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This textbook is based on the curriculum for US, UK, Canadian and Australasian Orthopedic trainees. It offers an in-depth summary of the knowledge needed to pass the boards and FRCS examination in Trauma and Orthopedic surgery. The focus is on basic information on every orthopedic subspecialty, including: surgical anatomy, basic sciences, adult reconstruction, pediatric orthopedics, foot and ankle surgery, orthopedic pathology, the spine, sports surgery, upper limb, wrist and hand surgery, and orthopedic traumas. All sections are written by experts in the respective field and utilize a consistent bullet-point format, chosen to facilitate the learning experience and help readers memorize and organize knowledge. A clear and concise “take-home message” section precedes each topic, and key references are highlighted at the end of each chapter.

This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and characterized. Several reports describe both approaches currently used in gene therapy: the introduction of a wild-type gene to restore normal gene function in diseased cells, and the use of antisense molecules to hinder abnormal gene expression. Clinical studies detail several different strategies for the treatment of cancer and cardiovascular diseases, using genetic material as therapeutic agents. The regulatory issues governing the use of gene therapy in Europe and the United States are also presented. This book highlights the range of applications and demonstrates the rapid progress being made in the field of gene therapy.

It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.