118 results on '"G. Dhillon"'
Search Results
2. Perceptions, attitudes, and clinical experiences of Brazilian dental practitioners towards molar incisor hypomineralisation: a cross-sectional study.
- Author
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da Costa Rosa T, Spinelli LR, da Silva FMF, de Castro Costa M, and de Almeida Neves A
- Subjects
- Humans, Brazil, Cross-Sectional Studies, Female, Male, Adult, Practice Patterns, Dentists' statistics & numerical data, Dentists psychology, Surveys and Questionnaires, Molar, Public Sector, Incisor, Private Sector, Middle Aged, Health Knowledge, Attitudes, Practice, Molar Hypomineralization, Dental Enamel Hypoplasia therapy, Attitude of Health Personnel
- Abstract
Purpose: To evaluate perceptions, attitudes, and clinical experience of Brazilian dental practitioners regarding molar incisor hypomineralisation (MIH)., Methods: An online survey with 27 questions, covering professional profile data, perceptions, and knowledge on clinical management of MIH, was employed. Descriptive analyses, chi-square, Fisher's exact, and Cramer's V tests were used., Results: Sample comprised 100 participants, equally distributed between those working in private or public sectors. Most private sector practitioners had 21-30 years of clinical experience (28%) and master's degree (50%), while most public sector practitioners had 11-20 years of clinical experience (32%) and a PhD degree (32%). Most participants (86%) recognized MIH in their practice. Statistically significant differences were observed in frequency (p = 0.001), incidence (p = 0.039), and lesion type (p = 0.043) between practitioners from both sectors. Uncertainly in management was reported by 49%, mainly in public sector. For mild MIH in incisors, no treatment was chosen (43%), and the treatment longevity was the only significant factor reported (p = 0.012). In cases of mild MIH in first permanent molars (FPMs), 51% of respondents opted to keep the affected tissue and apply fissure sealant. Glass ionomer (GI) restoration was commonly indicated for FPMs with severe MIH with moderate loss of structure and sensitivity (38%). In cases with substantial structural loss and pulpal involvement, the most chosen treatment was endodontic intervention combined with preformed crowns., Conclusion: Brazilian dental practitioners face MIH in clinical practice. Although, public sector professionals are less confident in diagnosis and treatment, no significant differences in treatment preferences between public and private sector dental practitioners were identified., Competing Interests: Declarations Conflict of interest The authors declare that they have no conflict of interest. Ethical approval The present study was approved by local Research Ethics Committee (Hospital Universitário Clementino Fraga Filho – HUCFF/UFRJ) under the protocol number 4.886.892. Informed consent All participants were informed about the study prior to enrolment and gave voluntary consent., (© 2024. The Author(s), under exclusive licence to European Academy of Paediatric Dentistry.)
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- 2024
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3. Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma.
- Author
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Wang H, Tao Y, Han J, Shen J, Mu H, Wang Z, Wang J, Jin X, Zhang Q, Yang Y, Lin J, Sun M, Ma X, Ren L, LeBlanc AK, Xu J, Hua Y, and Sun W
- Subjects
- Humans, Cell Line, Tumor, Animals, Mice, Synthetic Lethal Mutations, Xenograft Model Antitumor Assays, Cell Proliferation drug effects, Reactive Oxygen Species metabolism, Mice, Nude, Gene Expression Regulation, Neoplastic drug effects, Osteosarcoma metabolism, Osteosarcoma pathology, Osteosarcoma genetics, Osteosarcoma drug therapy, Glutamine metabolism, YAP-Signaling Proteins metabolism, Adaptor Proteins, Signal Transducing metabolism, Adaptor Proteins, Signal Transducing genetics, Transcription Factors metabolism, Transcription Factors genetics, Bone Neoplasms metabolism, Bone Neoplasms pathology, Bone Neoplasms genetics, Bone Neoplasms drug therapy
- Abstract
Purpose: Osteosarcoma, a highly malignant primary bone tumor primarily affecting adolescents, frequently develops resistance to initial chemotherapy, leading to metastasis and limited treatment options. Our study aims to uncover novel therapeutic targets for metastatic and recurrent osteosarcoma., Methods: In this study, we proved the potential of modulating the YAP1-regulated glutamine metabolic pathway to augment the response of OS to DFMO. We initially employed single-cell transcriptomic data to gauge the activation level of polyamine metabolism in MTAP-deleted OS patients. This was further substantiated by transcriptome sequencing data from recurrent and non-recurrent patient tissues, confirming the activation of polyamine metabolism in progressive OS. Through high-throughput drug screening, we pinpointed CIL56, a YAP1 inhibitor, as a promising candidate for a combined therapeutic strategy with DFMO. In vivo, we utilized PDX and CDX models to validate the therapeutic efficacy of this drug combination. In vitro, we conducted western blot analysis, qPCR analysis, immunofluorescence staining, and PuMA experiments to monitor alterations in molecular expression, distribution, and tumor metastasis capability. We employed CCK-8 and colony formation assays to assess the proliferative capacity of cells in the experimental group. We used flow cytometry and reactive oxygen probes to observe changes in ROS and glutamine metabolism within the cells. Finally, we applied RNA-seq in tandem with metabolomics to identify metabolic alterations in OS cells treated with a DFMO and CIL56 combination. This enabled us to intervene and validate the role of the YAP1-mediated glutamine metabolic pathway in DFMO resistance., Results: Through single-cell RNA-seq data analysis, we pinpointed a subset of late-stage OS cells with significantly upregulated polyamine metabolism. This upregulation was further substantiated by transcriptomic profiling of recurrent and non-recurrent OS tissues. High-throughput drug screening revealed a promising combination strategy involving DFMO and CIL56. DFMO treatment curbs the phosphorylation of YAP1 protein in OS cells, promoting nuclear entry and initiating the YAP1-mediated glutamine metabolic pathway. This reduces intracellular ROS levels, countering DFMO's anticancer effect. The therapeutic efficacy of DFMO can be amplified both in vivo and in vitro by combining it with the YAP1 inhibitor CIL56 or the glutaminase inhibitor CB-839. This underscores the significant potential of targeting the YAP1-mediated glutamine metabolic pathway to enhance efficacy of DFMO., Conclusion: Our findings elucidate YAP1-mediated glutamine metabolism as a crucial bypass mechanism against DFMO, following the inhibition of polyamine metabolism. Our study provides valuable insights into the potential role of DFMO in an "One-two Punch" therapy of metastatic and recurrent osteosarcoma., (© 2024. Springer Nature Switzerland AG.)
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- 2024
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4. Evaluation of the immune responses in buffaloes vaccinated with a live-attenuated lumpy skin disease vaccine (Lumpi-ProVac Ind ).
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Dhanda S, Sharma DK, Kamboj H, Kumar G, Mittal P, Kumar R, Verma A, Rathore K, Gaur M, Barua S, Tripathi BN, Sharma S, and Kumar N
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- Animals, India, Immunity, Cellular, Antibodies, Viral blood, Vaccination veterinary, Leukocytes, Mononuclear immunology, Female, Buffaloes immunology, Lumpy Skin Disease prevention & control, Lumpy Skin Disease immunology, Vaccines, Attenuated administration & dosage, Vaccines, Attenuated immunology, Lumpy skin disease virus immunology, Viral Vaccines administration & dosage, Viral Vaccines immunology
- Abstract
Since 2019, Lumpy skin disease (LSD) has suddenly spread in many Asian countries, including India. LSD primarily occurs in cattle. However, recent LSD outbreaks in India have also revealed significant morbidity and production losses in buffaloes. This has raised concerns about the role of buffaloes in the epidemiology and transmission of LSD and necessitates the inclusion of buffaloes in the mass vaccination program for the prevention and control of the disease in the country. However, there is no significant data on the immune response in buffaloes following vaccination with the LSD vaccine. In this study, we evaluated antibody- and cell-mediated immune responses following vaccination with a newly developed live-attenuated LSD vaccine (Lumpi-ProVac
Ind ). The detectable amount of anti-LSDV antibodies was observed at 1-2 months following vaccination, with a peak antibody titer at 3 months. Upon stimulation of the peripheral blood mononuclear cells (PBMCs) with the UV-inactivated LSDV antigen, there was a significant increase in CD8 + T cell counts in vaccinated animals as compared to the unvaccinated animals. Besides, vaccinated animals also showed a significant increase in IFN-γ levels upon antigenic stimulation of their PBMCs with LSDV antigen. In conclusion, the buffaloes also mount a potent antibody- and cell-mediated immune response following vaccination with Lumpi-ProVacInd ., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)- Published
- 2024
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5. Assessing the efficacy of Laser pulpotomy versus conventional pulpotomy in primary teeth: A systematic review and meta-analysis of clinical trials.
- Author
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Pandiyan R, Lehl GK, Kumar R, Sharma U, and Jagachandiran VV
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- Humans, Aluminum Compounds administration & dosage, Calcium Compounds administration & dosage, Drug Combinations, Ferric Compounds administration & dosage, Oxides administration & dosage, Oxides therapeutic use, Randomized Controlled Trials as Topic, Silicates administration & dosage, Silicates therapeutic use, Treatment Outcome, Formocresols administration & dosage, Laser Therapy methods, Pulpotomy methods, Tooth, Deciduous drug effects, Tooth, Deciduous surgery
- Abstract
Purpose: This study systematically reviewed the clinical and radiographic outcomes of laser versus conventional pulpotomy in primary teeth. It also compared the success and effectiveness of different lasers to enhance the understanding and use of laser pulpotomy as an alternative treatment., Methodology: An electronic search was carried out in PubMed and Cochrane from 1st January 1999 to 31st December 2023. The published articles in the English language were searched using MeSH terms and text words. Only randomized controlled trials with a sample size of more than 10 and follow-ups over 6 months were included. Meta-analysis and forest plots were evaluated by utilizing Review Manager 5.4 software. Two reviewers assessed the risk of bias using the RoB 2 tool and discrepancies were resolved by the third reviewer. The success rates were combined using a random effects model to determine clinical and radiographic outcomes. We used risk ratios with 95% confidence intervals (CI) as the primary effect measures and set the significance level at 0.05., Results: Only 18 studies met the inclusion criteria after an electronic search. Among them, 13 studies evaluated the clinical and radiographic outcomes of laser with formocresol pulpotomy, 2 studies compared with ferric sulfate pulpotomy, and the remaining studies with Mineral trioxide aggregate (MTA) pulpotomy. The various studies showed different levels of bias. There was no significant difference in the clinical success rate (p = 0.47; RR: 1.01; 95% CI 0.98-1.04; I2 = 0%; p = 0.70) and radiographic success rate (p = 0.94; RR: 1.00; 95% CI 0.91-1.09; I2 = 64%; p = 0.001) between laser pulpotomy and formocresol. Similarly, there was no significant difference between laser pulpotomy and ferric sulfate or MTA pulpotomy., Conclusion: Diode laser and LLLT can be considered as alternative pulpotomy agents to formocresol in primary teeth. However, high-quality trials are needed to confirm the accuracy and reliability of these findings., (© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
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- 2024
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6. Fine mapping of Ae-Ps4.5, a major locus for resistance to pathotype III of Aphanomyces euteiches in pea.
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Lavaud C, Lesné A, Leprévost T, and Pilet-Nayel ML
- Subjects
- Plant Diseases genetics, Plant Breeding, Quantitative Trait Loci, Pisum sativum genetics, Aphanomyces
- Abstract
Key Message: QTL mapping and recombinant screening confirmed the major effect of QTL Ae-Ps4.5 on pea resistance to pathotype III of Aphanomyces euteiches and fine-mapped the QTL to a 3.06-Mb interval. Aphanomyces root rot, caused by Aphanomyces euteiches, is the most important disease of pea (Pisum sativum L.) worldwide. The development of pea-resistant varieties is a major challenge to control the disease. Previous linkage studies identified seven main resistance quantitative trait loci (QTL), including the QTL Ae-Ps4.5 associated with partial resistance in US nurseries infested by the pea pathotype III of A. euteiches. This study aimed to confirm the major effect of Ae-Ps4.5 on A. euteiches pathotype III, refine its interval, and identify candidate genes underlying the QTL. QTL mapping on an updated genetic map from the Puget × 90-2079 pea recombinant inbred line population identified Ae-Ps4.5 in a 0.8-cM confidence interval with a high effect (R
2 = 89%) for resistance to the Ae109 reference strain of A. euteiches (pathotype III) under controlled conditions. However, the QTL mapping did not detect Ae-Ps4.5 for resistance to the RB84 reference strain of A. euteiches (pathotype I). Screening 224-pea BC5F2 plant progeny derived from three near-isogenic lines (NILs) carrying the 90-2079 allele at Ae-Ps4.5 in the Puget genetic background with 26 SNP markers identified 15 NILs showing recombination in the QTL interval. Phenotyping of the recombinant lines for resistance to the Ae109 strain of A. euteiches reduced the QTL to a physical interval of 3.06 Mb, containing 50 putative annotated genes on the Caméor pea genome V1a among which three candidate genes highlighted. This study provides closely linked SNP markers and putative candidate genes to accelerate pea breeding for resistant varieties to Aphanomyces root rot., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)- Published
- 2024
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7. Are you paying attention to me? The effect of social presence on spatial attention to gaze and arrows.
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Ha J and Hayward DA
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- Humans, Reaction Time, Cues, Communication, Fixation, Ocular, Recognition, Psychology
- Abstract
Prior research has shown that the presence of another individual and type of attention cue (social gaze vs. nonsocial arrow) can modulate attention, with little done to integrate the two. We thus investigate the role of two social presence factors when completing a joint cueing task with either social (gaze) or nonsocial (arrow) cues. Familiarity was operationalized as participants engaged in a prompted conversation either before (n = 60 dyads) or after (n = 59 dyads) the task. To determine the effect of previous responder identity on attention, we contrasted trials where participants responded twice in a row (same responder) with switch trials (different responder), along with whether the previous target was in the same or a different location. Although familiarity only affected global speed and not magnitudes of cueing, we did find that attention to gaze and arrows was differentially affected by previous responder and previous target location. Specifically, for gaze cues muted cueing effects occurred for trials where the previous responder was different, while for arrow cues there was less muting of the cueing effect regardless of previous responder. Taken together, previous responder and previous target location both modulated attention, with the effect on attention dependent on the type of cue, gaze, or arrow., (© 2022. The Psychonomic Society, Inc.)
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- 2023
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8. Pilot Study of a Virtual Reality Educational Intervention for Radiotherapy Patients Prior to Initiating Treatment.
- Author
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Gao J, Liu S, Zhang S, Wang Y, Liang Z, Feng Q, Hu M, and Zhang Q
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- Anxiety, Humans, Pain Measurement, Pilot Projects, Surveys and Questionnaires, Virtual Reality
- Abstract
Virtual reality (VR) presents opportunities for innovative patient educational methods. This study used a combination of subjective questionnaires and objective physiological measures to investigate the impact of a VR radiotherapy (RT) educational system on patients' understanding and anxiety prior to commencing RT. Sixty patients were randomized to control (n = 30) and intervention (n = 30) groups prior to initiating RT. The control group received the standard nursing care process. The intervention group additionally participated in a detailed introduction to RT positioning, procedures, treatments, and other RT-related information via VR education. All patients completed a data collection from pre- and postintervention, which included questions on RT comprehension, anxiety-related scales, and objective physiological data reflecting the patient's psychological state, such as blood pressure, heart rate, and respiration. Both groups had high anxiety levels before the intervention, and there was no significant difference between the questionnaire and physiological data of the two groups. Following the intervention, anxiety scores (state-trait anxiety scale and visual analog scale) of the intervention group decreased significantly compared with those of the control group, and there was a significant decrease in systolic blood pressure (p < 0.05) and increase in cognitive score (p < 0.05). This study reports the positive impact of a virtual reality radiotherapy (VRRT) patient educational system on increasing patient RT comprehension and reducing anxiety. Further work is needed to improve the acceptability of the system to patients and to explore further the impact of VR education on patients' psychological and physical needs., (© 2020. American Association for Cancer Education.)
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- 2022
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9. SocialAuth:Designing touch behavioral smartphone user authentication based on social networking applications
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Dhillon, Gurpreet, Zúquete, André, Karlsson, Fredrik, Hedström, Karin, Meng, Weizhi, Li, Wenjuan, Jiang, Lijun, Zhou, Jianying, Dhillon, Gurpreet, Zúquete, André, Karlsson, Fredrik, Hedström, Karin, Meng, Weizhi, Li, Wenjuan, Jiang, Lijun, and Zhou, Jianying
- Abstract
Modern smartphones expressed an exponential growth and have become a personal assistant in people’s daily lives, i.e., keeping connected with peers. Users are willing to store their personal data even sensitive information on the phones, making these devices an attractive target for cyber-criminals. Due to the limitations of traditional authentication methods like Personal Identification Number (PIN), research has been moved to the design of touch behavioral authentication on smartphones. However, how to design a robust behavioral authentication in a long-term period remains a challenge due to behavioral inconsistency. In this work, we advocate that touch gestures could become more consistent when users interact with specific applications. In this work, we focus on social networking applications and design a touch behavioral authentication scheme called SocialAuth. In the evaluation, we conduct a user study with 50 participants and demonstrate that touch behavioral deviation under our scheme could be significantly decreased and kept relatively stable even after a long-term period, i.e., a single SVM classifier could achieve an average error rate of about 3.1% and 3.7% before and after two weeks, respectively.
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- 2019
10. Photobiomodulation enhances the Th1 immune response of human monocytes.
- Author
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de Castro MS, Miyazawa M, Nogueira ESC, Chavasco JK, Brancaglion GA, Cerdeira CD, Nogueira DA, Ionta M, Hanemann JAC, Brigagão MRPL, and Sperandio FF
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- Cell Survival, Humans, Immunity, Macrophages, Lasers, Semiconductor, Monocytes
- Abstract
This study aims to evaluate the effects of photobiomodulation (PBM) on human monocytes, assessing the oxidative burst and ultimate fungicidal potential of these cells, as well as the gene expression at the mRNA level of CD68, CD80, CD163, CD204, IL-6, TNF-α and IL-10 in derived macrophages. Primary cultures of human monocytes were irradiated with an InGaAlP (660 nm)/GaAlAs (780 nm) diode laser (parameters: 40 mW, 0.04 cm
2 , 1 W/cm2 ; doses: 200, 400 and 600 J/cm2 ). Cells were submitted to the chemiluminescence assay, and a microbicidal activity assay against Candida albicans was performed. Reactive oxygen species (ROS) and nitric oxide (NO) production were measured, and cell viability was assessed by the exclusion method using 0.2% Trypan blue reagent. Irradiated monocytes were cultured for 72 h towards differentiation into macrophages. Total RNA was extracted, submitted to reverse transcription and real-time PCR. The results were analysed by ANOVA and the Tukey test (α = 0.05). Irradiated monocytes revealed a significant increase in their intracellular and extracellular ROS (P < 0.001). The 660 nm wavelength and 400 J/cm2 dose were the most relevant parameters (P < 0.001). The fungicidal capacity of the monocytes was shown to be greatly increased after PBM (P < 0.001). PBM increased the expression of TNF-α (P = 0.0302) and the production of NO (P < 0.05) and did not impair monocyte viability. PBM induces a pro-inflammatory Th1-driven response in monocytes and macrophages., (© 2020. Springer-Verlag London Ltd., part of Springer Nature.)- Published
- 2022
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11. SocialAuth:Designing touch behavioral smartphone user authentication based on social networking applications
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Meng, Weizhi, Li, Wenjuan, Jiang, Lijun, Zhou, Jianying, Dhillon, Gurpreet, Zúquete, André, Karlsson, Fredrik, and Hedström, Karin
- Subjects
Social networking ,Behavioral user authentication ,Smartphone security ,Machine learning ,Touch gestures ,Usable security - Abstract
Modern smartphones expressed an exponential growth and have become a personal assistant in people’s daily lives, i.e., keeping connected with peers. Users are willing to store their personal data even sensitive information on the phones, making these devices an attractive target for cyber-criminals. Due to the limitations of traditional authentication methods like Personal Identification Number (PIN), research has been moved to the design of touch behavioral authentication on smartphones. However, how to design a robust behavioral authentication in a long-term period remains a challenge due to behavioral inconsistency. In this work, we advocate that touch gestures could become more consistent when users interact with specific applications. In this work, we focus on social networking applications and design a touch behavioral authentication scheme called SocialAuth. In the evaluation, we conduct a user study with 50 participants and demonstrate that touch behavioral deviation under our scheme could be significantly decreased and kept relatively stable even after a long-term period, i.e., a single SVM classifier could achieve an average error rate of about 3.1% and 3.7% before and after two weeks, respectively.
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- 2019
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12. Advances in Artificial-Business Analytics and Quantum Machine Learning : Select Proceedings of the 3rd International Conference, Com-IT-Con 2023, Volume 1
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K. C. Santosh, Sandeep Kumar Sood, Hari Mohan Pandey, Charu Virmani, K. C. Santosh, Sandeep Kumar Sood, Hari Mohan Pandey, and Charu Virmani
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- Data protection, Artificial intelligence, Application software
- Abstract
This book presents select proceedings of the 3rd International Conference on “Artificial-Business Analytics, Quantum and Machine Learning: Trends, Perspectives, and Prospects” (Com-IT-Con 2023) held at the Manav Rachna University in July 2023. It covers topics such as artificial intelligence and business analytics, virtual/augmented reality, quantum information systems, cyber security, data science, and machine learning. The book is useful for researchers and professionals interested in the broad field of communication engineering.
- Published
- 2024
13. Metabolic Dysfunction-Associated Steatotic Liver Disease : Prevalence, Research Insights and the Future Directions
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Nahum Méndez-Sánchez, Xingshun Qi, Nahum Méndez-Sánchez, and Xingshun Qi
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- Gastroenterology
- Abstract
This book provides crucial insights into the most recent advancements in understanding pathophysiology of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and presents innovative treatment approaches. The emerging areas of study and potential avenues for further investigation are discussed in chapters. Additionally, the latest information on diagnostic tools, lifestyle interventions, and pharmacological treatments is also presented. With the worldwide prevalence of MASLD on the rise, it helps to equip medical professionals (hepatologists, gastroenterologists, endocrinologists, cardiologists, nephrologists, internists, and surgeons), researchers, and patients with up-to-date knowledge to effectively combat this multifaceted condition.
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- 2024
14. IR Playbook : A Comprehensive Introduction to Interventional Radiology
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Nicole A. Keefe, Ziv J.J Haskal, Auh Whan Park, John F. Angle, Nicole A. Keefe, Ziv J.J Haskal, Auh Whan Park, and John F. Angle
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- Interventional radiology
- Abstract
This fully updated new edition is a comprehensive guide to interventional radiology (IR) for medical students, residents, early career attendings, nurse practitioners and physician assistants. The IR Playbook includes procedures, new and updated data, and new images, to stay on the cutting edge of IR. As a specialty, IR is constantly changing and evolving to apply newer technologies and techniques to a breadth of disease pathologies. This book addresses the growing need for a reference for trainees and early career professionals to gain a solid foundation. Let this book serve as your only resource from the first day you find out about IR to the day you take your certifying exam. One and done.The textbook is divided into two main sections, with many images and key point boxes throughout that offer high-yield pearls along with the specific How To's necessary for practice. The first section is designed to give readers an introduction to IR, including radiation safety, commonly used devices, patient care, and anatomy. The second portion is divided by procedure. These chapters cover pathophysiology, indications for treatment, as well as alternative treatments before delving into interventional therapy. This new edition has been fully updated throughout including several brand-new procedures and divided chapters to allow a more in depth look at several disease pathologies. IR Playbook gives medical students, residents, and trainees a full perspective of interventional radiology.
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- 2024
15. Taktische Medizin : Notfallmedizin und Einsatzmedizin
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Christian Neitzel, Karsten Ladehof, Christian Neitzel, and Karsten Ladehof
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- Emergency medicine, Anesthesiology, Surgery, Internal medicine
- Abstract
In dem praxisrelevanten Nachschlagewerk beschreiben ausgewiesene Experten umfassend alle relevanten Aspekte der taktischen Notfallmedizin. Es richtet sich an Soldaten, Polizisten und Angehöriger anderer Behörden sowie der Rettungsdienst-/Hilfsorganisationen und Feuerwehren. Dargestellt werden u.a. die Grundlagen, wie Einsatzplanung, Ausrüstung, Evakuierung sowie die häufigsten Krankheitsbilder- und Verletzungsmuster, wie Schuss- und Sprengverletzungen, Verbrennungen, Augennotfälle und psychisches Trauma. Auch auf die Besonderheiten bei extremen klimatischen Bedingungen sowie das beste Vorgehen bei Verletzungen durch ABC-Waffen geht das Werk ein. Darüber hinaus werden die Rollen von Rettungsdienst, Feuerwehr und Polizei bei besonderen Einsatzlagen beleuchtet und auf die Schnittstellenproblematik zwischen diesen Organisationen eingegangen. Die 3. Auflage erscheint komplett überarbeitet, aktualisiert und um die Themen „Prolonged Field Care“, Crush-Syndrom und Warmblutspende erweitert.
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- 2024
16. Consumer Brand Relationships in Tourism : An International Perspective
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Raouf Ahmad Rather and Raouf Ahmad Rather
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- Tourism, Management, Customer relations—Management, Sales management
- Abstract
This book provides a comprehensive overview of consumer-brand relationships (CBR) in tourism and hospitality marketing management, including pre-, during- and post-COVID-19 pandemic. It critically investigates the current debates and questions within the field and includes both theory and practical cases from around the globe. It brings together leading specialists from various disciplinary backgrounds and geographical regions, to offer state-of-the-art theoretical reflections and empirical research on contemporary issues. This book is a reference point for scholars, researchers, academics and students in the field of CBR across disciplines including tourism marketing, hospitality, leisure, festivals, and events.
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- 2024
17. Entomopathogenic Fungi : Prospects and Challenges
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Sunil Kumar Deshmukh, Kandikere Ramaiah Sridhar, Sunil Kumar Deshmukh, and Kandikere Ramaiah Sridhar
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- Fungi, Mycology, Microbiology, Zoology, Agriculture, Forestry, Plant diseases, Biochemistry
- Abstract
This book brings together the molecular aspects of the pathogenesis of entomopathogenic fungi, various aspects of mycoinsecticide development, and regulatory aspects to highlight the immense contribution of the agricultural sector. The chapters address aspects of entomopathogenic fungi, including host-pathogen interactions (susceptibility and resistance), fungus-insect and fungus-fungus dual interactions, phylogeny and taxonomy, biochemistry, and molecular basis of enteropathogenesis, market potential of entomopathogens, regulatory aspects, bioprospecting of fungi, fungi as crop bodyguards and in disease suppression, and consortia for the control of insect pests and pathogens in single crop systems. Written by experts in academia and industry from Algeria, Brazil, Hungary, India, Italy, Malaysia, Oman, Pakistan, and the United States, the book overviews entomopathogenic fungi used as biological control agents against insect pests and other arthropods, their mode of action, pathogenesis, bioactive metabolites, mycotoxins involved, their mass production, limitations, and agricultural- and environment-related issues. It also includes developing various biopesticide products, with special references to formulations and prospects. In agriculture, crop protection and production depend on insect pests controlled by entomopathogenic fungi. Understanding the pathogenicity, mechanism of action, formulations, and applications of a wide array of entomopathogenic fungi as biopesticides is a valid eco-friendly approach. The book provides advances in pathogenicity, biochemistry, virulence, and interaction that facilitate the application of Beauveria, Metarhizium, and other entomopathogens as potential biopesticides against major insect pests. Developments in bioactive compounds, secondary metabolites, enzymes, and toxins of entomopathogenic fungi have facilitated precise applications and management to target insect pests. Further advances in molecular aspects, the formulation of nanobiopesticides, and biofabricated technology paved the way for insect pest control. This book will be a helpful resource for students, teachers, researchers, scientists, and professionals in the industry working on biological sciences, applied entomology, mycology, zoology, forestry, biochemistry, molecular biology, and nanotechnology.
- Published
- 2024
18. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
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Franz J. Hock, Michael K. Pugsley, Franz J. Hock, and Michael K. Pugsley
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- Pharmacology, Pharmaceutical chemistry, Medicinal chemistry
- Abstract
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This'sequential'strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the'druggability'of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term'Safety Pharmacology'was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. &nb
- Published
- 2024
19. Emerging Sustainable Technologies for Biofuel Production
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Maulin Shah, Deepanwita Deka, Maulin Shah, and Deepanwita Deka
- Subjects
- Biomass energy
- Abstract
This book is presented on biofuel production which includes different technologies developed and adopted to synthesize green renewable fuel alternatives for sustainable development. It also reflects different sources of biofuel, application of microbial community and microbial engineering to design fuel production and the biosynthetic pathways of biofuel production by microbes.Although the expenses for the physical and chemical technologies for energy production and fossil fuel utilization to protect our environment are very high, these technologies are not eco-friendly and safe. Hence, the need of certain modern eco-friendly and cost-effective techniques to protect our environment is deeply apprehended by different workers of this field. These techniques involve some feasible technologies utilizing different biological agents like microbes to produce renewable energy. This book provides an outline of the science behind the multidisciplinary aspects of biofuel production. It summarizes a solid foundation in the fundamentals and progresses to practical applications in this field. It structures stepwise route for a number of effective techniques to screen, select, identify and utilize microbes for biofuel production and utilization. It also focuses on the theoretical groundworks of biofuel production, recent technologies related to microbial engineering like myco-engineering technologies, microbial metabolism or modelling approaches to microbial physiology utilized for the same purpose. The techniques covered in this book ensure that scientists have the knowledge to practice effective biofuel production techniques themselves in a contaminated ecosystem in a sustainable way.Recent progress in the field of biofuels using microbial genetic engineering has larger perspectives in commercial-scale production. However, its large-scale production is still challenging; hence, to resolve this problem, it is essential to convert biomass into biofuels by developing novel technology to increase biofuel production to fulfil the current and future energy demand.
- Published
- 2024
20. Indigenous and Tribal Peoples and Cancer
- Author
-
Gail Garvey and Gail Garvey
- Subjects
- Cancer--Epidemiology, Indigenous peoples--Diseases
- Abstract
Although cancer survival has improved markedly in developed countries in recent decades, not all groups have benefited equally. In particular, Indigenous and Tribal peoples continue to have poorer cancer outcomes than their non-Indigenous counterparts. The available evidence suggests these disparities are linked to a complex combination of factors, including higher incidence of cancers associated with a high case fatality, later stage of diagnosis, reduced access to cancer treatment, and poorer overall health. Much research is underway to explore approaches to improving health system responses for Indigenous and Tribal peoples. A developing evidence base is supporting effective translation of knowledge into practice. This book offers a global perspective on this evidence base, written from Indigenous perspectives. This book is the first comprehensive publication to report on cancer incidence, mortality, prevalence, survival, and inequities for Indigenous and Tribal peoples globally, with the aim of enhancing global efforts to improve outcomes for these populations. Its content and approach are led by Indigenous researchers with international reputations in health and cancer research. Chapters provide important information and data to support Indigenous-specific, targeted cancer awareness and early detection campaigns. This book goes beyond a discussion of the issues and challenges in Indigenous health, with a strengths-based approach to discussing successful health interventions, research projects, research translation, and living well – both with and beyond cancer. This is an open access book.
- Published
- 2024
21. Molecular Interventions for Developing Climate-Smart Crops: A Forage Perspective
- Author
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Rajesh Kumar Singhal, Shahid Ahmed, Saurabh Pandey, Subhash Chand, Rajesh Kumar Singhal, Shahid Ahmed, Saurabh Pandey, and Subhash Chand
- Subjects
- Crops--Molecular genetics, Crops and climate
- Abstract
This edited book is collection of information on molecular interventions needed for climate-resilient forage crops. The main focus is to address the gap in the advanced scientific knowledge for the forage species. Agriculture is extremely vulnerable to climate, and even slight change in climatic factors such as temperature causes tremendous losses in yield potential. Forage crops are crucial in global food security and environmental sustainability and face several environmental challenges in field conditions. However, the research on forage crops is far-off compared to agricultural crops and causes a substantial gap in forage demand and productivity. Further, this gap is directly associated with animal health, reproduction, and productivity. Abiotic stresses mainly affect the plant's crucial processes, ultimately reducing the final yield. The problem of abiotic stresses is more frequent in forage crops as they are growing and cultivated in less productive soil and harsh conditions. This book discusses current aspects of crucial physiological, biochemical and molecular processes in forage crops, which are essential for forage crops improvement. The text's major focus is on the advanced technologies and approaches such as seed priming, bio-fortification, breeding, omics, transgenic and bioengineering of metabolic pathways in unique ways, which helps us develop innovative solutions for forage crops. This book covers all the crucial advance technologies, which help mitigate the abiotic stresses in forage crops. We believe that this book will initiate and introduce the readers to state-of-the-art developments and unique in this field of study. This book is of interest to teachers, researchers, climate change scientists, capacity builders, and policymakers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists and policymakers will also find this a worthwhile read.
- Published
- 2023
22. Current and Future Trends in Health and Medical Informatics
- Author
-
Kevin Daimi, Abeer Alsadoon, Sara Seabra Dos Reis, Kevin Daimi, Abeer Alsadoon, and Sara Seabra Dos Reis
- Subjects
- Medical informatics
- Abstract
This book is comprehensive with most of its contents following the recommendations of international health and medical informatics associations and societies. To this extent it covers the areas of healthcare and medical information systems, management of healthcare and medical information systems, healthcare/medical information systems supporting patients and the public, healthcare/medical networking and care sharing, medical imaging and 3D/4D surgical visualization, design and analysis of health/medical records, health/medical data representation and analysis, simulation and modeling in healthcare, and health and medical informatics education.The book provides an excellent professional development resource for educators and practitioners on the state-of-the-art Health and Medical Informatics. It covers many areas and topics of Health and Medical Informatics and contributes toward the enhancement of the community outreach and engagement component of Health and Medical Informatics. Various techniques, methods, and approaches adopted by Health and Medical Informatics experts in the field are introduced. Furthermore, it provides detailed explanation of the Health and Medical Informatics concepts that are aptly reinforced by applications and some practical examples and a road map of future trends that are suitable for innovative Health and Medical Informatics.
- Published
- 2023
23. Soft Tissue Injuries of the Head and Neck
- Author
-
Charilaos A. Ioannidis and Charilaos A. Ioannidis
- Subjects
- Maxilla--Surgery, Head--Wounds and injuries--Treatment, Neck--Wounds and injuries--Treatment, Soft tissue injuries--Treatment
- Abstract
This book provides a vividly illustrated description of a wide range of soft tissue injuries of the head and neck and their treatment, which forms part of the workload of both Plastic and Reconstructive Surgery and Cranio –Maxillofacial Surgery. Other medical and surgical disciplines are also involved, though to a lesser extent. It clarifies many topics, including the general principles of wound management, the treatment of various soft tissue injuries, burns, and wound healing disturbances.This book is intended for interns, residents and fellows of Plastic Surgery and Maxillofacial Surgery as well as surgeons and physicians of other disciplines dealing with soft tissue trauma of the head and neck. It may also prove useful to theatre and A & E nurses as well as medical students with interests in head and neck traumatology.
- Published
- 2023
24. Proceedings of the 6th International Conference on Economic Management and Green Development
- Author
-
Xiaolong Li, Chunhui Yuan, John Kent, Xiaolong Li, Chunhui Yuan, and John Kent
- Subjects
- Economic policy, Management, Sustainability
- Abstract
This proceedings book, together with the conference, looks forward to spark inspirations and promote collaborations. International Conference on Economic Management and Green Development (ICEMGD) is an annual conference aiming at bringing together researchers from the fields of economics, business management, public administration, and green development for the sharing of research methods and theoretical breakthroughs. The proceedings consist of papers accepted by the 6th ICEMGD, which are carefully selected and reviewed by professional reviewers from corresponding research fields and the editing committee of the conference. The papers have a diverse range of topics situated at the intersecting field of economic management, public administration, and green development. ICEMGD is working to provide a platform for international participants from fields like macro- and microeconomics, international economics, finance, agricultural economics, health economics, business management and marketing strategies, regional development studies, social governance, and sustainable development. The proceedings will be of interest to researchers, academics, professionals, and policy makers in the field of economic management, public administration, and development studies.
- Published
- 2023
25. Artificial Intelligence and Smart Environment : ICAISE’2022
- Author
-
Yousef Farhaoui, Alvaro Rocha, Zouhaier Brahmia, Bharat Bhushab, Yousef Farhaoui, Alvaro Rocha, Zouhaier Brahmia, and Bharat Bhushab
- Subjects
- Computational intelligence, Engineering—Data processing, Artificial intelligence
- Abstract
This book reviews the state of the art of big data analysis, artificial intelligence, and smart environments. Data is becoming an increasingly decisive resource in modern societies, economies, and governmental organizations. Data science, artificial intelligence, and smart environments inspire novel techniques and theories drawn from mathematics, statistics, information theory, computer science, and social science. This book reviews the state of the art of big data analysis, artificial intelligence, and smart environments. It includes issues that pertain to signal processing, probability models, machine learning, data mining, database, data engineering, pattern recognition, visualization, predictive analytics, data warehousing, data compression, computer programming, smart city, etc. The papers in this book were the outcome of research conducted in this field of study. The latter makes use of applications and techniques related to data analysis in general and big data and smart city in particular.The book appeals to advanced undergraduate and graduate students, post-doctoral researchers, lecturers, and industrial researchers, as well as anyone interested in big data analysis and artificial intelligence.
- Published
- 2023
26. Essentials of Non-Alcoholic Fatty Liver Disease : Complications and Extrahepatic Manifestations
- Author
-
Anca Trifan, Carol Stanciu, Cristina Muzica, Anca Trifan, Carol Stanciu, and Cristina Muzica
- Subjects
- Fatty liver
- Abstract
The book is a compact yet comprehensive practical resource that highlights all must-know information on non-alcoholic fatty liver disease (NAFLD). Covering the major issues dominating the field, this book offers a broad vision on NAFLD using key data for a deep and thorough understanding of the latest diagnostic methods, treatment options, potential complications, and disease management strategies to improve patient outcomes. The volume bridges the trans-disciplinary divide between hepatologists, cardiologists, nephrologists, psychiatrists, oncologists and dermatologists in order to cover the complex management of NAFLD in a single volume. It operates under a modern definition of NAFLD that acknowledges the range of presentations related to extrahepatic complications that hepatologists see in daily practice, while also delving into unanswered questions and future directions regarding treatment options. Offering practical, clinical guidance in addition to capturing the new promising therapeutic approaches in the pipeline, this book is an essential reference for clinicians, researchers and students.
- Published
- 2023
27. HCI in Business, Government and Organizations : 10th International Conference, HCIBGO 2023, Held As Part of the 25th HCI International Conference, HCII 2023, Copenhagen, Denmark, July 23–28, 2023, Proceedings, Part I
- Author
-
Fiona Nah, Keng Siau, Fiona Nah, and Keng Siau
- Subjects
- User interfaces (Computer systems), Human-computer interaction, Education—Data processing, Computer networks, Computer systems, Electronic commerce, Machine learning
- Abstract
This two-volume set of HCIBGO 2023, constitutes the refereed proceedings of the 10h International Conference on HCI in Business, Government and Organizations, held as Part of the 24th International Conference, HCI International 2023, which took place in July 2023 in Copenhagen, Denmark.The total of 1578 papers and 396 posters included in the HCII 2023 proceedings volumes was carefully reviewed and selected from 7472 submissions. The HCIBGO 2023 proceedings focuses in topics such as artificial intelligence and machine learning, blockchain, service design, live streaming in electronic commerce, visualization, and workplace design.
- Published
- 2023
28. Deep Learning Systems : Algorithms, Compilers, and Processors for Large-Scale Production
- Author
-
Andres Rodriguez and Andres Rodriguez
- Subjects
- Microprocessors, Computer architecture
- Abstract
This book describes deep learning systems: the algorithms, compilers, and processor components to efficiently train and deploy deep learning models for commercial applications. The exponential growth in computational power is slowing at a time when the amount of compute consumed by state-of-the-art deep learning (DL) workloads is rapidly growing. Model size, serving latency, and power constraints are a significant challenge in the deployment of DL models for many applications. Therefore, it is imperative to codesign algorithms, compilers, and hardware to accelerate advances in this field with holistic system-level and algorithm solutions that improve performance, power, and efficiency. Advancing DL systems generally involves three types of engineers: (1) data scientists that utilize and develop DL algorithms in partnership with domain experts, such as medical, economic, or climate scientists; (2) hardware designers that develop specialized hardware to accelerate the components in the DL models; and (3) performance and compiler engineers that optimize software to run more efficiently on a given hardware. Hardware engineers should be aware of the characteristics and components of production and academic models likely to be adopted by industry to guide design decisions impacting future hardware. Data scientists should be aware of deployment platform constraints when designing models. Performance engineers should support optimizations across diverse models, libraries, and hardware targets. The purpose of this book is to provide a solid understanding of (1) the design, training, and applications of DL algorithms in industry; (2) the compiler techniques to map deep learning code to hardware targets; and (3) the critical hardware features that accelerate DL systems. This book aims to facilitate co-innovation for the advancement of DL systems. It is written for engineers working in one or more of these areas who seek to understand the entire system stack in order to better collaborate with engineers working in other parts of the system stack. The book details advancements and adoption of DL models in industry, explains the training and deployment process, describes the essential hardware architectural features needed for today's and future models, and details advances in DL compilers to efficiently execute algorithms across various hardware targets. Unique in this book is the holistic exposition of the entire DL system stack, the emphasis on commercial applications, and the practical techniques to design models and accelerate their performance. The author is fortunate to work with hardware, software, data scientist, and research teams across many high-technology companies with hyperscale data centers. These companies employ many of the examples and methods provided throughout the book.
- Published
- 2022
29. Deep Neural Networks and Data for Automated Driving : Robustness, Uncertainty Quantification, and Insights Towards Safety
- Author
-
Tim Fingscheidt, Hanno Gottschalk, Sebastian Houben, Tim Fingscheidt, Hanno Gottschalk, and Sebastian Houben
- Subjects
- Vehicular ad hoc networks (Computer networks), Automated vehicles, Neural networks (Computer science)
- Abstract
This open access book brings together the latest developments from industry and research on automated driving and artificial intelligence.Environment perception for highly automated driving heavily employs deep neural networks, facing many challenges. How much data do we need for training and testing? How to use synthetic data to save labeling costs for training? How do we increase robustness and decrease memory usage? For inevitably poor conditions: How do we know that the network is uncertain about its decisions? Can we understand a bit more about what actually happens inside neural networks? This leads to a very practical problem particularly for DNNs employed in automated driving: What are useful validation techniques and how about safety?This book unites the views from both academia and industry, where computer vision and machine learning meet environment perception for highly automated driving. Naturally, aspects of data, robustness, uncertainty quantification, and,last but not least, safety are at the core of it. This book is unique: In its first part, an extended survey of all the relevant aspects is provided. The second part contains the detailed technical elaboration of the various questions mentioned above.
- Published
- 2022
30. Advances in Decision Science and Management : Proceedings of Third International Conference on Decision Science and Management (ICDSM 2021)
- Author
-
Taosheng Wang, Srikanta Patnaik, Andrew W.H. Ip, Madjid Tavana, Taosheng Wang, Srikanta Patnaik, Andrew W.H. Ip, and Madjid Tavana
- Subjects
- Decision making--Congresses, Management--Congresses
- Abstract
This book discusses an emerging area in computer science, IT, and management, i.e., decision sciences and management. It includes studies that employ various computing techniques like machine learning to generate insights from huge amounts of available data; and which explore decision making for cross-platforms that contain heterogeneous data associated with complex assets; leadership; and team coordination. It also reveals the advantages of using decision sciences with management-oriented problems. The book includes a selection of the best papers presented at the Third International Conference on Decision Science and Management 2021 (ICDSM 2021), held at Hang Seng University of Hong Kong in China.
- Published
- 2022
31. Age-Inclusive ICT Innovation for Service Delivery in South Africa : A Developing Country Perspective
- Author
-
Vera Roos, Jaco Hoffman, Vera Roos, and Jaco Hoffman
- Subjects
- Technology and older people--South Africa, Older people--Services for--South Africa, Information technology--South Africa
- Abstract
This open access book presents a step-by-step journey to address the problem of ineffective service delivery by local government that led to the leveraging of new technology to benefit older individuals. Based in South Africa, this exploration is in one sense peculiar to its setting--a developing country with huge inequalities--but the story goes beyond the immediate geographical setting of (South) Africa and transcends the temporal aspect of ICT technology. It reflects on older persons'participation, negotiation, and transition in the development of a technology artefact that offers the potential to access services and activities, and to participate in an inclusive society for all ages. This theme has wider resonance, and demonstrates a phenomenon witnessed in different ways and stages across the globe: cohorts of older persons negotiating waves of updated and new technologies. This edited volume details a workable, transdisciplinary and relational approach to 21st-century ICT innovation that helps create a technology artefact tailored for purpose. Worldwide, it is anticipated that care needs of older populations will outstrip available resources. Sub-Saharan Africa lacks relevant long-term care systems for older persons, and technology could play a crucial role in supporting families, communities and government in vital care management. This volume addresses, in three parts, the under-explored topic of age-inclusive ICT development and use in resource-poor countries. Part 1, Context and Project Background, sets out ICT service delivery to older persons globally and within South Africa, drawing on guiding legislative frameworks. It discusses the we-DELIVER project as an example of developing and applying age-inclusive technology in developing countries. Part 2, Principles, Process and Applications, proposes situationally and relationally informed ethical conduct in applying community-based research; the development of a questionnaire and application to present first-time baseline findings of older South Africans'cell phone use, highlighting its intergenerational facilitation. The development of the Yabelana (alluding to'sharing') ecosystem (consisting of a website, an app, and an unstructured supplementary service data (USSD) code) turned out to be a first of its kind: a digital self-sustaining technology artefact that serves as an eDirectory to provide information about local services or events for (but not exclusively) older individuals. Part 3, Critical Reflections and the Way Forward, considers the inclusion of marginalized older individuals and the future of ICT and cell phone technology to inform research, practice, and policy. This topical edited volume is of interest to social science researchers and students as well as policy makers and practitioners dealing with the life course, ageing and age care, intergenerational issues, technology, social policy, and social work.
- Published
- 2022
32. The Brassica Juncea Genome
- Author
-
Chittaranjan Kole, Trilochan Mohapatra, Chittaranjan Kole, and Trilochan Mohapatra
- Subjects
- Botany, Genetics, Biotechnology, Agriculture
- Abstract
This book is the first comprehensive compilation of deliberations on elucidation and augmentation of the genome of Brassica juncea, one of the leading oilseed crops of the world, popularly called as brown mustard, Indian mustard, Chinese mustard, or Oriental mustard. It includes discussions on genepools; genetic diversity and its characterization; classical genetic and traditional breeding; basics and application of heteroploidy; techniques and applications of introgressive hybridization; in vitro culture for micro-propagation, somatic mutation, somatic embryogenesis, and somatic hybridization; genetic engineering including genetic transformation and gene silencing; and molecular genetic mapping and mapping of genes and comprehensive delineations on genome sequencing and comparative genomics; resequencing for elucidation of origin and diversity; large-scale genome analysis; plastid genome sequence; transcriptomics; metabolomics; proteomics; evolutionary genomics; role of regulatory genes in development and adaptation and their utilization in trait improvement; precise breeding for yield, quality, and resistance to biotic and abiotic stresses; and prospects of genome editing.
- Published
- 2022
33. Critical Infrastructure Protection XV : 15th IFIP WG 11.10 International Conference, ICCIP 2021, Virtual Event, March 15–16, 2021, Revised Selected Papers
- Author
-
Jason Staggs, Sujeet Shenoi, Jason Staggs, and Sujeet Shenoi
- Subjects
- Data protection, Software engineering, Computer engineering, Computer networks
- Abstract
The information infrastructure – comprising computers, embedded devices, networks and software systems – is vital to operations in every sector: chemicals, commercial facilities, communications, critical manufacturing, dams, defense industrial base, emergency services, energy, financial services, food and agriculture, government facilities, healthcare and public health, information technology, nuclear reactors, materials and waste, transportation systems, and water and wastewater systems. Global business and industry, governments, indeed society itself, cannot function if major components of the critical information infrastructure are degraded, disabled or destroyed.Critical Infrastructure Protection XV describes original research results and innovative applications in the interdisciplinary field of critical infrastructure protection. Also, it highlights the importance of weaving science, technology and policy in crafting sophisticated, yet practical, solutions that willhelp secure information, computer and network assets in the various critical infrastructure sectors. Areas of coverage include: Industrial Control Systems Security; Telecommunications Systems Security; Infrastructure Security. This book is the fourteenth volume in the annual series produced by the International Federation for Information Processing (IFIP) Working Group 11.10 on Critical Infrastructure Protection, an international community of scientists, engineers, practitioners and policy makers dedicated to advancing research, development and implementation efforts focused on infrastructure protection. The book contains a selection of 13 edited papers from the Fifteenth Annual IFIP WG 11.10 International Conference on Critical Infrastructure Protection, held as a virtual event during the spring of 2021. Critical Infrastructure Protection XV is an important resource for researchers, faculty members and graduate students, as well as for policy makers, practitioners and other individuals with interests in homeland security.
- Published
- 2022
34. Ferrites and Multiferroics : Fundamentals to Applications
- Author
-
Gagan Kumar Bhargava, Sumit Bhardwaj, Mahavir Singh, Khalid Mujasam Batoo, Gagan Kumar Bhargava, Sumit Bhardwaj, Mahavir Singh, and Khalid Mujasam Batoo
- Subjects
- Ferroelectric crystals, Magnetic Materials, Nanoscience, Nanotechnology
- Abstract
This book highlights the fundamentals of ferrites and multiferroic materials with special attention to their structure, types, and properties. It presents a comprehensive survey about ferrite and multiferroic materials, in areas significant to research and development in academia as well as in industry. The book discusses various types of methods applied for their synthesis and characterizations. This book is concerned with the fascinating class of materials with the promise for wide-ranging applications, including electromagnets, magnetic fluid hyperthermia, antenna applications, memory devices, switching circuits, bio-medical applications, actuators, magnetic field sensors and water purification, etc.
- Published
- 2021
35. Innovation, Catch-up and Sustainable Development : A Schumpeterian Perspective
- Author
-
Andreas Pyka, Keun Lee, Andreas Pyka, and Keun Lee
- Subjects
- Schools of economics, Economic development, Finance, Public, Technological innovations
- Abstract
This volume presents selected contributions from the 2018 conference of the International Schumpeter Society (ISS). The selected chapters in this volume reflect the state-of-the-art of Schumpeterian economics dedicated to the three conference topics innovation, catch-up, and sustainability. Innovation is driving catch-up processes and is the condition for a transformation towards higher degrees of sustainability. Therefore, Schumpeterian economics has to play a key role in these most challenging fields of human societies'development in the 21st century. The three topics are well suited to capture the great variety of issues, which have the potential to shape the scientific discussion in economics and related disciplines in the years to come. The presented contributions show the broadness and high standard of Schumpeterian analysis. The ideas of dynamics, heterogeneity, novelty, and innovation as well as transformation are the most attractive fields in economics today and offer the most prolific interdisciplinary connections now and for the years to come when humankind, our global society, has to master the transition towards sustainable economic systems by solving the grand challenges and wicked problems with which we are confronted today. Therefore, the book is a must-read for scholars, researchers, and students, interested in a better understanding of innovation, catch-up, and sustainability, and Schumpeterian economics in general.The chapter “Industrial life cycle: relevance of national markets in the development of new industries for energy technologies – the case of wind energy” is available open access under a CC BY 4.0 License via link.springer.com.
- Published
- 2021
36. Regulatory Toxicology
- Author
-
Franz-Xaver Reichl, Michael Schwenk, Franz-Xaver Reichl, and Michael Schwenk
- Subjects
- Toxicity testing, Toxicology
- Abstract
This 2nd edition of the Handbook'Regulatory Toxicology'was written and updated by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It includes a number of new chapters that cover recent developments, such as regulation of nanoparticles, illicit designer drugs or tattoos.The Handbook deals comprehensively with the safety-ensuring methods and concepts employed for acute and chronic toxicity by regulatory agencies, industry and academics.
- Published
- 2021
37. Advances in Digital Marketing and ECommerce : Second International Conference, 2021
- Author
-
Francisco J. Martínez-López, David López López, Francisco J. Martínez-López, and David López López
- Subjects
- Electronic commerce--Congresses, Internet marketing--Congresses
- Abstract
This book highlights the latest research articles presented at the second Digital Marketing & eCommerce Conference in June 2021. Papers include a diverse set of digital marketing and eCommerce-related topics such as user psychology and behavior in social commerce, influencer marketing in social commerce, social media monetization strategies, social commerce characteristics and their impact on user behavior, branding on social media, social media-based business models, user privacy and security protection on social media, social video marketing and commerce, among other topics.
- Published
- 2021
38. Progress in Mycology : An Indian Perspective
- Author
-
Tulasi Satyanarayana, Sunil Kumar Deshmukh, Mukund V. Deshpande, Tulasi Satyanarayana, Sunil Kumar Deshmukh, and Mukund V. Deshpande
- Subjects
- Fungi, Mycology, Microbiology, Microbial populations, Biomedical engineering, Bioinformatics
- Abstract
Indian mycologists have extensively studied various groups of fungi such as soil fungi, aquatic fungi, marine fungi, endophytic fungi, fungi associated with man and animals. Though several books on various aspects of fungi are published, this is the first account of the history and developments in mycology in India. It discusses at length various stages of development of mycology including both classical and biotechnological aspects. It begins with a historical account of Indian mycology, followed by a description of research on fossil fungi. Further chapters cover the latest updates on different taxonomic groups of fungi. A dedicated section describes the roles and applications of fungal endophytes. The book also includes research in other important areas such as mushrooms and wood rotting fungi. Different chapters are written by leading mycologists. This book is useful to students, teachers and researchers in botany, microbiology, biotechnology and life sciences, agriculture and industries using fungi to produce various valuable products.
- Published
- 2021
39. Digital Transformation and Human Behavior : Innovation for People and Organisations
- Author
-
Concetta Metallo, Maria Ferrara, Alessandra Lazazzara, Stefano Za, Concetta Metallo, Maria Ferrara, Alessandra Lazazzara, and Stefano Za
- Subjects
- Technology and civilization, Technological innovations--Social aspects, Human behavior
- Abstract
The digital transformation is impacting various aspects of how we live and work. Due to the pervasive effects of the digital revolution on firms and societies, both scholars and practitioners are interested in better understanding the key mechanisms behind the related challenges. This book presents a collection of research papers focusing on the relationships between technologies (e.g. artificial intelligence, social media, and the Internet of Things) and behaviours (e.g. social learning, knowledge sharing, and decision-making). Moreover, it provides insights into how the digital transformation may improve quality of personal life and work life within public and private organisations. The plurality of views offered makes this book particularly relevant for practitioners, companies, scientists, and governments. It gathers a selection of the best papers - original double-blind peer-reviewed contributions - presented at the annual conference of the Italian chapter of theAIS which was held in Naples, Italy, in September 2019.
- Published
- 2021
40. Human Viruses: Diseases, Treatments and Vaccines : The New Insights
- Author
-
Shamim I. Ahmad and Shamim I. Ahmad
- Subjects
- Virus diseases--Treatment, Virus diseases, Viral vaccines
- Abstract
This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.
- Published
- 2021
41. Quantum Theory and Symmetries : Proceedings of the 11th International Symposium, Montreal, Canada
- Author
-
M. B. Paranjape, Richard MacKenzie, Zora Thomova, Pavel Winternitz, William Witczak-Krempa, M. B. Paranjape, Richard MacKenzie, Zora Thomova, Pavel Winternitz, and William Witczak-Krempa
- Subjects
- Quantum theory--Congresses, Symmetry (Physics)--Congresses
- Abstract
This volume of the CRM Conference Series is based on a carefully refereed selection of contributions presented at the'11th International Symposium on Quantum Theory and Symmetries', held in Montréal, Canada from July 1-5, 2019. The main objective of the meeting was to share and make accessible new research and recent results in several branches of Theoretical and Mathematical Physics, including Algebraic Methods, Condensed Matter Physics, Cosmology and Gravitation, Integrability, Non-perturbative Quantum Field Theory, Particle Physics, Quantum Computing and Quantum Information Theory, and String/ADS-CFT. There was also a special session in honour of Decio Levi. The volume is divided into sections corresponding to the sessions held during the symposium, allowing the reader to appreciate both the homogeneity and the diversity of mathematical tools that have been applied in these subject areas. Several of the plenary speakers, who are internationally recognized experts in theirfields, have contributed reviews of the main topics to complement the original contributions.
- Published
- 2021
42. Pathologie : Leber, Gallenwege und Pankreas
- Author
-
Andrea Tannapfel, Günter Klöppel, Andrea Tannapfel, and Günter Klöppel
- Subjects
- Pathology, Endocrinology, Internal medicine, Surgery, Medical genetics
- Abstract
Der Band „Leber, Gallenwege und Pankreas“ enthält die Pathologie der Leber, der intra- und extrahepatischen Gallenwege, der Gallenblase und des Pankreas. Die einzelnen Beiträge sind von renommierten Pathologen und Klinikern verfasst und haben zum Ziel, die Pathologie der häufigen, aber auch der seltenen Erkrankungen unter Einbeziehung von Epidemiologie, Ätiologie, Pathogenese, Genetik und Klinik darzustellen. Der praktizierende Pathologe erhält damit ein Nachschlagewerk, das ihn schnell und eingehend diagnostisch berät. Da die Beiträge über die Morphologie hinaus auch über den relevanten klinischen Befund informieren, ist dieses Buch nicht nur für Fachärzte für Pathologie, sondern auch für Ärzte in der Weiterbildung zum Pathologen, für Hepatologen, Gastroenterologen, Pankreatologen und Viszeralchirurgen sehr attraktiv.
- Published
- 2020
43. Deep Learning Systems : Algorithms, Compilers, and Processors for Large-Scale Production
- Author
-
Andres Rodriguez and Andres Rodriguez
- Subjects
- Computer algorithms, Compilers (Computer programs), Artificial intelligence--Data processing, Machine learning, Artificial intelligence
- Abstract
This book describes deep learning systems: the algorithms, compilers, and processor components to efficiently train and deploy deep learning models for commercial applications. The exponential growth in computational power is slowing at a time when the amount of compute consumed by state-of-the-art deep learning (DL) workloads is rapidly growing. Model size, serving latency, and power constraints are a significant challenge in the deployment of DL models for many applications. Therefore, it is imperative to codesign algorithms, compilers, and hardware to accelerate advances in this field with holistic system-level and algorithm solutions that improve performance, power, and efficiency. Advancing DL systems generally involves three types of engineers: (1) data scientists that utilize and develop DL algorithms in partnership with domain experts, such as medical, economic, or climate scientists; (2) hardware designers that develop specialized hardware to accelerate the components in the DL models; and (3) performance and compiler engineers that optimize software to run more efficiently on a given hardware. Hardware engineers should be aware of the characteristics and components of production and academic models likely to be adopted by industry to guide design decisions impacting future hardware. Data scientists should be aware of deployment platform constraints when designing models. Performance engineers should support optimizations across diverse models, libraries, and hardware targets. The purpose of this book is to provide a solid understanding of (1) the design, training, and applications of DL algorithms in industry; (2) the compiler techniques to map deep learning code to hardware targets; and (3) the critical hardware features that accelerate DL systems. This book aims to facilitate co-innovation for the advancement of DL systems. It is written for engineers working in one or more of these areas who seek to understand the entire system stack in order to bettercollaborate with engineers working in other parts of the system stack. The book details advancements and adoption of DL models in industry, explains the training and deployment process, describes the essential hardware architectural features needed for today's and future models, and details advances in DL compilers to efficiently execute algorithms across various hardware targets. Unique in this book is the holistic exposition of the entire DL system stack, the emphasis on commercial applications, and the practical techniques to design models and accelerate their performance. The author is fortunate to work with hardware, software, data scientist, and research teams across many high-technology companies with hyperscale data centers. These companies employ many of the examples and methods provided throughout the book.
- Published
- 2020
44. Cyber Defence in the Age of AI, Smart Societies and Augmented Humanity
- Author
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Hamid Jahankhani, Stefan Kendzierskyj, Nishan Chelvachandran, Jaime Ibarra, Hamid Jahankhani, Stefan Kendzierskyj, Nishan Chelvachandran, and Jaime Ibarra
- Subjects
- Computer security, Artificial intelligence
- Abstract
This publication highlights the fast-moving technological advancement and infiltration of Artificial Intelligence into society. Concepts of evolution of society through interconnectivity are explored, together with how the fusion of human and technological interaction leading to Augmented Humanity is fast becoming more than just an endemic phase, but a cultural phase shift to digital societies. It aims to balance both the positive progressive outlooks such developments bring with potential issues that may stem from innovation of this kind, such as the invasive procedures of bio hacking or ethical connotations concerning the usage of digital twins. This publication will also give the reader a good level of understanding on fundamental cyber defence principles, interactions with Critical National Infrastructure (CNI) and the Command, Control, Communications and Intelligence (C3I) decision-making framework. A detailed view of the cyber-attack landscape will be garnered; touching on thetactics, techniques and procedures used, red and blue teaming initiatives, cyber resilience and the protection of larger scale systems. The integration of AI, smart societies, the human-centric approach and Augmented Humanity is discernible in the exponential growth, collection and use of [big] data; concepts woven throughout the diversity of topics covered in this publication; which also discusses the privacy and transparency of data ownership, and the potential dangers of exploitation through social media. As humans are become ever more interconnected, with the prolificacy of smart wearable devices and wearable body area networks, the availability of and abundance of user data and metadata derived from individuals has grown exponentially. The notion of data ownership, privacy and situational awareness are now at the forefront in this new age.
- Published
- 2020
45. Proceedings of the Fourth International Conference on Microelectronics, Computing and Communication Systems : MCCS 2019
- Author
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Vijay Nath, J. K. Mandal, Vijay Nath, and J. K. Mandal
- Subjects
- Electronics, Electric power production, Telecommunication, Machine learning
- Abstract
This book presents high-quality papers from the Fourth International Conference on Microelectronics, Computing & Communication Systems (MCCS 2019). It discusses the latest technological trends and advances in MEMS and nanoelectronics, wireless communication, optical communication, instrumentation, signal processing, image processing, bioengineering, green energy, hybrid vehicles, environmental science, weather forecasting, cloud computing, renewable energy, RFID, CMOS sensors, actuators, transducers, telemetry systems, embedded systems and sensor network applications. It includes papers based on original theoretical, practical and experimental simulations, development, applications, measurements and testing. The applications and solutions discussed here provide excellent reference material for future product development.
- Published
- 2020
46. Circadian Rhythm Sleep-Wake Disorders : An Evidence-Based Guide for Clinicians and Investigators
- Author
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R. Robert Auger and R. Robert Auger
- Subjects
- Circadian rhythms, Sleep disorders
- Abstract
This book resolves to bridge the communication gap between research and clinical practice for circadian rhythm sleep-wake disorders. Beginning with a scientific background on biological timekeeping, opening chapters describe the crucial nature of maintaining delicate temporal organization of physiological and molecular events within the body. Following this are discussions on circadian physiology and methods of circadian assessments. Subsequent chapters then relay comprehensive information regarding the International Classification of Sleep Disorders-defined circadian rhythm sleep-wake disorders (CRSWDs), specifically discussing etiology and epidemiology, but focusing on evidence-based treatment data. Concluding discussions provide guidance for the application of light therapy and discuss future roles for optimized lighting environments. Nuanced and market-demanded, Circadian Rhythm Sleep-Wake Disorders: An Evidence-Based Guide for Clinicians and Investigators is an invaluable resource for Sleep Medicine clinicians, circadian researchers, and other interested parties.
- Published
- 2020
47. Innovations in Cybersecurity Education
- Author
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Kevin Daimi, Guillermo Francia III, Kevin Daimi, and Guillermo Francia III
- Subjects
- Computer security--Study and teaching
- Abstract
This book focuses on a wide range of innovations related to Cybersecurity Education which include: curriculum development, faculty and professional development, laboratory enhancements, community outreach, and student learning. The book includes topics such as: Network Security, Biometric Security, Data Security, Operating Systems Security, Security Countermeasures, Database Security, Cloud Computing Security, Industrial Control and Embedded Systems Security, Cryptography, and Hardware and Supply Chain Security. The book introduces the concepts, techniques, methods, approaches and trends needed by cybersecurity specialists and educators for keeping current their security knowledge. Further, it provides a glimpse of future directions where cybersecurity techniques, policies, applications, and theories are headed. The book is a rich collection of carefully selected and reviewed manuscripts written by diverse cybersecurity experts in the listed fields and edited by prominent cybersecurityresearchers and specialists.
- Published
- 2020
48. Biogas Production : From Anaerobic Digestion to a Sustainable Bioenergy Industry
- Author
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Nagamani Balagurusamy, Anuj Kumar Chandel, Nagamani Balagurusamy, and Anuj Kumar Chandel
- Subjects
- Biogas, Biogas industry
- Abstract
This book focuses on biogas production by anaerobic digestion, which is the most popular bioenergy technology of today. Using anaerobic digestion for the production of biogas is a sustainable approach that simultaneously also allows the treatment of organic waste. The energy contained in the substrate is released in the form of biogas, which can be employed as a renewable fuel in diverse industrial sectors. Although biogas generation is considered an established process, it continues to evolve, e.g. by incorporating modifications and improvements to increase its efficiency and its downstream applications. The chapters of this book review the progress made related to feedstock, system configuration and operational conditions. It also addresses microbial pathways utilized, as well as storage, transportation and usage of biogas. This book is an up-to-date resource for scientists and students working on improving biogas production.
- Published
- 2020
49. Advances in Usability, User Experience, Wearable and Assistive Technology : Proceedings of the AHFE 2020 Virtual Conferences on Usability and User Experience, Human Factors and Assistive Technology, Human Factors and Wearable Technologies, and Virtual Environments and Game Design, July 16-20, 2020, USA
- Author
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Tareq Ahram, Christianne Falcão, Tareq Ahram, and Christianne Falcão
- Subjects
- Biomedical engineering, User interfaces (Computer systems), Human-computer interaction, Virtual reality, Augmented reality, Educational technology, Computer games—Programming
- Abstract
This book addresses emerging issues in usability, interface design, human–computer interaction, user experience and assistive technology. It highlights research aimed at understanding human interactions with products, services and systems and focuses on finding effective approaches for improving the user experience. It also discusses key issues in designing and providing assistive devices and services for individuals with disabilities or impairment, offering them support with mobility, communication, positioning, environmental control and daily living. The book covers modeling as well as innovative design concepts, with a special emphasis on user-centered design, and design for specific populations, particularly the elderly. Further topics include virtual reality, digital environments, gaming, heuristic evaluation and forms of device interface feedback (e.g. visual and haptic). Based on the AHFE 2020 Virtual Conference on Usability and User Experience, the AHFE 2020 Virtual Conference on Human Factors and Assistive Technology, the AHFE Virtual Conference on Human Factors and Wearable Technologies, and the AHFE 2020 Virtual Conference on Virtual Environments and Game Design, held on July 16–20, 2020, it provides academics and professionals with an extensive source of information and a timely guide to tools, applications and future challenges in these fields.
- Published
- 2020
50. Re-imagining Diffusion and Adoption of Information Technology and Systems: A Continuing Conversation : IFIP WG 8.6 International Conference on Transfer and Diffusion of IT, TDIT 2020, Tiruchirappalli, India, December 18–19, 2020, Proceedings, Part I
- Author
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Sujeet K. Sharma, Yogesh K. Dwivedi, Bhimaraya Metri, Nripendra P. Rana, Sujeet K. Sharma, Yogesh K. Dwivedi, Bhimaraya Metri, and Nripendra P. Rana
- Subjects
- Communication--Technological innovations--Congresses, Information technology--Technological innovations--Congresses
- Abstract
This two-volume set of IFIP AICT 617 and 618 constitutes the refereed proceedings of the IFIP WG 8.6 International Working Conference'Re-imagining Diffusion and Adoption of Information Technology and Systems: A Continuing Conversation'on Transfer and Diffusion of IT, TDIT 2020, held in Tiruchirappalli, India, in December 2020.The 86 revised full papers and 36 short papers presented were carefully reviewed and selected from 224 submissions. The papers focus on the re-imagination of diffusion and adoption of emerging technologies. They are organized in the following parts: Part I: artificial intelligence and autonomous systems; big data and analytics; blockchain; diffusion and adoption technology; emerging technologies in e-Governance; emerging technologies in consumer decision making and choice; fin-tech applications; healthcare information technology; and Internet of ThingsPart II: information technology and disaster management; adoption of mobile andplatform-based applications; smart cities and digital government; social media; and diffusion of information technology and systems
- Published
- 2020
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