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This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms ofmechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Over the past?fty years, advanced techniques and strategies have arisen in the?eld of myocardial protection. Meticulous trials, focusing on pulmonary protection during heart surgery requiring cardiopulmonary bypass (CPB), have been missing. This te- book is intended to serve as a useful tool to spread information on strategies for lung protection during heart surgery with CPB. Emphasis on pulmonary protection will be turned to lung perfusion as an adjunct for minimizing the deleterious effects of pulmonary ischemia-reperfusion injury in heart surgery. Many renowned authors have contributed by presenting their expe- ence on lung perfusion in basic research and clinical trials. Furthermore, they have enlightened the quality of this textbook with new ideas, concepts, and future perspectives. The scope of this textbook is of interest to different professionals, such as card- vascular surgeons, pulmonary surgeons, transplantation physicians, cardiothoracic anesthesiologists, intensive care physicians, cardiothoracic fellows, radiologists, basic sciences physicians, cardiologists, pulmonary medicine physicians, perfusi- ists, nurses, students, and researchers. This textbook has 7 sections, aimed at addressing general and speci?c aspects of pulmonary protection during heart surgery with CPB. The?rst section on general concepts provides information about anatomic, physiologic, histologic, molecular, and radiologic considerations regarding the lungs. The second section focuses on ischemia-reperfusion injury and is composed of several interesting chapters, addressing the basic science aspects of pulmonary p- tection, as well as experimental and clinical experiences from different heart surgery centers worldwide.

Kardiologie konkret - komplett - kompaktErfahrene Kliniker führen übersichtlich, zusammenfassend und gewichtet durch das größte Gebiet der Inneren Medizin.Komplexe Inhalte werden anschaulich, klar und gut verständlich dargestellt.Differenzierte Diagnostik und Therapie: Was - Wann - Warum- Neueste diagnostische und therapeutische Konzepte- Rasche, präzise Information- Konzentration auf unmittelbar krankheitsbezogene klinische Informationen- Maximal praxisrelevantWichtige Kernaussagen und Fehlermöglichkeiten werden hervor gehoben- Mit EbM-Angaben entsprechend der aktuellsten Studien und Leitlinien aller wichtigen deutschen, europäischen und amerikanischen FachgesellschaftenAlles für die Facharztprüfung – und darüber hinausAlle Inhalte der neuen Weiterbildungsordnung „Facharzt Innere und Schwerpunkt Kardiologie'sind abgedeckt - mit diesem Buch bestehen Sie verlässlich die Facharztprüfung.NEU zusätzliche Kapitel:- Diabetes und Herz- Herz und Niere- Herz und Sport- Komplementäre Therapie bei Herzerkrankungen- Regeneration bei HerzerkrankungenFür Kardiologen, Internisten und Allgemeinmediziner als- etabliertes Lernbuch für die Facharztprüfung- hilfreicher Leitfaden bei der täglichen Arbeit- verlässliches Nachschlagewerk bei komplexen Fragestellungen

During the twentieth century we saw a veritable revolution in medicine. Some of the most notable advances have been in the elucidation of the risk factors for and treatment of cardio- and cerebral vascular disease. Identifying these factors through epidemiological studies has led to the development of guidelines for a healthy life style and therapies to control this major killer of the elderly. As a result of these efforts at the present time cardiovascular disease, rather than being the leading cause of death in the United States, has dropped to second behind cancer. Beginning with such seminal studies as the Seven Countries study and the Framingham program, these major advances have resulted from a collaboration among several disciplines, including epidemiology, clinical trials, cell biology, and basic biochemistry. The combined? ndings from these disparate disciplines have served as the foundation for the institution of public health measures, such as smoking cessation campaigns and new dietary recommendations, as well as the development of medications to prevent disease through the control of such major risk factors as hypertension and hyperlipidemia. One of the major insights into the underlying cause of vascular injury is that it is initiated by oxidant injury to the vessel wall. The current volume is - ganized around the role of oxidant damage in this disease process.

The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

The Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

15.000 Liter Pumpleistung pro Tag – Das Herz als Hochleistungsorgan Herz-, Kreislauf- und Gefäßkrankheiten in enger Verbindung mit der gesamten Inneren Medizin - erfahrene Kliniker führen übersichtlich, zusammenfassend und gewichtet durch das größte Gebiet der Inneren Medizin. Komplexe Inhalte werden anschaulich, klar und gut verständlich dargestellt. Differenzierte Diagnostik und Therapie: Was - Wann - Warum Rasche, präzise Information Konzentration auf unmittelbar krankheitsbezogene klinische Informationen Maximal praxisrelevantWichtige Kernaussagen und Fehlermöglichkeiten werden hervor gehoben NEU Inhalte deutlich gestrafft Mit zentralen Internetadressen Mit EbM-Angaben entsprechend der aktuellsten Studien und Leitlinien aller wichtigen deutschen, europäischen und amerikanischen Fachgesellschaften Das ideale Buch - komprimiert und kompakt für Klinik und Praxis Für Internisten und Allgemeinmediziner als etablierter Leitfaden bei der täglichen Arbeit. Für alle Ärzte in der Weiterbildung – Innere Medizin, Kardiologie, Allgemeinmedizin - zur sicheren Vorbereitung für die Facharztprüfung.

Stroke is a global health problem affecting approximately 15 million people annually in the world and about 700,000 in the United States. It is the third leading cause of death and the most common cause of disability in most developed countries. Acute Ischemic Injury and Repair in the Nervous System is intended to provide the most up-to-date knowledge of the mechanisms of neuronal death and repair after stroke. It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.