100 results on '"Guglielmo, M."'
Search Results
2. U.S. house prices by census division: persistence, trends and structural breaks
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Caporale, G.M. (Guglielmo M.) and Gil-Alana, L.A. (Luis A.)
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Persistence ,Fractional integration ,Structural breaks ,Trends ,U.S. house prices - Abstract
This paper uses fractional integration methods to examine persistence, trends and structural breaks in United States house prices, more specifically the monthly Federal Housing Finance Agency House Price Index for census divisions, and the United States as a whole over the period from January 1991 to August 2022. The full sample estimates imply that the order of integration of the series is above one in all cases, and is particularly high for the aggregate series, implying high levels of persistence. However, when the possibility of structural breaks is taken into account, segmented trends are detected. The subsample estimates of the fractional differencing parameter tend to be lower, with mean reversion occurring in a number of cases. This means that shocks in the series are expected to be transitory in these subsamples, disappearing in the long run by themselves. In addition, the time trend coefficient is at its highest in the last subsample, which in most cases starts around May 2020 coincident with the beginning of the coronavirus pandemic. The results provide clear evidence of differences between census divisions, which implies that appropriate housing policies should be designed at the local (rather than at the federal) level.
- Published
- 2023
3. The prognostic role of right ventricular dysfunction in patients with hypertrophic cardiomyopathy.
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Mushtaq S, Monti L, Rossi A, Pontone G, Conte E, Nicoli F, di Odoardo L, Guglielmo M, Indolfi E, Bombace S, Baggiano A, Gripari P, Pepi M, Bartorelli A, Oliveira M, Santos A, Francone M, and Andreini D
- Subjects
- Humans, Prognosis, Magnetic Resonance Imaging, Cine, Predictive Value of Tests, Hypertrophy, Right Ventricular, Ventricular Dysfunction, Right etiology, Ventricular Dysfunction, Right complications, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnostic imaging
- Abstract
Hypertrophic cardiomyopathy (HCM) primarily affects the left ventricle (LV) sparing the right ventricle (RV) in vast majority of cases. However, several studies employing CMR have revealed that myocardial hypertrophy may also involve the RV. To assess RV size and function in a large prospectively cohort of HCM patients and to evaluate whether these parameters in association with other MR findings can predict cardiac events. Two participating centers prospectively included patients with known or suspected HCM between 2011 and 2017. CMR studies were performed with three different scanners. Outcome measures were a composite of ventricular arrhythmias, hospitalization for HF and cardiac death. Of 607 consecutive patients with known or suspected HCM, 315 had complete follow-up information (mean 65 ± 20 months). Among them, 115 patients developed major cardiac events (MACE) during follow-up. At CMR evaluation, patients with events had higher left atrium (LA) diameter (41.5 ± 8 mm vs. 37.17 ± 7.6 mm, p < 0.0001), LV mass (156.7 vs. 144 g, p = 0.005) and myocardial LGE (4.3% vs. 1.9%, p = 0.001). Similarly, patients with events had lower RV stroke volume index (42.7 vs. 47.0, p = 0.0003) and higher prevalence of both RV hypertrophy (16.4% vs. 4.7%, p = 0.0005) and reduced RV ejection fraction (12.2% vs. 4.4%, p = 0.006). In the multivariate analysis, LA diameter and RV stroke volume index were the strongest predictors of events (p < 0.001 and p = 0.0006, respectively). Anatomic and functional RV anomalies detected and characterized with CMR may have may have a major role in predicting the prognosis of HCM patients., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2023
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4. Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion.
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Montino Pelagi G, Regazzoni F, Huyghe JM, Baggiano A, Alì M, Bertoluzza S, Valbusa G, Pontone G, and Vergara C
- Abstract
Accurate modeling of blood dynamics in the coronary microcirculation is a crucial step toward the clinical application of in silico methods for the diagnosis of coronary artery disease. In this work, we present a new mathematical model of microcirculatory hemodynamics accounting for microvasculature compliance and cardiac contraction; we also present its application to a full simulation of hyperemic coronary blood flow and 3D myocardial perfusion in real clinical cases. Microvasculature hemodynamics is modeled with a compliant multi-compartment Darcy formulation, with the new compliance terms depending on the local intramyocardial pressure generated by cardiac contraction. Nonlinear analytical relationships for vessels distensibility are included based on experimental data, and all the parameters of the model are reformulated based on histologically relevant quantities, allowing a deeper model personalization. Phasic flow patterns of high arterial inflow in diastole and venous outflow in systole are obtained, with flow waveforms morphology and pressure distribution along the microcirculation reproduced in accordance with experimental and in vivo measures. Phasic diameter change for arterioles and capillaries is also obtained with relevant differences depending on the depth location. Coronary blood dynamics exhibits a disturbed flow at the systolic onset, while the obtained 3D perfusion maps reproduce the systolic impediment effect and show relevant regional and transmural heterogeneities in myocardial blood flow (MBF). The proposed model successfully reproduces microvasculature hemodynamics over the whole heartbeat and along the entire intramural vessels. Quantification of phasic flow patterns, diameter changes, regional and transmural heterogeneities in MBF represent key steps ahead in the direction of the predictive simulation of cardiac perfusion., (© 2024. The Author(s).)
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- 2024
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5. High-accuracy coherent optical frequency transfer over a doubled 642-km fiber link
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Aldo Godone, Filippo Levi, Davide Calonico, Claudio E. Calosso, E. K. Bertacco, Alberto Mura, Nicola Poli, Giovanni Antonio Costanzo, Cecilia Clivati, D. V. Sutyrin, M. Frittelli, Guglielmo M. Tino, and Massimo Zucco
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Physics ,Optical fiber ,Physics and Astronomy (miscellaneous) ,frequency dissemination ,business.industry ,Resolution (electron density) ,General Engineering ,General Physics and Astronomy ,optical link ,law.invention ,Metrology ,Optics ,law ,Optical frequencies ,Transfer (computing) ,Fiber ,Allan variance ,business ,Link (knot theory) - Abstract
To significantly improve the frequency references used in radio-astronomy and precision measurements in atomic physics, we provide frequency dissemination through a 642 km coherent optical fiber link, that will be also part of a forthcoming European network of optical links. We obtained a resolution of 3e-19 at 1000 s on the frequency transfer, and an accuracy of 5e-19. The ultimate link performance has been evaluated by doubling the link to 1284 km, demonstrating a new characterization technique based on the double round-trip on a single fiber. The arming of a second fiber is avoided: this is beneficial to long hauls realizations in view of a continental fiber network for frequency and time metrology. The data analysis is based on the Allan deviation; its expression is theoretically derived for the observed noise power spectrum, which is seldom found in the literature.
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- 2014
6. Is it time to measure lung water by ultrasound?
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Trovato, Guglielmo M., Catalano, Daniela, Martines, Giuseppe Fabio, and Sperandeo, Marco
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Health care industry - Abstract
Author(s): Guglielmo M. Trovato [sup.1] , Daniela Catalano [sup.1] , Giuseppe Fabio Martines [sup.1] , Marco Sperandeo [sup.2] Author Affiliations: (1) grid.8158.4, 0000000417571969, University of Catania, , Catania, Italy (2) [...]
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- 2013
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7. Long Memory at the Long Run and at the Cyclical Frequencies:Modelling Real Wages in England: 1260-1994
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Gil-Alana, L.A. (Luis A.) and Caporale, G.M. (Guglielmo M.)
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Economía y Empresa [Materias Investigacion] - Published
- 2005
8. Diagnostic performance of deep learning algorithm for analysis of computed tomography myocardial perfusion
- Abstract
Purpose: To evaluate the diagnostic accuracy of a deep learning (DL) algorithm predicting hemodynamically significant coronary artery disease (CAD) by using a rest dataset of myocardial computed tomography perfusion (CTP) as compared to invasive evaluation. Methods: One hundred and twelve consecutive symptomatic patients scheduled for clinically indicated invasive coronary angiography (ICA) underwent CCTA plus static stress CTP and ICA with invasive fractional flow reserve (FFR) for stenoses ranging between 30 and 80%. Subsequently, a DL algorithm for the prediction of significant CAD by using the rest dataset (CTP-DLrest) and stress dataset (CTP-DLstress) was developed. The diagnostic accuracy for identification of significant CAD using CCTA, CCTA + CTP stress, CCTA + CTP-DLrest, and CCTA + CTP-DLstress was measured and compared. The time of analysis for CTP stress, CTP-DLrest, and CTP-DLStress was recorded. Results: Patient-specific sensitivity, specificity, NPV, PPV, accuracy, and area under the curve (AUC) of CCTA alone and CCTA + CTPStress were 100%, 33%, 100%, 54%, 63%, 67% and 86%, 89%, 89%, 86%, 88%, 87%, respectively. Patient-specific sensitivity, specificity, NPV, PPV, accuracy, and AUC of CCTA + DLrest and CCTA + DLstress were 100%, 72%, 100%, 74%, 84%, 96% and 93%, 83%, 94%, 81%, 88%, 98%, respectively. All CCTA + CTP stress, CCTA + CTP-DLRest, and CCTA + CTP-DLStress significantly improved detection of hemodynamically significant CAD compared to CCTA alone (p < 0.01). Time of CTP-DL was significantly lower as compared to human analysis (39.2 ± 3.2 vs. 379.6 ± 68.0 s, p < 0.001). Conclusion: Evaluation of myocardial ischemia using a DL approach on rest CTP datasets is feasible and accurate. This approach may be a useful gatekeeper prior to CTP stress..
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- 2022
9. Prediction of myocardial blood flow under stress conditions by means of a computational model
- Abstract
Purpose: Quantification of myocardial blood flow (MBF) and functional assessment of coronary artery disease (CAD) can be achieved through stress myocardial computed tomography perfusion (stress-CTP). This requires an additional scan after the resting coronary computed tomography angiography (cCTA) and administration of an intravenous stressor. This complex protocol has limited reproducibility and non-negligible side effects for the patient. We aim to mitigate these drawbacks by proposing a computational model able to reproduce MBF maps. Methods: A computational perfusion model was used to reproduce MBF maps. The model parameters were estimated by using information from cCTA and MBF measured from stress-CTP (MBFCTP) maps. The relative error between the computational MBF under stress conditions (MBFCOMP) and MBFCTP was evaluated to assess the accuracy of the proposed computational model. Results: Applying our method to 9 patients (4 control subjects without ischemia vs 5 patients with myocardial ischemia), we found an excellent agreement between the values of MBFCOMP and MBFCTP. In all patients, the relative error was below 8% over all the myocardium, with an average-in-space value below 4%. Conclusion: The results of this pilot work demonstrate the accuracy and reliability of the proposed computational model in reproducing MBF under stress conditions. This consistency test is a preliminary step in the framework of a more ambitious project which is currently under investigation, i.e., the construction of a computational tool able to predict MBF avoiding the stress protocol and potential side effects while reducing radiation exposure.
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- 2022
10. T1 mapping and cardiac magnetic resonance feature tracking in mitral valve prolapse
- Abstract
Objectives: T1 mapping (T1-map) and cardiac magnetic resonance feature tracking (CMR-FT) techniques have been introduced for the early detection of interstitial myocardial fibrosis and deformation abnormalities. We sought to demonstrate that T1-map and CMR-FT may identify the presence of subclinical myocardial structural changes in patients with mitral valve prolapse (MVP). Methods: Consecutive MVP patients with moderate-to-severe mitral regurgitation and comparative matched healthy subjects were prospectively enrolled and underwent CMR-FT analysis to calculate 2D global and segmental circumferential (CS) and radial strain (RS) and T1-map to determine global and segmental native T1 (nT1) values. Results: Seventy-three MVP patients (mean age, 57 ± 13 years old; male, 76%; regurgitant volume, 57 ± 21 mL) and 42 matched control subjects (mean age, 56 ± 18 years; male, 74%) were included. MVP patients showed a lower global CS (− 16.3 ± 3.4% vs. − 17.8 ± 1.9%, p = 0.020) and longer global nT1 (1124.9 ± 97.7 ms vs. 1007.4 ± 26.1 ms, p < 0.001) as compared to controls. Moreover, MVP patients showed lower RS and CS in basal (21.6 ± 12.3% vs. 27.6 ± 8.9%, p = 0.008, and − 13.0 ± 6.7% vs. − 14.9 ± 4.1%, p = 0.013) and mid-inferolateral (20.6 ± 10.7% vs. 28.4 ± 8.7%, p < 0.001, and − 12.8 ± 6.3% vs. − 16.5 ± 4.0%, p < 0.001) walls as compared to other myocardial segments. Similarly, MVP patients showed longer nT1 values in basal (1080 ± 68 ms vs. 1043 ± 43 ms, p < 0.001) and mid-inferolateral (1080 ± 77 ms vs. 1034 ± 37 ms, p < 0.001) walls as compared to other myocardial segments. Of note, nT1 values were significantly correlated with CS (r, 0.36; p < 0.001) and RS (r, 0.37; p < 0.001) but not with regurgitant volume. Conclusions: T1-map and CMR-FT identify subclinical left ventricle tissue changes in patients with MVP. Further studies are required to correlate these subclinical tissue changes with the outcome. Key Points: • T1 mapping (T1-map) and cardia
- Published
- 2021
11. Echocardiographic assessment of left ventricular mechanics in individuals with mitral valve prolapse: a systematic review and meta-analysis.
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Sonaglioni A, Fagiani V, Nicolosi GL, and Lombardo M
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- Humans, Female, Biomechanical Phenomena, Middle Aged, Male, Adult, Aged, Ventricular Dysfunction, Left physiopathology, Ventricular Dysfunction, Left diagnostic imaging, Echocardiography, Reproducibility of Results, Myocardial Contraction, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Prognosis, Mitral Valve Prolapse physiopathology, Mitral Valve Prolapse diagnostic imaging, Ventricular Function, Left, Predictive Value of Tests, Mitral Valve physiopathology, Mitral Valve diagnostic imaging
- Abstract
Purpose: During the last decade, a number of echocardiographic studies have employed speckle tracking echocardiography (STE) for assessing myocardial deformation properties in individuals with mitral valve prolapse (MVP), reporting not univocal results. Accordingly, we performed a systematic review and meta-analysis to summarize the main findings of these studies and to examine the overall influence of MVP on left ventricular (LV) global longitudinal strain (GLS)., Methods: All echocardiographic studies assessing conventional echoDoppler parameters and myocardial strain indices in MVP individuals vs. controls without MVP, selected from PubMed and EMBASE databases, were included. The risk of bias was assessed by using the National Institutes of Health (NIH) Quality Assessment of Case-Control Studies. Continuous data (LV-GLS) were pooled as a standardized mean difference (SMD) comparing MVP group with healthy controls. The overall SMD of LV-GLS was calculated using the random-effect model., Results: The full-texts of 15 studies with 1088 individuals with MVP and 591 healthy controls were analyzed. Average LV-GLS magnitude was significantly, even though modestly, reduced in MVP individuals in comparison to controls (19.4 ± 3.4% vs. 21.1 ± 2.8%, P < 0.001). The overall effect of MVP on LV-GLS was small-to-medium (SMD - 0.54, 95%CI -0.76,-0.32, P < 0.001). Substantial heterogeneity was detected for the included studies, with an overall I
2 statistic value of 75.9% (P < 0.001). Egger's test for a regression intercept gave a P-value of 0.58, indicating no publication bias. On meta-regression analysis, none of the moderators (the age, the percentage of females among MVP individuals, body mass index, heart rate and systolic blood pressure of MVP individuals, the degree of mitral regurgitation, the type of ultrasound machine employed for strain echocardiographic imaging and finally the beta blocker treatment) was significantly associated with effect modification (all P < 0.05). Regional strain analysis, performed by two-third of the studies, highlighted a more enhanced reduction in myocardial strain parameters at level of the LV basal infero-lateral segments in all directions (longitudinal, circumferential and radial), with apical sparing., Conclusions: The longitudinal strain impairment detected in MVP individuals is more regional than global, with peculiar involvement of the LV basal infero-lateral segments and relative apical sparing pattern., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)- Published
- 2024
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12. Image reconstruction method for incomplete CT projection based on self-guided image filtering.
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Song Q and Gong C
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- Humans, Artifacts, Tomography, X-Ray Computed methods, Phantoms, Imaging, Image Processing, Computer-Assisted methods, Algorithms
- Abstract
In some fields of medical diagnosis or industrial nondestructive testing, it is difficult to obtain complete computed tomography (CT) data due to the limitation of radiation dose or other factors. Therefore, image reconstruction of incomplete projection data is the focus of this paper. In this paper, a new image reconstruction model based on self-guided image filtering (SGIF) term is proposed for few-view and segmental limited-angle (SLA) CT reconstruction. Then the alternating direction method (ADM) is used to solve this model. For simplicity, we call it ADM-SGIF method. The key idea of ADM-SGIF method is to use the reconstructed image itself as a reference and utilize its structural features to guide CT reconstruction. This method can effectively preserve image structures and remove shading artifacts. To validate the effectiveness of the proposed reconstruction method, we conduct digital phantom and real CT data experiments. The results indicate that ADM-SGIF method outperforms competing methods, including total variation (TV), relative total variation (RTV), and L0-norm minimization solved by ADM (ADM-L0) methods, in both subjective and objective evaluations., (© 2024. International Federation for Medical and Biological Engineering.)
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- 2024
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13. Machine learning predictions of the adverse events of different treatments in patients with ischemic left ventricular systolic dysfunction.
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Chen W, Liu J, and Shi Y
- Abstract
This study aimed to develop several new machine learning models based on hibernating myocardium to predict the major adverse cardiac events(MACE) of ischemic left ventricular systolic dysfunction(LVSD) patients receiving either percutaneous coronary intervention(PCI) or optimal medical therapy(OMT). This study included 329 LVSD patients, who were randomly assigned to the training or validation cohort. Least absolute shrinkage and selection operator(LASSO) regression was used to identify variables associated with MACE. Subsequently, various machine learning models were established. Model performance was compared using receiver operating characteristic(ROC) curves, the Brier score(BS), and the concordance index(C-index). A total of 329 LVSD patients were retrospectively enrolled between January 2016 and December 2021. Utilizing LASSO regression analysis, five factors were selected. Based on these factors, RSF, GBM, XGBoost, Cox, and DeepSurv models were constructed. In the development and validation cohorts, the C-indices were 0.888 vs. 0.955 (RSF). The RSF model (0.991 vs. 0.982 vs. 0.980) had the highest area under the ROC curve (AUC) compared with the other models. The BS (0.077 vs. 0.095vs. 0.077) of RSF model were less than 0.25 at 12, 18, and 24 months. This study developed a novel predictive model based on RSF to predict MACE in LVSD patients who underwent either PCI or OMT., (© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)
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- 2024
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14. Evaluation of image quality on low contrast media with deep learning image reconstruction algorithm in prospective ECG-triggering coronary CT angiography.
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Yuan D, Wang L, Lyu P, Zhang Y, Gao J, and Liu J
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- Humans, Prospective Studies, Male, Female, Middle Aged, Aged, Reproducibility of Results, Heart Rate, Radiation Dosage, Multidetector Computed Tomography, Coronary Angiography methods, Contrast Media administration & dosage, Computed Tomography Angiography, Deep Learning, Radiographic Image Interpretation, Computer-Assisted, Predictive Value of Tests, Cardiac-Gated Imaging Techniques, Coronary Vessels diagnostic imaging, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Electrocardiography
- Abstract
To assess the impact of low-dose contrast media (CM) injection protocol with deep learning image reconstruction (DLIR) algorithm on image quality in coronary CT angiography (CCTA). In this prospective study, patients underwent CCTA were prospectively and randomly assigned to three groups with different contrast volume protocols (at 320mgI/mL concentration and constant flow rate of 5ml/s). After pairing basic information, 210 patients were enrolled in this study: Group A, 0.7mL/kg (n = 70); Group B, 0.6mL/kg (n = 70); Group C, 0.5mL/kg (n = 70). All patients were examined via a prospective ECG-triggered scan protocol within one heartbeat. A high level DLIR (DLIR-H) algorithm was used for image reconstruction with a thickness and interval of 0.625mm. The CT values of ascending aorta (AA), descending aorta (DA), three main coronary arteries, pulmonary artery (PA), and superior vena cava (SVC) were measured and analyzed for objective assessment. Two radiologists assessed the image quality and diagnostic confidence using a 5-point Likert scale. The CM doses were 46.81 ± 6.41mL, 41.96 ± 7.51mL and 34.65 ± 5.38mL for Group A, B and C, respectively. The objective assessments on AA, DA and the three main coronary arteries and the overall subjective scoring showed no significant difference among the three groups (all p > 0.05). The subjective assessment proved that excellent CCTA images can be obtained from the three different contrast media protocols. There were no significant differences in intracoronary attenuation values between the higher HR subgroup and the lower HR subgroup among three groups. CCTA reconstructed with DLIR could be realized with adequate enhancement in coronary arteries, excellent image quality and diagnostic confidence at low contrast dose of a 0.5mL/kg. The use of lower tube voltages may further reduce the contrast dose requirement., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2024
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15. The additive prognostic value of end-systolic pressure-volume relation by stress CMR in patients with known or suspected coronary artery disease.
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Meloni A, De Luca A, Nugara C, Cavallaro C, Cappelletto C, Barison A, Todiere G, Grigoratos C, Novo G, Grigioni F, Emdin M, Sinagra G, Mavrogeni S, Quaia E, Cademartiri F, and Pepe A
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- Humans, Female, Male, Middle Aged, Aged, Prognosis, Time Factors, Risk Factors, Dipyridamole, Myocardium pathology, Contrast Media, Myocardial Perfusion Imaging methods, Arterial Pressure, Retrospective Studies, Coronary Artery Disease physiopathology, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease mortality, Ventricular Function, Left, Predictive Value of Tests, Stroke Volume, Fibrosis, Magnetic Resonance Imaging, Cine, Myocardial Contraction, Vasodilator Agents
- Abstract
Purpose: The difference between rest and peak stress end-systolic pressure-volume relation (ΔESPVR) is an afterload-independent index of left ventricular (LV) contractility. We assessed the independent prognostic value of ΔESPVR index by dipyridamole stress-cardiovascular magnetic resonance (CMR) in patients with known/suspected coronary artery disease (CAD)., Methods: We considered 196 consecutive patients (62.74 ± 10.66 years, 49 females). Wall motion and perfusion abnormalities at rest and peak stress were analysed. Replacement myocardial fibrosis was detected by late gadolinium enhancement (LGE) technique. The ESPVR was evaluated at rest and peak stress from raw measurement of systolic arterial pressure and end-systolic volume by biplane Simpson's method., Results: A reduced ΔESPVR index (≤ 0.02 mmHg/mL/m2) was found in 88 (44.9%) patients and it was associated with a lower LV ejection fraction (EF) and with a higher frequency of abnormal stress CMR and myocardial fibrosis. During a mean follow-up of 53.17 ± 28.21 months, 50 (25.5%) cardiac events were recorded: 5 cardiac deaths, 17 revascularizations, one myocardial infarction, 23 hospitalisations for heart failure or unstable angina, and 4 ventricular arrhythmias. According to Cox regression analysis, diabetes, family history, LVEF, abnormal stress CMR, myocardial fibrosis, and reduced ΔESPVR were significant univariate prognosticators. In the multivariate analysis the independent predictors were ΔESPVR index ≤ 0.02 mmHg/mL/m2 (hazard ratio-HR = 2.58, P = 0.007), myocardial fibrosis (HR = 2.13, P = 0.036), and diabetes (HR = 2.33, P = 0.012)., Conclusion: ΔESPVR index by stress-CMR was independently associated with cardiac outcomes in patients with known/suspected CAD, in addition to replacement myocardial fibrosis and diabetes. Thus, the assessment of ΔESPVR index may be included into the standard stress-CMR exam to further stratify the patients., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2024
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16. Computed tomography imaging in preprocedural planning of transcatheter valvular heart interventions.
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Lopes V, Almeida PC, Moreira N, Ferreira LA, Teixeira R, Donato P, and Gonçalves L
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- Humans, Treatment Outcome, Heart Valve Prosthesis, Clinical Decision-Making, Tomography, X-Ray Computed, Heart Valves diagnostic imaging, Heart Valves surgery, Heart Valves physiopathology, Transcatheter Aortic Valve Replacement instrumentation, Risk Factors, Predictive Value of Tests, Patient Selection, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases surgery, Heart Valve Diseases physiopathology, Cardiac Catheterization instrumentation, Heart Valve Prosthesis Implantation instrumentation, Heart Valve Prosthesis Implantation adverse effects
- Abstract
Cardiac Computed Tomography (CCT) has become a reliable imaging modality in cardiology providing robust information on the morphology and structure of the heart with high temporal and isotropic spatial resolution. For the past decade, there has been a paradigm shift in the management of valvular heart disease since previously unfavorable candidates for surgery are now provided with less-invasive interventions. Transcatheter heart valve interventions provide a real alternative to medical and surgical management and are often the only treatment option for valvular heart disease patients. Successful transcatheter valve interventions rely on comprehensive multimodality imaging assessment. CCT is the mainstay imaging technique for preprocedural planning of these interventions. CCT is critical in guiding patient selection, choice of procedural access, device selection, procedural guidance, as well as allowing postprocedural follow-up of complications. This article aims to review the current evidence of the role of CCT in the preprocedural planning of patients undergoing transcatheter valvular interventions., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
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17. Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: do mitral valve leaflet length, septal thickness, or sex affect the outcome?
- Author
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Mustafic M, Jandér R, Marlevi D, Rickenlund A, Rück A, Saleh N, Abdi S, Eriksson MJ, and Damlin A
- Abstract
This retrospective cohort study aimed to assess whether basal septal wall thickness (BSWT), anterior (AML) and posterior (PML) mitral leaflet length, or sex were associated with remaining left ventricular outflow tract obstruction (LVOTO) in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing alcohol septal ablation (ASA). One hundred fifty-four patients who underwent ASA at the Karolinska University Hospital in Stockholm, Sweden, between 2009 and 2021, were included retrospectively. Anatomical and hemodynamic parameters were collected from invasive catheterization before and during ASA, and from echocardiography (ECHO) examinations before, during, and at 1-year follow-up after ASA. Linear and logistic regression models were used to assess the association between sex, BSWT, AML, PML, and outcome, which was defined as the remaining LVOTO (≥ 30 mmHg) after ASA. The median follow-up was 364 days (interquartile range 334-385 days). BSWT ≥ 23 mm (n = 13, 12%) was associated with remaining LVOTO at follow-up (p = 0.004). Elongated mitral valve leaflet length (either AML or PML) was present in 125 (90%) patients. Elongated AML (> 24 mm) was present in 67 (44%) patients, although AML length was not associated with remaining LVOTO at follow-up. Elongated PML (> 14 mm) was present in 114 (74%) patients and was not associated with remaining LVOTO at follow-up. No significant sex differences were observed regarding the remaining LVOTO. ECHO measurement of BSWT can be effectively used to select patients for successful ASA and identify those patients with a risk of incomplete resolution of LVOTO after ASA., (© 2024. The Author(s).)
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- 2024
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18. Diagnostic performance of deep learning to exclude coronary stenosis on CT angiography in TAVI patients.
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Mehier B, Mahmoudi K, Veugeois A, Masri A, Amabile N, Giudice CD, and Paul JF
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- Humans, Female, Retrospective Studies, Male, Aged, Aged, 80 and over, Reproducibility of Results, Radiographic Image Interpretation, Computer-Assisted, Aortic Valve diagnostic imaging, Aortic Valve surgery, Aortic Valve physiopathology, Coronary Vessels diagnostic imaging, Multidetector Computed Tomography, False Positive Reactions, Deep Learning, Predictive Value of Tests, Coronary Angiography, Computed Tomography Angiography, Coronary Stenosis diagnostic imaging, Transcatheter Aortic Valve Replacement, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Aortic Valve Stenosis physiopathology, Observer Variation, Severity of Illness Index
- Abstract
We evaluated the diagnostic performance of a deep-learning model (DLM) (CorEx®, Spimed-AI, Paris, France) designed to automatically detect > 50% coronary stenosis on coronary computed tomography angiography (CCTA) images. We studied inter-observer variability as an additional aim. CCTA images obtained before transcatheter aortic valve implantation (TAVI) were assessed by two radiologists and the DLM, and the results were compared to those of invasive coronary angiography (ICA) used as the reference standard. 165 consecutive patients underwent both CCTA and ICA as part of their TAVI work-up. We excluded the 42 (25.5%) patients with a history of stenting or bypass grafting and the 23 (13.9%) patients with low-quality images. We retrospectively subjected the CCTA images from the remaining 100 patients to evaluation by the DLM and compared the DLM and ICA results. All 25 patients with > 50% stenosis by ICA also had > 50% stenosis by DLM evaluation of CCTA: thus, the DLM had 100% sensitivity and 100% negative predictive value. False-positive DLM results were common, yielding a positive predictive value of only 39% (95% CI, 27-51%). Two radiologists with 3 and 25 years' experience, respectively, performed similarly to the DLM in evaluating the CCTA images; thus, accuracy did not differ significantly between each reader and the DLM (p = 0.625 and p = 0.375, respectively). The DLM had 100% negative predictive value for > 50% stenosis and performed similarly to experienced radiologists. This tool may hold promise for identifying the up to one-third of patients who do not require ICA before TAVI., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
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19. Metabolomics Profiling Predicts Ventricular Arrhythmia in Patients with an Implantable Cardioverter Defibrillator.
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Yang S, Zhao J, Liu X, Wang J, Gu M, Cai C, Niu H, Chen L, and Hua W
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- Humans, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac therapy, Arrhythmias, Cardiac complications, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac prevention & control, Treatment Outcome, Risk Factors, Defibrillators, Implantable adverse effects
- Abstract
Implantable cardioverter defibrillators (ICDs) reduce sudden cardiac death (SCD) when patients experience life-threatening ventricular arrhythmias (LTVA). However, current strategies determining ICD patient selection and risk stratification are inefficient. We used metabolomics to assess whether dysregulated metabolites are associated with LTVA and identify potential biomarkers. Baseline plasma samples were collected from 72 patients receiving ICDs. Over a median follow-up of 524.0 days (range 239.0-705.5), LTVA occurred in 23 (31.9%) patients (22 effective ICD treatments and 1 SCD). After confounding risk factors adjustment for age, smoking, secondary prevention, and creatine kinase MB, 23 metabolites were significantly associated with LTVA. Pathway analysis revealed LTVA associations with disrupted metabolism of glycine, serine, threonine, and branched chain amino acids. Pathway enrichment analysis identified a panel of 6 metabolites that potentially predicted LTVA, with an area under the receiver operating characteristic curve of 0.8. Future studies are necessary on biological mechanisms and potential clinical use., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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20. Pathophysiological alterations of left ventricular myocardial systolic function during normal pregnancy assessed by speckle tracking echocardiography: a prospective cohort echocardiography study.
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Tryfou ES, Kostakou PM, Kostopoulos VS, Olympios CD, Mihas C, Paraskevaidis I, and Kouris NT
- Subjects
- Pregnancy, Humans, Female, Stroke Volume, Prospective Studies, Predictive Value of Tests, Ventricular Function, Left, Echocardiography
- Abstract
Purpose: By using conventional echocardiographic indices, cardiac pumping function remains unaltered during pregnancy. However, two-dimensional speckle tracking echocardiography (2D-STE) can detect subclinical changes of myocardial function even in patients with normal and stable left ventricular ejection fraction (LVEF).The aim of this study was to evaluate LV systolic performance during normal low risk pregnancy by using both conventional 2D and 3D echo indices and 2D-STE., Methods: One hundred and twelve pregnant women without any history of heart disease were prospectively recruited. They underwent serial echocardiographic evaluation in each pregnancy trimester and 6 months after delivery (time indicated as 1,2,3 and 4). 2D LVEF, 3D LVEF, LV global longitudinal strain (LVGLS), LV global circumferential strain (LVGCS) and LV-twist were measured and compared to the control group (c)., Results: 2D-LVEF and 3D-LVEF were not significantly different among the three trimesters, postpartum and controls. LVGLS progressively decreased during pregnancy (1st :21.71 ± 2.13%, 2nd : 21.20 ± 2.30%, 3rd : 19.82 ± 2.10%, 4th : 21.81 ± 2.05%, c: 21.71 ± 2.2%, overall p < 0,001) which receded during puerperium. No significant difference was noted in LVGCS (1st : 18.08 ± 5.54%, 2nd : 18.57 ± 3.41%, 3rd :18.20 ± 3.33%, 4th : 17.95 ± 3.39%, c: 18.8 ± 2.2%, p > 0.3). LV-Twist was significantly higher in the 1st trimester compared to controls (p = 0.04) and remained constantly high during the rest of the pregnancy and puerperium (1st :13.80 ± 5.09°, 2nd :13.46 ± 5.35°, 3rd :13.58 ± 4.32°, 4th :13.37 ± 4.26°, c: 11.5 ± 4.3°)., Conclusions: In low risk individuals with normal pregnancy, a redistribution of force occurs especially in the 3rd trimester. Longitudinal strain decreases, while torsional movement of the heart increases and counterbalances the temporal change of longitudinal systolic function. These changes would probably reflect the pathophysiological alterations related to pregnancy., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2022
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21. Detection of stage of lung changes in COVID-19 disease based on CT images: a radiomics approach.
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Mehrpouyan M, Zamanian H, Mehri-Kakavand G, Pursamimi M, Shalbaf A, Ghorbani M, and Abbaskhani Davanloo A
- Subjects
- Humans, Lung diagnostic imaging, Thorax, Tomography, X-Ray Computed methods, COVID-19 diagnostic imaging, Lung Neoplasms
- Abstract
The aim of this study is to classify patients suspected from COVID-19 to five stages as normal, early, progressive, peak, and absorption stages using radiomics approach based on lung computed tomography images. Lung CT scans of 683 people were evaluated. A set of statistical texture features was extracted from each CT image. The people were classified using the random forest algorithm as an ensemble method based on the decision trees outputs to five stages of COVID-19 disease. Proposed method attains the highest result with an accuracy of 93.55% (96.25% in normal, 74.39% in early, 100% in progressive, 82.19% in peak, and 96% in absorption stage) compared to the other three common classifiers. Radiomics method can be used for the classification of the stage of COVID-19 disease with good accuracy to help decide the length of time required to hospitalize patients, determine the type of treatment process required for patients in each category, and reduce the cost of care and treatment for hospitalized individuals., (© 2022. Australasian College of Physical Scientists and Engineers in Medicine.)
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- 2022
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22. Cancer Rehabilitation and Physical Activity: the "Oncology in Motion" Project.
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Bednarova R, Biancuzzi H, Rizzardo A, Dal Mas F, Massaro M, Cobianchi L, Barcellini A, Orlandi E, and Miceli L
- Subjects
- Exercise, Humans, Medical Oncology, Neoplasms rehabilitation
- Published
- 2022
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23. Reliability and feasibility of automated function imaging for quantification in patients with left ventricular dilation: comparison with cardiac magnetic resonance.
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Chen Y, Hua W, Yang W, Shi Z, and Fang Y
- Abstract
Automated function imaging (AFI, GE Healthcare) is a novel promising algorithm of speckle-tracking echocardiography that combines two-dimensional strain and AI technology. It shortens the analysis time, saves the cost associated with streamlining of image acquisition, rapid analysis, and reporting, and has greater accuracy and reproducibility of measurements. This study aimed to evaluate the reliability and feasibility of AFI for the quantification of left ventricular (LV) volumes and function in patients with LV dilation by comparison with CMR. We retrospectively studied 50 patients with LV dilation on echocardiography whom both underwent CMR and coronary angiography within three days. LV volumes, ejection fraction (EF), and global longitudinal strain (GLS) were measured from 3 long-axis cine-views via the AFI technique in two modes: without editing (auto-AFI) and with partial border editing (semi-auto-AFI). The LV volumes and EF were also measured with 2D Simpson's biplane method, and CMR, as the standard method, was used for comparison. The AFI method still had significantly underestimated the LV volumes compared with CMR (P<0.01), but there were no significant differences between the AFI method and the conventional Simpson's biplane method. There were no significant differences in EF between CMR and the AFI method with good correlations (auto-AFI: r = 0.81, semi-auto-AFI: r = 0.86). The auto-AFI method provided the most rapid analysis and excellent reproducibility, while the semi-auto-AFI method further improved measurement accuracy. However, there were no significant differences in LV volumes and EF between these two AFI methods. The accuracy of AFI seems to be more affected by the image quality than the left ventricular morphology. AFI enables accurate, efficient, and rapid evaluation of LV volumes and EF in patients with dilated LV, with good reproducibility and correlations with CMR., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2022
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24. Biventricular myocardial function in Covid-19 recovered patients assessed by speckle tracking echocardiography: a prospective cohort echocardiography study.
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Tryfou ES, Kostakou PM, Chasikidis CG, Kostopoulos VS, Serafetinidis II, Ferdianaki EK, Mihas C, Olympios CD, and Kouris NT
- Abstract
Although severe acute respiratory syndrome coronavirus 2 causes respiratory disease, it may also lead to cardiovascular involvement with unknown long-term consequences. The aim of our study was to evaluate prospectively cardiac involvement in patients after the recovery from Covid-19, using two-dimensional speckle tracking echocardiography. 100 Covid-19 recovered patients with preserved left ventricular ejection fraction, were included, divided based upon clinical manifestation into two groups, those who were treated ambulant and those who were hospitalized. All patients underwent echocardiographic evaluation after their recovery. Although overall LV systolic function expressed by EF was normal, left ventricular global longitudinal strain (LVGLS) was significantly lower in Covid-19 recovered patients (33.28 ± 9.4 days after diagnosis) compared to controls (- 18.47 ± - 2.4 vs. - 21.07 ± - 1.76% respectively, p < 0.0001). Εspecially the lateral wall longitudinal strain (LATLS) and posterior wall longitudinal strain (POSTLS) were significantly reduced in all patients compared to controls (- 17.77 ± - 3.48 vs. - 20.97 ± - 2.86%, p < 0.0001 and - 19.52 ± - 5.3 vs. - 22.23 ± - 2.65%, p = 0.01). right ventricular global longitudinal strain (RVGLS) was significantly diminished only in the hospitalized group of Covid-19 recovered patients, compared to controls (- 18.17 ± - 3.32 vs. - 26.03 ± - 4.55% respectively, p < 0.0001). LVGLS is affected in almost all individuals after Covid-19 infection independently of the infection severity, with LATLS being the most sensitive marker of LV impairment and with POSTLS to follow. RV shows impaired GLS in severely ill patients highlighting RVGLS as a helpful tool of prognosis. Recovered patients from Covid-19 infection have to be monitored for a long time, since the term "long Covid disease" might also include the cardiac function., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2022
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25. Editor's Choice to the April 2022 issue : Cardiac computed tomographic angiography after abnormal ischemia test as a gatekeeper to invasive coronary angiograph.
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Reiber JHC
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- 2022
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26. Functional Coronary Artery Assessment: a Systematic Literature Review.
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Freitas SA, Nienow D, da Costa CA, and Ramos GO
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- Coronary Angiography methods, Humans, Predictive Value of Tests, Severity of Illness Index, Coronary Artery Disease diagnosis, Coronary Stenosis, Fractional Flow Reserve, Myocardial, Plaque, Atherosclerotic
- Abstract
Cardiovascular diseases represent the number one cause of death in the world, including the most common disorders in the heart's health, namely coronary artery disease (CAD). CAD is mainly caused by fat accumulated in the arteries' internal walls, creating an atherosclerotic plaque that impacts the blood flow functional behavior. Anatomical plaque characteristics are essential but not sufficient for a complete functional assessment of CAD. In fact, plaque analysis and visual inspection alone have proven insufficient to determine the lesion severity and hemodynamic repercussion. Furthermore, the fractional flow reserve (FFR) exam, which is considered the gold standard for stenosis functional impair determination, is invasive and contains several limitations. Such a panorama evidences the need for new techniques applied to image exams to improve CAD functional assessment. In this article, we perform a systematic literature review on emerging methods determining CAD significance, thus delivering a unique base for comparing these methods, qualitatively and quantitatively. Our goal is to guide further studies with evidence from the most promising methods, highlighting the benefits from both areas. We summarize benchmarks, metrics for evaluation, and challenges already faced, thus shedding light on the requirements for a valid, meaningful, and accepted technique for functional assessment evaluation. We create a base of comparison based on quantitative and qualitative indicators and highlight the most relevant geometrical metrics that correlate with lesion significance. Finally, we point out future benchmarks based on recent literature., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
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- 2022
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27. Improved diastolic dysfunction is associated with higher forward flow and better prognosis in chronic heart failure.
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Dini FL, Ballo P, Pugliese NR, Bytyçi I, D'Agostino A, Bajraktari G, Pedrinelli R, and Henein MY
- Abstract
The benefit of repeat assessment of left ventricular (LV) systolic and diastolic function in heart failure (HF) remains uncertain. We assessed the prognostic value of repeat echocardiographic assessment of LV filling pressure (LVFP) and its interaction with cardiac index (CI) in ambulatory patients with chronic HF and reduced ejection fraction (HFrEF). We enrolled 357 patients (age 68 ± 11 years; 22% female) with chronic HFrEF. Patients underwent a clinical and echocardiographic examination at baseline. LVFP as assessed by the 2016 Guidelines and Doppler-derived CI were estimated. After the second echocardiographic examination, patients were followed for a median time of 30 months. The study endpoint included all-cause death and hospitalization for worsening HF. Patients who normalized LVFP or showed persistently normal LVFP at the follow-up examination had a significantly lower mortality rate than those with worsening or persistently raised LVFP (p < 0.0001). After stratification by CI, patients with elevated LVFP and CI < 2.0 l/min/m
2 had a further worse outcome than those with elevated LVFP and CI ≥ 2.0 l/min/m2 (p < 0.0001). Multivariate survival analysis confirmed an independent prognostic impact of changes in LVFP, incremental to that of established clinical, laboratory and echocardiographic predictors. Repeat assessment of LVFP and CI significantly improved risk stratification of chronic HFrEF outpatients compared to baseline evaluation., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)- Published
- 2022
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28. Preoperative Cardiopulmonary Exercise Test Associated with Postoperative Outcomes in Patients Undergoing Cancer Surgery: A Systematic Review and Meta-Analyses.
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Steffens D, Ismail H, Denehy L, Beckenkamp PR, Solomon M, Koh C, Bartyn J, and Pillinger N
- Subjects
- Humans, Length of Stay, Postoperative Complications etiology, Postoperative Period, Quality of Life, Exercise Test, Neoplasms surgery
- Abstract
Backgrounds: There is mixed evidence on the value of preoperative cardiorespiratory exercise test (CPET) to predict postoperative outcomes in patients undergoing a cancer surgical procedure. The purpose of this review was to investigate the association between preoperative CPET variables and postoperative complications, length of hospital stay, and quality of life in patients undergoing cancer surgery., Methods: A search was conducted on MEDLINE, Embase, AMED, and Web of science from inception to April 2020. Cohort studies investigating the association between preoperative CPET variables, including peak oxygen uptake (peak VO
2 ), anaerobic threshold (AT), or ventilatory equivalent for carbon dioxide (VE /VCO2 ), and postoperative outcomes (complications, length of stay, and quality of life) were included. Risk of bias was assessed using the QUIPS tool. A random-effect model meta-analysis was performed whenever possible., Results: Fifty-two unique studies, including 10,030 patients were included. Overall, most studies were rated as having low risk of bias. Higher preoperative peak VO2 was associated with absence of postoperative complications (mean difference [MD]: 2.28; 95% confidence interval [CI]: 1.26-3.29) and no pulmonary complication (MD: 1.47; 95% CI: 0.49-2.45). Preoperative AT and VE /VCO2 also demonstrated some positive trends. None of the included studies reported a negative trend., Conclusions: This systematic review and meta-analysis demonstrated a significant association between superior preoperative CPET values, especially peak VO2 , and better postoperative outcomes. The assessment of preoperative functional capacity in patients undergoing cancer surgery has the potential to facilitate treatment decision making., (© 2021. Society of Surgical Oncology.)- Published
- 2021
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29. Pharmacological properties of ginsenosides in inflammation-derived cancers.
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Luong Huynh D, Nguyen NH, and Nguyen CT
- Subjects
- Animals, Humans, Neoplasms etiology, Neoplasms pathology, Antineoplastic Agents, Phytogenic therapeutic use, Ginsenosides therapeutic use, Inflammation complications, Neoplasms drug therapy
- Abstract
Ginseng is commonly used as an herbal medicine for improvement of life quality. It is also used as a supplemental medication with anti-cancer drugs to enhance chemotherapy efficacy and shows some beneficial effects. Ginsenosides, also known as saponins, are the major active pharmacological compounds found in ginseng and have been extensively using in treatment of not only cancers but also the other inflammatory diseases such as atherosclerosis, diabetes, acute lung injury, cardiovascular, and infectious diseases. The anti-cancer activities of ginsengs and ginsenosides in different types of cancers have been well studied experimentally and clinically. The major anti-cancer mechanisms of ginseng compounds include inhibition of angiogenesis and metastasis as well as induction of cell cycle arrest and apoptosis. Herein, we review and summarize the current knowledge on the pharmacological effects of ginsengs and ginseng-derived compounds in the treatment of cancers. Moreover, the molecular and cellular mechanism(s) by which ginsengs and ginsenosides modulate the immune response in cancer diseases as well as ginsengs-drugs interaction are also discussed., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2021
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30. Incremental diagnostic role of left atrial strain analysis in thrombotic risk assessment of nonvalvular atrial fibrillation patients planned for electrical cardioversion.
- Author
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Sonaglioni A, Lombardo M, Nicolosi GL, Rigamonti E, and Anzà C
- Subjects
- Aged, Atrial Appendage physiopathology, Case-Control Studies, Echocardiography, Echocardiography, Transesophageal, Electric Countershock, Female, Humans, Male, Retrospective Studies, Stroke Volume physiology, Thrombosis physiopathology, Atrial Appendage diagnostic imaging, Atrial Fibrillation physiopathology, Risk Assessment, Thrombosis diagnostic imaging
- Abstract
During the COVID-19 pandemic, transesophageal echocardiography (TEE) for left atrial appendage thrombosis (LAAT) detection should be limited to situations of absolute necessity. We sought to identify the main conventional and functional echocardiographic parameters associated with LAAT on TEE in non-valvular atrial fibrillation (NVAF) patients planned for electrical cardioversion (ECV). This retrospective study included 125 consecutive NVAF patients (71.5±7.8 yrs, 75 males), who underwent TEE at our Institution between April 2016 and January 2020, to exclude LAAT before scheduled ECV. All patients underwent a transthoracic echocardiography (TTE) implemented with speckle tracking echocardiography (STE) analysis of left atrial (LA) strain and strain rate (SR) parameters. 28% of patients were diagnosed with LAAT, while 72% without LAAT. Compared to controls, patients with LAAT had significantly higher CHA
2 DS2 -Vasc Score and average E/e' ratio, and significantly lower left ventricular ejection fraction (LVEF). Moreover, LA-peak positive global atrial strain (GSA+) and LA-SR parameters were significantly reduced in patients with LAAT. Multivariate logistic regression revealed that, differently from CHA2 DS2 -Vasc Score, LVEF (OR 0.88, 95%CI 0.81-0.97, p = 0.01), average E/e' ratio (OR 2.36, 95%CI 1.41-3.98, p = 0.001), and LA-GSA+ (OR 0.57, 95%CI 0.36-0-90, p = 0.01) were independently associated with LAAT. LA-GSA+ (optimal cut-off ≤ 9.1%, AUC 0.95) showed the highest diagnostic performance. Finally, a strong linear correlation of LA peak-to-peak SR with both LA appendage filling (r = 0.86) and emptying (r = 0.83) velocities was demonstrated. TTE implemented with STE analysis of LA mechanics improves thrombotic risk assessment of NVAF patients.- Published
- 2021
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31. Diagnostic and Prognostic Value of Coronary Computed Tomography Angiography in Patients with Severe Calcification.
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Díaz-Antón B, Solís J, Morales RD, López-Melgar B, Barrio P, Moreno A, Unzué L, Alvarez-Vieitez A, Medina J, García E, Jiménez FJP, and Fernández-Friera L
- Subjects
- Aged, Female, Follow-Up Studies, Humans, Male, Prognosis, Retrospective Studies, Risk Factors, Calcinosis diagnosis, Computed Tomography Angiography methods, Coronary Angiography methods, Coronary Artery Disease diagnosis, Coronary Vessels diagnostic imaging, Registries
- Abstract
Our aim was to analyze its diagnostic and prognostic value in patients with high coronary calcium score (CCS). A total of 113 patients with CCS > 400 were included. Significant coronary artery disease (CAD) was defined as stenosis ≥ 50%. Invasive coronary angiography and major cardiovascular events were recorded. The CCS and heart rate during the acquisition were significantly lower in the diagnostic coronary computed tomography angiography (CCTA) group. The cut-off value of CCS to establish the diagnostic utility of CCTA was 878. The rate of cardiovascular events was 9.3%. The positive predictive value of CCTA to detect significant CAD was 73.5% and the negative predictive value for predicting cardiovascular events was 96%. In patients with high CCS, CCTA is useful to evaluate CAD, especially when the CCS is lower or equal to 878; moreover, the prognostic value of CCTA is better in patients where significant CAD has been ruled out.
- Published
- 2021
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32. Clinical outcomes in patients with left ventricle trabeculation or noncompaction.
- Author
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Kim H, Kim IC, and Chung JW
- Subjects
- Aged, Disease Progression, Echocardiography, Female, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Ventricular Function, Left, Isolated Noncompaction of the Ventricular Myocardium complications, Isolated Noncompaction of the Ventricular Myocardium diagnostic imaging, Isolated Noncompaction of the Ventricular Myocardium physiopathology, Isolated Noncompaction of the Ventricular Myocardium therapy
- Abstract
Trabeculation exhibits highly varied presentations, whereas noncompaction (NC) is a specific disease entity based arithmetically on wall thickness. We aimed to evaluate the clinical implications of trabeculation and its relevance to outcomes. A total of 296 patients (age 63 ± 12 years; 64% men) with trabeculation who underwent echocardiography were retrospectively identified between January 2011 and December 2012. Analyses were conducted on distinguished trabeculation which was divided into NC (maximum noncompacted/compacted ratio ≥ 2.0) or hypertrabeculation (HT) (ratio < 2.0). We evaluated features of trabeculation and explored cardiovascular (CV) outcome events (coronary revascularization, hospitalization for worsening heart failure (HF), stroke, nonsustained ventricular tachycardia (VT), implantation of an implantable cardioverter defibrillator (ICD), and CV death). Over a mean of 4.2 years, CV outcome events occurred in 122 (41%) patients who were older and exhibited an increased frequency of diabetes mellitus, stroke, implantation of ICD, HF and dilated cardiomyopathy. The frequencies of NC or HT, the trabeculation ratio and its manifestation were similar among patients with and without events. NC/HT with concomitant apical hypocontractility and worsening systolic function were univariable predictors of adverse events. On multivariable analysis, concomitant apical hypocontractility on NC/HT remained significant (hazard ratio 8.94, 95% confidence interval 2.9-27.2, p < 0.001) together with old age, HF and increased E/e' ratio. NC/HT with concomitant apical hypocontractility provided clues about the current medical illness and aided in risk stratification.
- Published
- 2021
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33. Recent updates on novel therapeutic targets of cardiovascular diseases.
- Author
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Afzal M
- Subjects
- Angina Pectoris metabolism, Animals, Antihypertensive Agents, Arrhythmias, Cardiac metabolism, Cardiology trends, Cardiovascular Diseases metabolism, Catecholamines metabolism, Female, Heart Diseases, Heart Failure drug therapy, Humans, Hypertension drug therapy, Ligands, Male, Myocardial Infarction drug therapy, Renin-Angiotensin System, Risk Factors, Smoking, Cardiovascular Diseases physiopathology, Cardiovascular Diseases therapy, Inflammation
- Abstract
In recent times cardiovascular diseases (CVDs) are the leading cause of mortality universally, caused more or less 17.7 million casualties with 45% of all illnesses (except communicable ones) in 2015 as per World Health Organization (WHO). According to American National Center for Health Statistics, cardiac disorders are costliest. Moreover, health care expenditures related to cardiac disorders are anticipated to exceed than diabetes and Alzheimer's. Straining of reactive oxygen species with diminished neutralization & inflammation critically adds to atherosclerosis and also proceed to other cardiovascular diseases such as cardiac remodeling and myocardial infarction (MI). In the past few years, researchers revealed multiple drug targets from animal studies and evaluated them in the therapeutics of cardiac disorders, which offered exciting clues for novel therapeutic strategies. Although, only few newer agents approved clinically and actual approaches for treatment are lagging behind. Several novel drugs found effective for the treatment of hypertension, congestive heart failure, cardiac arrhythmia and angina pectoris. Detailed mechanism of action, basic and clinical pharmacology of all novel drugs has been discussed in this review.
- Published
- 2021
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34. Research progress of fibroblast growth factor 23 in acute kidney injury
- Author
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Zhang, Lina and Qin, Wei
- Subjects
Acute renal failure -- Risk factors -- Diagnosis -- Care and treatment ,Fibroblast growth factors -- Health aspects -- Physiological aspects ,Health - Abstract
Fibroblast growth factor 23 (FGF23) is primarily produced in bones and mainly regulates calcium and phosphorus metabolism. The level of circulating FGF23 increases rapidly in the early stage of acute kidney injury (AKI). Recent studies have shown that FGF23 may serve as a biomarker for the diagnosis and poor prognosis of AKI. The mechanism of increased FGF23 in AKI may include increased production of FGF23, decreased renal clearance of FGF23, and some new regulatory factors, such as inflammation and glycerol 3-phosphate. However, the biological effects of elevated FGF23 in AKI are still unclear. It is also not known whether reducing the level of circulating FGF23 could alleviate AKI or its poor prognosis. Here, we review the pathophysiological mechanism and possible regulation of FGF23 in AKI and discuss the possibility of using FGF23 as a therapeutic target., Author(s): Lina Zhang [sup.1] [sup.2] , Wei Qin [sup.1] Author Affiliations: (1) grid.412901.f, 0000 0004 1770 1022, Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, , 37 [...]
- Published
- 2023
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35. Foundations and Practice of Security : 16th International Symposium, FPS 2023, Bordeaux, France, December 11–13, 2023, Revised Selected Papers, Part I
- Author
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Mohamed Mosbah, Florence Sèdes, Nadia Tawbi, Toufik Ahmed, Nora Boulahia-Cuppens, Joaquin Garcia-Alfaro, Mohamed Mosbah, Florence Sèdes, Nadia Tawbi, Toufik Ahmed, Nora Boulahia-Cuppens, and Joaquin Garcia-Alfaro
- Subjects
- Data protection, Computer engineering, Computer networks
- Abstract
This book constitutes the refereed proceedings of the 16th International Symposium on Foundations and Practice of Security, FPS 2023, held in Bordeaux, France, during December 11–13, 2023. The 27 regular and 8 short papers presented in this book were carefully reviewed and selected from 80 submissions. The papers have been organized in the following topical sections:Part I: AI and cybersecurity, security analysis, phishing and social network, vulnerabilities and exploits, network and system threat, malware analysis.Part II : security design, short papers.
- Published
- 2024
36. Handbook of Cliometrics
- Author
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Claude Diebolt, Michael Haupert, Claude Diebolt, and Michael Haupert
- Subjects
- Economic history, Economics--History, Econometrics
- Abstract
This handbook is a milestone in the field of historical economics and econometric history through its emphasis on the concrete contribution of cliometrics to our knowledge in economics and history. The articles in the handbook authored by the leading scholars in the fields, stress the usefulness of cliometrics for economists, historians and social scientists in general. The handbook offers a comprehensive coverage of topics with each article providing an overview of the contributions of cliometrics to a particular topic. The handbook has set a new standard of quality in the field by offering a world-wide forum of discussion in cliometrics. This updated and extended third edition of the handbook of cliometrics offers a substantially enlarged collection of articles and thus stresses its unique position as authoritative reference work in this field.
- Published
- 2024
37. Onkologische Krankenpflege
- Author
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Patrick Jahn, Andrea Gaisser, Marika Bana, Christoph Renner, Patrick Jahn, Andrea Gaisser, Marika Bana, and Christoph Renner
- Subjects
- Cancer--Nursing
- Abstract
100% Onkologische Pflege! Dieses Buch bietet allen Pflegenden und Teilnehmenden der Fachweiterbildung zur onkologischen Pflegefachperson umfassendes, aktuelles Fachwissen für die spezielle Betreuung ihrer Patienten. Lernen Sie solide Grundlagen, z.B. wie maligne Tumoren entstehen und wachsen, wie man sie erkennt und welche Probleme bei der Behandlung auftreten können, sowie spezielle Kompetenzen, um pflegerisch angemessen zu handeln. Das Standardwerk ist der ideale Begleiter für die Weiterbildung und zum Nachschlagen für die tägliche Praxis.Empfohlen von der Konferenz Onkologischer Kranken- und Kinderkrankenpflege (KOK), der Onkologie Pflege Schweiz (OPS) und der Arbeitsgemeinschaft hämatologischer und onkologischer Pflegepersonen in Österreich (AHOP).
- Published
- 2024
38. Tumorassoziierte Fatigue
- Author
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Joachim Weis, Markus Horneber, Stephanie Otto, Joachim Weis, Markus Horneber, and Stephanie Otto
- Subjects
- Internal medicine, Family medicine, Oncology
- Abstract
Dieses Buch beleuchtet die tumorassoziierte Fatigue, welche Patientinnen und Patienten mit bösartigen Tumoren in allen Phasen der Erkrankung treffen kann, ob als frühes Zeichen, während und nach der onkologischen Therapie, oder als Langzeitfolge. Nach einer kurzen Einführung in Epidemiologie, Ätiologie, Pathogenese und Diagnostik stellen Autorin und Autoren praxisorientiert und prägnant die verschiedenen Behandlungsansätze und Möglichkeiten des Selbstmanagements vor. Diese umfassen nicht-medikamentöse Therapien, wie Bewegungstherapie, psychosoziale und Mind-Body Interventionen sowie medikamentöse Therapien. Ziel des Buchs ist es, Behandelnde zu unterstützen, die individuell effektivsten Therapieoptionen zu finden, um das Syndrom erfolgreich zu behandeln und die Lebensqualität der Betroffenen zu verbessern: Ärztinnen und Ärzte in der Onkologie, Allgemeinmedizin und Inneren Medizin.
- Published
- 2023
39. Noninvasive Ventilation Outside Intensive Care Unit : Rationale and Practice
- Author
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Antonio M. Esquinas, Lucia Spicuzza, Raffaele Scala, Antonio M. Esquinas, Lucia Spicuzza, and Raffaele Scala
- Subjects
- Respiratory therapy, Artificial respiration
- Abstract
This book aims to highlight the importance of the development of health conditions and demand for the application of noninvasive mechanical ventilation (NIMV) outside the intensive care units (ICUs); the diversification of possible scenarios outside the ICUs; the need to establish references that consolidate this phenomenon and the healthcare organizations models.In the last decades the extension of the use of NIMV outside of the ICUs has led to the generation of protocols and to the creation of new in-hospital care models. In this field, the main determining factors are a better knowledge of technique, technological advancement, better monitoring capacity, the creation of multidisciplinary teams adequately trained in their application, and social and health events that have overloaded ICUs. All these elements have promoted the creation of these NIMV units outside ICUs. This new reality entails the need for clarification of concepts, recommendations, and analysis of how to planNIMV.Although the literature that clearly determine the indications and aids on the use of NIMV is considerable, this volume, pointing out the diversity of different healthcare models to define how to organize NIMV outside the ICUs, shed a light and bring a clear benefit to the scientific community involved.The book is structured in eleven main sections analyzing the epidemiology and trends for NIMV healthcare models and determining factors for these models outside ICUs.The originality of the work, its clear clinical-practical impact and the multidisciplinary approach given by all healthcare professionals involved (intensivists, pneumologists, internal medicine and emergency medicine specialists, geriatricians, chest respiratory therapists, etc.) is very relevant for the thoroughness of the book.
- Published
- 2023
40. Noninvasive Mechanical Ventilation in High Risk Infections, Mass Casualty and Pandemics
- Author
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Antonio M. Esquinas and Antonio M. Esquinas
- Subjects
- Emergency medicine, Lungs--Diseases--Treatment, Artificial respiration
- Abstract
The second edition of this book describes the clinical indications of NIV in patients hospitalized with high-risk infections as well as in the prehospital management of mass casualty incidents, including chemical or biological disasters and pandemics. In recent decades, we have learned the impact that different pandemics and mass casualty disasters can outcome in terms of health resource use, health costs and human lives. The development of respiratory failure in these patients, either infectious or non-infectious causes, has led to develop employment plans related both to invasive or noninvasive mechanical ventilation during acute respiratory failure.In this book authors evaluate a rational basis for indications, specific noninvasive mechanical ventilation indications in hospitalized patients (tuberculosis, bacterial, virus, etc.) and prehospital applications (mass casualty: chemical, biological disaster), equipment (ventilators, interfaces) and plan organization for health systems: how and when apply NIV. A critical review of already published studies is described as well as implications and how will be the future according to international expert opinions.Therefore, this updated edition represents a useful scientific reference point according to what it has been experienced in the last pandemics, with respect to the growing role that NIV has and must have in the world.
- Published
- 2023
41. Noninvasive Mechanical Ventilation and Neuropsychiatric Disorders : Essential Practical Approaches
- Author
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Antonio M. Esquinas, Andrea Fabbo, Filiz Koc, Agnieszka Prymus, Małgorzata Farnik, Antonio M. Esquinas, Andrea Fabbo, Filiz Koc, Agnieszka Prymus, and Małgorzata Farnik
- Subjects
- Neurobehavioral disorders--Complications, Artificial respiration
- Abstract
In different sections of this book the relationships between the patterns of psychological response in acute and chronic respiratory failure, as well as the epidemiology of neuropsychiatric disorders in ventilator management, are collected and analyzed. Main concepts such as “vulnerability to stress”, critical illness-psychological stress and susceptibility that may develop during NIV support, as well as the diagnosis of neuropsychiatric disorders in respiratory failure are also summarized. A section is devoted to the most frequent indications of NIV, also including a special use of NIV in pandemic and high-risk infections, as well as in several other conditions such as acute and chronic respiratory failures and neurological disorders. A summary of practical approaches for treatment and prevention in neurologic and psychiatric disorders during noninvasive mechanical ventilation, as well as the perspective in terms of outcomes, quality-of-life, palliative care is also given.The book is intended for all those healthcare professionals treating patients suffering from neurological or psychiatric disorders and who develop acute or chronic respiratory failure. Neurologists, psychiatrists, pulmonary critical care professionals, geriatricians, internists and psychologists will find in the book a valuable guide for their everyday clinical practice.
- Published
- 2023
42. Handbook of Food Bioactive Ingredients : Properties and Applications
- Author
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Seid Mahdi Jafari, Ali Rashidinejad, Jesus Simal-Gandara, Seid Mahdi Jafari, Ali Rashidinejad, and Jesus Simal-Gandara
- Subjects
- Food science, Food—Analysis, Chemistry, Food—Microbiology, Biotechnology
- Abstract
Bioactive ingredients, including both bioactive compounds and bioactive live organisms, are present in small amounts in natural sources such as fruits and vegetables. These ingredients have been continuously investigated during the last few decades and the epidemiological data suggest that their intake is associated with significant decreased risk of various disorders and chronic diseases owing to their anti-oxidant, anti-bacterial and anti-inflammatory qualities. Some of these natural ingredients such as catechins, curcumin, resveratrol, oleuropein, quercetin, rutin, hesperidin, sulforaphane, ellagic acid, and anthocyanins, have been studied as factors with possible direct or indirect effect on specific molecular pathways which are playing vital roles in the association with the pathophysiology of the chronic diseases such as cancer. In light of this, natural foods and food-derived products rich in bioactives have received recent growing attention. It has been reported that frequent consumption of fruits, vegetables, and their associated natural products have many health-promoting benefits that protect against degenerative illnesses including heart disease, arthritis, cancer, immune system decline, brain dysfunction, inflammation and cataracts. Functional foods and medicinal supplements containing encapsulated bioactive materials will be the future of new emerging products in the food and pharma industries. Such products present therapeutical and medicinal properties that can prevent and/or cure specific chronic diseases and disorders. Handbook Of Bioactive Ingredients provides a systematic overview of different food bioactive ingredients describing their chemistry, structure, functionality, safety/toxicity, oral delivery and their applications in functional foods. Detailed chapters will describe various bioactive ingredients including polyphenolic compounds such as phenolic acids, flavonoids and anthocyanins, carotenoids, sterols such as non-oxygenated carotenoids, xanthophylls and phytosterols, bioactive peptides such as marine bioactive peptides, animal bioactive peptides, plant bioactive peptides, microbial bioactive peptides, essential fatty acids like fish and marine oils and plant oils, live organisms like probiotics and yeasts, essential oils and oleoresins like monoterpens, sequiterpens and oleoresins, vitamins and minerals including liposoluble vitamins, hydrosoluble vitamins and trace minerals), and other bioactive compounds including prebiotics, oligosaccharides, dietary fibers and beta-glucan. This book is the first comprehensive collection of scientific evidence form published literature on natural bioactive ingredients.
- Published
- 2023
43. Case-based Atlas of Cardiovascular Magnetic Resonance
- Author
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Andrea Barison, Santo Dellegrottaglie, Gianluca Pontone, Ciro Indolfi, Andrea Barison, Santo Dellegrottaglie, Gianluca Pontone, and Ciro Indolfi
- Subjects
- Cardiovascular system--Magnetic resonance imaging--Atlases, Cardiovascular system--Magnetic resonance imaging--Case studies
- Abstract
This book offers a practical guidance to healthcare professionals interested in learning how to make adequate clinically-oriented use of cardiovascular MRI. Thanks to its case-based approach, it provides a detailed guide to MRI applications in the most common clinical cardiovascular scenarios. Chapters describe a number of real clinical cases, including concise clinical data, clear descriptions of the most relevant information obtained from MRI and of their meaning in terms of patient management. Emphasis is placed on traditional as well as newer MRI techniques, always keeping a practical format, focused on the hands-on knowledge required for an accurate image interpretation. In the online version, the text of each case is supplemented with additional images and videos, certainly making this book a useful resource for understanding how MRI principles apply to real clinical cardiovascular situations.
- Published
- 2023
44. Advances in Natural, Human-Made, and Coupled Human-Natural Systems Research : Volume 1
- Author
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Svetlana G. Maximova, Roman I. Raikin, Alexander A. Chibilev, Marina M. Silantyeva, Svetlana G. Maximova, Roman I. Raikin, Alexander A. Chibilev, and Marina M. Silantyeva
- Subjects
- Computational intelligence, Environmental sciences—Social aspects, Economic development, Control engineering
- Abstract
This book is a collection of cutting-edge and cross-disciplinary studies on natural, human-made, and coupled human-natural systems, addressing the challenge of developing integrated knowledge from multiple disciplines. The authors explore the structure, function, and dynamic mechanisms of various systems, both natural and human-made, as well as analyze their reciprocal interactions under the concept of “coupled human-natural systems.” These interactions are used to understand feedback, nonlinearities, thresholds, time lags, legacy effects, and path dependencies, emerging across multiple spatial, temporal, and organizational scales. In other words, this book is a collection of advanced research on unique properties of natural and human-made systems, as well as human-environment dynamics, reciprocal relationships, and cross-scale interactions.The authors outline prospects on building a holistic view of social development and coherent sustainability. Among the topics covered are the following: human networks research; adaptation of local people to social and environmental challenges; coupled dynamics of socioeconomic and environmental systems; critical issues in social science climate change research; education for greater sustainability; peace, justice, and strong institutions; advances in cultural traditions and strategies for social stability; innovative development and barriers to sustainable development; economic systems in the age of digital changes and unstable external environments. The scholars analyze how more effective technologies can enhance resilience, reduce vulnerability, and minimize human impacts on natural systems, taking into consideration critical thresholds to prevent harmful feedback to human systems.The authors grasp the complexity of systems by integrating knowledge of constituent subsystems and their interactions. The framework developed by the authors is used to integrate human and natural systems for achieving greater sustainability, covering critical threats, challenges, and best governance approaches and practices. The research results obtained from studies on coupled human-natural systems are stronger, the authors argue, if compared with traditional (discipline) approaches.
- Published
- 2023
45. Foundations and Practice of Security : 15th International Symposium, FPS 2022, Ottawa, ON, Canada, December 12–14, 2022, Revised Selected Papers
- Author
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Guy-Vincent Jourdan, Laurent Mounier, Carlisle Adams, Florence Sèdes, Joaquin Garcia-Alfaro, Guy-Vincent Jourdan, Laurent Mounier, Carlisle Adams, Florence Sèdes, and Joaquin Garcia-Alfaro
- Subjects
- Data protection
- Abstract
This book constitutes the refereed proceedings of the 15th International Symposium on Foundations and Practice of Security, FPS 2022, held in Ottawa, ON, Canada, during December 12–14, 2022.The 26 regular and 3 short papers presented in this book were carefully reviewed and selected from 83 submissions. The papers have been organized in the following topical sections: Cryptography; Machine Learning; Cybercrime and Privacy; Physical-layer Security; Blockchain; IoT and Security Protocols; and Short Papers.
- Published
- 2023
46. Glissonean Pedicles Approach in Minimally Invasive Liver Surgery
- Author
-
Benedetto Ielpo, Edoardo Rosso, Alessandro Anselmo, Benedetto Ielpo, Edoardo Rosso, and Alessandro Anselmo
- Subjects
- Endoscopic surgery, Surgery, Gastroenterology
- Abstract
Aim of this book is to present the main minimally invasive approaches to the Glissonean pedicles. This kind of technique for hepatectomy has been gaining interest in recent years and may represent the ideal method to achieve anatomical liver resections. Currently the most performed procedure for liver surgery is still the classic intrafascial approach in which, after entering the Glissonean sheath, the portal triad elements are singularly dissected and isolated. However, this is a quite challenging technique to pursue in a minimally invasive setting. Nowadays the laparoscopic and robotic approach for liver resections are increasing worldwide and the intra or extra hepatic Glissonean approach, in which the portal triad elements are dissected and isolated “en bloc” without entering the Glissonean sheath, can facilitate the surgical technique. Furthermore this strategy allows better identification of the ischemic area and could decrease bloodloss during dissection, as the liver inflow is kept under control. This book includes a step-by-step description of each pedicle isolation and section, with original laparoscopic and robotic pictures and videos. HPB surgeons who are interested in this technique may find these pages, written in cooperation with some of the most prominent worldwide experts, to be highly informative and valuable.
- Published
- 2023
47. Hepatocellular Carcinoma
- Author
-
Giuseppe Maria Ettorre and Giuseppe Maria Ettorre
- Subjects
- Liver--Cancer, Liver--Cancer--Surgery
- Abstract
This open access book offers a comprehensive review of hepatocellular carcinoma (HCC) with a particular focus on the pathobiology and clinical aspects of the disease, including diagnosis and treatment. HCC is becoming one of the most common causes of cancer-related death worldwide. It is the fifth most common malignancy in men and the ninth in women, with an estimated 500,000 to 1 million new cases annually around the world. Independent of its cause, cirrhosis is considered a major clinical and histopathological risk factor for HCC development. Five percent of all cirrhotic patients develop HCC every year. Diagnostic tools for HCC include blood tests, high-quality imaging studies and liver biopsy. The treatment of HCC depends on the size and location of the HCC and includes surgical resection, liver transplantation, endovascular approaches, percutaneous ablation, and medical treatments. The book is organized into four parts – overview, diagnosis, management strategies, and recommendations – and aims to provide surgeons and clinicians with a valuable resource for complete and up-to-date research on the clinical aspects and management of HCC.
- Published
- 2023
48. Functional Imaging and Modeling of the Heart : 12th International Conference, FIMH 2023, Lyon, France, June 19–22, 2023, Proceedings
- Author
-
Olivier Bernard, Patrick Clarysse, Nicolas Duchateau, Jacques Ohayon, Magalie Viallon, Olivier Bernard, Patrick Clarysse, Nicolas Duchateau, Jacques Ohayon, and Magalie Viallon
- Subjects
- Computer vision
- Abstract
This book constitutes the refereed proceedings of the 12th International Conference on Functional Imaging and Modeling of the Heart, held in Lyon, France, in June 2023.The 72 full papers were carefully reviewed and selected from 80 submissions. The focus of the papers is on following topics: increased imaging resolutions, data explosion, sophistication of computational models and advent of AI frameworks, while new imaging modalities have emerged (e.g. combined PET-MRI, Spectral CT).
- Published
- 2023
49. Academic Integrity in Canada : An Enduring and Essential Challenge
- Author
-
Sarah Elaine Eaton, Julia Christensen Hughes, Sarah Elaine Eaton, and Julia Christensen Hughes
- Subjects
- Education, Higher--Moral and ethical aspects, Education, Higher--Canada, Plagiarism, Plagiarism--Canada, College teachers--Professional ethics
- Abstract
This open access book presents original contributions and thought leadership on academic integrity from a variety of Canadian scholars. It showcases how our understanding and support for academic integrity have progressed, while pointing out areas urgently requiring more attention.Firmly grounded in the scholarly literature globally, it engages with the experience of local practicioners. It presents aspects of academic integrity that is specific to Canada, such as the existence of an'honour culture', rather than relying on an'honour code'. It also includes Indigenous voices and perspectives that challenge traditional understandings of intellectual property, as well as new understandings that have arisen as a consequence of Covid-19 and the significant shift to online and remote learning.This book will be of interest to senior university and college administrators who are interested in ensuring the integrity of their institutions. It will also be of interest to those implementing university and college policy, as well as those who support students in their scholarly work.
- Published
- 2022
50. Proceedings of the 12th International Conference on Computer Engineering and Networks
- Author
-
Qi Liu, Xiaodong Liu, Jieren Cheng, Tao Shen, Yuan Tian, Qi Liu, Xiaodong Liu, Jieren Cheng, Tao Shen, and Yuan Tian
- Subjects
- Telecommunication, Internet of things, Computer networks, Computational intelligence, Computer science
- Abstract
This conference proceeding is a collection of the papers accepted by the CENet2022 – the 12th International Conference on Computer Engineering and Networks held on November 4-7, 2022 in Haikou, China. The topics focus but are not limited to Internet of Things and Smart Systems, Artificial Intelligence and Applications, Communication System Detection, Analysis and Application, and Medical Engineering and Information Systems. Each part can be used as an excellent reference by industry practitioners, university faculties, research fellows and undergraduates as well as graduate students who need to build a knowledge base of the most current advances and state-of-practice in the topics covered by this conference proceedings. This will enable them to produce, maintain, and manage systems with high levels of trustworthiness and complexity.
- Published
- 2022
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