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This reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.​

This book is a comprehensive guide on microbiome research, from the fundamentals of to the latest advancements in microbiome-based therapeutics. The initial chapters introduce the concept of the human microbiome delving into the intricate relationship between the human host and its microbiome. The chapter also examines the various tools and techniques used in microbiome research and the role of computational biology in analyzing vast amounts of microbiome data. The subsequent chapters review the role of the microbiome in various health conditions, including metabolic disorders, immunological disorders, gastrointestinal tract disorders, management of cancers, metabolic disorders, and mental health disorders. Towards the end, the book examines the regulatory considerations surrounding microbiome-based therapeutics, and ethical considerations surrounding microbiome-based therapeutics. This book is a comprehensive and cutting-edge guide for researchers, healthcare professionals, and students interested in the field of microbiome research and its potential for transforming healthcare.

This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.

The book presents the proceedings of four conferences: The 24th International Conference on Image Processing, Computer Vision, & Pattern Recognition (IPCV'20), The 6th International Conference on Health Informatics and Medical Systems (HIMS'20), The 21st International Conference on Bioinformatics & Computational Biology (BIOCOMP'20), and The 6th International Conference on Biomedical Engineering and Sciences (BIOENG'20). The conferences took place in Las Vegas, NV, USA, July 27-30, 2020, and are part of the larger 2020 World Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE'20), which features 20 major tracks. Authors include academics, researchers, professionals, and students.Presents the proceedings of four conferences as part of the 2020 World Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE'20);Includes the tracks on Image Processing, Computer Vision, & Pattern Recognition, Health Informatics &Medical Systems, Bioinformatics, Computational Biology & Biomedical Engineering;Features papers from IPCV'20, HIMS'20, BIOCOMP'20, and BIOENG'20.

This text provides an overview of venous diseases and focuses on clinical evaluation and management. It is intended to guide the treating physician by summarizing the evidence, giving technical tips, and outlining algorithms for common conditions. A unique feature of this book is clinical pearls given by experts in the field that are highlighted in each chapter. The first section of the book describes the essential anatomy and physiology/pathophysiology. It also includes evaluation of common presentations of venous diseases such as extremity edema and lower extremity ulceration with a summary for work up that includes conditions that can mimic venous diseases. The organization of the book follows the basic pathophysiology of venous disorders with chapters addressing special conditions of common interest such as pelvic congestion syndrome, thoracic outlet syndrome, and May-Thurner syndrome. There is emphasis on novel treatment modalities and emerging technologies through dedicated chapters to anticoagulant agents, emerging modalities to treat superficial venous reflux and venous stent technology. Finally, this book is a melting pot for physicians who have shown dedication and passion to the care of patients with venous disease regardless of specialty and location.The authors are an international panel of vascular experts who trained in vascular surgery, interventional radiology, interventional cardiology, hematology, pulmonology and critical care medicine. Therefore, the book will be of great value to the physicians and trainees in those specialties and to any person interested in developing in depth knowledge of the management of venous diseases.

This handbook offers comprehensive coverage of recent advancements in Big Data technologies and related paradigms. Chapters are authored by international leading experts in the field, and have been reviewed and revised for maximum reader value. The volume consists of twenty-five chapters organized into four main parts. Part one covers the fundamental concepts of Big Data technologies including data curation mechanisms, data models, storage models, programming models and programming platforms. It also dives into the details of implementing Big SQL query engines and big stream processing systems. Part Two focuses on the semantic aspects of Big Data management including data integration and exploratory ad hoc analysis in addition to structured querying and pattern matching techniques. Part Three presents a comprehensive overview of large scale graph processing. It covers the most recent research in large scale graph processing platforms, introducing several scalablegraph querying and mining mechanisms in domains such as social networks. Part Four details novel applications that have been made possible by the rapid emergence of Big Data technologies such as Internet-of-Things (IOT), Cognitive Computing and SCADA Systems. All parts of the book discuss open research problems, including potential opportunities, that have arisen from the rapid progress of Big Data technologies and the associated increasing requirements of application domains. Designed for researchers, IT professionals and graduate students, this book is a timely contribution to the growing Big Data field. Big Data has been recognized as one of leading emerging technologies that will have a major contribution and impact on the various fields of science and varies aspect of the human society over the coming decades. Therefore, the content in this book will be an essential tool to help readers understand the development and future of the field.

This handbook covers Electronic Medical Record (EMR) systems, which enable the storage, management, and sharing of massive amounts of demographic, diagnosis, medication, and genomic information. It presents privacy-preserving methods for medical data, ranging from laboratory test results to doctors'comments. The reuse of EMR data can greatly benefit medical science and practice, but must be performed in a privacy-preserving way according to data sharing policies and regulations. Written by world-renowned leaders in this field, each chapter offers a survey of a research direction or a solution to problems in established and emerging research areas. The authors explore scenarios and techniques for facilitating the anonymization of different types of medical data, as well as various data mining tasks. Other chapters present methods for emerging data privacy applications and medical text de-identification, including detailed surveys of deployed systems. A part of the book is devoted to legislative and policy issues, reporting on the US and EU privacy legislation and the cost of privacy breaches in the healthcare domain. This reference is intended for professionals, researchers and advanced-level students interested in safeguarding medical data.

Dem in der Frauenarztpraxis häufigen und unspezifischen Symptom Chronischer Unterbauchschmerz liegen oft mehrere Ursachen gleichzeitig zugrunde. Ein multimodaler Therapieansatz ist bei diesem komplexen Beschwerdebild, das häufig eine Herausforderung für den Diagnostiker und Therapeuten gleichermaßen darstellt, in den meisten Fällen sinnvoll.Dieses Buch, geschrieben von klinisch erfahrenen Herausgebern und Autoren, bietet eine hilfreiche Unterstützung bei der Gewichtung der einzelnen pathogenetischen Faktoren und der Differenzialdiagnostik.So finden sich unter anderem Kapitel zu- Endometriose- Reizdarmsyndrom- Uterus myomatosus - Urologischen Ursachen/muskulären BeckenbodenschmerzenDie Säulen der Therapie werden ausführlich erörtert- Diagnosespezifische medikamentöse und operative Maßnahmen- Symptomorientierte multimodale Therapie- Psychosomatische Behandlungsansätze- Selbsthilfe und komplementäre BehandlungsansätzeEin Überblick über die derzeitige Versorgungsrealität in Deutschland rundet das Werk ab.

Chronic Abdominal Pain is a comprehensive resource focused on the management of chronic abdominal pain. Chapters begin with an overview of pain generation, adaptive mechanisms and various diagnostic approaches. A complete range of novel, conservative, minimally invasive and surgical therapeutic options and their proper selection are then discussed along with evidence-based and practical clinical aspects of patient care. Authored by a team of world-renowned physicians and researchers, this definitive guide provides novel algorithms for contemporary treatment of chronic abdominal pain, giving pain medicine clinicians and practitioners the knowledge needed to assess and treat patients with abdominal pain.

This book, written by experts from across the world, provides comprehensive coverage of acne and rosacea, focusing in particular on pathogenesis and treatment but also considering clinical aspects, prognostic factors, and impacts on quality of life. Both standard knowledge and important, clinically relevant insights that have emerged over the past decade are presented with the goal of assisting the reader in understanding these diseases and improving treatment outcome. It is explained how high-level research has recently given rise to a variety of new concepts in etiology and treatment, and emerging trends are also discussed. The book is in a reader-friendly format that highlights core messages with a very practical and clinical focus. Pathogenesis and Treatment of Acne and Rosacea will be an indispensable reference for all physicians who care for patients with acne or rosacea and for scientists working in the field.

Over the years, medical informatics has matured into a true scientific discipline. Fundamental and applied aspects are now taught in various fields of health, including medicine, dentistry, pharmacy, nursing and public health. Medical informatics is also often included in the curricula of many other disciplines, including the life sciences, engineering and economics.Medical informatics is a complex and rapidly changing discipline. Relatively few books have been published on the subject, and they rapidly become obsolete. This book is the fruit of a collaborative effort between authors teaching medical informatics in France and others who are conducting research in this field. In addition, an international perspective was pursued, as reflected in the inclusion of various developments and actions in both the USA and Europe.This book is divided into 18 chapters, all of which include learning objectives, recommendations for further reading, exercises and bibliographic references.

The book provides the newest definitive text on the current techniques used in assessing vascular disorders. Readers will receive authoritative information and will be guided through the establishment and accreditation of a vascular laboratory and introduced to the physics of diagnostic testing. The chapters comprehensively explain the use of ultrasound in diagnosing cerebrovascular, renovascular, visceral ischemia and peripheral arterial disease, as well as venous disorders and deep abdominal vascular conditions. The book contains over 300 illustrations, many of them in color. The book will be invaluable to physicians who treat vascular disorders, surgeons, cardiologists, vascular radiologists and the vascular laboratory staff.

Chronic venous insufficiency, manifesting as disabling open leg ulcers, lipodermatosclerosis and severe cutaneous hyperpigmentation is thought to affect five percent of the population over age 80 and a significant proportion, probably greater than one percent, of Western populations under age 65. To date little has been known about how to treat this condition cost-effectively beyond supportive and palliative care. Thus, the most important feature of Chronic Venous Insufficiency is that it describes the interventions which markedly ameliorate, and in some cases cure, the condition. The authoritative text has been skilfully illustrated to show how new methods of endovascular and endoscopic interventions can be integrated with radiologic techniques to correct totally the abnormalities which produce chronic venous insufficiency. Taken as a whole this volume will enable general surgeons, vascular surgeons, dermatologists and interventional radiologists to treat a condition that was, until recently, thought to be untreatable.

For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli­ cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the'classic'and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide.

Optimale Praxisrelevanz: Evidenz-basierte Empfehlungen zur empirischen Initialtherapie mit Antibiotika, gezielte Therapie nach erfolgter Erregerdiagnose, Berücksichtigung der aktuellen Resistenzsituation Optimale Effizienz: Unter Berücksichtigung u.a. von Wirkungsspektrum, Pharmakokinetik, Eradikatonsrate, Therapiedauer, Nebenwirkungen Optimale Patientenorientierung: Unter Berücksichtigung u.a. von Compliance, Begleiterkrankungen/Alter, Ausprägung der Erkrankung, lokalen/epidemiologischen Bedingungen Zusatzinfos: Zulassungen und Bewertung der Antibiotika, Klinik, Differentialdiagnosen, Diagnostik, Klassifikationen von Erkrankungen

'Noninvasive Vascular Diagnosis: A Practical Guide to Therapy'is the newest definitive text on the current techniques used in assessing vascular disorders. Readers of Noninvasive Vascular Diagnosis will receive authoritative information and will be guided through the establishment and accreditation of a vascular laboratory and introduced to the physics of diagnostic testing. Chapters, written by selected experts, comprehensively explain the use of ultrasound in diagnosing cerebrovascular, renovascular, visceral ischemia and peripheral arterial disease as well as venous disorders and deep abdominal vascular conditions. Noninvasive Vascular Diagnosis contains over 300 illustrations, many of them in colour. Due to the special sections which give clinical correlations, this book will be invaluable to physicians who treat vascular disorders, surgeons, cardiologists, vascular radiologists and the vascular laboratory staff.

ThePaci?c-AsiaConferenceonKnowledgeDiscoveryandDataMining(PAKDD) has been held every year since 1997. This year, the eighth in the series (PAKDD 2004) was held at Carlton Crest Hotel, Sydney, Australia, 26–28 May 2004. PAKDD is a leading international conference in the area of data mining. It p- vides an international forum for researchers and industry practitioners to share their new ideas, original research results and practical development experiences from all KDD-related areas including data mining, data warehousing, machine learning, databases, statistics, knowledge acquisition and automatic scienti?c discovery, data visualization, causal induction, and knowledge-based systems. The selection process this year was extremely competitive. We received 238 researchpapersfrom23countries,whichisthehighestinthehistoryofPAKDD, and re?ects the recognition of and interest in this conference. Each submitted research paper was reviewed by three members of the program committee. F- lowing this independent review, there were discussions among the reviewers, and when necessary, additional reviews from other experts were requested. A total of 50 papers were selected as full papers (21%), and another 31 were selected as short papers (13%), yielding a combined acceptance rate of approximately 34%. The conference accommodated both research papers presenting original - vestigation results and industrial papers reporting real data mining applications andsystemdevelopmentexperience.Theconferencealsoincludedthreetutorials on key technologies of knowledge discovery and data mining, and one workshop focusing on speci?c new challenges and emerging issues of knowledge discovery anddatamining.ThePAKDD2004programwasfurtherenhancedwithkeynote speeches by two outstanding researchers inthe area of knowledge discovery and data mining: Philip Yu, Manager of Software Tools and Techniques, IBM T.J.