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This book provides all the information required for the optimal and practical use of nuclear medicine techniques, which are undergoing rapid development yet remain underutilized. Each chapter focuses on one particular clinical system or disease area. The first section of each chapter describes the nuclear medicine protocols and illustrates normal image patterns observed on commonly and uncommonly performed scans as a reference and explains when and how the procedures should be performed. The following section illustrates both the imaging patterns of different diseases and the diagnostic role of individual studies. Comparisons with other modalities are provided, and the rationale for and effective utilization of each study are discussed. In the 2nd edition of the book, there are above 300 case reviews, a new chapter for radionuclide treatments and new imaging protocols. In addition, the normal patterns on relevant morphologic modalities are documented in an appendix. The book is aimed at Nuclear Medicine physicians and technologists with different levels of training and expertise and also at radiologists who practice nuclear medicine and to radiology residents.

This book presents a universal picture of the impact of climate change on food production, diversity, and concerns regarding food safety. The book also highlights the traditional and modern techniques for sustainably improving the production of food crops and their nutritional quality aligning with the “zero hunger” goal (Sustainable Development Goal 2) of the United Nations. The book holistically includes the contributions of scientists and academicians working in the fields of Food and Nutrition, Plant and Microbial Sciences, Agriculture, etc. The book also offers insights into the strategies adopted worldwide for ensuring food availability and safety, taking the aid of advanced technologies like climate-smart agriculture along with nanotechnology and artificial intelligence in the event of climate change. Above all, the book transpires the subject matter using illustrative figures and outlines and therefore will be an asset for the post-graduate students, researchers, and faculties.

This Handbook paints a portrait of what the international field of curriculum entails in theory, research and practice. It represents the field accurately and comprehensively by preserving the individual voices of curriculum theorist, researchers and practitioners in relation to the ideas, rules, and principles that have evolved out of the history of curriculum as theory, research and practice dealing with specific and general issues. Due to its approach to both specific and general curriculum issues, the chapters in this volume vary with respect to scope. Some engage the purposes and politics of schooling in general. Others focus on particular topics such as evaluation, the use of instructional objectives, or curriculum integration. They illustrate recurrent themes and historical antecedents and the curricular debates arising from and grounded in epistemological traditions. Furthermore, the issues raised in the handbook cut across a variety of subject areas and levels of educationand how curricular research and practice have developed over time. This includes the epistemological foundations of dominant ideas in the field around theory, research and practice that have led to marginalization based on race, class, gender, sexuality, ethnicity, age, religion, and ability. The book argues that basic curriculum issues extend well beyond schooling to include the concerns of anyone interested in how people come to acquire the knowledge, skills, and values that they do in relation to subjectivity and experience.

This 2nd edition is a definitive resource on issues pertaining to the full range of topics in scientific and other scholarly research on the quality of life, including health-related quality of life research or also called patient-reported outcomes research. Altogether 500 new and updated entries appear in this new edition. This single, multidimensional reference work connects the most salient and important contributions to the relevant fields from the behavioral and social sciences as well as health and healthcare. New topics in this 2nd edition are on disabilities, religion/spirituality, sex, sports, politics, government, science, literature, performance and visual arts, environmental quality and sustainable development. The 2nd edition of the Encyclopedia of Quality of Life and Well-being Research is an indispensable reference point for future research and writing topics on quality of life.

This book explains the main problems of industrial wastewater treatments and how they are being treated by innovative biological processes. The need for clean water in developing countries has become difficult to achieve as a result of globalization and industrialization and because of an increase in population, urbanization, and per capita water use. Residential, commercial, industrial, and educational institutions produce immense amounts of wastewater. Wastewater is treated to extract toxins to produce processed effluent by physical, chemical, and biological processes. Most of these innovative treatment systems are membrane filtration, advanced oxidation processes, and electrochemical approaches, which are strongly committed to offering solutions to help protect public health and the environment. For wastewater treatment, different forms of bioreactors are used which are reliable, cost-efficient, and effective in removing a wide variety of contaminants. This book outlines the capacity of various bioreactors that are most widely used for the treatment of different industrial and domestic wastewater, such as a rotating biological contactor, biological fluidized bed reactor, packed bed reactor, membrane bioreactor, continuous stirred tank bioreactor, up-flow anaerobic sludge blanket reactor, and photobioreactor, etc. Despite this, the acceptance of these technologies and their commercialization on an industrial scale, the performance is still limited. Therefore, a broader use of cost-effective in situ remedial approaches to natural phenomena like bioremediation is needed. The role of numerous bioreactors in industrial effluent treatment has, including recent developments, also been explored in depth. Furthermore, it includes the operational factors affecting their performances, advances in their architectural design, their amalgamation with the existing setup, scale-up studies, life cycle assessment of those reactors, materials and cost analysis, etc. This information helps the reader to understand the insight into the mechanism, pros and cons, moreover efficient utilization, and commissioning of bioreactors.

This book presents the growing interconnection of two pillars from the world's higher education institutions: academic integrity and libraries. It provides sound examples to extant questions and conversations about whose job it is to teach academic integrity, and what library work is. The role of libraries in supporting academic integrity is not always clear and has not been fully explored. Drawing from library literature and that of academic integrity more broadly, readers are exposed to how libraries are necessary in a holistic approach to academic integrity. Education about academic integrity and the prevention of academic misconduct, for not only students but other institutional stakeholders, are demonstrated as occurring optimally in positive, supportive, and proactive ways. The book details numerous ways in which librarians can work with faculty and other stakeholders using established frameworks such as information literacy and blended librarianship as well as innovative platforms and content. Other contributions involve the identification of potential academic misconduct and administration of academic integrity policies to complete the cycle recommended by the frameworks of global educational quality organizations (QAA, TEQSA). Initiatives presented in the book include those at the course level and institution-wide initiatives involving curriculum, policy, and supports for faculty and students. Also contained are efforts occurring at a national level within professional networks, in addition to international library curriculum. This book provides inspiration to institutions and academic libraries of any size and scope to embrace this emerging role in creating cultures of academic integrity.

This book offers a detailed guide to MR-Linac, a unique and fast growing radiation treatment modality. MR-linac is new technology that is a fusion of an MRI and a linear accelerator on the same gantry. It can change both target volume delineation and tumor visualization in real time using MR-cine images and treatment. Tumor location changes moment to moment as radiation is delivered, but this cannot be visualized in current radiation therapy practices. This new and rapidly growing technology can provide adaptive therapy that was not possible before. This book presents current knowledge on MR-linac technology, clinical practices, and ultimately patient outcome where dose escalation is not possible due to limiting normal tissue structures in the vicinity of tumor. There are two commercial MR-linac machines under consideration and both will be covered in detail. The book is divided into four sections. The first gives a general introduction to MR-Linac, covering the role of MRI inradiation oncology, the clinical necessity of this technology, and patient selection. The next section details the physics and technology of MR-Linac, covering image sequence, motion management, and treatment planning. Section three offers the clinical applications of MR-Linac and is divided by body area, including lung, prostate, and breast. Finally, the fourth section looks to the future and what this technology can mean for radiation oncology. This is an ideal guide for radiation oncologists, medical physicists, and relevant trainees.

This fully updated new edition is a comprehensive guide to interventional radiology (IR) for medical students, residents, early career attendings, nurse practitioners and physician assistants. The IR Playbook includes procedures, new and updated data, and new images, to stay on the cutting edge of IR. As a specialty, IR is constantly changing and evolving to apply newer technologies and techniques to a breadth of disease pathologies. This book addresses the growing need for a reference for trainees and early career professionals to gain a solid foundation. Let this book serve as your only resource from the first day you find out about IR to the day you take your certifying exam. One and done.The textbook is divided into two main sections, with many images and key point boxes throughout that offer high-yield pearls along with the specific How To's necessary for practice. The first section is designed to give readers an introduction to IR, including radiation safety, commonly used devices, patient care, and anatomy. The second portion is divided by procedure. These chapters cover pathophysiology, indications for treatment, as well as alternative treatments before delving into interventional therapy. This new edition has been fully updated throughout including several brand-new procedures and divided chapters to allow a more in depth look at several disease pathologies. IR Playbook gives medical students, residents, and trainees a full perspective of interventional radiology.

This book will be a collection of the conference manuscripts presented at the 2022 2nd International Joint Conference on Energy, Electrical and Power Engineering covering new and renewable energy, electrical and power engineering. It is expected to report the latest technological developments in the fields developed by academic researchers and industrial practitioners. The application and dissemination of these technologies will benefit the research community, as new research directions are becoming increasingly interdisciplinary, requiring researchers from different research areas to come together and share ideas. It will also benefit the electrical engineering and energy industry, as we are now experiencing a new wave of industrial revolution, i.e. the electrification, intelligentisation and digitalisation of our transport, manufacturing processes and way of thinking.

Stellen Sie sich vor, ein demokratischer Staat muss ein komplexes Problem lösen. Der Lösung muss eine Mehrheit der Bevölkerung zustimmen. Es stehen zwei Lösungen zur Wahl: Eine komplizierte, die schwer zu verstehen ist, das Problem aber löst und eine einfache, die leicht verständlich dargestellt werden kann, aber falsch ist, und das Problem nicht löst. Welche wird die Wahl gewinnen? Vermutlich die leichte, falsche Lösung. Wir Menschen tragen den „sense making Trieb“ in uns. Wir wollen verstehen, was um uns herum geschieht. Die Welt ist aber zu schwierig und zu kompliziert, um sie tatsächlich begreifen zu können. Das macht die leichten Scheinlösungen so verführerisch. Wir lieben sie, weil sie uns vorgaukeln, wir wüssten Bescheid. Politiker wissen das und bedienen uns mit leichter Kost und die Medien wissen es auch. Das führt zu der Frage: Sind Demokratien mit Ihrer breiten politischen Mitbestimmung überhaupt in der Lage, die hochkomplexen Probleme unserer Zeit zu lösen? Früher hat uns das Denken in weltanschaulichen Bahnen geholfen. Aber die Zeit ist darüber hinweggegangen und heute gibt keine klaren'linken'oder'rechten'Lösungen mehr. Wir brauchen deshalb dringend neue Wege, um als Demokratie zu überleben. Das Besondere an diesem Buch: Es enthält in jedem Kapitel auch eine Audioversion des Textes.

It is well known that certain diseases and patient conditions are associated with increased perioperative risk. The aim of this book is to define and identify the clinical factors that warrant a broader and more detailed assessment of pre-operative surgical risk in difficult and unusual clinical settings. One of the sections is dedicated to the main pathway of peri- and post-surgical critical care based on the patient-specific deterioration risk and associated diseases; here, a panel of selected experts describes the correct patient-oriented pathways for complex or unscheduled surgical operations in order to reduce the operative risk. In addition, the book describes the latest trends in minimally invasive surgical techniques that are associated with peri- and post-operative risk reduction, and provides an overview of recent advances in surgical simulation, focusing on perspectives in surgical research to increase patient safety.Guidance is also provided on extracorporeal membrane oxygenation (ECMO), Left Ventricular Assist Devices (LVADs), and their management in patients requiring emergency surgery. The book will help surgical trainees recognize cases with the highest surgical risk and identify the most common complications at an early stage.

This Springer Handbook comprehensively covers the topic of semiconductor devices, embracing all aspects from theoretical background to fabrication, modeling, and applications.Nearly 100 leading scientists from industry and academia were selected to write the handbook's chapters, which were conceived for professionals and practitioners, material scientists, physicists and electrical engineers working at universities, industrial R&D, and manufacturers.Starting from the description of the relevant technological aspects and fabrication steps, the handbook proceeds with a section fully devoted to the main conventional semiconductor devices like, e.g., bipolar transistors and MOS capacitors and transistors, used in the production of the standard integrated circuits, and the corresponding physical models. In the subsequent chapters, the scaling issues of the semiconductor-device technology are addressed, followed by the description of novel concept-based semiconductor devices. The last section illustrates the numerical simulation methods ranging from the fabrication processes to the device performances.Each chapter is self-contained, and refers to related topics treated in other chapters when necessary, so that the reader interested in a specific subject can easily identify a personal reading path through the vast contents of the handbook.

This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox).The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

Land is fundamental to the human life. The upper layer of land is a non-renewable resource, and source of food. Therefore, land health is essential to long-term food security and to promote sustainable livelihoods. On account of urbanization, industrialization and population growth, land pollution is one of the major issues worldwide. As a result, land pollution is continuing across the world, and has been linked with a wide range of potentially toxic contaminants at rates that deteriorate land quality. Land pollution can result either anthropogenic activities or natural activities. The major contaminants of land pollution are metalloids, petroleum hydrocarbon, radioactive elements, polyaromatic hydrocarbons (PAHs), Pesticide, other organic pollutants, etc. that comes from different types of sources. In urban and peri-urban areas, irrigation of agricultural land with polluted water is also a reason of land pollution. Therefore, land security is an important issue for future sustainability. Its remediation and management are important issue worldwide to protect land quality and functions. Land pollution means degradation of earth's surface. Polluted land comes under the category of degraded land. Hence, the remediation of polluted land is essential for regaining biodiversity and ecosystems services and thereby achieving United Nations-Sustainable Development Goals (UN-SDGs).This fact showed the need to develop research into land remediation. Bio-inspired land remediation has undergone a huge development. Therefore, Biomanagement has a lot of potential to secure upper earth's surface through the land remediation programs targeted during the United Nations Decade on Ecosystem Restoration (2021-2030). This book explores the remediation of land pollution that includes Phytoremediation, Bioremediation (bacterial remediation and fungal remediation), Vermiremediation, Biochar-based remediation and other Bio-inspired remediation. This book will be a remarkable asset for research scholars, environmentalists, ecological scientist, agriculturist, practitioners, policy makers, entrepreneurs, and other stakeholders alike.

This book reviews the common clinical scenarios that might trigger emergent consultation for neurosurgical intervention, with attention to key components of the clinical interview and exam, optimal diagnostic evaluation, indications for and the goals of operative intervention, perioperative considerations, and strategies for complication mitigation. This is not a surgical atlas, but rather, a road map for the journey to the operating room door. The intent is to establish a systematic, evidence-based action plan for the patient presenting in neurologic crisis. Each chapter opens with a relevant case vignette and then unfolds through uniform sections to tell the story of how one might approach the disease entity in question, from initial request for consultation to definitive management, highlighting steps of the decision-making process: • What are the highest yield questions to ask during a focused interview? • What are the most pertinent objective exam findings? • What is the proper differential diagnosis? • What is the most appropriate and efficient plan for diagnostic evaluation – with respect to laboratories and imaging? • Does this patient have an indication for emergent or urgent neurosurgical intervention? • If so, what is the goal of that intervention? • What are the most common potential complications of the proposed procedure, and what steps might be taken to mitigate those risks? Each chapter is punctuated by 3-5 teaching pearls, summarizing these key elements. The overall goal is to create a framework for assessment that might be applied in the emergency department, the trauma bay, or the ICU when a neurologic emergency arises. The scope of the text encompasses not only cranial and spinal trauma, but also entities such as shunt failure, stroke, aneurysmal subarachnoid hemorrhage, pituitary apoplexy, cauda equina syndrome, and central nervous system infection that might require time-sensitive intervention. An additional section addresses issues requiring emergent neurosurgical response in the ICU setting, including sudden neurologic worsening, status epilepticus, and abnormal clotting/ coagulopathy. The text will not only serve as a valuable resource for those preparing to take the oral board exam, but will also provide a targeted refresher for clinicians taking general neurosurgical call in the community as well as an educational reference for mid-level practitioners and those in training who are serving as first responders on behalf of a neurosurgical service.

This book focuses on low carbon fuels a preferable class of fuels for Internal Combustion Engines (ICEs) highlighting the effect of low carbon fuels on tailpipe emissions. This book aims to strengthen the knowledge base dealing with low carbon fuels as a sustainable transport fuel. The volume includes recent results and are focused on current trends of automotive sector. This book will be of interest to those in academia and industry involved in fuels, IC engines, engine instrumentation, and environmental research.

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Stellen Sie sich vor, ein demokratischer Staat muss ein komplexes Problem lösen. Der Lösung muss eine Mehrheit der Bevölkerung zustimmen. Es stehen zwei Lösungen zur Wahl: Eine komplizierte, die schwer zu verstehen ist, das Problem aber löst und eine einfache, die leicht verständlich dargestellt werden kann, aber falsch ist, und das Problem nicht löst. Welche wird die Wahl gewinnen? Vermutlich die leichte, falsche Lösung. Wir Menschen tragen den „sense making Trieb“ in uns. Wir wollen verstehen, was um uns herum geschieht. Die Welt ist aber zu schwierig und zu kompliziert, um sie tatsächlich begreifen zu können. Das macht die leichten Scheinlösungen so verführerisch. Wir lieben sie, weil sie uns vorgaukeln, wir wüssten Bescheid. Politiker wissen das und bedienen uns mit leichter Kost und die Medien wissen es auch. Das führt zu der Frage: Sind Demokratien mit Ihrer breiten politischen Mitbestimmung überhaupt in der Lage, die hochkomplexen Probleme unserer Zeit zu lösen? Früher hat uns das Denken in weltanschaulichen Bahnen geholfen. Aber die Zeit ist darüber hinweggegangen und heute gibt keine klaren'linken'oder'rechten'Lösungen mehr. Wir brauchen deshalb dringend neue Wege, um als Demokratie zu überleben.

Volume CCIS 1655 is part of the refereed proceedings of the 24th International Conference on Human-Computer Interaction, HCII 2022, which was held virtually during June 26 to July 1, 2022. A total of 5583 individuals from academia, research institutes, industry, and governmental agencies from 88 countries submitted contributions, and 1276 papers and 275 posters were included in the proceedings that were published just before the start of the conference. Additionally, 296 papers and 181 posters are included in the volumes of the proceedings published after the conference, as “Late Breaking Work” (papers and posters). The contributions thoroughly cover the entire field of human-computer interaction, addressing major advances in knowledge and effective use of computers in a variety of application areas.

This text consists of neoplastic and non-neoplastic lung pathology. It discusses frequently encountered issues and diagnostic problems using a Q&A format and case presentations. Emphasis is placed on differentiating one from another based on the histopathological features, ancillary tests including immunohistochemical and molecular analyses, and clinical and radiologic correlation. In particular, clinical-radiologic-pathologic correlation is emphasized in the diagnosis of interstitial lung disease (ILD). This text addresses the issues and diagnostic criteria in segregating a reactive process from adenocarcinoma, poorly differentiated adenocarcinoma from poorly differentiated squamous cell carcinoma, small cell carcinoma from other types of neuroendocrine tumors, large cell carcinoma from large cell neuroendocrine carcinoma, spindle cell/sarcomatoid carcinoma from sarcomatoid mesothelioma, and carcinoma from epithelioidmesothelioma in small biopsy specimens. It also discusses key features useful for differentiating usual interstitial pneumonia (UIP) pattern from non-UIP patterns of ILD such as hypersensitivity pneumonitis, nonspecific interstitial pneumonia, and organizing pneumonia patterns in wedge biopsy specimens as well as highlights the differential diagnosis in the granulomatous inflammation. As a whole, this text answers many of the difficult questions relevant to daily practice of lung pathology. Each chapter addresses a specific diagnostic question significantly related to patients'treatment options.

Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and'co-act'with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

This book gathers cutting-edge research and best practices relating to occupational risk and safety management, healthcare and ergonomics. It covers strategies for different types of industry, such as construction, food, chemical and healthcare. It gives a special emphasis on challenges posed by automation, discussing solutions offered by technologies, and reporting on case studies carried out in different countries. Chapters are based on selected contributions to the 17th International Symposium on Occupational Safety and Hygiene (SHO 2021), held virtually on November 17–19, 2021, from Portugal. By reporting on different perspectives, such as the ones from managers, workers and OSH professionals, and covering timely issues, such as safety evaluation of human-robot collaboration, this book offers extensive information and a source of inspiration to OSH researchers, practitioners and organizations operating in both local and global contexts.

This book describes many novel approaches of microbial bioremediation including conventional and modern approaches, metagenomics, biosurfactants and nano-based bioremediation. Also presents up-to-date knowledge about biodegradation of solid and liquid contaminants in the rhizospheric zone by plant (rhizo)-microbiome interface. It also illustrates communication pathways based on evolving methodologies, bioinformatic tools which provides insights into the functional dynamics of bioremediation process by the host-microbiome interface. The different chapters explain the mechanism and outcomes during the process of bioremediation. The book broadly depicts the following: Advances in bioremediation through nanoremediation, rhizo-remediation, bioremediation of different ecosystems like polluted waters, industrial effluents, bioremediation of metal and organic pollutants, toxic dyes etc. The book is very useful for researchers and students in the fields of applied and environmental microbiology. It is also meant for industry experts and professionals working in the field of bioremediation and waste management.

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in thesurface science, pharmaceutical, and medicinal chemistry areas.

This comprehensive, twelve volume reference work reflects the interdisciplinary influences on evolutionary psychology and serves as a major resource for its history, scientific contributors and theories.It draws on biology, cognitive science, anthropology, psychology, economics, computer science and paleoarchaeology to provide a multifaceted picture of behavioral adaptation in humans and how it adds to our academic and clinical understanding. Edited by a noted figure in evolutionary psychology, with many seminal and renowned contributors, this encyclopedia offers the full breadth of an area that is the forefront of behavioral thinking and investigation.

This book examines the problems in the field of energy and related fields (chemical, transport, aerospace, construction, metallurgy, engineering, etc.) and consists of 4 subsections: Electrical Engineering, Heat Power Engineering, Cybersecurity and Computer Science & Environmental Safety. In the first section, authors pay attention to contemporary issues related to the development of the electric power industry, electrical engineering, the physics of electrical phenomena and renewable energy sources (such as solar energy and wind energy). The second section is devoted to modern problems in heat power engineering and considers modern means and methods that increase the efficiency and reliability of the functioning of heat power facilities. The third section is devoted to issues of cybersecurity of critical facilities, in particular energy facilities, as well as the development of computer science and the introduction of modern information and measurement systems in the energy sector. The fourth subsection deals with the problems of rational use of natural resources, accounting for emissions of harmful substances, environmental issues at energy facilities, as well as the development of a methodology for environmental safety. The book includes 21 chapters. A book is for researchers, engineers, as well as lecturers and postgraduates of higher education institutions dealing with issues of control, diagnosis and monitoring of energy facilities.

The book discusses all aspects of expanded dengue syndrome (EDS), an emerging entity of dengue infection, and serves as definitive source of information for health care professionals.With each chapter focusing on a different type of EDS, the book covers the definition, concept, prevalence, pathophysiology, management, complications and outcomes of the condition. It also highlights the impact of the disease on healthcare. Further, based on both basic and the latest, cutting-edge research, it examines treatments, algorithms, standard treatment guidelines and the pharmacotherapy of EDS.EDS is referred to as atypical/unusual manifestations of the dengue infections, also termed as isolated organopathies, including hepatic, renal, cardiac, respiratory and neurological involvements that could be explained as a result of severe, profound shock or associated with underlying host conditions or co-infections. Raising awareness of this neglected and little-known complication of dengue infection, the book serves as an educational and teaching aid and useful resource for upper-undergraduate students. It also provides up-to-date reference material for researchers in academia and corporations as well as for clinicians wanting to improve the management of EDS during dengue outbreaks.

This book reviews the latest trends in glycobiotechnology, it offers an authoritative discussion about future directions of glycoengineering, and it provides a comprehensive overview about the current and emerging approaches to identify, quantify and characterize glycosylated proteins.Divided into 14 chapters, the book outlines recombinant glycoprotein expression in mammalian cells, insect cells, yeast, and bacterial systems. It covers the chemical and enzymatic syntheses of glycans and glyconjugates, and addresses the impact of glycosylation on protein function for the development of biologicals including vaccines. In the final chapters of the book, readers will discover more about the state-of-the-art in glycomics, glycoproteomics and glycan array technologies.

The three-volume set CCIS 1419, CCIS 1420, and CCIS 1421 contains the extended abstracts of the posters presented during the 23rd International Conference on Human-Computer Interaction, HCII 2021, which was held virtually in July 2021. The total of 1276 papers and 241 posters included in the 39 HCII 2021 proceedings volumes was carefully reviewed and selected from 5222 submissions.The posters presented in these three volumes are organized in topical sections as follows: Part I: ​HCI theory and methods; perceptual, cognitive and psychophisiological aspects of interaction; designing for children; designing for older people; design case studies; dimensions of user experience; information, language, culture and media. Part II: ​interaction methods and techniques; eye-tracking and facial expressions recognition; human-robot interaction; virtual, augmented and mixed reality; security and privacy issues in HCI; AI and machine learning in HCI. Part III: ​interacting and learning; interacting and playing; interacting and driving; digital wellbeing, eHealth and mHealth; interacting and shopping; HCI, safety and sustainability; HCI in the time of pandemic.

Pollution is one of the most serious issues facing mankind and other life forms on earth. Environmental pollution leads to the degradation of ecosystems, loss of services, economic losses, and various other problems. The eco-friendliest approach to rejuvenating polluted ecosystems is with the help of microorganism-based bioremediation. Microorganisms are characterized by great biodiversity, genetic and metabolic machinery, and by their ability to survive, even in extremely polluted environments. As such, they are and will remain the most important tools for restoring polluted ecosystems / habitats. This three-volume book sheds light on the utilization of microorganisms and the latest technologies for cleaning up polluted sites. It also discusses the remediation or degradation of various important pollutants such as pesticides, wastewater, plastics, PAHs, oil spills etc. The book also explains the latest technologies used for the degradation of pollutants in several niche ecosystems. Given its scope, the book will be of interest to teachers, researchers, bioremediation scientists, capacity builders and policymakers. It also offers valuable additional reading material for undergraduate and graduate students of microbiology, ecology, soil science, and the environmental sciences.

This book addresses various aspects of acoustic–phonetic analysis, including voice quality and fundamental frequency, and the effects of speech fluency and non-native accents, by examining read speech, public speech, and conversations. Voice is a sexually dimorphic trait that can convey important biological and social information about the speaker, and empirical findings suggest that voice characteristics and preferences play an important role in both intra- and intersexual selection, such as competition and mating, and social evaluation. Discussing evaluation criteria like physical attractiveness, pleasantness, likability, and even persuasiveness and charisma, the book bridges the gap between social and biological views on voice attractiveness. It presents conceptual, methodological and empirical work applying methods such as passive listening tests, psychoacoustic rating experiments, and crowd-sourced and interactive scenarios and highlights the diversity not only of the methods usedwhen studying voice attractiveness, but also of the domains investigated, such as politicians'speech, experimental speed dating, speech synthesis, vocal pathology, and voice preferences in human interactions as well as in human–computer and human–robot interactions. By doing so, it identifies widespread and complementary approaches and establishes common ground for further research.

This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy.Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike.Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Plants create a dynamic micro-biosphere in the soil, around the roots, called as ‘rhizosphere', which harbors diverse number of microorganisms for sustaining their growth and development. A soil with diverse and multi-traits microbial communities is considered healthy to enhance crop productivity. In the last decades, rhizosphere biology has gained attention due to unraveling of new mechanisms, processes and molecules in the rhizosphere that contributes towards the promotion of plant productivity. The rhizospheric microbes and associated processes are being utilized for harnessing potential of soils in effective and sustainable functioning in the agro-ecosystems. Broadly, the book discusses rhizospheric microbes and their role in modulating functions of soil and crop plant. Specifically, it highlights conventional and modern aspects of rhizosphere microbes such as – microbiome in the rhizosphere, microbes as an indicator and promoter of soil health, rhizosphere microbes as biofertilizer, biostimulator and biofortifyer, microbial signaling in the rhizosphere, recent tools in deciphering rhizobiome, and regulatory mechanisms for commercialization of biofertilizer, biopesticide and biostimulator. The book is useful for agriculture scientist, biotechnologist, plant pathologist, mycologist, and microbiologist, farming community, scientist of R&D organization, as well as teaching community, researcher and student and policy maker.

This extensively updated textbook comprehensively reviews the latest developments in evidence-based critical care. Topics are covered in a case study format with an emphasis on the principles of diagnosis and therapy. Each topic is covered using a variety of case studies and features a case vignette, clinical question and an additional discussion section to clarify areas of particular importance. Topics including cytokine release syndrome, sympathomimetic overdose and palliative care in the intensive care unit have been extensively revised, while new sections focusing on neuromuscular disease and subarachnoid hemorrhages have been added. Evidence-Based Critical Care, 2nd edition is a critical resource for critical care practitioners, fellows, residents; allied health professionals and medical students who wish to expand their knowledge within critical care. The case study-based approach taken in the textbook makes this an idealresource for those preparing for board examinations.

This book contains selected papers from the International Conference on Progress in Automotive Technologies (ICPAT) 2019. The contents focus on several aspects of the automobile industry from design to manufacture, and the challenges involved therein. The book covers latest research trends in the automotive domain including topics such as aerodynamic design, vehicle sensors and electronics, engine combustion modeling, noise and vibration in vehicles, electric and hybrid vehicles, automotive tribology, and battery and fuel cell technologies. The book highlights the use of emerging technologies to tackle the growing environmental challenges. This book will be of interest to students, researchers as well as professionals working in automotive engineering and allied fields.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

This book provides a state-of-art overview of the significant advances in understanding the impacts of wind energy on wildlife. However, many challenges remain regarding planning and policy, assessment of direct and indirect effects on wildlife, methodological approaches, technology development, and mitigation strategies and their effectiveness. The book comprises a selection of the best contributions presented at the 4th Conference on Wind energy and Wildlife impacts, held in Estoril, Portugal, 2017. The contents promote the international cooperation among researchers, developers, regulators and stakeholders that have contributed to building knowledge on this topic.

Rapid industrialization is a serious concern in the context of a healthy environment. With the growth in the number of industries, the waste generated is also growing exponentially. The various chemical processes operating in the manufacturing industry generate a large number of by-products, which are largely harmful and toxic pollutants and are generally discharged into the natural water bodies. Once the pollutants enter the environment, they are taken up by different life forms, and because of bio-magnification, they affect the entire food chain and have severe adverse effects on all life forms, including on human health. Although, various physico-chemical and biological approaches are available for the removal of toxic pollutants, unfortunately these are often ineffective and traditional clean up practices are inefficient. Biological approaches utilizing microorganisms (bacterial/fungi/algae), green plants or their enzymes to degrade or detoxify environmental pollutants such as endocrine disruptors, toxic metals, pesticides, dyes, petroleum hydrocarbons and phenolic compounds, offer eco- friendly approaches. Such eco-friendly approaches are often more effective than traditional practices, and are safe for both industry workers as well as environment. This book provides a comprehensive overview of various toxic environmental pollutants from avariety natural and anthropogenic sources, their toxicological effects on the environment, humans, animals and plants as well as their biodegradation and bioremediation using emerging and eco-friendly approaches (e.g. Anammox technology, advanced oxidation processes, membrane bioreactors, membrane processes, GMOs), microbial degradation (e.g. bacteria, fungi, algae), phytoremediation, biotechnology and nanobiotechnology. Offering fundamental and advanced information on environmental problems, challenges and bioremediation approaches used for the remediation of contaminated sites, it is a valuable resource for students, scientists and researchers engaged in microbiology, biotechnology and environmental sciences.

This book focuses on the importance and roles of seed microbiomes in sustainable agriculture by exploring the diversity of microbes vectored on and within seeds of both cultivated and non-cultivated plants. It provides essential insights into how seeds can be adapted to enhance microbiome vectoring, how damaged seed microbiomes can be assembled again and how seed microbiomes can be conserved. Plant seeds carry not only embryos and nutrients to fuel early seedling growth, but also microbes that modulate development, soil nutrient acquisition, and defense against pathogens and other stressors. Many of these microbes (bacteria and fungi) become endophytic, entering into the tissues of plants, and typically exist within plants without inducing negative effects. Although they have been reported in all plants examined to date, the extent to which plants rely on seed vectored microbiomes to enhance seedling competitiveness and survival is largely unappreciated. How microbesfunction to increase the fitness of seedlings is also little understood. The book is a unique and important resource for researchers and students in microbial ecology and biotechnology. Further, it appeals to applied academic and industrial agriculturists interested in increasing crop health and yield.

This thesis explores an amazing family of oxide compounds - the nickelates - known for their metal-to-insulator transition and, in the case of LaNiO3, to be a possible building block for designing a synthetic high Tc superconductor. Competition between various fascinating phases makes these materials very sensitive to external parameters and it is thus possible to dramatically tune their properties. This work on ultrathin LaNiO3 and the solid solution Nd1-xLaxNiO3 has important implications for the search for superconductivity in this class of materials.