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This book provides updated knowledge on esophageal cancer diagnosis and treatment options. Esophageal cancer has become one of the cancers that can be detected early with the widespread use of endoscopy. Combinations of chemotherapy, radiotherapy and surgical treatment are used in the treatment. Depending on the planning of the surgery, operation is performed in two or three anatomical areas such as abdomen, thorax or cervical region. A good preoperative evaluation and postoperative follow-up and treatment are very important. In the book each stage of the disease is explained by different branches with a multidisciplinary approach. The book addresses professionals in oncology, radiology and surgery.

The book comprehensively discusses the surgical management of thyroid and parathyroid diseases. It includes separate chapters dedicated to preliminary evaluation enabling the reader to understand the decision making process. It discusses details of specific preparation for optimizing the conditions suitable for operation. It provides comprehensive description of the complex anatomy of neck and the variations supported by representative photographs. It includes appropriate flowcharts and videos of procedures for better understanding. The book describes the steps of all surgical procedures of thyroid and parathyroid glands emphasizing practical aspects of surgical techniques, supported by representative photographs. It covers chapters on the management of immediate and late complications, adjuvant treatment as well as treatment of late recurrences. Parathyroid diseases are not common but are known to induce disabling complications. The book also discusses various aspects of presentation and treatment of parathyroid diseases in detail. It stresses upon the role of specialists in different department in the postoperative management of thyroid cancers. The book meets the curriculum requirements of postgraduate students in specialties like general surgery, head and neck surgery, and endocrine surgery. It also serves as a reference for junior surgeons and enables them to prepare and perform proper thyroid surgeries as well provides guidance in the postoperative management of all thyroid diseases especially thyroid cancer.

Authored by over 500 internationally acclaimed expert editors and chapter authors from around the world. Completely updated and expanded with almost 40 new chapters. Significantly increased attention to the role of culture in all aspects of evaluation and care. New sections on Digital Mental Health Services and Technologies, Treatment Issues in Specific Populations and Settings, and on Prevention, Systems of Care, and Psychosocial Aspects of Treatment address key advances. This edition is the first comprehensive reference work to cover the entire field of psychiatry in an updateable format, ensuring access to state of the art information. Earlier editions were called “the best current textbook of psychiatry” by the New England Journal of Medicine, and “the gold standard” by the American Journal of Psychiatry. Tasman's Psychiatry, 5th Edition, builds on the initial vision in prior editions of approaching psychiatric evaluation and care from an integrative bio-psycho-social-cultural perspective. It is designed to be an essential and accessible reference for readers at any level of experience. This editorial approach encompasses the importance of the first encounter between patient and clinician, followed by the complex task of beginning to develop a therapeutic relationship and to develop and implement a treatment plan in collaboration with the patient. The importance of increasing attention to the role of culture and social determinants of mental health is reflected both in specific chapters and in components of many chapters throughout the book, especially in those pertaining to clinical evaluation, the therapeutic alliance, and treatment. The global scope of this edition is reflected throughout the book, including the section on psychiatric disorders where evaluation using both ICD 11 and DSM 5-TR is discussed. Most chapters are authored by experts from at least two different countries or continents, adding a critically important dimension which often is missing in major psychiatric textbooks. Tasman's Psychiatry, 5th Edition, is an essential reference for all medical professionals and students who need a trusted reference or learning tool for psychiatry, psychology, clinical research, social work, counseling, therapy, and all others.

This dictionary of toxicology provides curated and authentic information on the terminologies used with their description as per modern toxicology and associated declines. It aims to have a collection of over 3500 terminologies with their basic information and roles with relevance in toxicology and associated disciplines in alphabetical order. This book has a flow of information in alphabetical order starting from word A to Z. The contents cover all the possible facets of contemporary. It is an unparalleled reservoir of information with a practical understanding of the subject for undergraduates, post-graduate, doctorate and post-doctorate, researchers of toxicology, medical and dental sciences, veterinary sciences, pharmacy sciences, life sciences, forensic sciences, etc. Besides this, target readers would also be personnel working in academia, pharma industries, contract research organizations involved in regulatory studies, regulatory agencies and implementing agencies, and people having an interest in toxicological sciences.

Progress in understanding the association between the health benefits of foods, prevention of diseases and immunity enhancers has led researchers to focus on functional components of foods. Considerable evidence from epidemiological, clinical and laboratory studies have shown numerous functional components in foods which may enhance immunity and help in preventing various lifestyle diseases. This book specifically documents the therapeutic roles of functional foods and their ingredients and explains their bioavailability and accessibility. Functional Foods and Nutraceuticals: Chemistry, Health Benefits and the Way Forward addresses recent advances and future prospects of health benefits in different functional foods. It also provides a thorough understanding of the bioavailability of fortificants, their mechanisms of action, extraction techniques, effects of processing, nutraceutical and nanomaterial development and legislation. The book also delivers up-to-date information regarding the techniques of fortification, their bio-accessibility and trends along with the application of nanotechnology for the development of functional foods. This text serves as a multidisciplinary source appropriate for researchers from food science and technology, biotechnology, pharmaceutical and allied sciences, Provides recent advances in extraction of phytochemicalsExplores the role of Nutraceuticals as immunity boosters and in combatting lifestyle diseases

The beginning of the 2020's witnessed dozens of commercial astronauts fly to space on a variety of vehicles. These spacecraft included SpaceX's Crew Dragon, which supported the Inspiration4 and Axiom Space missions, Virgin Galactic's SpaceShipTwo, which supported several suborbital science flights, and Blue Origin's New Shepard spacecraft, which not only flew celebrities but also its fair share of commercial astronauts. The story of this new breed of spacefarer has only just begun. As evidenced by these missions, commercial spaceflight has grown beyond passengers simply traveling to space just for the ride. With orbital flights involving commercial astronauts staying in space for several days and weeks, companies such as Sierra Space, Axiom Space and Blue Origin are preparing for the next steps in commercial space travel which include the construction of orbiting habitats. But how will the opportunities for commercial astronauts develop, how will they be trained, and will this new group of astronauts evolve? This book describes how the commercial spaceflight industry is evolving, how it will continue to evolve as barriers to entry are reduced, competition grows, and costs are lowered, and how, because of these efforts, opportunities for commercial astronauts will increase.

Older adults represent the most rapidly growing demographic in the U.S. and in many developed countries around the world. The field of geriatric medicine is still relatively young, and is only recently seeing a significant increase in peer reviewed literature. Medicare and Medicaid expenditures related to older adults are nearly a trillion dollars/year in the US. How our healthcare system cares for older adults, and how those older adults navigate an increasingly complex system, is of the utmost importance. According to the Institute of Medicine, physicians and other healthcare professionals receive an inadequate amount of training in geriatric medicine. Geriatric medicine is based on the concept of delivering person centered care with a focus on function and quality of life. It is essential that physicians, nurse practitioners, physician assistants, pharmacists, social workers and other health care professionals all be knowledgeable about thegeriatric approach to care.Geriatric medicine varies from most other fields in medicine. While many specialties function on the basis of evidence-based literature, geriatricians and other clinicians caring for older adults must integrate relatively limited evidence with variable physiological changes and complex psychosocial determinants. Geriatricians are used to caring for 90 year olds with multiple chronic illnesses. Their variable physiology leads to uncertain responses to pharmacotherapy, and their personal goals and wishes need to be incorporated into any plan of care. Practicing geriatric medicine requires the ability to see patterns. But it goes one step further, as the rules are constantly in flux. Every patient is an individual with particular needs and goals. In order to provide true person centered care to older adults, one has to incorporate these factors into the decision making process. The proposed handbookis designed to present a comprehensive and state-of the-art update that incorporates existing literature with clinical experience. Basic science and the physiology of aging create a background, but are not the main focus. This is because every chapter has been written through the lens of “person centered care.” This book is about focusing on what matters to the person, and how that is not always about pathology and physiology. The reader generally will not find simple solutions to symptoms, diseases and syndromes. In fact, the key to caring for geriatric patients is the ability to think both critically and divergently at the same time. Geriatrics encompasses multiple disciplines and spans all of the subspecialties. It requires knowledge of working within an interdisciplinary team. It requires an appreciation of how quality of life varies with each individual and creates treatment and care plans that also vary. And most of all, it requires a firm commitment to first learning who the person is so that all of the necessary data can be analyzed and integrated into a true person centered plan of care. This book aims to serve as an unparalleled resource for meeting these challenges. Updated and revised from the previous edition, this text features over 40 new peer-reviewed chapters, new references, and a wide array of useful new tools that are updated on a regular basis by interdisciplinary and interprofessional experts in geriatric medicine.

This textbook assembles the wealth of clinical experiences across multiple medical specialties and offers clinical pearls that will result in better patient care and are highly relevant to daily practice. This book has been compiled by many renowned clinicians, medical educators, and researchers who are experts in their respective disciplines across Australia, New Zealand and the United States. The chapters provide multiple cases in vignette format, illustrating the clinical pearls, and finish with a discussion and practical tips. This format will allow the reader to easily understand how the clinical pearls can be applied in clinical practice. Evidence-based medicine and clinical guidelines help us choose the best management and treatment options for our patients. However, many questions in medicine have not been researched or are not readily amenable to research. In fact, there is more to the art and mastery of practicing clinical medicine than the evidence-based approach. Information gained over years of reflective clinical practice and cumulative wisdom adds value to evidence-based clinical medicine. With experience and clinical gestalt playing an equal, if not a more prominent role than what evidence can offer in a physician's approach to solving clinical problems, this book offers unique perspectives on the practice of medicine.Beyond Evidence-Based Medicine: Clinical Pearls from Experienced Physicians will be valuable for later-year medical students, medical educators, doctors in training, and consultant physicians alike. Aiming to improve the day-to-day medical practices of professionals, the Editors have invited experienced physicians to share their expertise culminating in a unique book with broad applicability and appeal.

The second edition of this essential work presents how to diagnose, treat and develop an appropriate management plan for patients with chronic kidney disease (CKD). Significantly updated chapters cover the fundamental sciences associated with CKD, its clinical assessment, evaluation, management of risk factors, along with cardiovascular disease in the context of CKD. Detailed insight is provided on how to assess for and manage a variety of CKD complications and special circumstances in CKD patients. The path to renal replacement therapy is also thoroughly described. New topics featured include associated rheumatic and electrolyte disorders. Furthermore, diagnostic and therapeutic approaches are presented according to the latest staging system for CKD, with patient care being discussed separately for each disease stage. The book also recognizes the needs of busy clinicians by including helpful boxes summarizing the evidence on diagnostic and therapeutic issues and practice pearls based upon the latest guidelines.Management of Chronic Kidney Disease: A Clinician's Guide is a comprehensive practically applicable guide to the management of patients with CKD. Its didactic features enable the reader to quickly identify the key points covered and disseminate the information they require, making it a valuable resource for all practicing and trainee medical practitioners who encounter these patients..

This book aims to create a bedside resource for physiotherapists and exercise specialists dealing with a defined movement problem and plan and apply functional therapeutic exercises that can be diversified for the patient.For physiotherapists, exercise is undoubtedly the greatest weapon in treating diseases and improving health. Functional exercise approaches aim to improve physical performance and activities of daily life by adapting exercise prescriptions to the movements that the individual makes frequently in daily life or in sports. The daily activities vary from person to person due to our different habits and lifestyles. Therefore, functional exercise training should be designed differently for everyone. When designing a functional exercise prescription, physiotherapists should consider previous injuries or surgeries that may limit physical activity, as well as general health, muscular strength, endurance and strength, aerobic capacity, and activities that the patient should do in daily life. The functional exercise prescription should be customized considering both the fragility of the patient due to injury or surgery, and the strengths of the patient such as sports/exercise history and healthy eating habits.The book consists of four different parts: the concepts of exercise and physical activity, exercise types, and prescriptions are presented in the first part. The second part is dedicated to musculoskeletal anatomy specific to functional exercise, while the third part explores functional exercise-specific systems physiology and illustrates the compliance of each system with exercise, basic exercise physiology information, and the evaluation and treatment of individuals who are healthy and have diseases that affect each system. Finally, the book has the part of a special topic dealing with nutrition/nutritional supplements affecting recovery in the rehabilitation process after injury or surgery and supporting physical performance duringexercise/sports. This book will be of interest to physiotherapists as well as health and sports professionals.

The second edition of this critical text features heavily revised chapters detailing how to approach the anesthetic and perioperative management of adult and pediatric patients with congenital heart disease. Initially, a broad overview of relevant concepts in pediatric cardiovascular embryology, physiology, and pharmacology is provided. Subsequently, relevant diagnostic approaches including the use of three-dimensional modeling in surgical planning and preoperative considerations are described. The intraoperative management of a wide range of specific lesions is discussed, with full descriptions of anesthesia plans and the appropriate diagnostic methods and surgical interventions. New topics detailed include the use of hybrid techniques and applications of electrophysiology in patients with congenital heart disease. Postoperative care and potential future approaches are also addressed.Congenital Heart Disease in Pediatric and Adult Patients: Anesthetic and Perioperative Management provide a comprehensive, up-to-date overview of the care of the pediatric patient undergoing cardiac surgery and anesthesia. It is therefore of interest to all practicing and trainee medical professionals who encounter these patients in their day-to-day practice.

This book is an inclusive collection of topics on research on UVB for its impact on plants with a focus on its use as an emerging technology for crop growth and protection. This book covers role of UV-B on biological systems, and its transformation from generic stressor to specific regulator. It also explores the past research in UVB studies and the changing mind-sets regarding UV-B in recent time with respect to the plant growth. It also explores the discovery of specific UV-B photoreceptor, UVR8 and UVR8 mediated plants responses. This book is of interest to teachers, researchers, agriculture scientists and plant physiologists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences

This open access book focuses on of the impact of endocrine disrupting chemicals (EDCs) on human reproduction. It comprehensively discusses the three most important topics in the field: the basic biology of EDCs; the effects of EDCs on human reproduction and human reproductive systems; and potential interventions and practical advice for dealing with the problems caused by EDCs.Presenting a translational approach to endocrine disrupting chemicals research, spanning both basic biology and clinical applications, the book provides a critical link between laboratory investigations and clinical practice. Written by international experts in the field, it is a valuable reference resource for gynaecologists, obstetricians, endocrinologists and experts in reproductive medicine, and a useful tool for anyone interested in the impact of the environment on human reproduction.

This book gathers the latest advances, innovations, and applications in the field of effective methods of calculation, resource-saving technologies, and advanced materials in civil and environmental engineering, as presented by leading international researchers and engineers at the XVIII International Scientific Conference Current Issues of Civil and Environmental Engineering “Lviv- Košice – Rzeszów”, held in Rzeszów, Poland, on September 6–8, 2023. It covers highly diverse topics, including structural shaping and optimization; aspects of structural behavior and modeling; advanced analysis methods; experimental tests and numerical simulations; design codes, in particular Eurocodes and other national and regional limit state codes; and highway and bridges engineering. It also discusses modern architectural and structural solutions; innovative materials and products; durability and maintenance; fabrication and erection; sustainability in construction; renewable energy sources; heat, gas, and water supply; ventilation and air-conditioning; ecological and energy-saving technologies, modern water purification, and treatment technologies; and the protection of water ecosystems. This book, which was selected by means of a rigorous international peer-review process, highlights numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaborations.

The textbook is intended for the undergraduate and postgraduate students of chemistry, biology and medicine. It covers diverse topics of biophysical chemistry ranging from the structure of cells, lipids, and proteins to nonequilibrium thermodynamics, enzyme catalysis, and fast reaction kinetics. The book discusses the fundamental structural concepts in the first part and provides a systematic account of different experimental techniques such as chromatography, electrophoresis, and gel filtration that are extensively employed in biochemical research in the second part. It also includes typical applications using NMR, ESR, and SPR to comprehend the power of spectroscopic tools in biophysical chemistry. This textbook also deals with advanced topics of entropy production and biosensors. It consists of a large number of schematic diagrams as well as tabular compilations of kinetic, electrochemical, and thermochemical data. It includes multiple-choice questions, numerical examples, and descriptive questions in various chapters to aid self-learning among students. In view of the diverse coverage of topics, this textbook is a valuable asset to undergraduate and postgraduate students. It is also a useful reference for researchers and professionals in chemistry, biology, and medicine.

This new edition is a high-yield review that is an ideal study guide for the ENT in-service and board exams. While other review guides are low yield, this is quick, concise, and easy-to-use, providing everything you need to know in a easy to digest format. ENT Board Prep offers review on sections such as cancer, ear, sinus, plastics, sleep, and laryngology, as well as case studies useful for studying for the oral board exams. Written and edited by leaders in the field, this book aims to serve future residents and fellows in those crucial weeks leading up to the ENT board exam. The new edition includes fully updated sections, illustrations, and board review material. Specific updates include head and neck cancer staging and therapies, sleep apnea therapy advances, and virtual reality planning for skull base surgery. This is an ideal guide for ENT specialists, and specifically those studying for board exams.

Reducing the amount of meat in our diet would have major environmental benefits, including reducing greenhouse gas emissions, pollution, deforestation, and biodiversity loss. Moreover, it would have wide-ranging ethical benefits by decreasing the huge number of livestock animals confined and killed each year for food. For consumers, there may also be health benefits from a meat-less diet, provided it was carefully planned. Advances in modern science and technology, including plant-based, microbial, lab-grown, and insect meats, are revolutionizing the food industry and making it easier for consumers worldwide to maintain a meat-less diet. In Meat Less: The Next Food Revolution I outline my own journey as a food scientist who became a vegetarian in solidarity with my daughter. In writing this book I take the viewpoint that there are no easy answers and that everyone must make the decision to eat meat or not based on their own values. The first chapters examine the impact of meat consumption on the environment, human health, and animal welfare, including the important questions of how much does eating meat really contribute to greenhouse gas emissions, pollution, and biodiversity loss, what are the ethical implications of raising and killing animals for food, and the impact of reducing meat consumption on human nutrition and health. I then discuss some of the new technologies that are being developed to create alternatives to meat, including plant-based meat, cultured (lab-grown) meat, microbial meat, and insect meat. I present the science behind these new technologies and their potential for making a difference to climate change and human health. In the final chapter, I discuss why I remain a vegetarian and have decided to dedicate the rest of my scientific career to finding sustainable and healthy alternatives to meat, presenting my vision of the human diet in 2050.

This volume discusses: (1) the treatment of hazardous sludge, wastewater, textile effluent, contaminated groundwater, laboratory waste, toxic dye, heavy metals, acid mine drainage and palm oil effluent; (2) the technologies of stabilization, solidification, natural coagulation-flocculation, river catchment control and mitigation, dredging and mining operations, and (3) the management of acid mines, laboratories, nano pollutants and plant effluents.

This book offers a comprehensive collection of cutting-edge research on feed additives for a sustainable animal production, including insects and aquaculture. In five clearly structured sections, the sources of feed additives, details on their biochemistry, feed security as well as specific applications for individual farm animal species, livestock health and product characteristics (meat, milk and eggs) find attention. International expert authors provide a full description on the use of aromatic plants, extracts and essential oils as feed additives alone or in combination with functional feeds of different categories. Readers will explore the potential of feed additives to tackle environmental issues. Practical examples include the use of local feedstuffs in combination with herbal additives and enzymes. Emphasis is placed on the consequences of using local feed sources versus imported feedstuffs on global warming potential, primary energy use, nutrient excretion and the feedadditive influence on lessening the pollution from animal operations. The results presented will support realization of the Sustainable Development Goals, in particular SDG 12 which stands for Responsible Consumption and Production worldwide. The use of novel and different feed additives can be an important tool to enhance sustainability, support productivity, and match increased food demands around the globe. Animal production depends on feed efficiency to sustain growth and profitability. Along these lines, the present volume is an essential reading for all future-oriented veterinarians, animal nutritionists, agricultural scientists, and moreover the feed, food and plant industry.

This textbook for undergraduate students aims at providing an in-depth understanding of the relationship between diet, nutrients, health, diseases, and drug treatment. The book presents a comprehensive but detailed view of the field of Nutritional Biochemistry; balancing the historical with contemporary findings, the descriptive with the experimental, structure with function as well as the mechanistic and the clinical aspects of any particular nutrient. Though the major emphasis of the book is on Nutritional Biochemistry, the book also attempts to provide an insight into other related and relevant areas. Amongst the topics that are covered are: nutraceuticals, food, and nutrient interactions; the newly emerging field of the human microbiome, its interdependence on diet and human health as well as the public health concerns which is a looming burden of non-communicable diseases. Each chapter begins with an insight into the history of discovery and structure of the nutrient, its absorption, and metabolism, physiological functions, ending with diseases associated with nutrient deficiency/toxicity along with a clinical perspective. Apart from this, the book emphasizes the biochemical basis of physiological responses and correlates the same with symptoms identifying the pathophysiology. This textbook caters to students of undergraduate courses like Biochemistry, Biomedical Sciences, Biological Sciences, Life Sciences, Home Science; Nutrition and Dietetics, Clinical Nutrition and Dietetics, and Nursing. ​

This book provides the reader with an updated comprehensive view of the rapidly developing and fascinating field of fluorescence spectroscopy and microscopy. In recent years, fluorescence spectroscopy and microscopy have experienced rapid technological development, which has enabled the detection and monitoring of single molecules with high spatial and temporal resolution. Thanks to these developments, fluorescence has become an even more popular method in physical, biological and related fields. This book guides the reader through both basic and advanced fluorescence spectroscopy and microscopy approaches with a focus on their applications in membrane and protein biophysics. Each of the four parts: A - Fluorescence Spectroscopy, B - Fluorescence Microscopy, C - Applications of Fluorescence Spectroscopy and Microscopy to biological membranes and D - Applications of Fluorescence Spectroscopy to protein studies are written by experts within the field. The book isintended for both complete beginners who want to quickly orient themselves in the large number of existing fluorescent methods, as well as for advanced readers who are interested in particular methods and their proper use. Chapter “Dynamics and Hydration of Proteins Viewed by Fluorescence Methods: Investigations for Protein Engineering and Synthetic Biology” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This fourth edition comprehensively covers peritoneal dialysis. Peritoneal dialysis represents an intracorporeal technique for blood purification. This unique dialysis system represents one of many human attempts to manipulate nature for sustenance of life. Recent advances have focused on further improvement of the technique, which are covered in full throughout the text. During the past decade, the time during which this therapy has been increasingly utilized, the 3rd Edition has continued to be recognized as the major source of the discipline's base knowledge. The evolution of this text to its newest edition parallels the growth of peritoneal dialysis from Continuous Ambulatory Peritoneal Dialysis in the eighties to the current therapy that encompasses manual and automated therapies with full emphasis on adequacy of dialysis dose. Nolph and Gokal's Textbook of Peritoneal Dialysis is the most in-depth publication on this dialysis technique and is an ideal resource for all clinicians practicing peritoneal dialysis.

The book covers all aspects of anesthesia in newborns, neonates (under 28 days) and premature babies. These patients are highly vulnerable, very small in size and weight, at very high risk, and have high mortality and morbidity, which gets further aggravated by the medical diseases and congenital abnormalities these babies may suffer from. The book provides knowledge that equips the anesthetists with the regional techniques used to provide both anesthesia and analgesia, including information about the drugs used, skills in providing neuraxial blocks, nerve blocks, etc., complications thereof and the specially designed equipment for these patients (IV cannula, endotracheal tubes, ryles tubes, laryngoscopes, SpO2 probes, monitors, incubators, warmers and heaters, mattresses, OT tables). The book covers the pharmacology of drugs used, the effect of anesthetic drugs on the developing brain, pulmonary physiology, airway assessment and management, ventilation modes, getting IV and arterial access, preoperative workup, anesthetic management, and postoperative care. It includes care and concerns from both surgical and anesthesia aspects. It covers all the common surgical diseases along with some rare cases such as oncological concerns, palliative care, ethical concerns and pain management. The book also discusses the role and use of ultrasound. The chapter on anesthesia for short procedures includes common birth and neonatal care injuries. The book contains chapters on fluid therapy, blood and blood product transfusion guidelines and indications, resuscitation of a newborn and neonate, and neonatal rehabilitation to improve neonatal outcomes. It contains a dedicated chapter on why these babies are at a high risk of morbidity and mortality and contributing maternal factors. All the chapters are written by experts in their fields with vast experience. This book bridges the gap in the knowledge of an anesthesiologist between anesthesia for children and adults and newborns, neonates and preterm babies.

The book surveys common complications in the procedure of dialysis, including those due to inherent complexities related to advanced kidney disease and the disorders that cause it. The chapters review the pathophysiology or mechanisms of each complication, how it can be recognized and managed, and more importantly how it can be prevented. The text also addresses whether the complication is due to conditions associated with kidney disease, such as frailty and muscle weakness, or whether the complication occurs as the consequence of treatment. The complications addressed include infections, AV access and catheter issues, problems in procedure, coagulation-related disorders, and falls, among others. Written by experienced dialysis experts, this book is a resource and learning tool for anyone involved in caring for patients undergoing renal replacement therapy.

This is the second and fully updated edition of the successful volume on intestinal failure in adults and children. The book provides a comprehensive coverage of all aspects of intestinal failure: from acute and chronic intestinal failure management and treatment, to outcomes, consequences and problems of treatment. In addition, 20 new chapters have been added, covering acute and chronic pancreatitis, critical care and abdominal pain among other topics. Each of the chapters contains a section with top tips on the topic, summarizing the essential take-home messages. Highly educational, this book is a must have for gastroenterologists but is of use for all members of a hospital nutrition support team including nurses, dietitians and pharmacists, whom it will serve as a practical guide for management of intestinal failure both in the hospital and in an outpatient setting. Written by a multidisciplinary author team, this book brings this important subject to a wide readership. With extensive referencing the book provides a detailed overview of the topic, discussing the latest research in the subject and how this relates to current clinical practice and potential future treatments.

This textbook presents the full spectrum of musculoskeletal disorders, covering their definitions, epidemiology, physiopathology, diagnosis and treatment. Ranging from fractures, through infections and tumors, to dystrophies, the authors provide an up-to-date overview of the methodologies used in the diagnosis and management of common orthopedic conditions.The content is divided into several sections: disorders are grouped by typology in the opening section, and subsequently grouped anatomically, offering readers a quick and convenient reference guide to fundamental concepts in everyday orthopedic care.Written by an international panel of experts, it offers a valuable asset for students and residents approaching the study of orthopedics, pediatric orthopedics, sports medicine, rheumatology and rehabilitation. It further can be of interest also for practicing orthopedic surgeons, as well as nurses, physical therapists and athletictrainers.

This book summarizes the broad and rapidly evolving field of geriatric pharmacotherapy, which is becoming increasingly relevant for practicing physicians who care and prescribe medications for older patients. Around the globe, ageing populations are associated with an increased prevalence of chronic diseases. Older adults are often affected by multimorbidity, i.e., suffer from more than one chronic disease. The main consequence of multimorbidity is polypharmacy, which is commonly defined as the regular use of five or more medicines. Polypharmacy has now reached epidemic proportions in our societies, and is associated with an increased risk of drug-drug interactions, drug-disease interactions and adverse drug reactions. The management of polypharmacy in older patients with complex multimorbidity poses several challenges and needs to be based on specific knowledge and prescribing expertise.The aim of this book is to provide a comprehensive update on thefield, and to share the expertise needed to optimize the management of pharmacotherapy in older patients.

This excellently illustrated book, now in a revised and extended second edition, not only describes the radiological findings which can be found in child abuse cases but also places them in a forensic perspective – a crucial aspect often underrepresented in radiological books. The aim is to enable physicians involved in non-accidental trauma cases to interpret radiological findings in light of the forensic circumstances under which these findings have arisen. Accordingly, the book will assist in determining whether a fracture is accidental or the result of abuse. Fractures are addressed not only by anatomical location but also by trauma mechanism, with careful attention to evidence regarding the reported mechanism and the clinical outcome. Drawing on the latest literature, the authors explain whether a particular form of trauma can cause a particular injury and identify where the reader can find the supporting evidence. The book will be essential reading and a superb reference for all who are involved in the diagnosis of child abuse, including pediatricians, emergency room physicians, and radiologists. It will also be a valuable resource for legal medicine physicians, lawyers, and judges.

This book is a quick-reference guide to osteoporosis that equips the reader with easy-to-follow guidelines for lifelong maintenance of skeletal structure and function, with an emphasis on the diagnosis, therapy and prevention of osteoporosis. Organized into 20 chapters it provides a concise, yet complete evidence-based overview of osteoporosis prevention and management “from paediatrics to geriatrics”. This practical guide is aimed at raising awareness and educate physicians across disciplines about this preventable, treatable and now even curable disease and emphasizing how every doctor can contribute to stop the “osteoporosis treatment gap” recognized over the last ten years. Covering bone biology, pathophysiology, secondary and drug-induced osteoporosis, as well as risk factors, diagnostic measurements, treatment and monitoring strategies, new drugs, management of osteoporotic fractures, and much more, this book is a must-have for all those involved in the prevention and care of this global threat.

This book focuses on the management strategies of complex conditions of frail pediatric patients. The clinical condition of frailty is usually seen as the physiological and multidimensional decline of organ systems related to age: paradoxically, a frailty condition can also occur in children as a disability resulting from various congenital or acquired diseases. The fragile patients are more vulnerable to developing severe clinical events and often need surgical interventions. Moreover, those patients have significant morbidity and lower quality of life. The improvement in managing fragile patients has improved their life expectancy, but in most health care systems, the passage from childhood to adulthood is a critical point for the lack of medical figures able to provide the continuity of care. The book aims to provide guidance for dealing with medical and surgical emergencies and to develop short and long-term treatment strategies, and will provide an analysis of the different and the most innovative techniques. This book will be an unvaluable tool for Pediatric surgeons, Anesthesiologists, Critical Care Physicians, Hospital and family Pediatricians, nurses, Physiotherapists and Psychologists.

This book covers the diverse complications noted in medical, radiation, surgical and pediatric oncology. The various chapters target the common complications that the clinicians encompass in the practice day in and day out. It assists in identifying/ stratification the patients at higher risk of complications so that they may be offered alternative options or get a de-intensified treatment. It also covers the determinants/predictors-clinical alarm signs or the safety flags associated with specific high-risk procedures. The chapters are designed to offer a preventive strategy to reduce the incidence of complications, such as the early introduction of corrective measures, supportive care measures, and refining the procedure in case of anticipated risk of certain complications. The manual addresses the management strategies of complications and will propose a formulation of treatment policies as per the severity of the disease. Manual includes discussion on evidence-based treatment strategies and recent advances in management. It consists of a summarized algorithm on leadership based on guidelines (if available). Since it is a multimodality approach-based book, it is an exciting read to the students and the practitioners of medical, surgical, radiation, and nursing. It addresses the disclosure of complications and the medicolegally correct way of taking consent for complications.

This book presents mercury toxicity with respect to remediation and health issues. It covers sources of mercury contamination, its impact on human health, and prospective remediation by both bioremediation and phytoremediation with the application of recent advanced techniques such as genetic engineering and nanotechnology.Both anthropogenic activities and natural processes cause the release of mercury into different spheres of the environment resulting in severe adverse impacts. Increased anthropogenic discharge of mercury leads to disturbance in its natural biogeochemical cycle, which results in unenviable diseases and hazardous health effects. Mercury pollution is responsible for causing neurobehavioral, kidney, heart, gastrointestinal, liver, and other diseases. Many published works about the impact of mercury on health are also available worldwide; however, there is no complete understanding available on toxicological studies of mercury that covers the broader spectrum of findings ranging from sources of exposure to mercury toxicity to its remediation strategies.This book brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by mercury contamination. The book also proposes solutions to contamination through multi-disciplinary approaches.The book contains three sections. The first part describes the different sources and distribution of mercury in soil and plant ecosystems. The second part explains the health risks linked to mercury toxicity. The third part addresses sustainable mercury toxicity mitigation strategies and the potential applications of recent technology in providing solutions. This book is a valuable resource to students, academics, researchers, and environmental professionals working in the field of mercury contamination.

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers.Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented.This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

Now in a revised and expanded third edition, the aims of The Active Female are threefold: first, to increase the awareness of wellness and fitness issues for active females and their family members; second, to provide an avenue for medical practitioners, allied health professionals, health educators/providers, and certified individuals in sports medicine/athletics to gain critical, updated knowledge of a field specific to active females; and third, to introduce the concept of obesity as a growing health concern even for normal weight individuals. Part I of the book offers a foundation for understanding the interrelationships between female physiology, body image and other psychological issues, the female reproductive cycle, and the musculoskeletal anatomy and physiology of females that makes their health risks and concerns unique. In Part II, the concepts of eating disorders from a global perspective and the health disparities and inequities in women's health are discussed in detail. Part III describes the prevention and management of common musculoskeletal injuries in active females across the lifespan, including the management of osteoporosis. Appropriate exercise and nutritional guidelines and recommendations for active females are discussed in detail in Parts IV and V. Part VI is a new addition to the book and highlights the obesity epidemic and co-morbid diseases associated with obesity even for normal weight obese individuals. Each chapter is bookended by clear learning objectives and review questions for additional pedagogical appeal. An invaluable addition to the literature, The Active Female: Health Issues throughout the Lifespan, 3e will be of great interest to all clinicians and allied health care professionals concerned with women's health and related issues, from sports medicine and family practitioners to endocrinologists, gynecologists and orthopedic surgeons.

The latest edition of this essential text provides a comprehensive overview of the unique pediatric issues of inflammatory bowel disease. Through new and thoroughly revised chapters, the volume features updates on all aspects of etiology, diagnosis, and treatment, with an emphasis on recent understanding of pharmacokinetics and the utilization of cutting edge therapeutic monitoring to maximize efficacy of medical management. The new edition also highlights newer, recently approved drugs, emerging therapies, and the most recent recommendations regarding post-operative management for patients who ultimately require surgery. Written by experts in the field, Pediatric Inflammatory Bowel Disease, Fourth Edition is a valuable resource for both pediatric and adult gastroenterologists involved in the care of children with inflammatory bowel disease.

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues. The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduate students, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.

Bioactive ingredients, including both bioactive compounds and bioactive live organisms, are present in small amounts in natural sources such as fruits and vegetables. These ingredients have been continuously investigated during the last few decades and the epidemiological data suggest that their intake is associated with significant decreased risk of various disorders and chronic diseases owing to their anti-oxidant, anti-bacterial and anti-inflammatory qualities. Some of these natural ingredients such as catechins, curcumin, resveratrol, oleuropein, quercetin, rutin, hesperidin, sulforaphane, ellagic acid, and anthocyanins, have been studied as factors with possible direct or indirect effect on specific molecular pathways which are playing vital roles in the association with the pathophysiology of the chronic diseases such as cancer. In light of this, natural foods and food-derived products rich in bioactives have received recent growing attention. It has been reported that frequent consumption of fruits, vegetables, and their associated natural products have many health-promoting benefits that protect against degenerative illnesses including heart disease, arthritis, cancer, immune system decline, brain dysfunction, inflammation and cataracts. Functional foods and medicinal supplements containing encapsulated bioactive materials will be the future of new emerging products in the food and pharma industries. Such products present therapeutical and medicinal properties that can prevent and/or cure specific chronic diseases and disorders. Handbook Of Bioactive Ingredients provides a systematic overview of different food bioactive ingredients describing their chemistry, structure, functionality, safety/toxicity, oral delivery and their applications in functional foods. Detailed chapters will describe various bioactive ingredients including polyphenolic compounds such as phenolic acids, flavonoids and anthocyanins, carotenoids, sterols such as non-oxygenated carotenoids, xanthophylls and phytosterols, bioactive peptides such as marine bioactive peptides, animal bioactive peptides, plant bioactive peptides, microbial bioactive peptides, essential fatty acids like fish and marine oils and plant oils, live organisms like probiotics and yeasts, essential oils and oleoresins like monoterpens, sequiterpens and oleoresins, vitamins and minerals including liposoluble vitamins, hydrosoluble vitamins and trace minerals), and other bioactive compounds including prebiotics, oligosaccharides, dietary fibers and beta-glucan. This book is the first comprehensive collection of scientific evidence form published literature on natural bioactive ingredients.

This book provides a comprehensive and up-to-date overview of all the upper and lower airways disorders and broadens their understanding by combining ENT and pulmonology disciplines. The volume opens with a general overview on the airways, before describing symptoms, infections and allergies. In addition to the upper airway tumors, specific lower, and upper airway disorders, other topics addressed by the book are pediatric lower airway disorders, sleep related breathing disorders, trauma, reflux, and interventional pulmonology. The closing part discusses the airway protection and includes a chapter on gender and pulmonary diseases. Written by experts in the fields, the book is a valuable resource for both specialists and trainees in ENT, pulmonology, and pediatrics.

The book covers all uncommon ulcers of the extremities which remain a difficult diagnosis for clinicians most of the times. A variety of causes like metabolic, infective, rheumatoid, drug induced or inflammation may lead to ulcerations. Diagnosis of these ulceration is difficult as these diseases are systemic, and treatment is carried out by physicians but ulcers are managed by the surgeons. Any lacunae or gap in assessment or work-up may lead to failure in diagnosis and increased morbidity. This book provides a systematic and step wise approach to the differential diagnosis of every possible uncommon ulcers in the extremities with detailed work-up, flow chart and summary. The book is systematically designed to serve the purpose of covering every possible uncommon ulcer with elaborate clinical presentationin the background of etiology and pathogenesis with risk factors included investigations and treatment with medical, surgical options well discussed as per the requirement. The book includes illustrations, flow diagrams, images, charts and tables. The book provides every information clinically relevant and useful about the uncommon ulcers and serves as a complete resource for general surgeons, vascular surgeons, plastic surgeons, orthopedic surgeons, surgical trainees, family physicians. It may also be useful for podiatrists, phlebologists, radiologists, cardiologists, nephrologists, neurologists, wound care nurses, physicians and primary care workers.

This edited book is collection of information on molecular interventions needed for climate-resilient forage crops. The main focus is to address the gap in the advanced scientific knowledge for the forage species. Agriculture is extremely vulnerable to climate, and even slight change in climatic factors such as temperature causes tremendous losses in yield potential. Forage crops are crucial in global food security and environmental sustainability and face several environmental challenges in field conditions. However, the research on forage crops is far-off compared to agricultural crops and causes a substantial gap in forage demand and productivity. Further, this gap is directly associated with animal health, reproduction, and productivity. Abiotic stresses mainly affect the plant's crucial processes, ultimately reducing the final yield. The problem of abiotic stresses is more frequent in forage crops as they are growing and cultivated in less productive soil and harsh conditions. This book discusses current aspects of crucial physiological, biochemical and molecular processes in forage crops, which are essential for forage crops improvement. The text's major focus is on the advanced technologies and approaches such as seed priming, bio-fortification, breeding, omics, transgenic and bioengineering of metabolic pathways in unique ways, which helps us develop innovative solutions for forage crops. This book covers all the crucial advance technologies, which help mitigate the abiotic stresses in forage crops. We believe that this book will initiate and introduce the readers to state-of-the-art developments and unique in this field of study. This book is of interest to teachers, researchers, climate change scientists, capacity builders, and policymakers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists and policymakers will also find this a worthwhile read.

In this book, Donald Rapp looks at human missions to Mars from a technological perspective. He divides the mission into a number of stages: Earth's surface to low-Earth orbit (LEO); departing from LEO toward Mars; Mars orbit insertion and entry, descent and landing; ascent from Mars; trans-Earth injection from Mars orbit and Earth return.A mission to send humans to explore the surface of Mars has been the ultimate goal of planetary exploration since the 1950s, when von Braun conjectured a flotilla of 10 interplanetary vessels carrying a crew of at least 70 humans. Since then, more than 1,000 studies were carried out. This third edition provides extensive updating and additions to the last edition, including new sections, and many new figures and tables, and references.

This edited volume studies gut microbiota peculiarities in elderly, in senescence-related and environmental-related alterations of gut microbiota in chronic diseases. Aging, as a physiological process mediated through several regulatory pathways and transcription factors, is generally speaking associated to a relentless functional decline and increasing risk of chronic diseases. Growing data on gut microbiota quali-quantitative changes in aging gut, and the opportunity to study by advanced NGS and metabolomic technologies, now offers novel horizons to link such changes to disease risks and to theoretically the weapons for gut microbiota intervention as an effective therapeutic tool. Chapters are divided into clear sections, starting with the aging perspective, then moving from chronic diseases to neurodegenerative diseases and cancer. The final parts focusses on interventions. Contributors are well-reputed and dedicated scientists in clinics and experimentalmedicine from 4 different continents who have provided their contribution keeping the polar star on aging as a guide while investigating their gut microbiota in occurrence and progression of disease together with proposed preventing, monitoring and therapeutic interventions. In the wide offer of books on gut microbiota, this age-thematic volume will be a valuable source of updated information for a wide group of readership including gerontologists, geriatricians, medical specialists of several fields, PhDs, basic scientists and public/private research entities focused on potential intervention in and through gut ecosystem. This book will stimulate a large number of basic scientists and clinicians to review their once organ (or cellular line)-specific knowledge and widen either their pathophysiological mechanisms understanding while providing novel ways to prevent, monitor and treat diseases from eyes to bones.

Fluorescence-guided surgery (FGS) is defined as a medical imaging technique that uses a fluorescent dye or a near-infrared emitting light source to identify anatomic structures during surgical procedures. In 2020 alone, over 1200 academic articles were published on the topic of fluorescence-guidance surgery, a sign that this modality is making significant inroads into surgical practice. The use of near-infrared imaging and FGS is a rapidly growing modality, allowing surgeons to see more intraoperatively, enhance surgical precision, and improve surgical decision-making and patient outcomes. This manual provides a comprehensive, state-of-the art review of this field and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in fluorescence-guided surgery, guiding patient management and stimulating investigative efforts. After initial chapters discussing the history of FGS and the current platforms and devices, it presents the most up-to-date data regarding the use of FGS in multiple surgical fields - colorectal, hepatic, endocrine, reconstructive, pediatric, among others - as well as in the treatment of specific conditions such as burns. Chapters are generously illustrated with full-color figures and intraoperative photographs, and selected chapters include video segments. Access to a comprehensive resource such as this is currently limited by the relatively new inroads that fluorescence-guided technology has made into surgery. The SAGES Manual of Fluorescence-Guided Surgery fills this gap in the literature.

This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.

The extensively revised third edition of this text offers an in-depth practical guide to clinical conditions encountered in pediatric nephrology. Extensively updated disease-specific chapters offer detailed coverage of relevant basic science, diagnostic work-up, laboratory evaluation methods, appropriate management options and potential complications. Topics covered include disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, chronic kidney disease, dialysis, kidney transplantation and hypertension. Information is also provided on important related issues, including the genetic origins of diseases, the role of complement in the pathogenesis of kidney disease, and pharmacological aspects related to the kidney. Pediatric Kidney Disease comprehensively reviews a range of clinical conditions encountered in pediatric nephrology, assisting the reader to develop their skills and improve their clinical decision-making. It is a vital resource for trainees and practicing clinicians alike and a useful reference for those preparing for pediatric nephrology board examinations.

This book provides an evidence based guide to the management of common kidney conditions. Concise and highly structured chapters outline a diagnosis and treatment framework for kidney diseases encountered within daily practice. Particular attention is given to the management of chronic kidney disease, genetic kidney diseases, cardiovascular complications, haemodialysis, kidney cancer, peritoneal dialysis, and kidney transplantation. Management of Kidney Disease aims to improve outcomes for patients with kidney diseases and is relevant to trainee and practising nephrologists, as well as healthcare professional treating kidney diseases.Additional questions and answers via app: Download the Springer Nature Flashcards app free of charge and use exclusive additional material to test your knowledge.

The 2nd edition of the successful book also summarises the factual knowledge of visceral surgery in a condensed, keyword-like form. It is suitable for preparation for the specialist examination as well as for quick reference in everyday clinical practice.All articles have been written by renowned experts. The focus is on detailed recommendations on the diagnostic procedure, the indication and the implementation of therapy; for the most important interventions, the steps of the surgical procedure are also presented. Brief overviews facilitate the targeted memorisation of the most important facts.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calciumchannel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

This volume discusses renal function and the mechanisms by which the kidney regulates the composition and volume of the extracellular fluid. It also highlights the role of the kidney in the development and progression of arterial hypertension. Most textbooks of renal physiology are based in mammalians physiology and mostly human physiology of the kidney, but the authors considered that this book should also include other species to include the broad spectrum of students and researchers in the life and biomedical sciences. In this sense, we included chapters such as comparative osmoregulation in non-mammalian vertebrates and we emphasize that in vertebrates like fish, reptiles, amphibians and birds, the kidneys and extrarenal organs are vital to maintain fluid homeostasis. The purpose of the book is to provide a concise frame of knowledge in a clear and direct language, of the renal function to medical and biological sciences students. In the context of normal renal function, we providepathophysiological basis for chronic renal diseases and hypertension with the participation of renal vasoactive hormones. This book is used as textbook in several physiology courses for medical, nursing and biological sciences students at the Pontifical Catholic University of Chile, Finis Terrae University, Universidad San Sebastian as well as other universities.