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This book presents extensive and up-to-date information on the anti-proliferative properties of various plant seeds for their application in pharmaceutical industry and medicinal research. This information is imperative for understanding and developing high quality products from the seeds.The book provides insights about anticancer and antitumour activities present in seeds. Different chapters cover the traditional knowledge as well as recent innovations in various seeds, such as prune, pumpkin, grape fruit, sesame, sunflower, bitter gourd, papaya, mango, apple, black plum, cumin, water melon, musk melon, cotton, carambola, pear, cardamon, moringa, wallich, Chinese cabbage, pistachio, etc. and their bioactivities for the applications in cancer and malignancy proliferation. The book introduces the readers to seed as a bioactive compound, and delineates the various health effects. It further explains the relation between the different metabolites and their effect on cell proliferation. Finally the book goes on to explain different seeds and their specific anti-cancer properties. This book is useful for students and researchers of pharmacology, botany and cancer research. It also caters to industry experts in pharmaceutical sciences.

This innovative book offers a multidimensional exploration of the epistemological foundations of psychiatry and its major disorders. By emphasizing the importance of phenomenology in unravelling the intricate interplay between basic categories of human experience and neurobiological processes, it advocates for a shift in both psychiatric research and clinical practice. Phenomenological Neuropsychiatry presents psychiatry as a hybrid discipline that synthesizes subjective mental experiences with objective neuroscientific findings and forms an integrative and interdisciplinary structure that provides a dialectical bridge between understanding, compassion, and explanation. The first section of the book presents the lived experience of psychosis and argues for a more inclusive approach to mental health issues. The second section examines the ways in which psychiatric knowledge is constructed and the unique challenges posed by combining understanding and explanation of mental disorders. Section three sheds light on how disruptions in bodily experiences, memory processes, and self-perception can contribute to the development and manifestation of psychiatric issues. The following section discusses disorders of mood and anxiety, including the phenomena of depression, obsessions, and depersonalization. The fifth and final section provides an in-depth examination of psychotic disorders. It covers a range of topics, such as timing, intentionality, self-monitoring of action in schizophrenia, and the neurobiology of prodromal psychosis. As a singular work dedicated to revitalizing and advancing cross-fertilization between psychiatry and phenomenology, this groundbreaking book clears the foggy operationalized clusters of mental symptoms that may obscure diagnosis and treatment and argues for systematic integration of patient subjectivity and collaboration in clinical research. It features an authorship of the leading clinicians and thinkers from throughout the world in psychiatry, psychology, neuroscience, social sciences, and philosophy. Phenomenological Neuropsychiatry: How Patient Experience Bridges the Clinic with Clinical Neuroscience is a major contribution to the clinical literature and a must-read for psychiatrists, neurologists, psychologists, and professionals and students from other disciplines concerned with absorbing a deeper understanding of psychiatric disorders.

This book examines women's behavioral health (defined as alcohol, drug use, and mental health) problems from a population or public health perspective. It provides the current state of knowledge for women's behavioral health and examines the need for behavioral health services and implications for policy. It also reviews major issues in the organization, financing, and provision of women's behavioral health services. Global and national studies show that women are nearly twice as likely as men to have selected mental disorders. There also has been increasing attention to the social, behavioral, institutional, and economic determinants of health that result in service inequities for women in the United States compared to women in other countries. This textbook highlights mental and substance use disorders of particular concern to women, emphasizes services research issues in women's behavioral health, incorporates the social determinants of health, and provides a discussion of these critical issues from an interprofessional and interdisciplinary public health perspective. It also presents an overview of the epidemiology of mental and substance use disorders across the lifespan of women and service delivery issues from a population and system-level perspective. Applied services research chapters comprise the book's 14 chapter contributions that are organized into three parts: Part I. Framing Women's Behavioral Health; Part II. Selected At-Risk Populations; and Part III. Services Delivery issues. Women's Behavioral Health: A Public Health Perspective is a textbook for advanced undergraduate and graduate students in many academic disciplines, including the social and behavioral sciences, public health, women's studies, medical anthropology, and medical sociology. It also is useful for postdoctoral students in public health, population health, and the health professions. This volume can serve as a reference book for academicians and researchers in community and social psychology, community health, community nursing, community and preventive medicine, and public health; practitioners and policymakers at various levels of government; and behavioral health professionals at mental health and substance use programs in various national and global healthcare organizations.

This book is a comprehensive exploration of the science and clinical applications of fasting, with a particular focus on its effects on body weight and metabolic disease risk factors. It delves into various fasting methods, including time-restricted eating, intermittent fasting, alternate day fasting, and periodic fasting.The key concepts explored in this book include the physiological and cellular adaptations to different types of fasting, their impact on body weight and metabolic health, and their potential role in longevity, aging and disease prevention. The book addresses critical questions such as: What are the safety and efficacy of time-restricted eating? How does alternate day fasting affect body weight and metabolic disease risk factors? What are the evolutionary perspectives explaining the clinical benefits of periodic fasting? And how effective is periodic fasting in treating human chronic diseases? This book is aimed at healthcare professionals, researchers, nutritionists, and anyone interested in understanding the science behind fasting. Readers with a scientific or professional background will appreciate the rigorous research and clinical studies presented in this book. They will learn about the latest findings in this field and gain a deeper understanding of how different types of fasting can impact health, wellbeing and aging.

This book offers a new look at well-being from a multidisciplinary standpoint. Research from industry clearly indicates that factors such as creativity, critical awareness, well-being, interdisciplinary understanding of positive psychology, and the ability to form strong relationships will determine the viability of organizations as collectively we enter the second half of the twenty-first century. Thus, a sound understanding of how these facets become melded into entrepreneurship, the workplace environment, and creative innovation is a requirement for individuals in the workplace. With a dearth of information about these facets as individual components and as a collective whole, this book draws these elements of overall well-being into a multidisciplinary focus. Thus, with chapters covering diverse fields such as philosophy, education, economics, mathematics, and medicine, the book offers a fresh approach to how positive psychology impacts entrepreneurship.

This book is about access to mental health care in South Asia. South Asia consists of eight countries with low and middle-income backgrounds. The region contains a combined population of about 2 billion, making up about a quarter of the global population. The people of this region share common cultures, beliefs, and behavioral patterns regarding physical and mental health. Among them, about 15% (about 300 million) have been suffering from common mental disorders. However, there is a persisting high treatment gap for mental illness in the region. Hence, despite having a mental illness, only a small percentage of the population is able to have access to essential mental healthcare. Though governments are trying to bridge the gap by improving mental health policies and programs, it is still a major challenge delivering mental healthcare to all people in need. Due to the income category and dual disease burden of the countries, there are some additional enduring challenges like poor funding and research, inadequate and inequitable manpower, huge out-of-pocket expenses, poor mental health literacy, income disparity, and high stigma. This book aims to highlight the issues related to accessing mental health services in a densely populated low and middle-income setting. This book is the first of its kind in comparing and contrasting the delivery status of mental health services in South Asian countries.

Kinder- und Jugendpsychiatrie und Psychotherapie und Kinder- und Jugendlichenpsychotherapie haben in den letzten Jahren in der Forschung und Versorgung eine enorme Entwicklung gemacht. Durch die Einführung des Grundständigen Psychotherapiestudiums und der damit verbundenen Einführung einer fachspezifischen Weiterbildung in Kinder- und Jugendpsychotherapie, wird es zukünftig zwei heilberufliche Weiterbildungsgänge im Bereich der psychischen Gesundheit von Kindern und Jugendlichen geben. Die Neuauflage der Kinder- und Jugendpsychiatrie und Psychotherapie mit zahlreichen neuen Themen und fast komplett neuen Texten, spiegelt diese Entwicklung wider. Hierfür wurde das Herausgeberboard und das Autorenteam deutlich erweitert. Ausgewiesene Kinder- und Jugendlichenpsychotherapeutinnen und Psychotherapeuten sind gleichberechtigte Mitherausgeber. Insofern steht das Buch in der Tradition des Springer-Referenzlehrbuchs, ist aber dennoch weit mehr als eine dritte Auflage der Kinder- und Jugendpsychiatrie und Psychotherapie, denn hier wird kooperativ und interdisziplinär das Fachgebiet der Psychiatrie und Psychotherapie des Kindes- und Jugendalters präsentiert. Die Fülle an Information und Wissen ist ein unerlässliches Werkzeug für die tägliche Arbeit von Assistenzärzt•innen, Fachärzt•innen, Assistenzpsychotherapeut•innen in Fachweiterbildung Kinder- und Jugendpsychotherapie, Kinder- und Jugendlichenpsychotherapeut•innen in Ausbildung, Psychotherapeut•innen und Psycholog•innen und Sozialarbeiter•innen, auch in angrenzenden Fachgebieten. Das Buch beschreibt Schulen übergreifend die am besten geeigneten Therapieverfahren und bietet einen evidenzbasierten Handlungsleitfaden für alle, die in ihrem beruflichen Leben mit Kindern und Jugendlichen mit psychischen Störungen zu tun haben. Bedingt durch diese inhaltliche Ausweitung und angesichts der Fülle neuen Wissens, wurde zwar die klare Struktur und didaktische Aufbereitung im Lehrbuch beibehalten, gleichzeitig wurde das Buch in zwei Teile aufgeteilt. Ein allgemeiner Teil und ein spezieller störungsspezifischer Teil wird in zwei Bänden präsentiert, die durch die gleiche Struktur und didaktische Merkmale alle Leser•innen bei der Orientierung im Text unterstützen.

This book focuses on ocular manifestations of general human diseases with chapters divided according to the human organ system. Specialists in each field detail individual illnesses and ophthalmologists present an overview of ocular complications of these diseases. Manifestations of vascular, endocrine, autoimmune, rheumatological, pulmonary, gastrointestinal, hematological, infectious, skin, neurological, sexually transmitted and cancer diseases are discussed in detail throughout the book. Ocular Manifestations of Systemic Diseases is a highly illustrated guide with the basic data presented in clear tables and graphs with a further reading lists included for each topic. Ophthalmologists and experts in other fields, including general practitioners, will find this book to be an essential resource for their clinical and academic activities.

This book shows how psychological and social interventions can help people with psychosis. It brings together both theoretical chapters that contribute to the reconceptualization of psychosis and clinical cases illustrating how contemporary psychotherapeutic intervention models can be applied in the treatment of this mental health condition, with reflections, strategies and practical guidelines demonstrating how these models can inform professional practice in mental healthcare. Chapters brought together in this volume aim to reflect a paradigm shift in psychosis care. They present person-centered models that lead to a way of seeing, understanding and treating psychosis that is very different from the traditional biomedical model. Current authors and approaches are revolutionizing an outdated model trapped in purely pharmacological actions and tautological explanations of a biological nature, where symptom control is the basic and fundamental form of approach, and in which psychotherapeutic actions take second place as subsidiary to the former. Approaches such as Acceptance and Commitment Therapy, Acceptance and Recovery Therapy by Levels, Open Dialogue, Compassion-Centered Therapy or the Hearing Voices movement, to name but a few of those presented in this book, represent a journey of self-knowledge and learning for those recovering from psychosis, and have an intense transformative potential for the therapeutic team. The fundamental principle that guides this book is to share models belonging to psychology that aim at personal development while respecting the needs, values and goals of each person, and that can be adopted by any professional or student of clinical psychology, psychiatry, nursing, social work or any other discipline searching for more humanistic approaches to treat psychosis.

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

This book provides a comprehensive overview of various chronic diseases - including their clinical characteristics, diagnostic methods, treatment options, and recent research findings - with a special focus on the psychosexual impacts of these conditions on patients and their partners. Each chapter in the book is dedicated to a specific chronic illness, examining its impact on the patient's sexual health and relationships. The book starts with an overview of the disease and its management, including both traditional and contemporary therapies, diagnostic tools, and international research studies. This is followed by a thorough discussion of the psychosexual consequences of the disease, along with the potential interventions that a multidisciplinary healthcare team can offer to provide comprehensive support to the patient. The book's primary objective is to improve healthcare professionals'approach to chronic patients by emphasizing the importance of addressing the patient's sexual health and intimacy. By acknowledging and addressing these aspects of the patient's life, healthcare providers can offer more holistic and effective care, leading to better patient outcomes. Overall, this book serves as a practical and essential guide for healthcare professionals seeking to enhance their knowledge and understanding of the psychosexual impacts of chronic illnesses. It is a valuable resource for those looking to provide compassionate, patient-centered care to those living with chronic conditions.

This book presents the ‘state of the art'of biomarkers research in neuropsychiatric conditions, from dementia to eating disorders, as well as providing methodological, practical and ethical issues related to the development of biomarkers. Biomarkers have revolutionized clinical research and practice in most fields of medicine, but psychiatry has lagged behind. However, in the last decade, there has been a growing expectation that biomarkers will advance and, ultimately, reframe psychiatry research and practice. Biomarkers might inform about diagnosis, therapeutics, prognosis, contributing to a ‘personalized medicine'. Understanding their meaning, possibilities and limitations will help clinicians, researchers and students in the related areas navigate and excel in the challenging and ever changing field of neuropsychiatric disorders.

This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone's life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears.The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.

The handbook examines the latest research and clinical advancements in assessing and treating ADHD (attention deficit hyperactivity disorder) across the lifespan. It synthesizes the most current research data and trends combined with best-practice interventions to form a comprehensive, state-of-the-art resource. The handbook identifies the most relevant, effective treatments for individuals with ADHD. Key areas of coverage include: Core symptoms of ADHD in minority children. Lifestyles for children with ADHD. Digital interventions for children and adolescents with ADHD. Telemedicine to manage ADHD across the lifespan. Healthcare use and costs for adults with ADHD. The Clinical Handbook of ADHD Assessment and Treatment Across the Lifespan is an essential reference for researchers, professors, and graduate students as well as clinicians and other professionals across such interrelated disciplines as clinical child, school, and developmental psychology, child and adolescent psychiatry, social work, rehabilitation medicine/therapy, pediatrics, and special education.

This book provides an overview on current trends and developments in precision nutrition and personalized health preservation, focussing on a field which is undergoing rapid change. Today, personalized strategies contrast generally accepted guidelines for specified groups and improved health and disease markers are shifting health care toward preventive strategies. At the same time, advances in food additives, nutraceuticals, functional, and medical foods are breaking down the traditional domains of health-related disciplines. This book aims to provide an overview on these processes, discusses arising problems, and provides an outlook on the future of personalized health care and the role of precision nutrition. It covers preliminary thoughts on what has been achieved and focusses on developments in the area of metabolic diseases, aging, and neurology. The book is intended as a primer in the field of precision nutrition and is aimed at researchers, clinicians, and students in health-related disciplines, who would like to get insights into current trends and developments in this area

The book provides a clear and comprehensive description of both personal and clinical recovery in severe mental disorders, including schizophrenia and related disorders, and mood disorders such as major depression and bipolar disorders. Divided into two main parts: recovery in schizophrenia and related disorders, and recovery in mood disorders, it offers a broad overview of the factors associated with better or worse outcomes in terms of recovery, as well as the rates (how many people affected by mental disorders may gain recovery), and the time course (how long people affected by mental disorders take to recover) of recovery. It also discusses in detail the pharmacological and psychosocial interventions that can be considered recovery-oriented. Covering the main aspects of recovery in major mental disorders, the book is intended for professionals, scholars, students and anyone interested in mental health.

This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.

This book is a practical guide in understanding how to prevent HIV transmission, to recognize risk behaviors, and to add something else to their repertoires. It aims to empower clinicians and provide a sense of security and competence with the recognition and understanding of some of the psychiatric illnesses that complicate and perpetuate the HIV pandemic that continue to persist throughout every area of the world despite the magnitude of the progress that has transformed the illness from a rapidly fatal to chronic illness that is no longer life-limiting. Missing in most of the literature on HIV is the subtle, and sometimes not so subtle, contribution of psychiatric symptoms, psychiatric illness, and risk behaviors that drive the pandemic and serve as catalysts for new infections. This practical guide provides state-of-the-art understanding of not only prevention but also a way to recognize risk behaviors, psychiatric symptoms, and psychiatric illnesses that will demystify and decode the sometimes enigmatic and frustrating reasons for nonadherence with diagnostic procedures and life-saving treatments and care. All behaviors and pathology are covered as well as the resources and treatments available. The goal of this text is to refresh knowledge on the current state of psychiatric illness management among people living with HIV, to provide a concise volume on the psychiatric aspects of HIV prevention and treatment that substantially impact the overall care of the patient, and to help understand the psychiatric catalysts of the pandemicWritten by experts in the field, HIV Psychiatry: A Practical Guide for Clinicians provides enduring guidance to medical and other professionals caring for complicated clinical patients as they face ongoing challenges in working with persons with HIV and AIDS.

Burnout and trauma related employment stress (TRES), which includes compassion fatigue, secondary traumatic stress, and vicarious trauma, are increasing in prevalence as attrition rates, mental health disturbances, and suicide rates are climbing for those in the helping professions. This book highlights the imperative for prevention and early intervention using acceptance and commitment strategies. It includes cognitive, acceptance, and mindfulness techniques to assist the individual in achieving goals through values-based living. Among the topics discussed: Definitions of Burnout and TRESPrevalence rates of burnout and TRES in the helping professionsMindfulness and acceptance practicesDefusion and cognitive techniquesValues based goal settingOrganizational responsibilities and strategiesAssessment resources Burnout and Trauma Related Employment Stress will be a valuable resource for clinicians working with those experiencing the symptoms of TRES and burnout, as well as the individuals themselves.

Therapieresistente depressive und bipolare Störungen stellen ungebrochen eine klinische Herausforderung dar: Therapeutisches Nichtansprechen bzw. Therapieresistenz depressiver und bipolarer Erkrankungen sind nicht nur häufig, sie erfordern oft auch eine stationäre Behandlung. Für Betroffene und Angehörige bedeutet das erhebliche Einschränkungen der Lebensqualität und der sozialen und beruflichen Funktionsfähigkeit. Therapieresistente Verläufe verursachen gleichzeitig sehr hohe Behandlungskosten.Um dieser Herausforderung zu begegnen, steht heute ein breites Spektrum pharmakologischer, psychotherapeutischer und psychosozialer Behandlungsmöglichkeiten zur Verfügung, das spezielle Kenntnisse und Erfahrungen voraussetzt. In diesem Buch stellen daher namhafte ExpertInnen in kurzen, prägnanten Kapiteln wissenschaftlich fundiert und mit hohem Praxisbezug den aktuellen Wissensstand dar und bieten Leitlinien für die Behandlung in Klinik und Praxis.Dabei werden auch neue Methoden, wie weiterentwickelte Hirnstimulationsverfahren, Chancen und Grenzen pharmakogenetischer Methoden zur präziseren Therapieempfehlung („bedside genotyping“), neue psychotherapeutische und pharmakologische Ansätze sowie innovative integrierte Versorgungsformen berücksichtigt. Das Buch richtet sich an PsychiaterInnen, NervenärztInnen, PsychotherapeutInnen und PsychologInnen, insbesondere im stationären Setting, aber auch in spezialisierten Praxen, sowie WissenschaftlerInnen von Forschungseinrichtungen und Industrieunternehmen.

This book provides a structured and analytical guide to the use of artificial intelligence in medicine. Covering all areas within medicine, the chapters give a systemic review of the history, scientific foundations, present advances, potential trends, and future challenges of artificial intelligence within a healthcare setting. Artificial Intelligence in Medicine aims to give readers the required knowledge to apply artificial intelligence to clinical practice. The book is relevant to medical students, specialist doctors, and researchers whose work will be affected by artificial intelligence.

This book discusses all aspects infectious CNS pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on meningitis and encephalitis of different bacterial and viral aetiologies, influenza, COVID-19 and other viral and bacterial generalized infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infection, as well as pathological changes in different age groups including newborns. A special chapter is devoted to the probable role of biological pathogens in noninfectious brain pathology.

​This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.

Chapter “Depression in the Emergency Department” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. This fully updated second edition focuses on mental illness, both globally and in terms of specific mental-health-related visits encountered in emergency department settings, and provides practical input from physicians experienced with adult emergency psychiatric patients. It covers the pre-hospital setting and advising on evidence-based practice; from collaborating with psychiatric colleagues to establishing a psychiatric service in your emergency department. Potential dilemmas when treating pregnant, geriatric or homeless patients with mental illness are discussed in detail, along with the more challenging behavioral diagnoses such as substance abuse, factitious and personality disorders, delirium, dementia, and PTSD. The new edition of Behavioral Emergencies for Healthcare Providers will be an invaluable resource for psychiatrists, psychologists, psychiatric and emergency department nurses, trainee and experienced emergency physicians, and other mental health workers.

This book covers recent advances in neural technology that provide for enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits involved in perception, cognition, emotion and action, that represent the building blocks of behavior and cognition. Augmentation of brain function can be achieved by using brain implants for recordings, stimulation, or drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. This volume evaluates existing methods of brain augmentation while discussing the brain circuitry and neuronal mechanisms that make augmentation possible. This volume offers novel insights into brain disorders, and explores new devices for brain repair while also addressing the philosophical and ethical implications of brain augmentation. The information in this book is relevant to researchers in the fields of neuroscience, engineering, and clinical practice. Advance Praise for Modern Approaches to Augmentation of Brain Function: “This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.”Ray Kurzweil, best-selling author, inventor, entrepreneur and a recipient of the National Medal of Technology and Innovation (1999), and the Lemelson-MIT Prize (2001)'This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field.'Ioan Dumitrache, Prof. Dr. Eng. Faculty of Computer Science, Polytechnic University of Bucharest, Bucharest, Romania “This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.”György Buzsáki, MD, PhD is the Biggs Professor of Neuroscience, NYU School of Medicine, New York, NY

The 2nd edition of this book incorporates the tremendous clinical advances that have occurred in the field of transcranial direct current stimulation (tDCS) over the past 5 years. Since the 1st edition was published, the clinical use of tDCS has moved from its infancy, and is now in a thrilling new phase with numerous possibilities as well as challenges. tDCS is a technique that excels in terms of safety and tolerability, and within a few years, novel technological developments will allow its use at home. At the same time, large, phase III trials have been exploring the clinical efficacy of tDCS, the results of which have been published in leading journals such as the New England Journal of Medicine and JAMA Psychiatry. This 2nd edition summarizes the state of the art of the field. Written by leading experts in the field, the book is divided into 5 parts: Introduction and Mechanisms of Action; Research Methods; tDCS in the life cycle; Applications of tDCS in neuropsychiatric disorders (further divided into Psychiatry and Neurology); and The clinical use of tDCS. It also includes several new chapters, covering topics such as precision stimulation of tDCS; combination of tDCS with different neuroimaging modalities; and use of tDCS in new clinical conditions. Moreover, all chapters have been rewritten and updated. This book will be of significant interest to psychiatrists, neurologists and neuroscientists new to the field as well as those with a background in tDCS who want to increase their understanding of particular psychiatric conditions.

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression…) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

This book addresses the adoption of intelligent algorithms for resolving challenges in different aspects of the society such as sport, cyber-security, COVID-19 pandemic, advertising, driving, smart environment—sensors, blockchain, cloud computing, and health. In addition, the book also covers machine learning fundamentals such as feature selection. The book presents practical simulation results and different illustrations in different chapters for easy understanding of concepts and approaches. The types of contributions in the book are as follows: original research, survey, and theoretical insight that describe advancement in the adoption of technique for resolving the broad range of challenges. Researchers, undergraduates, postgraduates, and industry experts will find the book as a valuable resource that bridges theory and practice.

Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.

This book reports on theoretical and experimental research answering key questions in neuroscience, philosophy of mind, and cognitive research. It gives a special emphasis on findings achieved within the territory of the former U.S.S.R, which has remained largely unknown to an international readership. The volume gathers authoritative studies on cognitive development, consciousness, attention and perception. It covers research on eye movements, language, speech and semantics, emotion, as well as brain functional states, and a variety of decision-making processes. It also highlights important advances in cognitive robotics and artificial intelligence, discussing brain-computer interfaces and other practically-relevant technologies. It includes studies on human subjects, in both healthy and disease conditions, and investigations on the molecular mechanisms of cognition in animal models.Chapters are based on invited lectures and peer-reviewed contributions to the 9th International Conference on Cognitive Sciences, Intercognsci–2020, held on October 10-16, 2020, in Moscow. The conference was organized by the Interregional Association of Cognitive Studies, with the participation of the Pavlov Society for Neurophysiology and Higher Nervous Activity, and supported by the Russian Academy of Sciences, the Russian Foundation for Basic Research and a number of the north eastern European research institutions. All in all, this book provides cognitive scientists around the world with a timely snapshot of interdisciplinary research and cutting-edge models, and a major source of inspiration for future collaborations in the areas of artificial intelligence and cognitive neuroscience.

This is the second edition of a well-received book in the series “Drug Discovery and Evaluation” The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series'Drug Discovery and Evaluation'in the form of a recommendation document. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology'. For the 2nd edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases.

This book provides primary care clinicians, researchers, and educators with a guide that helps facilitate comprehensive, evidenced-based healthcare of women and gender diverse populations. Many primary care training programs in the United States lack formalized training in women's health, or if they do, the allotted time for teaching is sparse. This book addresses this learning gap with a solid framework for any program or individual interested in learning about or teaching women's health. It can serve as a quick in-the-clinic reference between patients, or be used to steer curricular efforts in medical training programs, particularly tailored to internal medicine, family medicine, gynecology, nursing, and advanced practice provider programs. Organized to cover essential topics in women's health and gender based care, this text is divided into eight sections: Foundations of Women's Health and Gender Based Medicine, Gynecologic Health and Disease, Breast Health and Disease, Common Medical Conditions, Chronic Pain Disorders, Mental Health and Trauma, Care of Selected Populations (care of female veterans and gender diverse patients), and Obstetric Medicine. Using the Maintenance of Certification (MOC) and American Board of Internal Medicine blueprints for examination development, authors provide evidence-based reviews with several challenge questions and annotated answers at the end of each chapter. The epidemiology, pathophysiology, evaluation, diagnosis, treatment, and prognosis of all disease processes are detailed in each chapter. Learning objectives, summary points, certain exam techniques, clinical pearls, diagrams, and images are added to enhance reader's engagement and understanding of the material. Written by experts in the field, Sex and Gender-Based Women's Health is designed to guide all providers, regardless of training discipline or seniority, through comprehensive outpatient women's health and gender diverse care.

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, andpublic health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

This book analyzes schizophrenia management in the context of recent clinical therapeutic advances that have transformed the measurements and outcomes landscape. Unlike any other resource, this volume carefully develops the social and clinical guidelines that affect the life of the patient and defines its role in schizophrenia treatment outcomes. The text begins by determining the concepts, development, neuroscience, and guidelines for positive outcomes before analyzing the gaps in the literature. The text addresses medical concerns in relation to outcomes in schizophrenic patients, including substance use, impact from antipsychotic medications, and medical comorbidities. The text also covers external determinants that may inhibit positive outcomes, including cultural factors, stigma, and environmental issues. Written by experts in schizophrenia care, this book compiles sound research, current clinical trends, and modern measurement markers into a well-organized compendium that delivers this data into a practical guide for measuring treatment outcomes in patients suffering from the disease.Schizophrenia Treatment Outcomes is the ultimate guide for psychiatrists, psychologists, nurses, social workers, and all medical practitioners interested in improving outcomes for schizophrenia patients.

The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.

Begutachtungen von Menschen mit psychischen Störungen sind anspruchsvoll und gelten als schwierig. Das vorliegende Standardwerk bietet deshalb einen kompakten und gleichzeitig praxisnahen Leitfaden für ärztliche und psychologische Sachverständige, aber auch eine unverzichtbare und umfassende Grundlage für Juristen. Denn richtige und faire Entscheidungen der Gerichte können nur gefällt werden, wenn sich Mediziner, Psychologen und Juristen untereinander verständigen können. Dieses Buch leistet einen wesentlichen Beitrag zu diesem nicht immer einfachen, aber notwendigen und nicht zuletzt besonders interessanten und spannenden interdisziplinären Austausch. Das Werk zeichnet sich aus durch eine praxisbezogene, verständliche und klare Darstellung der wesentlichen Aspekte der psychiatrischen und psychologischen Begutachtung, ausführliche Beispielgutachten sowie zahlreiche Fallbeispiele aus der Praxis viele Tipps zum Erstellen einesGutachtens die Darstellung des aktuellen Stands der medizinischen, psychologischen und juristischen Literatur, inklusive der neuesten Rechtsprechung und Gesetzgebung. Mit der nun vorliegenden vierten Auflage wurde das Werk zudem grundlegend aktualisiert. Das Buch ist ein wertvoller Begleiter für Mediziner, Psychologen, Juristen und alle anderen Interessierten, die mit psychiatrischen und psychologischen Gutachten zu tun haben.

This book provides an overview of the state of the art in research on and treatment of gambling disorder. As a behavioral addiction, gambling disorder is of increasing relevance to the field of mental health. Research conducted in the last decade has yielded valuable new insights into the characteristics and etiology of gambling disorder, as well as effective treatment strategies. The different chapters of this book present detailed information on the general concept of addiction as applied to gambling, the clinical characteristics, epidemiology and comorbidities of gambling disorder, as well as typical cognitive distortions found in patients with gambling disorder. In addition, the book includes chapters discussing animal models and the genetic and neurobiological underpinnings of the disorder. Further, it is examining treatment options including pharmacological and psychological intervention methods, as well as innovative new treatment approaches. The book also discusses relevantsimilarities to and differences with substance-related disorders and other behavioral addictions. Lastly, it examines gambling behavior from a cultural perspective, considers possible prevention strategies and outlines future perspectives in the field.

Brain disorders (neurodevelopmental, neurodegenerative, and affective disorders) can be investigated, treated, and prevented using person-centered methods. Because researchers have not reached a clear consensus on whether or not personality is stable or changeable, it has been difficult to outline how to use these methods in the care of people with brain disorders. Thus, the first part aims to identify the ways in which brain disorders and personality are linked. The second part explores different person-centered approaches that can be incorporated in a healthcare or education setting to help people with various brain disorders and to promote physical, mental and social health. The third part focuses on challenges and new venues.

This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.

This book examines sex and gender differences in the causes and expression of medical conditions, including mental health disorders. Sex differences are variations attributable to individual reproductive organs and the XX or XY chromosomal complement. Gender differences are variations that result from biological sex as well as individual self-representation which include psychological, behavioural, and social consequences of an individual's perceived gender. Gender is still a neglected field in psychopathology, and gender differences is often incorrectly used as a synonym of sex differences. A reconsideration of the definition of gender, as the term that subsumes masculinity and femininity, could shed some light on this misperception and could have an effect in the study of health and disease. This second edition of Psychopathology clarifies the anthropological, cultural and social aspects of gender and their impact on mental health disorders. It focuses ongender perspective as a paradigm not only in psychopathology but also in mental health disorders. As such it promotes open mindedness in the definition and perception of symptoms, as well as assumptions about those symptoms, and raises awareness of mental health.

This book is the newest edition on the series ‘advances in psychiatry'. The previous 3 volumes can be found online at http://www.wpanet.org/detail.php?section_id=10&content_id=660. They were highly successful in covering a broad area of psychiatry from different perspectives and angles and by reflecting both specialized but also international and global approaches. This series have guaranteed quality therefore can be used by different scientific groups for teaching and learning and also as a means for fast dissemination of advanced research and transformation of research findings into the everyday clinical practice.

This book illustrates the clinical interface between neurology and psychiatry by focusing on neuropsychiatric conditions characterised by alterations at the level of both motor function and behaviour. The neuropsychiatric approach to movement disorders and epilepsy is of key importance in clinically assessing and treating these common and often disabling conditions. While addressing the clinical challenges posed by the behavioural aspects of movement disorders and epilepsy, it invites readers on a journey through the evolving discipline of neuropsychiatry / behavioural neurology – both in the past and today. This discipline has an illustrious history, and continues its ascending trajectory in the new millennium through the activity of long-established national organisations (British Neuropsychiatry Association, BNPA, and American Neuropsychiatric Association, ANPA) as well as newly developed strategic research initiatives (Michael Trimble Neuropsychiatry Research Group, MTNRG).

This book addresses the fundamental importance of the proper assessment and treatment of sexual disorders in patients with mental disorders with regard to their treatment outcomes and adherence to therapies. In fact, patients with mental disorders often suffer from sexual dysfunctions and in many cases, pharmacological treatment causes sexual-dysfunction side-effects. However, anxiety disorders, personality disorders, eating disorders and psychotic disorders are often also characterized by sexual symptoms that have a profound impact on sexual function. The psychopathology of sexual behavior investigates deficits in the mind-body relationship that are expressed through sexual symptoms such as erectile dysfunction, premature ejaculation, vaginismus, orgasmic disorders, or lack of sexual desire. These symptoms can be considered both prodromal and as a consequence of psychological or psychiatric suffering. Written by a multidisciplinary team of experts, this book offers a valuable guide for psychiatrists, andrologists, gynecologists and psychologists.