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Neutrinos play an intriguing role in modern physics linking central questions of particle physics, cosmology and astrophysics. The contributions in this book reflect the present status of neutrino physics with emphasis on non-accelerator or beyond-accelerator experiments. Since a nonvanishing neutrino mass would yield an important boundary condition for GUT, SUSY or Superstring models and since neutrinos are the best candidates for dark matter in the universe, the many efforts to look for a neutrino mass, ranging from neutrino oscillation experiments using reactors, accelerators or the sun as neutrino sources, to tritium decay experiments and the search for neutrinoless double beta decay, are described in some detail. One of the sections is devoted to neutrinos from collapsing stars, including the supernova SN 1987 A. Possibilities for detecting cosmological neutrinos are discussed and an outlook to future experiments is given.

This volume chronicles the proceedings of the Symposium on Particles on Surfaces: Detection, Adhesion and Removal held under the auspices of the Fine Particle Society in San Francisco, July 28-August 2, 1986. The study of particles on surfaces is extremely important in many areas of human endeavor (ranging from microelectronics to optics to biomedical). A complete catalog of modern precision and sophisticated technologies where particles on surfaces are of cardinal importance will be prohibitively long, but the following eclectic examples should underscore the concern about particles on a variety of surfaces. In the semiconductor world of shrinking dimensions, particles which, a few years ago, were cosmetically undesirable but functionally innocuous can potentially be killer defects now. As the device sizes get smaller, there will be more and more concern about smaller and smaller particles. In the information storage technology, the gap between the head and the disk is very narrow, and if a particle is trapped in the gap that can have very grave consequences. The implications of particulate contamination on sensitive optical surfaces is all too manifest. So the particulate contamination on surfaces is undesirable from functional, yield and reliability points of view. This symposium was organized with the following objectives in mind: to bring together active practitioners in this field; to provide a forum for discussion of the latest research and development activities in this area; to provide opportunity for cross-pollination of ideas; and to highlight topics which needed intensified effort.

This book describes an original, empirical study of judicial decision making. The process of determining sentences is a difficult one for judges and often unnecessarily intuitive, subjective, and complex. The present study introduces a conceptual outline and empirical technique for increasing the precision of sentencing policy, thus offering an aid to judges who sentence in the light of this policy. The primary purpose of this model of judicial decision making is to provide a framework for scaling the seriousness of any single case in relation to the facts of that case and for relating this assessment to the appropriate quantum of sentence. The validity of the model is tested and cross-validated in an archival study. This innovative research serves as an important prototype for a system of numerical guidance to judges and sentencers.

Nuclear physics is presently experiencing a thrust towards fundamental phy­ sics questions. Low-energy experiments help in testing beyond today's stan­ dard models of particle physics. The search for finite neutrino masses and neutrino oscillations, for proton decay, rare and forbidden muon and pion de­ cays, for an electric dipole moment of the neutron denote some of the efforts to test today's theories of grand unification (GUTs, SUSYs, Superstrings,...) complementary to the search for new particles and symmetries in high-energy experiments. The close connections between the laws of microphysics, astrophysics and cosmology open further perspectives. This concerns, to mention some of them, properties of exotic nuclei and nuclear matter, and star evolution; the neutrino and the dark matter in the universe; relations between grand unification and evolution of the early universe. The International Symposium on Weak and Electromagnetic Interactions in Nuclei (W.E.LN. 1986)'held in Heidelberg 1-5 July 1986, in conjunction with the 600th anniversary of the University of Heidelberg, brought together experts in the fields of nuclear and particle physics, astrophysics and cosmol­ ogy.

The book contains reviews and posters of the 31st Congress of the EUROTOX (Maastricht 1991). - Forensic Toxicology - Drug Toxicology - Environmental Toxicology

The author's aim in writing this book is to integrate currently available knowledge concerning the basic scientific and technological aspects of breadmaking processes with the diverse breadmaking methods used to manufacture bread in Europe and on the North American continent today. To date, the main technological advances have been in process mechanization, starting with oven development, then dough­ processing or make-up equipment, followed by continuous and batch mixing techniques from the 1950s to the present time. On the engineering side, universal emphasis is now being placed on the application of high technology, in the form of microprocessors, computer-controlled equipment and robotization, the long-term objective being computer integrated manufacture (CIM) with full automation within the large chain bakery groups in the capitalist countries and the state-run collectives of Eastern Europe. The application of these key technologies with biotechnology, as yet only applied to a limited degree in food manufacture, coupled with advances in biochemical and rheological understanding of dough as a biomass for breadmaking, should provide us with more expertise and ability to control the processes with greater efficiency. The application of fermentable substrates and industrial enzymes under strict kinetic control should contribute to improving the flavour characteristics of bread. Current trends towards improving the nutritional contribution of bread to the daily diet are improving the competitive edge of bread as a basic food in the market-place.

The regenerative capacity of the liver cell is almost unlimited. Therefore after acute liver damage, be it viral, toxic, hypoxic, or surgical in origin, restitutio ad integrum is the usual outcome. In two forms of liver disease, however, this is not the case: in fulmi­ nant hepatic failure, liver regeneration often is not fast enough to keep the organism alive; in end-stage cirrhosis, regeneration is dis­ turbed by a hypertrophic architecture of fibrotic tissue. For these extreme forms of liver disease and for critical situations before and after liver surgery, artificial liver support is needed. This book contains the latest results in this area of research pre­ sented by scientists from allover the world at an international symposium held in Celle, Germany, June 2-4, 1980. Exciting new methods like continuous membrane plasma sepa­ ration and liver cell transplantation into the spleen have been de­ veloped. The older methods of hemoperfusion and dialysis have been improved. Enzymological methods and liver transplantation have made good progress. We hope that this volume will help the clinician in his decision-making and stimulate ingenious new re­ search for the benefit of our liver patients.

In the last decade, the incidence of acute poisoning in the developed world has risen considerably, so that hospital admissions from this cause now repre~ sent a significant part of the work load of most medical units. The purpose of this book is to provide an up-to-date account of the diag­ nosis and treatment of all the clinically important poisons. Throughout the text the aim has been to emphasize the mechanisms of toxicity - wherever they are known - so that a rational approach to therapy may be devised. In addition, substantial chapters have been devoted to the psychiatric assess­ ment of self-poisoned patients and to the role of the laboratory. Two styles of presentation have been adopted. Certain topics are discussed in depth either because of their clinical importance or because recent data have become available concerning pathophysiology or treatment. In contrast, when subjects have been well described previously in general medical texts, for example, carbon monoxide poisoning, the discussion is far more brief and to the point. A similar style has been adopted with recently introduced drugs, where little is known about the effects in overdose. The value of cer­ tain chapters, especially those on poisonous plants and snake bites, has been enhanced by the inclusion of a large number of colour photographs.

There is a rapid increase in interest related to novel approaches in artificial kidneys, artificial liver, and detoxifi­ cation. Recent research has included the successful clinical appli­ cations of the principle of artificial cells for adsorbent hemo­ perfusion. Since it is 20 years ago at McGill that the first report on'Artificial Cells'was presented, I thought it might be useful to get together a small group of speakers and participants for a day before the ASAIO meeting to discuss some recent advances in the area of the clinical applications of artificial kidney, artificial liver and artificial cells with emphasis on adsorbent hemoperfusion. However, the enthusiastic supports of distinguished speakers, session chairmen and participants were such that the original pro­ jection of 100 participants had expanded to a preregistration total of 250, from Australia, Canada, England, France, Germany, Israel, Italy, Japan, The Netherlands, Scotland, Sweden and U. S. A. The program also expanded to include a review section on hemodialysis, dialysate regeneration, hemofiltration, resin hemoperfusion and oxystarch given by their respective originators. The remaining of the symposium emphasizes the status of the art on different encap­ sulated adsorbent hemoperfusion approaches. I would like to apolo­ gize to those who we could not accommodate beca~se of space limita­ tions. It is hoped that this symposium volume may be useful for them and for others who are interested in this area. Special thanks are due to Ms Joanne Toms for her excellent secretarial assistance for the conference and Mrs.

This book presents the state-of-the-art in modeling and simulation on supercomputers. Leading German research groups present their results achieved on high-end systems of the High Performance Computing Center Stuttgart (HLRS) for the year 2002. Reports cover all fields of supercomputing simulation ranging from computational fluid dynamics to computer science. Special emphasis is given to industrially relevant applications. Moreover, by presenting results for both vector sytems and micro-processor based systems the book allows to compare performance levels and usability of a variety of supercomputer architectures. It therefore becomes an indispensable guidebook to assess the impact of the Japanese Earth Simulator project on supercomputing in the years to come.

This volume contains the papers which were presented at the First Altschul Symposium, Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall. The symposium was held in Saskatoon, at the University of Saskatchewan in May 1990 in memory of Dr. Rudolph Altschul, a pioneer in the field of vascular biology and the prevention of atherosclerosis. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The challenge for biomedical scientists is to unravel the multifactorial etiology of atherosclerosis. For the last hundred and sixty years, anatomical pathologists have carefully studied the morphological changes of the human vascular wall during the initiation and evolution of the fibrofatty atherosclerotic plaque. Based on these elegant morphological observations, theories on atherogenesis were put forth by pathologists in the 1840's. Rudolf Virchow suggested that the movement of substances from the blood into the vessel wall was important for atherogenesis while Carl von Rokitansky felt that the deposition of substances on the lumenal surface of the artery resulted in the formation of atherosclerotic plaque. Since these original theories, it has become apparent that the pathogenesis of atherosclerosis is multifactorial and the disease evolves in stages. It is also likely that not all plaques arise through the same sequence of events and that many steps are involved in the development of each plaque. Today, our understanding of the complicated processes of atherogenesis is still incomplete.

Proceedings of the 2nd International Meeting on Current Therapy in Nephrology (Sorrento, Italy, May 22-25, 1988)

The provision of optimal dialysis therapy to children requires a thorough understanding of the multi-disciplinary manner in which the pediatric patient is affected by renal insufficiency. Knowledge of the technical aspects of peritoneal dialysis, hemodialysis and continuous renal replacement therapy must be complemented by attention to issues such as anemia, renal osteodystrophy, hypertension, growth, cognitive development, nutrition, nursing care and the psychosocial adaptation of the child and family to chronic disease. The inaugural edition of Pediatric Dialysis provides a comprehensive review of these and other related topics with a singular emphasis on the unique aspects of their application to children. With authoritative, clinically relevant, well-referenced chapters written by a host of recognized international experts who emphasize key aspects of contemporary management, Pediatric Dialysis has been designed to serve as a primary resource to all clinicians involved in the care of the pediatric dialysis patient.

Today, veterinary science experiences major development in all its fields as a consequence of continuous technological advances in diagnostic tools and breakthrough in applied genomics and biology. This book contains 33 proceedings that were selected among those presented at the 64th Italian Veterinary Science Congress held at ASTI in 2010. It provides a timely overview of the current progress made by Italian researchers and would be of great value to anyone interested in the field of veterinary science, from animal health and care to food hygiene, and from basic to applied disciplines.

Internists, surgeons, critical care physicians and nephrologists all treat critically ill patients with renal failure and the multiple system organ dysfunction syndrome. A comprehensive review of the state of the art of this topic is definitely needed both in academic and clinical medicine, and Critical Care Nephrology fulfils this need. It is a useful reference tool for both nephrologists and intensive care specialists and it is therefore no coincidence that the editors of the book are themselves specialists in these particular fields. The book addresses the following: definitions of critical illness, epidemiology, monitoring and diagnostic procedures, pathophysiology of organ systems in relation to kidney function, concepts of renal physiologic and pathologic responses to various derangements, oxygen transport and cardiovascular adaptations, hemodynamic parameters, respiratory parameters, mechanical ventilation and cardiac support, and severity score parameters. The book is also devoted to all forms of acute renal failure with specific reference to intensive care patients. The nature of the multiple organ dysfunction syndrome is discussed with special emphasis on the impact of different organs dysfunction and kidney failure. Kidney function and acute renal failure in patients with kidney, liver and heart transplants is also considered, as well as acute illness occurring in chronic hemodialysis patients. Special emphasis is placed on therapeutic interventions and treatment procedures. Different forms of organ support are discussed including liver, lung and cardiac therapy.

developed. When I did not identify European colleagues In this rapidly evolving field it is appropriate to update frequently our state of the art knowledge of uremia therapy. who had the expertise who could expend the time and with Hence, this third edition of Replacement of Renal Function whom I could work so smoothly, I began alone. by Dialysis appears before many of its predecessors have Although I was tempted to ask all the same authors as had been destroyed by normal wear and tear over 11 and 6 years written so well previously to contribute again, I realized that the new edition must be revitalized. Accordingly a fraction of use, respectively. The first two editions of this book were designed to be of the authors changed, some new topics have been added integrated comprehensive reviews of the pertinent aspects and others have been deleted. The multinational character of dialysis and related fields with sufficient clarity for the of authorship has been maintained. Existing chapters have novice to learn, yet adequate depth for the expert to rely on been rewritten thoroughly, and new authors have provided them as encyclopedic desk references on renal replacement as requested a full discussion and bibliography in keeping therapy. Based on the favorable readers'comments and with the previous editions.

Proceedings of a NATO ASI held in Limin Hersonissou, Greece, June 18-27, 1994.

Over the past two decades, two-phase flow and heat transfer problems associated with two-phase phenomena have been a challenge to many investigators. Two-phase flow applications are found in a wide range of engineering systems, such as nuclear and conventional power plants, evaporators of refrigeration systems and a wide vari­ ety of evaporative and condensive heat exchangers in the chemical industry. This publication is based on the invited lectures presented at the NATO Advanced Research Workshop on the Advances in Two-Phase Flow and Heat Transfer. The Horkshop was attended by more than 50 leading scientists and practicing engineers who work actively on two-phase flow and heat transfer research and applications in dif­ ferent sectors (academia, government, industry) of member countries of NATO. Some scientific leaders and experts on the subject matter from the non-NATO countries were also invited. They convened to discuss the state-of-the-art in two-phase flow and heat transfer and formulated recommendations for future research directions. To achieve these goals, invited key papers and a limited number of contributions were presented and discussed. The specific aspects of the subject were treated in depth in the panel sessions, and the unresolved problems identified. Suitable as a practical reference, these volumes incorporate a systematic approach to two-phase flow analysis.

There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis.

The Advanced Study Institute on Synthesis, Functional Properties and Applications of Nanostructures, held at the Knossos Royal Village, Heraklion, Crete, Greece, July 26, 2002 - August 4, 2002, successfully reviewed the state-of-the-art of nanostructures and nanotechnology. It was concluded that Nanotechnology is widely agreed to be the research focus that will lead to the next generation of breakthroughs in science and engineering. There are three cornerstones to the expectation that Nanotechnology will yield revolutionary advances in understanding and application: • Breakthroughs in properties that arise from materials fabricated from the nanoscale. • Synergistic behavior that arise from the combination of disparate types of materials (soft vs. hard, organic vs. inorganic, chemical vs. biological vs. solid state) at the nanoscale. • Exploitation of natural (e.g. chemical and biological) assembly mechanisms that can accomplish structural control at the nanoscale. It is expected that this will lead to paradigms for assembling bio-inspired functional systems that accomplish desirable properties that are either unavailable or prohibitively expensive using top-down approaches.

Dissociative Recombination of Molecular Ions with Electrons is a comprehensive collection of refereed papers describing the latest developments in dissociative recombination research. The papers are written by the leading researchers in the field. The topics covered include the use of microwave afterglows, merged beams and storage rings to measure rate coefficients and to identify the products and their yields. The molecules studied range in size from the smallest, H2+, to bovine insulin ions. The theoretical papers cover the important role of Rydberg states and the use of wave packets and quantum defect theory to deduce cross sections, rate constants and quantum yields. Several theoretical and experimental papers address the controversial topic of H3+ dissociative recombination and its importance in the interstellar medium. Dissociative recombination studies of other molecular ions in the interstellar medium and in cometary and planetary atmospheres are covered. Ionization is an important competitive process to dissociative recombination and its competition with predissociation and its role in the reverse process of the association of neutral species is presented. Dissociative attachment, in which an electron attaches to a neutral molecule, has many similarities to dissociative recombination. The topics covered include the accurate calculation of electron affinities, attachment to molecules, clusters, and to species absorbed on solid surfaces and electron scattering by a molecular anion.

ISIAME 2000 was organized by the Condensed Matter and Materials Physics Research Group at Old Dominion University, Norfolk, Virginia. It brought together an international group of research scientists and engineers from academia and industry to present details of the most recent investigations on industrially related topics and projects using Mössbauer Spectroscopy as a primary analytical technique. These proceedings inciude the papers presented under the broad topics of Chemistry, Surfaces, Materials Processing, Industrial Processing, and Magnetic and Electronic Materials. Specific research areas drawing much interest include corrosion, catalysis, mechanical alloying, petrochemical, steel and mineralogical processing, nano-phase materials and environmental and pollution monitoring. The book is of particular interest to university researchers and a very broad range of industrial R&D groups who desire to broaden their knowledge of the latest applications and methods of highly resolved spectroscopic analysis of their products.

Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three­ dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start­ ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem­ istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com­ plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.

This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha­ nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron­ storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.

Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K.), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.

The Yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

In recent years both doctors and patients have become increasingly aware that many essential drugs may induce unfortunate side-effects in susceptible individuals. The kidney is the principal route of excretion for many of these substances and may as a result become involved in pathological processes. Developments in haemodialysis and haemo­ perfusion may be of value in increasing the rate of excretion of potentially toxic substances but it is essential that the advantages and disadvantages of these techniques are fully appreciated by all with an interest in clinical practice. This book details the recent advances in understanding of analgesic nephropathy, interstitial nephritis, elimination of poisons and drug monitoring. Each chapter has been written by a recognized expert in the field and provides information of relevance and practical import­ ance to the average clinician. The developments of the last decade have emphasized that drug toxicity is a subject on which all clinicians, but perhaps especially nephrologists, should be fully informed. ABOUT TH E EDITOR Professor Graeme R. D. Catto is Professor in Medicine and Thera­ peutics at the University of Aberdeen and Honorary Consultant Phy­ sician/Nephrologist to the Grampian Health Board. His current interest in transplant immunology was stimulated as a Harkness Fellow at Harvard Medicial School and the Peter Bent Brighton Hospital, Boston, USA. He is a member of many medical societies including the Association of Physicians of Great Britain and Ireland, the Renal Association and the Transplantation Society.

The migration of country dwellers towards the urban areas has been a most important factor in the development of the West European society in which we live today. Therefore, those engaged in research and policy making in the social field must acquire a better under­ standing of this form of migration if they are to deal effectively with a number of the problems confronting them. This is particularly true since the schemes for European integration which are going ahead so rapidly are sure to produce new patterns of migration. At a meeting of the F.A.O. Working Group on Rural Sociology held in Oslo in 1960, it was suggested that an inventory should be made of all available data and studies on the subject of migration in Europe. This suggestion was taken up by the European Society for Rural Sociology and the Netherlands Ministry of Social Work which, after deliberating together, decided to ask the Dutch expert, Dr. G. Beijer, to draw up such an inventory under their joint auspices. As secretary of the Research Group for European Migration Problems (R.E.M.P.), Dr. Beijer has been engaged for many years in an intensive study of the phenomenon of migration.

Jlmbulatory monitoring of signals, related to cardiovascular system per­ formances, is one of the biomedical technologies of wider interest. This interest is well documented by the literature, by the number of instruments available on the market and by the increasing diffusioo of this technique at routine clinical level. The wide distribution of ambulatory monitoring is however not yet well supported by commonly accepted criteria of clinical interpretation, by an assessment of the minimal requirements for instrumentation performances, or by indications of costjbenefit figures in relation to different situations. Several European centres have a recognized expertise and are well suited to the examinatioo of the problem of defining comnon guidelines and of making recommendations so as to stimulate an improvement of the clinical usage and of the performance of the instrumentation. The Biomedical Engineering Standing Group of the Committee for Medical and Public Health Research approved the organization of this \\Orksrop which had as its aims the assessment of the state-of-the-art of different aspects of ant>ulatory monitoring and the discussion within a group of experts of the feasibility and interest in promoting the coordination in Europe of these activities in the frame\\Ork of a'concerted action'. The \\Orkshop was held in Pisa over two full days (April 11-12, 1983). The participants were physicians and engineers, experts in their fields.

Following the long-standing tradition of the Seeheim-Workshops on Mössbauer Spectroscopy, 1978, 1983, 1988, 1994 always held in the same traditional place of the Lufthansa Training Center in Seeheim/Germany, the 5th workshop took place in 2002. The main topics covered are: -new technical developments such as the techniques of Nuclear Inelastic Scattering (NIS) and Nuclear Forward Scattering (NFS) of Synchrotron Radiation and their applications in studying lattice dynamics, magnetism and surface phenomena; -investigations of molecular structural and bonding properties in biomolecules and coordination compounds; -problems related to geochemistry and earth sciences; -applications of Mössbauer spectroscopy in molecular magnetism and photomagnetism.The book will serve as a source of great actuality to physicists, chemists and geoscientists employing the Mössbauer effect and other hyperfine interaction techniques to explore solid state properties of bulk materials as well as surface phenomena.

The PUILS series delivers up-to-date reviews of progress in Ultrafast Intense Laser Science, a newly emerging interdisciplinary research field spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed chapters authored by researchers at the forefront of each their own subfields of UILS. Every chapter begins with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, as well as graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries. This seventh volume covers a broad range of topics from this interdisciplinary research field, focusing on the ionization of atoms and molecules, ultrafast responses of protons and electrons within a molecule, molecular alignment, high-order harmonics and attosecond pulse generation, and acceleration of electrons and ions in laser plasmas.

Selenium has a long history of association with human health and disease. This essential trace element exerts its important biological role in selenoproteins.'Selenoproteins and Mimics'presents the latest developments in selenoproteins, their functional imitation by biomimetic chemistry and biology, and their relationship with human health and diseases. This book provides both the basic biology and biochemistry knowledge of selenoproteins, and sophisticated approaches for the development of new selenoprotein mimics. It's a valuable reference for researchers in biological technology, chemical syntheses, and medicine design. Junqiu Liu is a professor at the State Key Lab of Supramolecular Structure and Materials, Jilin University, China. Guimin Luo is a professor at the Key Lab of Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, China.Ying Mu is a professor at the State Key Lab of Industrial Control Technology, Zhejiang University, and guest professor at the Key Lab of Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, China.

Increasingly, medicine in general and nephrology specifically is based on clinical trials and verifiable presumption. Still, however, much of everyday clinical practice is the consensus of pundits and experts unable to validate their suggestions beyond personal bias. In this unique volume, several core beliefs in renal medicine are examined and challenged. Starting as assignments for nephrology fellows, this book grew out of surprising `revelations'indicating that `the emperor has no clothes'. The book is suitable as a stimulus for provocative discussions for nephrologists, internists, house staff, and medical students.

This book investigates the history of the post-war welfare state in Germany and its normative foundations, with special emphasis on constitutional issues. The author, formerly Director of the Max-Planck-Institute for Foreign and International Social Law, Munich, and President of the Max-Planck-Society, argues that social policy – not only in Germany – is about struggles over the “social”. The “social” is an open and changing concept that reflects the modern quest for equality, voiced in semantics like justice, participation, inclusion and security. The “social” and the “social state” (the German term for welfare state) are enshrined in the German Constitution of 1949, the Grundgesetz. The book sets out the phases of welfare state development in depth. Social policies are analyzed in view of wider contexts, especially the nation state, the rule of law (Rechtsstaat), federalism and democracy. The author emphasizes the dialectics between the national character of the welfare state and its manifold international references.

This book constitutes the refereed proceedings of the 24th International Conference on Architecture of Computing Systems, ARCS 2011, held in Lake Como, Italy, in February 2011. The 22 revised full papers presented in seven technical sessions were carefully reviewed and selected from 62 submissions. The papers are organized in topical sections on customization and application specific accelerators; multi/many-core architectures; adaptive system architectures; processor architectures; memory architectures optimization; organic and autonomic computing; network-on-chip architectures.

I feel very honored that I have been asked to write a Foreword to this book. The subject of the book – “Coupled cluster theory” – has been around for about half a century. The basic theory and explicit equations for closed-shell ground states were formulated before 1970. At the beginning of the seventies the rst ab initio calcu- tion were carried out. At that time speed and memory of computers were very limited compared to today's standards. Moreover, the size of one-electron bases employed was small, so that it was only possible to achieve an orientation in methodical aspects rather than to generate new signi cant results. Extensive use of the coupled-cluster method started at the beginning of the eighties. With the help of more powerful computers the results of coupled-cluster approaches started to yield more and more interesting results of relevance to the interpretation of experimental data. New ideas in methodology kept appearing and computer codes became more and more ef cient. This exciting situation continues to this very day. Remarkably enough, even the - quired equations can now be generated by a computer with the help of symbolic languages. The size of this monograph and the rich variety of articles it contains attests to the usefulness and viability of the couple-cluster formalism for the h- dling of many-electron correlation effects. This represents a vivid testimony of a tremendous work that has been accomplished in coupled-cluster methodology and its exploitation.

Advances in the Theory of Atomic and Molecular Systems, is a collection of contributions presenting recent theoretical and computational developments that provide new insights into the structure, properties, and behavior of a variety of atomic and molecular systems. This volume (subtitled: Conceptual and Computational Advances in Quantum Chemistry) focuses on electronic structure theory and its foundations. This volume is an invaluable resource for faculty, graduate students, and researchers interested in theoretical and computational chemistry and physics, physical chemistry and chemical physics, molecular spectroscopy, and related areas of science and engineering.

Advances in the Theory of Atomic and Molecular Systems, is a collection of contributions presenting recent theoretical and computational developments that provide new insights into the structure, properties, and behavior of a variety of atomic and molecular systems. This volume (subtitled “Dynamics, Spectroscopy, Clusters, and Nanostructures”) deals with the topics of “Quantum Dynamics and Spectroscopy”, “Complexes and Clusters”, and “Nanostructures and Complex Systems”. This volume is an invaluable resource for faculty, graduate students, and researchers interested in theoretical and computational chemistry and physics, physical chemistry and chemical physics, molecular spectroscopy, and related areas of science and engineering.

Non-malignant, or'benign', diseases can be successfully treated using ionizing rad- tion technologies. It was first proposed in 1898 by Sokoloff, who reported the analgesic effects of radiotherapy for painful rheumatoid arthritis. Since then, the use of these techniques for painful muscle-skeletal diseases has gained acceptance particularly in Europe but is still carried out actively in the United States. Non-malignant diseases that are amenable to radiotherapy can be classified as inflammatory, degenerative, hype- roliferative, functional, or other disorders. However, the topographic and morphologic considerations are more relevant. Even though radiation therapy for'benign'diseases has not been pursued actively since the 1950s, more recent interest has dictated that it can be a very effective treatment modality. The use of radiotherapy can be justified for invasive and aggressive growth such as that seen with desmoids, for cosmetic d- figurations and functional loss as seen with keloids or endocrine orbitopathy, or for life-threatening complications such as hepatic hemangiomas or juvenile angiofibromas that occur in children or adolescents. Many of the non-malignant diseases can have a major and lasting effect on quality of life by causing pain or other serious symptoms, particularly when other methods of treatment are unavailable, have failed, or may induce more side effects. It is not generally the first choice of therapy in these non-malignant diseases, but it is acceptable as defined. The book edited by Seegenschmiedt et al.

In December 2002, the world's first commercial magnetic levitation super-train went into operation in Shanghai. The train is held just above the rails by magnetic levitation (maglev) and can travel at a speed of 400 km/hr, completing the 30km journey from the city to the airport in minutes. Now consumers are enjoying 50 GB hard drives compared to 0.5 GB hard drives ten years ago. Achievements in magnetic materials research have made dreams of a few decades ago reality. The objective of the four volume reference, Handbook of Advanced Magnetic Materials, is to provide a comprehensive review of recent progress in magnetic materials research. Each chapter will have an introduction to give a clear definition of basic and important concepts of the topic. The details of the topic are then elucidated theoretically and experimentally. New ideas for further advancement are then discussed. Sufficient references are also included for those who wish to read the original work. In the last decade, one of the most significant thrust areas of materials research has been nanostructured magnetic materials. There are several critical sizes that control the behavior of a magnetic material, and size effects become especially critical when dimensions approach a few nanometers, where quantum phenomena appear. The first volume of the book, Nanostructured Advanced Magnetic Materials, has therefore been devoted to the recent development of nanostructured magnetic materials, emphasizing size effects. Our understanding of magnetism has advanced with the establishment of the theory of atomic magnetic moments and itinerant magnetism. Simulation is a powerful tool for exploration and explanation of properties of various magnetic materials. Simulation also provides insight for further development of new materials. Naturally, before any simulation can be started, a model must be constructed. This requires that the material bewell characterized. Therefore the second volume, Characterization and Simulation provides a comprehensive review of both experimental methods and simulation techniques for the characterization of magnetic materials. After an introduction, each section gives a detailed description of the method and the following sections provide examples and results of the method. Finally further development of the method will be discussed. The success of each type of magnetic material depends on its properties and cost which are directly related to its fabrication process. Processing of a material can be critical for development of artificial materials such as multilayer films, clusters, etc. Moreover, cost-effective processing usually determines whether a material can be commercialized. In recent years processing of materials has continuously evolved from improvement of traditional methods to more sophisticated and novel methods. The objective of the third volume, Processing of Advanced Magnetic Materials, is to provide a comprehensive review of recent developments in processing of advanced magnetic materials. Each chapter will have an introduction and a section to provide a detailed description of the processing method. The following sections give detailed descriptions of the processing, properties and applications of the relevant materials. Finally the potential and limitation of the processing method will be discussed. The properties of a magnetic material can be characterized by intrinsic properties such as anisotropy, saturation magnetization and extrinsic properties such as coercivity. The properties of a magnetic material can be affected by its chemical composition and processing route. With the continuous search for new materials and invention of new processing routes, magnetic properties of materials cover a wide spectrum of soft magnetic materials, hard magnetic materials, recording materials, sensor materials and others

Complicated many-particle problems abound in nature and in research alike. Plasma physics, for example, or statistical and condensed matter physics are all heavily dependent on efficient methods for solving such problems. Addressing graduate students and young researchers, this book presents an overview and introduction to state-of-the-art numerical methods for studying interacting classical and quantum many-particle systems. A broad range of techniques and algorithms are covered, and emphasis is placed on their implementation on modern high-performance computers.

This volume contains a representative selection of papers presented at the Tenth European Workshop on Quantum Systems in Chemistry and Physics (QSCP-X), held at Beït al-Hikma, seat of the Académie Tunisienne des Sciences, des Arts et des Lettres, in Carthage, Tunisia, September 1-7, 2005. About 90 scientists from 18 countries, half of them from North Africa, attended the meeting, which foc- sed on the evolution of current issues and problems in methods and applications. This workshop continued the series that was established by Roy McWeeny near Pisa (Italy), in April 1996, then continued on a yearly basis: Oxford (1997), Granada (1998), Paris (1999), Uppsala (2000), Sofia (2001), Bratislava (2002), Athens (2003), Grenoble (2004) …. The purpose of QSCP workshops is to bring together chemists and physicists with a common field of interest – the quantum mechanical theory of the many-body problem – and foster collaboration at the fundamental level of innovative theory and conceptual development. Quantum mechanics provides a theoretical foundation for our understanding of the str- ture and properties of atoms, molecules and the solid state in terms of their c- ponent particles, electrons and nuclei. The study of ‘Quantum Systems in Ch- istry and Physics'therefore underpins many of the emerging fields in science and technology: nanostructures, smart materials, drug design, and so on. The tenth workshop was the first in the series held outside Europe.

Globally, major network operators have incorporated network convergence into their strategy to grow service revenues and reduce capital and operating costs. Conv- gence occurs in applications (integrated messaging, voice over IP), in network control (portable numbers, SIP, mobile IP), in the transport layer, as well as in the access network. This convergence of networks means that various types of traffic flows, which have been carried by separate specialized networks, now share the resources of a single core IP-based network. In the access, the trends are towards fixed/wireless convergence as well as convergence of various wireless access technologies. Network convergence will be successful only if the quality of the individual s- vices is maintained in the new network environment without undue increased costs. The quality of service delivery is critically dependent on how network performance and availability, as experienced by the traffic flows, are managed. Managing traffic performance is a critical enabler for success. Reaching the desired performance levels requires adapting processes such as network planning, resource engineering, and network monitoring to the converged network milieu.

Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g., 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.