sinus surgery; scalp and cranial surgery; brain tumor treatment; psychosurgery, neurodegenerative surgery, and epilepsy surgery; skull base surgery, including transsphenoidal resection; temporal bone surgery, including various ossicular prostheses; orthognathic surgery; head and neck oncologic surgery, including neck dissection and flap reconstruction; CSF diversion procedures and devices; spine surgery; and vascular and endovascular neurosurgery. The book is written by experts in the field and contains an abundance of high-quality images and concise descriptions. It will be of value for neuroradiologists, neurosurgeons, and otolaryngologists wishing to deepen their knowledge of the imaging correlates of postsurgical findings and to improve their ability to interpret images correctly.

This is the second of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume addresses a range of management issues in oral cancer, from imaging and staging through to the roles of radiation therapy and chemotherapy. Principles of ablative surgery are explained, and neck dissection and sentinel lymph node biopsy techniques, described. Detailed consideration is also given to the management of complications, salvage surgery and re-radiation, the biologic basis of treatment failure, and emerging approaches to overcome treatment resistance. The inclusion of resource-stratified guidelines will meet the needs of practitioners in different geographic regions with varying resources.Overview on all volumes:Volume 1: Biology, Epidemiology, Etiology, and PreventionVolume 2: Diagnosis and ManagementVolume 3: Oral and Maxillofacial Reconstructive Surgery Volume 4: Rehabilitation and Supportive Care

This is the first of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume, on tumor biology, epidemiology, etiology, emerging role of cancer stem cells and prevention of oral cancer, opens by discussing oral carcinogenesis in general and the role of particular carcinogens and human papillomavirus. Global epidemiology and changes in disease prevalence are then addressed. Up-to-date information is provided on emerging cancer biomarkers, and the biologic basis of personalized therapy is explained. Histopathological features of malignant and premalignant neoplasms and their relevance to management are described. Further chapters focus on the current status of chemoprevention, the management of oral submucous fibrosis, and the value of various diagnostic adjuncts. The volume concludes by critically evaluating theefficacy of oral screening methods.Volume 1: Biology, Epidemiology, Etiology, and PreventionVolume 2: Diagnosis and ManagementVolume 3: Oral and Maxillofacial Reconstructive SurgeryVolume 4: Rehabilitation and Supportive Care

​Written for residents and practitioners of otolaryngology, medical oncology, radiation oncology, and maxiollofacial surgery, this book provides the reader with a comprehensive, concise discussion of the best evidence available on which to base clinical decisions needed when managing patients with squamous cell carcinomas of the oral cavity, pharynx and larynx. Because of its accessible and practical format, this book is considerably different than other related titles on the market. Formatted with questions at the beginning of each chapter that are then answered with evidence and best practices available for each case, each chapter addresses situations the clinician is likely to face in the diagnostic evaluation and treatment of a patient with cancer of the head and neck.​Most clinical decisions in the management of cancers of the head and neck region are based on the results of a few controlled, randomized clinical trial trials (Evidence Level I). However, most decision-making is based on the results of case-control studies (Evidence Level II), descriptive studies, reports of expert committees, or opinions of respected authorities (Evidence Level III). This information is scattered throughout the literature and often comingled with information about other topics. Therefore, there is a need for a publication in which the evidence pertinent to making decisions regarding a particular clinical problem is distilled from the literature and presented in a single concise, clinical, situation-driven source. Cancer of the Oral Cavity, Pharynx and Larynx: Evidence-Based Decision Making is just such a resource.

Dieses Buch enthält 300 Fragen und Antworten aus der Hals-Nasen-Ohren-Heilkunde. Der Leser findet nicht nur Fragen zu Erkrankungen, Diagnosemethoden und Therapien, sondern auch viel Kurioses und Seltenes aus der HNO und der Medizin, worüber auch erfahrene HNO-Ärzte ins Grübeln geraten.

The first of a multi-volume set, this textbook covers sinonasal and nasopharyngeal pathology. An ideal sign-out resource for head and neck pathology, it includes anatomy, staging, diagnostic, and prognostic information. Richly illustrated and well-structured, the easily accessible format includes glossaries, boxes of key points, and self-assessment questions at the end of each chapter. Nose, Paranasal Sinuses, and Nasopharynx: Textbook of Head and Neck Pathology: Volume 1 is aimed at trainees and practicing pathologists worldwide, and will also be of interest to oral pathologists and oral pathology trainees.

This book provides a comprehensive description of the pathology of the head and neck region, concentrating especially on those pathologic entities that are unique to or characteristic of the head and neck. The new edition retains the ten chapters of the first edition, all updated and improved, and additionally contains seven entirely new chapters and a more detailed subject index. The number of illustrations has been substantially increased, and various lesions absent in the original edition have been included. Throughout, attention is paid to correlation of pathology with epidemiology, clinical features, pathogenesis, and molecular genetics. Differential diagnosis is addressed, and information is also provided on staging, prognosis, and therapy. The authors include foremost experts in the field, some of whom are senior members of the Working Group on Head and Neck Pathology of the European Society of Pathology.

​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

This book, now in its third edition, aims to promote a deeper understanding of the scientific and clinical basis of nuclear medicine and the new directions in medical imaging. The new edition has been revised and updated to reflect recent changes and to ensure that the contents are in line with likely future directions. The book starts by providing essential information on general pathophysiology, cell structure and cell biology as well as the mechanisms of radiopharmaceutical localization in different tissues and cells. The clinical applications of nuclear medicine are then presented in a series of chapters that cover every major organ system and relate the basic knowledge of anatomy, physiology and pathology to the clinical utilization of various scintigraphic modalities. The therapeutic applications of nuclear medicine are discussed in a separate chapter, and the final chapter is devoted to the biologic effects of ionizing radiations, including radiation from medical procedures.

Over the last 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes most diagnostic challenges and problems for general pathologists. During courses the author has given, consultants and trainees alike have expressed the lack of a comprehensive, useful book on salivary gland pathology. Such a book needs to be broad and to illustrate almost every variant of all tumor entities. Another important feature to incorporate is the newly gained knowledge about genetics in salivary gland tumors, a knowledge that has emerged during the last 3-4 years only (and is growing continuously). A mapping of the immunophenotypes of salivary gland tumors is neither available today and will greatly benefit in routine diagnostic work.

This book provides foundational knowledge of intraoperative monitoring (IOM) and is written for the range of clinicians who monitor the function of the nervous system during surgery, from new technologists to neurophysiologists and neurosurgeons. Early chapters describe the building blocks of IOM in accessible terms and are followed by practical chapters on monitoring and mapping that show basic and clinical science “in action”. Anesthesiologists and trainees with an interest in diagnosing and managing pain will appreciate the inclusion of chapters on the electrophysiological assessment of spinal cord pathology and on the treatment of pain. Principles of Neurophysiological Assessment, Mapping, and Monitoring is designed for use as a text in academic courses or in corporate training programs. It also provides a concise refresher for experienced clinicians and for physicians, neurophysiologists, and technologists preparing for board exams.

Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed'next generation'analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers.Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.

Moderne endokrine Chirurgie erfolgt immer in enger interdisziplinärer Zusammenarbeit mit Internisten, Nuklearmedizinern und Pathologen. Die chirurgisch relevanten Erkrankungen der endokrinen Organe sind mit allen Aspekten umfassend in diesem Buch dargestellt: Physiologie und Pathophysiologie der endokrinen Regelkreise, Diagnostik und interdisziplinäre Therapie, praxisorientierte detaillierte Empfehlungen zum Vorgehen und zur Verfahrenswahl. Alle Beiträge wurden dem aktuellen Stand angepasst und sind, wie in den Vorauflagen, von renommierten Autoren der beteiligten Fachgebiete verfasst.

Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.

As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident.

To an unusual degree, the shared “working space” of otolaryngologists and anesthesiologists means that issues important to one are important to the other. Anesthesiology and Otolaryngology is the first book to address the closely overlapping information needs of both groups of specialists. It is collaboratively written and edited by anesthesiologists and otolaryngologists, and the chapters are carefully designed to insure maximal relevance to members of both specialties. The heart of the book consists of chapters on managing patients during the full range of otolaryngologic procedures. These chapters are structured chronologically, and otolaryngologic and anesthesiologic perspectives are systematically presented for each operative stage. Foundational topics such as gross and radiographic anatomy, physiology, and pharmacology are covered. The book includes a unique chapter on oxygen delivery systems that serves as a comprehensive review for anesthesiologists and an overview for the otolaryngologist. Special topics addressed include acute and chronic pain management, and the logistics of managing an office-based surgical practice. · “All-in-one” reference for otolaryngologists and otolaryngologic anesthesiologists· Surgical and anesthesiologic perspectives marshaled for pre-operative, intraoperative, and postoperative periods · Pearls and Insights at end of chapters· Organized by surgical region· Special challenges of difficult airway and of pediatric otolaryngologic procedures addressed

Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a “first knowledge base” in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.

So geht Radioonkologie heute!Das Standardwerk für alle Strahlentherapeuten, Radioonkologen, Radiologen und Onkologen ist jetzt wieder erhältlich in zweiter, komplett überarbeiteter Auflage. Von den physikalischen und strahlenbiologischen Grundlagen bis hin zu organspezifischen Therapien sind alle weiterbildungsrelevanten Inhalte detailliert beschrieben.Auf Ihre Bedürfnisse in Klinik und Praxis zugeschnitten…Konkrete Handlungs- und Therapieanweisungen mit DosierungsempfehlungenHervorhebung von Warnhinweisen und praktischen TippsAusführliche Behandlung aller relevanten Studien und StudienergebnisseVollständig…Detailliertes Fachbuch zu allen Aspekten der Strahlentherapie und Radioonkologie Alle Inhalte der Weiterbildungsordnung und darüber hinausAlle Grundlagen, Techniken und organspezifische TherapienKonkrete Vorlagen und Hinweise zur Dokumentation und NachsorgeTumorklassifikation und StagingNeu in dieser Auflage…Intensitätsmodulierte Radiotherapie (IMRT)Bildgestützte Radiotherapie (IGRT)Neue Kombinationspartner zur Radiotherapie insbesondere'Biologicals'(Antikörper, Thyrosinkinaseinhibitoren u.v.m.)Verfasst von renommierten Autoren und Herausgebern lässt dieses umfangreiche Werk keine Fragen offen.

Conformal radiation therapy represents a new challenge for radiation oncologists. It offers the prospect of either increasing the radiation dose to target tissues while delivering a similar dose to organs at risk, or reducing the dose to organs at risk while maintaining the dose to target tissues. First, lymph node areas at risk are established using the available data from pathological examination of surgical specimens and/or pattern of locoregional relapse. Then, based on a three-dimensional description of the anatomical regions where the areas at risk are located, guidelines for the delineation of the clinical target volumes are proposed. The data presented should enable the reader to make appropriate decisions regarding the selection and delineation of the target volumes when confronted with the most frequent tumor types and sites.The book will contribute to paving the way for more effective radiation oncology in the twenty-first century.

Die Inzidenz der bösartigen Tumoren der oberen Luft- und Speisewege nimmt eindeutig zu. Diese im Hals-Bereich lokalisierten (zumeist Plattenepithel-) Karzinome gehen häufig mit dort lokalisierten Lymphknotenmetastasen einher. Häufig fallen sie durch diese überhaupt erst auf, zumal der Primärtumor gelegentlich kaum Beschwerden bereitet. Das vorliegende Buch bietet als Nachschlagewerk einen umfassenden Überblick der für alle Ärzte (auch Internisten, Allgemeinmediziner und Dermatologen) absolut notwendigen Kenntnis um die Differenzialdiagnostik der Lymphknotenerkrankungen und deren Therapie, insbesondere der verschiedenen Formen der Neck-Dissection. Hochqualitative Abbildungen und Tabellen ermöglichen es, die Thematik mit hohem didaktischen Wert vorzustellen.

Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl­ edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re­ cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in­ creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im­ prove diagnostic accuracy while reducing operative morbidity is the'sentinel node'technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu­ mor biological viewpoints. World-renowned experts with long­ term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.

The seventeenth annual symposium sponsored by the Texas Research Institute of Mental Sciences was held October 23-26, 1983, in Houston, Texas. The theme was Aging 2000: Our Health Care Destiny. This volume on biomedical aspects and a companion volume on psycho­ social aspects include edited versions of the presentations by about 80 speakers. Their papers were directed at practitioners, researchers, and medical educators who will be active and productive in the year 2000, and we focused on those who would influence the evolution of care of elderly persons during the next 17 years. We chose topics that would be of particular interest to teachers and current planners in the disciplines concerned with delivery of health and social services. We believe that having a core of more qualified and better trained practitioners will help the population of aged persons achieve a higher level of physical and mental health, life satisfaction and happiness, to find better coping techniques and control of environmental stresses, and to attain personal and social goals. Our Goals While preparing for the symposium we knew that the status of the art in 1983 obviously would be the base from which we would work, but we asked our speakers to give priority to future planning and directions.

I wrote the first edition of this work in 1987 with the object of providing a review of the aetiology, pathogenesis and morphological basis of diseases of the ear, nose and throat. Since that time important changes have taken place in the disciplines of both histopathology and otorhinolaryngology. Pathology has shifted its research orientation towards a molecular one; notable successes with new medical and surgical treatments in ENT have resulted in a striking expansion of that field. To provide a precis of the scientific principles of a subject lying between two such mobile territories was a daunt­ ing prospect. Help was indeed necessary and I welcome Henrik Hellquist as the co­ author of this second edition. He has had a longstanding interest in both head and neck and molecular pathology and has not only produced scholarly publications, but has also played an important role in enhancing international cooperation in this combined field.

Understanding the brain mechanisms which underlie behavior is one of the most challenging tasks of modern biology. The study of these mechanisms can be approached using a variety of biological systems as models, depending essentially on the type of question being asked and the technical approach which is considered. In vertebrates, the study of brain neurochemistry in relation to behavior e,xpression has made tremendous progress during the last two decades. In particular, much at­ tention has been devoted to the effect of steroid hormones on brain structure and activity in connection with social and mainly reproductive behavior. This book exemplifies some of the major trends in the field. I did not attempt to cover exhaustively all the work that has been done in this area but rather to present a series of selected reviews on the molec­ ular and cellular brain mechanisms most directly related to social behavior. This selection obviously reflects my own interests but also, I believe, highlights those areas of research in which important progress has been made in recent years. A number of brain biochemical or cellular mechanisms which could be related to behavior, but have not been formally demonstrated to be so, are consequently ignored. The focus here is on social behavior and thus steroid-dependent processes are covered in priority. This choice of course leads us to ignore major trends in brain and behavior research but this is, I hope, clearly reflected in the title of the volume.

Latest issue in the CURRENT TOPICS IN NEUROENDOCRINOLOGY se- ries which has been gaining a great deal of reputation as a primary source for reviews in neuroendocrinology and related areas in the past few years.

This volume brings together the work of experts from clinical and basic sciences specialties and addresses some of the controversial issues and advances in the management of oral cancer. Improving the outcome for the oral cancer patient will require dedicated work from many disciplines working together as multidisciplinary units. The book is meant for medical students, residents and consultants in various disciplines, including otolaryngology, head and neck surgery, neurosurgery, plastic surgery, maxillofacial surgery and oncology.

As a result of the increasing number of surgical procedures on the brain, head, neck, and spine, postoperative changes are being encountered more frequently on neuroradiological examinations. However, these findings are often unfamiliar to neuroradiologists and neurosurgeons and can be difficult to interpret. This book, which contains numerous images and to-the-point case descriptions, is a comprehensive yet concise reference guide to postsurgical neuroradiology. It will enable the reader to identify the type of surgery performed and the hardware implanted and to differentiate expected sequelae from complications. Topics reviewed include trauma, tumors, vascular disorders, and infections of the head, neck, and spine; cerebrospinal fluid abnormalities; and degenerative diseases of the spine. This book will serve as a unique and convenient resource for both neuroradiologists and neurosurgeons.

-Richly illustrated; 109 illustrations, 57 in color -Cover a wide range of diagnostic and theraputic techniques, i.e. MRI, PET, surgical treatment, radiation therapy

The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis, and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists, oncologists, nuclear medicine physicians, radiation oncologists, primary care physicians, and surgeons who deal with head and neck cancer.

In der 3. Auflage des Standardwerkes Pathologie bietet der vorliegende Band eine umfassende deutschsprachige Darstellung der Zytopathologie. Nach Organkapiteln geordnet sind alle in der Zytodiagnostik relevanten Erkrankungen übersichtlich dargestellt. Sämtliche Gebiete der Exfoliativ- und Aspirationszytologie unter Einbeziehung der neueren Entwicklungen auf zytotechnischem und diagnostischem Gebiet finden ihren Raum. Die flüssigkeitsbasierte Zytologie und molekularbiologischen Methoden werden, ihrer heutigen Bedeutung entsprechend, stärker berücksichtigt als in der Vorauflage. Da sich das Buch auch an zytotechnisches Personal wendet, werden die für das Verständnis der zytologischen Befunde wichtigen histologischen und tumorbiologischen Aspekte beschrieben. Zahlreiche repräsentative, meist farbige Abbildungen und Schemata ergänzen den Text.

In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

Nuclear Medicine Technology Study Guide presents a comprehensive review of nuclear medicine principles and concepts necessary for technologists to pass board examinations. The practice questions and content follow the guidelines of the Nuclear Medicine Technology Certification Board (NMTCB) and American Registry of Radiological Technologists (ARRT), allowing test takers to maximize their success in passing the examinations. The book is organized by sections of increasing difficulty, with over 600 multiple-choice questions covering all areas of nuclear medicine, including radiation safety; radionuclides and radiopharmaceuticals; instrumentation and quality control; patient care; and diagnostic and therapeutic procedures. Detailed answers and explanations to the practice questions follow. Supplementary chapters will include nuclear medicine formulas, numbers, and a glossary of terms for easy access by readers. Additionally, test-taking strategies are covered.