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This Handbook discusses the pathology, etiology, pathogenesis, and therapeutic interventions of different neurodegenerative diseases. The initial section of the Handbook reviews the recent advances in understanding neurodegenerative diseases and the commonalities and differences between the major pathologies. The subsequent section presents recent developments in understanding fundamental biological mechanisms that influence the onset and development of neurodegenerative diseases. It provides current biomedical studies that are aimed at identifying the underlying causes of neurodegeneration. The book also examines the recent observations from biological, cellular, and studies from the model organisms for gaining mechanistic insights into neurodegenerative disorders. It also presents the epidemiological and genetics studies relevant to clinical aspects of neurodegenerative diseases. The book's subsequent chapters offer new and more effective therapeutic strategies to combat these devastating diseases. Towards the end, the Handbook presents recent advances in molecular diagnostics for neurodegenerative disorders and a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative diseases.

Authored by over 500 internationally acclaimed expert editors and chapter authors from around the world. Completely updated and expanded with almost 40 new chapters. Significantly increased attention to the role of culture in all aspects of evaluation and care. New sections on Digital Mental Health Services and Technologies, Treatment Issues in Specific Populations and Settings, and on Prevention, Systems of Care, and Psychosocial Aspects of Treatment address key advances. This edition is the first comprehensive reference work to cover the entire field of psychiatry in an updateable format, ensuring access to state of the art information. Earlier editions were called “the best current textbook of psychiatry” by the New England Journal of Medicine, and “the gold standard” by the American Journal of Psychiatry. Tasman's Psychiatry, 5th Edition, builds on the initial vision in prior editions of approaching psychiatric evaluation and care from an integrative bio-psycho-social-cultural perspective. It is designed to be an essential and accessible reference for readers at any level of experience. This editorial approach encompasses the importance of the first encounter between patient and clinician, followed by the complex task of beginning to develop a therapeutic relationship and to develop and implement a treatment plan in collaboration with the patient. The importance of increasing attention to the role of culture and social determinants of mental health is reflected both in specific chapters and in components of many chapters throughout the book, especially in those pertaining to clinical evaluation, the therapeutic alliance, and treatment. The global scope of this edition is reflected throughout the book, including the section on psychiatric disorders where evaluation using both ICD 11 and DSM 5-TR is discussed. Most chapters are authored by experts from at least two different countries or continents, adding a critically important dimension which often is missing in major psychiatric textbooks. Tasman's Psychiatry, 5th Edition, is an essential reference for all medical professionals and students who need a trusted reference or learning tool for psychiatry, psychology, clinical research, social work, counseling, therapy, and all others.

This edited volume describes key domains of the emerging research literature linking exercise and mental health. The volume is divided into three sections. The first section provides an overview of foundational knowledge regarding basic processes of exercise, including neurocircuitry, neurotransmitter, and immunology systems. The second section describes emerging research on the acute impact of exercise on affect, mood, and cognition. The third section explores the role of exercise in the etiology and treatment of related mental and physical health disorders, including depression, PTSD, eating disorders, and autoimmune disorders. Collectively, this volume provides readers with foundational knowledge of what exercise is, the basic brain, behavioral and cognitive processes engaged by exercise, and a role of exercise in developing and treating mental health disorders.

This book provides a comprehensive and updated review of the concepts, models, and interventions related to the process of adjustment to life course transitions. In times of transition, an individual is exposed to experiences that require them to assume new roles and exhibit updated behaviors. Regardless of the characteristics of these transitions, exposure to normative trajectories imposes on the person an intensive engagement in a process of (re-)adjustment. Sometimes this demand is beyond the scope of one's ability, motivation, or comprehension. Hence, some people might ineffectively perceive and/or react to the change and end up feeling unable to handle the change and inclined to escape the situation. A preventive intervention that either reduces the impact of possible risk factors or fosters possible protective factors would support the people in managing the transition. While the importance of prevention of maladjustment is repeatedly mentioned in the literature, this is the first-known book on how to prevent maladjustment. It examines how the sense of transition emerges, what adjustment means, the models that elaborate on how people manage in times of transition, what the antecedents of maladjustment are, and especially how maladjustment could be prevented. Out of these discussions, a new model, The Transitional Stress and Adjustment (TSA) Model, is suggested as a grand framework for paving a way forward to better prevent people's maladjustment to life course transitions. Prevention of Maladjustment to Life Course Transitions is a much-needed cornerstone in the future development within the prevention science framework. This book has interdisciplinary appeal for researchers, practitioners, and graduate students in psychology, sociology, public health, social work, criminology, medicine, health sciences, public policy, economics, and education who consider prevention an important vehicle of intervention to promote health and wellbeing. Its focus on the topic of adjustment also would be of special interest to those who explore child and youth development.

This book provides a comprehensive overview of fibromyalgia syndrome that focuses on integrating concepts relevant to the pathogenesis, epidemiology and treatment of the condition. Details of how to manage sleep disorders, assess related disabilities, use pharmacological and complementary treatments are provided. Relevant aspects of neuromodulation, genetics, and neuromodulation are also covered. Therefore, enabling the reader to develop a deep understanding of the underlying triggers of and tools for assessing and treating fibromyalgia. Fibromyalgia Syndrome features a wealth of information on the basic science and contains guidance on how to make clinical decisions when treating patients with this condition, and is a valuable resource for any medical professional or trainee seeking a dedicated up-to-date resource on the topic.

This book offers the most up-to-date and evidence-based information surrounding integrative treatments for acne and rosacea. Ranging from topical solutions, to nutrition, to mind-body medicine, each chapter addresses evidence for use and patient outcomes. Discussions regarding oral and topical botanical supplements and dietary modifications are complemented by the examination of non-Western healing systems'approach to acne and rosacea. Backed by clinical evidence, chapters feature real patient outcomes with complete explanations of the viability of the treatment. Concise and unique, Integrative Dermatology: Practical Applications in Acne and Rosacea, is an invaluable text for not only the dermatologist, but the pediatrician, family practitioner, internist, and holistic/alternative provider.

This handbook examines health and medical care in the Arab world from a systems biology approach. It features comprehensive coverage that includes details of key social, environmental, and cultural determinants. In addition, the contributors also investigate the developed infrastructure that manages and delivers health care and medical solutions throughout the region.More than 25 sections consider all aspects of health, from cancer to hormone replacement therapy, from the use of medications to vitamin deficiency in emergency medical care. Chapters highlight essential areas in the wellbeing and care of this population. These topics include women's health care, displaced and refugee women's health needs, childhood health, social and environmental causes of disease, health systems and health management, and a wide range of diseases of various body systems. This resource also explores issues related to access and barriers to health delivery throughout the region.Health in the Arab world is complex and rapidly changing. The health burden in the region is distributed unevenly based on gender, location, as well as other factors. In addition, crises such as armed conflicts and an expanding migrant population place additional stress on systems and providers at all levels. This timely resource will help readers better understand all these major issues and more. It will serve as an ideal guide for researchers in various biological disciplines, public health, and regulatory agencies.

This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery. Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options.Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Dieses interdisziplinär ausgerichtete Handbuch ist ein umfassendes Nachschlagewerk zum Thema Stressregulation und Sport. Es bietet einen fundierten Überblick zu zentralen Theorien der Stressentstehung und Stressbewältigung, zu Persönlichkeitsfaktoren, welche die Stressbewältigung beeinflussen, sowie zu den physiologischen, kognitiven, emotionalen und verhaltensbezogenen Reaktionen, die durch akute und chronische Stressbelastungen ausgelöst werden. Das Werk behandelt das Thema sowohl aus der Sicht des Gesundheitssports (Stressregulation durch Sport) als auch aus dem Blickwinkel des Leistungssports (Stressregulation im Sport). So geht es zum einen darum, inwieweit sich Belastungen des Alltags durch Sport und Bewegung besser bewältigen lassen, so dass Gesundheitsbeeinträchtigungen vermieden oder reduziert werden, und zum anderen darum, wie Sportler mit hohen Trainingsbelastungen und psychischem Druck in einer Weise umgehen können, dass die optimale Leistungsfähigkeit erhalten bleibt. Last but not least enthält das Handbuch aktuelles Grundlagenwissen zum Einfluss von Stress auf die Gesundheit und liefert eine Übersicht zu Stressmanagement-Programmen und deren Wirksamkeit. Auch aktuelle methodische Fragen und Entwicklungen der Stressforschung werden beleuchtet. Sämtliche Kapitel wurden von ausgewiesenen Experten verfasst und sind übersichtlich strukturiert. Das Handbuch ist ein wichtiges Referenzwerk für verschiedene Professionen, d.h. sowohl bestens geeignet für Wissenschaftler wie auch Professionals im Bereich des Gesundheits- und Leistungssports, einschlägig interessierte Praktiker, Lehrende und Master-Studierende. Des Weiteren eignet es sich als ideale Textsammlung für Lehrveranstaltungen.

There are few clinical problems in the sleep medicine field that are more challenging than the sleep difficulties experienced by individuals suffering from post-traumatic stress disorder (PTSD). This book offers a unique, complete resource addressing all the basic concepts and clinical applications in sleep medicine in settings where combat-related PTSD is commonplace. Authored by leading international experts in the field of sleep/military medicine, Sleep and Combat-Related Post Traumatic Stress Disorder is organized in six sections and provides a broad perspective of the field, from the established theories to the most recent developments in research, including the latest neuroscientific perspectives surrounding sleep and PTSD. The result is a full assessment of sleep in relation to combat-related PTSD and a gold standard volume that is the first of its kind. This comprehensive title will be of great interest to a wide range of clinicians -- from academics and clinicians working within or in partnership with the military health care system to veteran hospital physicians and all health personnel who work with war veterans.

The series “Clinical Approach and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume addresses themost important physical approaches in cosmetic dermatology, disclosing their uses and advantages. Here are discussed in detail the applicability of lasers and other lights, photodynamic therapy, radiofrequency, ultrasound and transepidermal drug delivery.

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Das umfangreiche Nachschlagewerk von Möller, Laux und Kapfhammer darf zu Recht als Standardwerk für Psychiatrie im deutschsprachigen Raum bezeichnet werden. Die aktuelle Auflage wurde komplett überarbeitet und aktualisiert, zahlreiche Autoren tragen mit ihrem Expertenwissen dazu bei, dass sowohl Ärzte in Weiterbildung als auch Fachärzte für Psychiatrie und Psychotherapie auf alle Fragen umfassende Antworten erhalten. Insgesamt vier Bände enthalten alle Grundlagen der Psychiatrie, Prinzipien der Diagnostik und Behandlung und selbstverständlich einen umfangreichen Teil zu den einzelnen Störungen.Von der Geschichte über Klassifikation, Diagnostik und Therapie aller Krankheitsbilder bis hin zu speziellen Aspekten der Psychiatrie finden Sie hier das gesamte Wissen auf aktuellem Stand.

This book presents a comprehensive overview of the roles of ᴅ-amino acids and latest research findings, to reveal their fascinating aspects and to facilitate better understanding of their important roles in physiology and diseases. It also provides useful hints for the development of drugs and functional foods. ᴅ-Amino acids were once called unnatural amino acids and were considered to be insignificant for eukaryotes especially in mammals. However, different ᴅ-amino acids have been revealed to be distributed in various mammalian tissues and to bear important physiological roles. For example, ᴅ-serine is implicated in memory formation and learning, and its abnormal concentration in tissues have been reported in neurological diseases such as schizophrenia and amyotrophic lateral sclerosis. ᴅ-Aspartate is found in a variety of mammalian tissues, particularly in the central nervous system and the genitals. ᴅ-Aspartate facilitates the endocrine secretion of prolactin, inhibits the secretion of melatonin, and plays a peculiar role in the control of reproductive functions in mammals, including the stimulation of testosterone synthesis. Written by the leading scientists in the field, this book is a valuable source of information for researchers in biochemistry, physiology, and neuroscience, as well as in the pharmaceutical and food industries.

This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allowing clinicians to distinguish between the various mood disorders. Further, they: review the course, outcome, and genetics of this highly heritable condition; offer a thorough overview of the neurobiology of the disorder, including what is known from neuroimaging work; delineate the treatment of bipolar depression in special populations such as children and pregnant women; address suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient's symptoms and history; and cover acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.

This book provides an overview of recent trends in the management of trauma and post-traumatic stress disorders that may ensue from distressing experiences associated with the process of migration. Although the symptoms induced by trauma are common to all cultures, their specific meaning and the strategies used to deal with them may be culture-specific. Consequently, cultural factors can play an important role in the diagnosis and treatment of individuals with psychological reactions to extreme stress. This role is examined in detail, with an emphasis on the need for therapists to bear in mind that different cultures often have different concepts of health and disease and that cross-cultural communication is therefore essential in ensuring effective care of the immigrant patient. The therapist's own intercultural skills are highlighted as being an important factor in the success of any treatment and specific care contexts and the global perspective are also discussed.

This book takes a case-based approach to addressing the challenges psychiatrists and other clinicians face when working with American combat veterans after their return from a war zone. Written by experts, the book concentrates on a wide variety of concerns associated with posttraumatic stress disorder (PTSD), including different treatments of PTSD. The text also looks at PTSD comorbidities, such as depression and traumatic brain injury (TBI) and other conditions masquerading as PTSD. Finally, the authors touch on other subjects concerning returning veterans, including pain, disability, facing the end of a career, sleep problems, suicidal thoughts, violence,, and mefloquine “toxidrome”. Each case study includes a case presentation, diagnosis and assessment, treatment and management, outcome and case resolution, and clinical pearls and pitfalls.Post-Traumatic Stress Disorder and Related Diseases in Combat Veterans is a valuable resource for civilian and military mental health practitioners, and primary care physicians on how to treat patients returning from active war zones.

This book offers an evidence based guide for clinical psychologists, psychiatrists, psychotherapists and other clinicians working with trauma survivors in various settings. It provides easily digestible, up-to-date information on the basic principles of traumatic stress research and practice, including psychological and sociological theories as well as epidemiological, psychopathological, and neurobiological findings. However, as therapists are primarily interested in how to best treat their traumatized patients, the core focus of the book is on evidence based psychological treatments for trauma-related mental disorders. Importantly, the full range of trauma and stress related disorders is covered, including Acute Stress Reaction, Complex PTSD and Prolonged Grief Disorder, reflecting important anticipated developments in diagnostic classification. Each of the treatment chapters begins with a short summary of the theoretical underpinnings of the approach, presents a case illustrating the treatment protocol, addresses special challenges typically encountered in implementing this treatment, and ends with an overview of related outcomes and other research findings. Additional chapters are devoted to the treatment of comorbidities, special populations and special treatment modalities and to pharmacological treatments for trauma-related disorders. The book concludes by addressing the fundamental question of how to treat whom, and when.

Zu den häufigsten Alterserkrankungen zählen heute die Parkinson'sche Erkrankung sowie Demenzen. Eine Reihe neuer Erkenntnisse der Grundlagenforschung sowie die Entwicklung neuer Neuro-Psychopharmaka für die genannten Indikationen machten eine Neubearbeitung des Bandes erforderlich. In den vergangenen zwei Jahren wurden unter den Parkinson-Mitteln neue Dopamin-Agonisten, COMT-Hemmer sowie NMDA-Antagonisten zugelassen. Zur Behandlung der Alzheimer-Demenz wurden Antidementiva (Cholinesterosehemmer) entwickelt, weitere medikamentöse Therapieeinsätze befinden sich im Stadium der klinischen Prüfung und werden ebenfalls dargestellt. In gewohnter Form illustrieren zahlreiche Tabellen und Abbildungen die einzelnen Parkinsonmittel und Antidementiva (Nootropika). In Übersichtstabellen finden Sie Einzelpräparate – farblich abgesetzt mit wichtigen praktisch-klinischen Angaben – zur raschen Information. Ergänzend widmen sich mehrere Exkurse speziellen Fragen wie z. B. der Therapie von Dystonien oder der Chorea Huntington. Mit Beiträgen von A. Andrich, E. Auff, H. Baas, G. Becker, T. Becker, S. Bleich, H. M. Brecht, W. Danielczyk, G. Deuschl, T. Dierks, O. Dietmaier, A. Enz, E. Fertl, P.-A. Fischer, L. Frölich, M. Gerlach, H. Hampel, U. Hegerl, A. Heidrich, H. Herrschaft, C. Hock, S. Hoyer, K. Jellinger, K. Jorga, W. Juretzek, S. Kanowski, J. Kornhuber, P. H. Kraus, W. Kuhn, B. Lack, K. W. Lange, G. Laux, K. Maurer, H.-J. Möller, Th. Müller, W. E. Müller, F. Müller-Spahn, M. Naumann, N. Nedopil, W. Oertel, W. Poewe, W. Pöldinger, H. Przuntek, H. Reichmann, W. Retz, P. Riederer, M. Rösler, E. Savaskan, E. Schneider, M. Streifler, O. Tucha, G. Ulm, H.-P. Volz, H. Wachtel, G. K. Wenning, J. Wiltfang, G. Zürcher.

Nach dem Trauma.... Extremereignisse wie z.B. sexueller Missbrauch, Unfälle, Katastrophen, Kriege oder Folter können zu schweren posttraumatischen Belastungsstörungen führen. Psychologen und Mediziner finden hier fundierte Informationen zum Krankheitsbild und den Behandlungsmöglichkeiten: - Konkrete Anleitung für die Diagnosestellung (ICD-10- und DSM-IV-Klassifikation) - Relevante Therapiemethoden - Praktische Hinweise zur Psychopharmakotherapie - Patienteninformationssysteme Neu in dieser Auflage: - Akutinterventionen - Posttraumatische Belastungsstörungen bei Kindern Die übersichtliche Gliederung, viele Graphiken und konkrete Beispiele zum Vorgehen dienen der schnellen Orientierung und erleichtern Ihnen die Arbeit.....die Patienten adäquat versorgen!

This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

This book is a concise, easy to read professional text with a focus on practical aspects. All chapters include tables on sex/gender differences in symptoms and management and a series of suggestions to the novice in the field. Chapters are specialty-specific. The focus is not on women's health, but the presentation of differences in clinical symptoms, management and outcomes in women and men. Gender Medicine strives to employ the knowledge about these differences to improve diagnosis, better understand pathogenesis and advance patient-oriented therapy.

Der „MLK“ hat sich inzwischen zum Standardwerk entwickelt. Das zweibändige Nachschlagewerk beantwortet jede Frage rund um die Fachgebiete Psychiatrie, psychosomatische Medizin und Psychotherapie. Mit diesem enzyklopädischen Titel haben Sie mit Sicherheit das gesamte aktuelle Facharztwissen in Ihrem Regal. - Alle psychischen Störungen werden systematisch dargestellt - Therapieprinzipien und Therapieempfehlungen – sowohl Psychopharmaka als auch Psychotherapie - Mit neuen Kapiteln zu den Themen Ethik, störungsspezifische Psychotherapien, Komplementärmedizin, Aggression – Amok und Stalking - Angabe der Evidenz - Das beste Autorenteam im deutschsprachigen Raum Dieses Werk darf in keiner psychiatrischen Station, Klinik oder Praxis fehlen.

Extensive studies have shown cognitive-behavioral therapy to be highly effective in treating anxiety disorders, improving patients'social functioning, job performance, and quality of life. Yet every CBT clinician faces some amount of client resistance, whether in the form of “This won't work”, “I'm too depressed”, or even “You can't make me!” Avoiding Treatment Failures in the Anxiety Disorders analyzes the challenges presented by non-compliance, and provides disorder- and population-specific guidance in addressing the impasses and removing the obstacles that derail therapy. Making use of extensive clinical expertise and current empirical findings, expert contributors offer cutting-edge understanding of the causes of treatment complications—and innovative strategies for their resolution—in key areas, including: The therapeutic alliance The full range of anxiety disorders (i.e., panic, PTSD, GAD) Comorbidity issues (i.e., depression, personality disorders, eating disorders, substance abuse, and chronic medical illness) Combined CBT/pharmacological treatment Ethnic, cultural, and religious factors Issues specific to children and adolescents. Both comprehensive, and accessible, Avoiding Treatment Failures in the Anxiety Disorders will be welcomed by new and seasoned clinicians alike. The window it opens onto this class of disorders, plus the insights into how and why this treatment works, will also be of interest to those involved in clinical research.

The book is part of a series on Current Topics in Behavioral Neurosciences, which has as its focus anxiety and its treatment. We have brought together a distinguished cadre of authors with the aim of covering a broad array of topics related to anxiety disorders, ranging from clinical diagnosis, epidemiology, preclinical neuroscience, and animal models to established and innovative therapeutic approaches. The book aims at bridging these disciplines to provide an update of literature relevant to understanding anxiety, its consequences, and its management. Following is a brief overview of the chapters and their content, meant to serve as a guide to navigating the book. The?rst section covers clinical aspects of anxiety disorders. Joe Bienvenu and colleagues provide an incisive overview of diagnostic considerations in the anxiety disorders in which they emphasize the strengths and shortcomings of our current nosologic systems. This is followed by a review and update of the epidemiology of anxiety disorders by Ron Kessler and colleagues, which provides an authoritative survey of anxiety disorder incidence, prevalence, and risk factors. This is comp- mented by a comprehensive review of the literature on disorders that co-occur with anxiety disorders by Kathleen Merikangas and Sonja Alsemgeest Swanson. Their review highlights the tremendous comorbidity that occurs not only within the anxiety disorders, but also with other mental and physical health conditions.

DAS Buch für die Psychiatrische Pharmakotherapie. Jetzt gibt es endlich ein Buch, das die Wichtigkeit der medikamentösen Therapie in der Psychiatrie widerspiegelt. Denn in kaum einem anderen Fach ist die Wahl des'richtigen'Medikaments schwieriger. Das Wissen um Wirkungsweisen, Nebenwirkungen, Kontraindikationen und Interaktionen wächst rasant, die Entwicklung neuer Substanzen geht in beeindruckendem Tempo voran. Umso wichtiger, ein Grundlagenwerk zu besitzen, das alle offenen Fragen beantwortet. Von den Grundlagen....Physiologie von Nervenzellen - Prinzipien neuronaler Signalketten- Verhaltenspharmakologie - Neurotransmitter und Modulatoren- Tiermodelle etc....über Substanzgruppen und psychische Störungen, ausführliche Kapitel zu allen Präparategruppen und sämtlichen Störungen...bis hin zu den speziellen Aspekten der Psychopharmakotherapie! In Akutsituationen, forensische Aspekte, bei internistischen und neurologischen Erkrankungen, im Alter, bei Kindern und Jugendlichen, in Schwangerschaft und Stillzeit. Endlich ein großes Psychopharmakologie-Werk für Psychiater, Neurologen und Neurowissenschaftler.

Four years have passed since the last edition (3rd) of this book was published. In the intervening years, several reviews of this book have provided highly encouraging remarks about the value of this book in transmitting information on classification and treatment of psychiatric disorders to the audience. We are proposing to revise all chapters with an eye on accuracy and ease of use, and this is an especially timely endeavor with the upcoming publication of the Diagnostic and Statistical Manual V. All the appropriate new information on biology, etiology, diagnosis and treatment of psychiatric disorders will be added to the current proposed edition. It is our goal to recruit the same authors (if possible) who contributed to the previous edition. While all chapters will be updated (see TOC), those marked by asterisks will be the most likely to undergo more revision. Psychiatry has emerged as a burgeoning scientific field with major advances in etiology and treatment of several disorders. Just as there was excitement in the anatomic advances that took place a hundred years ago when Emil Kraepelin and his collaborators took on the enormous task of classification of psychiatric disorders based on rational scientific thinking, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of mental disorders have brought us even closer to a better understanding of complex disorders like schizophrenia, bipolar disorder, depression and even autism. The major goal of the previous edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders. This goal remains the focus of the fourth edition of this book. In this updated and expanded edition, the reader will be provided with the most contemporary information and literature supported by a close survey of the field. This new edition of this classic title, with its focus on biologic and medical aspects of psychiatry, will continue to be of significant help to all interested in the scientific practice of psychiatry.

Few syndromes in psychopathology generate as much popular curiosity and clinical exploration as does obsessive-compulsive disorder (OCD). Since the 1970s, research on OCD has increased exponentially. Speci?c advances include an improved grasp of the heterogeneity of the disorder, identi?cation of putative subtyping schemes, and the development of increasingly sophisticated theoretical models of the etiology and maintenance. Perhaps most importantly, research has led to advances in treatment; andwhereasthe?rstlinetherapies(cognitive-behaviortherapyandserotonergicm- ication) are not entirely effective for every sufferer, they have transformed OCD from an unmanageable lifetime af?iction into a treatable problem that need not reduce quality of life. Despite the aforementioned advances, there have emerged a number of sharp disagreements concerning OCD. Differences have surfaced over phenomenological issues, etiological models, and approaches to treatment, and often occur (but not exclusively) along disciplinary lines between biologically oriented and cogniti- behaviorally oriented authorities. For example, medical approaches posit that abn- mal biological processes cause OCD, whereas psychosocial formulations emphasize the role of learning and dysfunctional cognitions. Yet because theoretical conjecture andempirical?ndingsfromwithineachtraditionaretypicallyaddressedtowardd- tinct and narrow audiences, clinicians, researchers, and students with broad interests are hindered from gaining a clear grasp of the diverse (and sometimes polarized) perspectives.