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This article explores the impact of the recent recession on the well-being of the UK working age population by comparing two measures of well-being. One is a measure of evaluative subjective well-being, a measure which previous research has shown to be stable in the UK throughout the economic crisis. The second is a different but complementary measure of positive psychological health. By comparing the trajectories of these two measures using the same sample and modelling techniques the analysis examines how different measures may lead to different interpretations. Six waves of longitudinal data from Understanding Society and the British Household Panel Survey (BHPS) are used. Latent curve models are used to analyse change over time. The results corroborate previous research showing that people’s evaluative subjective well-being remained relatively stable, on average, throughout the economic crisis. In contrast, the positive psychological health measure was found to decline significantly during the recession period. The paper highlights that what we measure matters. Using single measures as summaries of well-being masks the complexity of the term, and given their appeal in the social policy arena, single measures of well-being can be seen as problematic in some scenarios. Electronic supplementary material The online version of this article (doi:10.1007/s11482-016-9465-8) contains supplementary material, which is available to authorized users.

Self-prioritization is a robust phenomenon whereby judgments concerning self-representational stimuli are faster than judgments toward other stimuli. The present paper examines if and how self-prioritization causes more vivid short-term memories for self-related objects by giving geometric shapes arbitrary identities (self, mother, stranger). In Experiment 1 participants were presented with an array of the three shapes and required to retain the location and color of each in memory. Participants were then probed regarding the identity of one of the shapes and subsequently asked to indicate the color of the probed shape or an unprobed shape on a color wheel. Results indicated no benefit for self-stimuli in either response time for the identification probe or for color fidelity in memory. Yet, a cuing benefit was observed such that the cued stimulus in the identity probe did have higher fidelity within memory. Experiments 2 and 3 reduced the cognitive load by only requiring that participants process the identity and color of one shape at a time. For Experiment 2, the identity probe was memory-based, whereas the stimulus was presented alongside the identity probe for Experiment 3. Results demonstrated a robust self-prioritization effect: self-related shapes were classified faster than non-self-shapes, but this self-advantage did not lead to an increase in the fidelity of memory for self-related shapes’ colors. Overall, these results suggest that self-prioritization effects may be restricted to an improvement in the ability to recognize that the self-representational stimulus is present without devoting more perceptual and short-term memory resources to such stimuli.

The puzzle of resultant moral luck arises when we are disposed to think that an agent who caused a harm deserves to be blamed more than an otherwise identical agent who did not. One popular (but controversial) perspective on resultant moral luck explains our dispositions to produce different judgments with regard to the agents who feature in these cases as a product not of what they genuinely deserve but of our epistemic situation. On this account, there is no genuine resultant moral luck; there is only luck in what evidence becomes available to observers. In this paper, I develop an evolutionary account of our inclination to take the results of actions as evidence for the mental states of agents, thereby explaining why the resulting intuitions are recalcitrant to correction. The account explains why the puzzle of resultant moral luck arises: because our disposition to take the harms agents cause as evidence of their mental states can produce intuitions which conflict with those that arise when we examine agents’ mental states without reference to the results of their actions. The account also helps to solve the puzzle of resultant moral luck, by providing a strong reason to ignore the intuitions caused by our disposition to regard actual harms as evidence of mental states. Since these intuitions arise using an unreliable proxy for agents’ mental states, they ought to be trumped by more reliable evidence.

Funder: Isaac Newton Trust; doi: https://doi.org/10.13039/501100004815, Reverse engineering typically requires expensive equipment, skilled technicians, time, a cross section of the component to be sliced out and a dedicated reconstruction software. In this paper, we present a low-cost alternative, combining fast frontside sample preparation, electron microscopy imaging, error-free standard cell recognition and within and between-die standard cell statistical analysis (SCSA). Step-by-step, we depict the process to access the transistor’s drain/source area, to acquire the full area of a single chip layer, to adapt pattern recognition for standard cells and to analyze the standard cell width, local/global location and occurrences number. The inner workings of each step are accompanied by results on 45–65-nm FCBGA devices enabling to locate specific areas (e.g. registers, hardware accelerator). We particularly point out the importance of such design information extraction for local fault injection and hardware assurance. The primary goal is to analyze how much design information of a complex integrated circuit can be retrieved with minimal costs and without outsourcing.

In the present paper, we introduce the backdoor set approach into the field of temporal logic for the global fragment of linear temporal logic. We study the parameterized complexity of the satisfiability problem parameterized by the size of the backdoor. We distinguish between backdoor detection and evaluation of backdoors into the fragments of Horn and Krom formulas. Here we classify the operator fragments of globally-operators for past/future/always, and the combination of them. Detection is shown to be fixed-parameter tractable (FPT) whereas the complexity of evaluation behaves differently. We show that for Krom formulas the problem is paraNP-complete. For Horn formulas, the complexity is shown to be either fixed parameter tractable or paraNP-complete depending on the considered operator fragment. DFG/ME 4279/1-1

Groundwater flow models are usually subject to uncertainty as a consequence of the random representation of the conductivity field. In this paper, we use a Gaussian process model based on the simultaneous dimension reduction in the conductivity input and flow field output spaces in order quantify the uncertainty in a model describing the flow of an incompressible liquid in a random heterogeneous porous medium. We show how to significantly reduce the dimensionality of the high-dimensional input and output spaces while retaining the qualitative features of the original model, and secondly how to build a surrogate model for solving the reduced-order stochastic model. A Monte Carlo uncertainty analysis on the full-order model is used for validation of the surrogate model.\ud \ud

In this paper, we develop a new framework for mining predictive patterns that aims to describe compactly the condition (or class) of interest. Our framework relies on a classification model that considers and combines various predictive pattern candidates and selects only those that are important for improving the overall class prediction performance. We test our approach on data derived from MIMIC-III EHR database, focusing on patterns predictive of sepsis. We show that using our classification approach we can achieve a significant reduction in the number of extracted patterns compared to the state-of-the-art methods based on minimum predictive pattern mining approach, while preserving the overall classification accuracy of the model.

Cardiovascular diseases (CVDs) are the leading cause of death in Latin America and the Caribbean (LAC) region as well as worldwide. Lifestyle, nutritional habits and the upsurge of obesity have contributed to the increase in the prevalence of CVDs in the region. The role of nuclear cardiology in the management of patients with CVDs is well established. Particularly, myocardial perfusion imaging is widely used in LAC countries and has been increasingly integrated into the healthcare systems in the region for the diagnosis of coronary artery disease, risk stratification and to guide patient management. In its role to support countries around the world to address their health needs through the peaceful applications of nuclear techniques, the International Atomic Energy Agency (IAEA) has provided assistance to the LAC region for the establishment and strengthening of the nuclear cardiology practice. To that extent, the IAEA provides support in building capacities of multidisciplinary teams of professionals, the provision of medical equipment and the promotion of communication and exchange of knowledge among the different stakeholders. In addition, the IAEA encourages the participation of nuclear medicine centers in international multi-center research studies. In this paper, we present some of the projects through which the IAEA has supported the LAC region, including regional technical cooperation projects and coordinated research projects related to cardiology within the current multimodality approach to cardiac imaging. © 2019, The Author(s).

A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important regulators of neural stem/precursor cells (NSPC) proliferation. GC are released from the adrenal glands in ultradian secretory pulses that generate characteristic circadian oscillations. Here, we investigated the hypothesis that GC oscillations prevent NSPC activation and preserve a quiescent NSPC pool in the aging hippocampus. We found that hippocampal NSPC populations lacking expression of the glucocorticoid receptor (GR) decayed exponentially with age, while GR-positive populations decayed linearly and predominated in the hippocampus from middle age onwards. Importantly, GC oscillations controlled NSPC activation and GR knockdown reactivated NSPC proliferation in aged mice. When modeled in primary hippocampal NSPC cultures, GC oscillations control cell cycle progression and induce specific genome-wide DNA methylation profiles. GC oscillations induced lasting changes in the methylation state of a group of gene promoters associated with cell cycle regulation and the canonical Wnt signaling pathway. Finally, in a mouse model of accelerated aging, we show that disruption of GC oscillations induces lasting changes in dendritic complexity, spine numbers and morphology of newborn granule neurons. Together, these results indicate that GC oscillations preserve a population of GR-expressing NSPC during aging, preventing their activation possibly by epigenetic programming through methylation of specific gene promoters. Our observations suggest a novel mechanism mediated by GC that controls NSPC proliferation and preserves a dormant NSPC pool, possibly contributing to a neuroplasticity reserve in the aging brain., The experimental work wasfinanced by grantsfrom the Innovational Research Incentives Scheme VIDI 864.09.016from the Netherlands organization for Scientific Research (NWO); theInternational Foundation for Alzheimer’s Research (ISAO), and Alz-heimer Nederland to CPF. HM and LG-C were supported by theSpanish Ministry of Economy and Competitiveness, grant SAF2015-70433-R to HM and Juan de la Cierva Program to LG-C. EG and NTwerefinanced by the Swiss National Science Foundation. PJL wassupported by Alzheimer Nederland. SM-S wasfinanced by the Jesusde Gangoiti Foundation. We acknowledge the assistance of RafaelHortigüela and Tijana Radic during the paper preparation and RonaldBreedijk and Mark Hink at the Leeuwenhoek Centre for AdvancedMicroscopy, University of Amsterdam for providing technical assis-tance with the confocal microscope.

The traditional Dutch rental contract is permanent (i.e. time unlimited), but there are indications that in recent years the number of temporary rental contracts has increased considerably. Dutch housing policy appears to be responding to this by pursuing deregulation of the conditions under which temporary rent is permitted. It is in this regard startling that there is no reliable data available about the size or character of the temporary sector, and it has thus far not attracted any scholarly attention. Given that temporary rent can be viewed as a form of precarisation, a transfer of risk to citizens, with corresponding negative effects on the lives of those involved, it is imperative to close this knowledge gap. This paper is a first attempt to do this. Firstly, I systematically review the scarce evidence that is currently available, and secondly, I explore why the rise of temporary rent has thus far failed to stimulate any social debate; it appears to constitute a silent precarisation that contrasts with the politically sensitive issue of labour precarisation. In doing so, I will identify the research questions that must be answered if the significance of this process for both tenants and wider welfare-state restructuring is to be fully understood.

Surface color results from a reflected light bounced off a material, such as a paper. By contrast, self-luminous color results directly from an emitting light, such as a Liquid Crystal (LC) display. These are completely different mechanisms, and thus, surface color and self-luminous color cannot be matched even though both have identical tristimulus values. In fact, previous research has reported that metameric color matching fails among diverse media. However, the reason for this failure remains unclear. In the present study, we created isomeric color-matching pairs between self-luminous and surface colors by modulating the spectral distribution of the light for surface colors. Then, we experimentally verified whether such color matching can be performed. The results show that isomeric color matching between self-luminous and surface colors can be performed for all participants. However, metameric color matching fails for most participants, indicating that differences in the spectral distributions rather than the different color-generating mechanisms themselves are the reason for the color matching failure between different devices. We experimentally demonstrated that there is no essential problem in cross-media color matching by generating isomeric pairs. Our results can be considered to be of great significance not only for color science, but also for the color industry.

Difficulties with social interaction have been reported in both children with an autism spectrum disorder (ASD) and children with developmental coordination disorder (DCD), although these disorders have very different diagnostic characteristics. To date, assessment of social skills in a DCD population has been limited to paper-based assessment or parent report. The present study employed eye tracking methodology to examine how children attend to socially-relevant stimuli, comparing 28 children with DCD, 28 children with ASD and 26 typically-developing (TD) age-matched controls (aged 7-10). Eye movements were recorded while children viewed 30 images, half of which were classed as 'Individual' (one person in the scene, direct gaze) and the other half were 'Social' (more naturalistic scenes showing an interaction). Children with ASD spent significantly less time looking at the face/eye regions in the images than TD children, but children with DCD performed between the ASD and TD groups in this respect. Children with DCD demonstrated a reduced tendency to follow gaze, in comparison to the ASD group. Our findings confirm that social atypicalities are present in both ASD and to a lesser extent DCD, but follow a different pattern. Future research would benefit from considering the developmental nature of the observed findings and their implications for support.

The growing scholarly interest in research top performers comes from the growing policy interest in research top performance itself. A question emerges: what makes someone a top performer? In this paper, the upper 10% of Polish academics in terms of research productivity are studied, and predictors of entering this class are sought. In the science system (and Poland follows global patterns), a small number of scholars produce most of the works and attract huge numbers of citations. Performance determines rewards, and small differences in talent translate into a disproportionate level of success, leading to inequalities in resources, research outcomes, and rewards. Top performers are studied here through a bivariate analysis of their working time distribution and their academic role orientation, as well as through a model approach. Odds ratio estimates with logistic regression of being highly productive Polish academics are presented. Consistently across major clusters of academic disciplines, the tiny minority of 10% of academics produces about half (44.7%) of all Polish publications (48.0% of publications in English and 57.2% of internationally co-authored publications). The mean research productivity of top performers across major clusters is on average 7.3 times higher than that of the other academics, and in terms of internationally co-authored publications, 12.07 times higher. High inequality was observed: the average research productivity distribution is highly skewed with a long tail on the right not only for all Polish academics but also for top performers. The class of top performers is as internally stratified as that of their lower-performing colleagues. Separate regression models for all academics, science, technology, engineering and mathematics academics, and social sciences and humanities academics are built based on a large national sample (2525 usable observations), and implications are discussed.

While the paradigm of utility maximisation has formed the basis of the majority of applications in discrete choice modelling for over 40 years, its core assumptions have been questioned by work in both behavioural economics and mathematical psychology as well as more recently by developments in the RUM-oriented choice modelling community. This paper reviews the basic properties with a view to explaining the historical pre-eminence of utility maximisation and addresses the question of what departures from the paradigm may be necessary or wise in order to accommodate richer behavioural patterns. We find that many, though not all, of the behavioural traits discussed in the literature can be approximated sufficiently closely by a random utility framework, allowing analysts to retain the many advantages that such an approach possesses.

Aims/hypothesis:\ud \ud Substantial weight loss in type 2 diabetes can achieve a return to non-diabetic biochemical status, without the need for medication. The Diabetes Remission Clinical Trial (DiRECT), a cluster-randomised controlled trial, is testing a structured intervention designed to achieve and sustain this over 2 years in a primary care setting to determine practicability for routine clinical practice. This paper reports the characteristics of the baseline cohort.\ud Methods:\ud \ud People with type 2 diabetes for

Algorithms with operations on large regular data structures such as image processing can be highly accelerated when executed as hardware tasks in an FPGA fabric. The Dynamic Partial Reconfiguration (DPR) feature of new SRAM-based FPGA families allows a dynamic swapping and replacement of hardware tasks during runtime. Particularly embedded systems with processing chains that change over time or that are too large to be implemented in an FPGA fabric in parallel, benefit from DPR. In this paper we present a complete framework for hardware acceleration using DPR in the microkernel based Genode OS. This makes the DPR feature available not only for the high-performance computing field, but also for safety-critical applications. The new framework is evaluated for an exemplary imaging application running on a Xilinx Zynq-7000 SoC.

This special issue of Ambio compiles a series of contributions made at the 8th International Phosphorus Workshop (IPW8), held in September 2016 in Rostock, Germany. The introducing overview article summarizes major published scientific findings in the time period from IPW7 (2015) until recently, including presentations from IPW8. The P issue was subdivided into four themes along the logical sequence of P utilization in production, environmental, and societal systems: (1) Sufficiency and efficiency of P utilization, especially in animal husbandry and crop production; (2) P recycling: technologies and product applications; (3) P fluxes and cycling in the environment; and (4) P governance. The latter two themes had separate sessions for the first time in the International Phosphorus Workshops series; thus, this overview presents a scene-setting rather than an overview of the latest research for these themes. In summary, this paper details new findings in agricultural and environmental P research, which indicate reduced P inputs, improved management options, and provide translations into governance options for a more sustainable P use., Ambio, 47, ISSN:0044-7447, ISSN:1654-7209

This paper establishes a structural typology of the organisational configurations of public research organisations which vary in their relative internal sharing of authority between researchers and managers; we distinguish between autonomous, heteronomous and managed research organisations. We assume that there are at least two sources of legitimate authority within research organisations, one derived from formal hierarchy (organisational leadership) and another derived from the research community (professional); the balance of authority between researchers and managers is essentially structural but is empirically mediated by the funding portfolio of organisations and the corresponding endowment of resources at the disposal of leaders or researchers. Changes in the level, sources and strings of organisational and individual research funding are expected to affect the balance of internal authority in different ways depending on the organisational configuration, and to open the door to the influence of external actors in the development of research agendas.

It remains a standing problem how and why the first nervous systems evolved. Molecular and genomic information is now rapidly accumulating but the macroscopic organization and functioning of early nervous systems remains unclear. To explore potential evolutionary options, a coordination centered view is discussed that diverges from a standard input–output view on early nervous systems. The scenario involved, the skin brain thesis (SBT), stresses the need to coordinate muscle-based motility at a very early stage. This paper addresses how this scenario with its focus on coordination also deals with sensory aspects. It will be argued that the neural structure required to coordinate extensive sheets of contractile tissue for motility provides the starting point for a new multicellular organized form of sensing. Moving a body by muscle contraction provides the basis for a multicellular organization that is sensitive to external surface structure at the scale of the animal body. Instead of thinking about early nervous systems as being connected to the environment merely through input and output, the implication developed here is that early nervous systems provide the foundation for a highly specific animal sensorimotor organization in which neural activity directly reflects bodily and environmental spatiotemporal structure. While the SBT diverges from the input–output view, it is closely linked to and supported by ongoing work on embodied approaches to intelligence to which it adds a new interpretation of animal embodiment and sensorimotor organization.

Does anthropogenic environmental change constrain long-term sociopolitical outcomes? It is clear that human colonization of islands radically alters their biological and physical systems. Despite considerable contextual variability in the local specificities of this alteration, in this paper I argue that these processes are to some extent regular, predictable, and have socio-political implications. Reviewing the data for post-colonization ecodynamics, I show that Neolithic colonization of previously insulated habitats drives biotic homogenization. I argue that we should expect such homogenization to promote regular types of change in biophysical systems, types of change that can be described in sum as environmentally convergent. Such convergence should have significant implications for human social organization over the long term, and general dynamics of this sort are relevant in the context of understanding remarkably similar social evolutionary trajectories towards wealth-inequality not only islands, but also more generally.

Population ageing is a phenomenon affecting the whole world. The countries that make up the Gulf Cooperation Council (GCC) are no exception but transitions in population ageing are still in the early stages of the process. With current demographic dividends experienced by the GCC and the rest of the Middle-East, the pace of population ageing will be faster than that experienced by many European countries. The purpose of this paper is to explore the population ageing experience of different GCC countries while situating this within a context of social policies that still at the very early stages of acknowledging such change. We utilise data from sources such as the United Nations and the World Bank, complemented by policy analysis of current age-related social security measures in the GCC. Given the importance of the family aged care system in the region, we consider the implications of changes in family structures, living conditions, and care needs for the elderly. The findings confirm the declining trend in fertility combined with increased life expectancy in all the six GCC countries. However, they highlight that social policy measures focused on the older generations and their care needs are still relatively at the early stages of each country’s policy agenda. The implications of such changes are serious in term of both the demand for and supply of care. Policy-makers need to adapt cohesive social policy strategies that strengthen the complementing relationships between the state, family and wider community as stakeholders in the provision of aged care. Electronic supplementary material The online version of this article (doi:10.1007/s12126-017-9303-9) contains supplementary material, which is available to authorized users.

This paper is concerned with the implementation of efficient solution algorithms forelliptic problems with constraints. We establish theory which shows that including a simple scaling within well-established block diagonal preconditioners for Stokes problems can result in significantly faster convergence when applying the preconditioned MINRES method. The codes used in the numerical studies are available online.

This paper aims to improve the accuracy of parametric extrapolations of the death rates into old age by constraining the extrapolation model on presumed life expectancy at old age. Such a task is particularly important in cases where the data quality at old age, in particular the age exaggeration, is not sufficient for reliable mortality estimates. Our tests are based on period data from the Human Mortality Database and the use of the Horiuchi–Coale and Mitra formulas for reducing the bias of life expectancy in the open age interval. We show that extrapolation accuracy is substantially improved when the extrapolation is constrained by either the empirical life expectancy or the Horiuchi–Coale or Mitra estimates. Unconstrained extrapolations and those constrained by conventional life table estimates of life expectancy in the open age interval show substantial biases and should be avoided. Combining extrapolation with life expectancy estimates which are robust to the effects of age exaggeration appears to be a valuable way of improving mortality estimation.

Abortion is among the most widely discussed concepts of medical ethics. Since the well-known ethical theories have emerged from Western world, the position of Islamic ethics regarding main issues of medical ethics has been overlooked. Muslims constitute a considerable amount of world population. Turkish Republic is the only Muslim country ruled with secular democracy and one of the three Muslim countries where abortion is legalized. The first aim of this paper is to present discussions on abortion in Islamic ethics in the context of major ethical concepts; the legal status of the fetus, respect for life and the right not to be born. The second aim is to put forth Turkey's present legislation about abortion in the context of Islamic ethical and religious aspects.

Extortion racketeering is a crime that blights the lives of everyone in societies where it takes hold. Whilst most European countries have some form of extortion racketeering, in most countries it is isolated to some ethnic communities. In Southern Italy and Sicily, extortion racketeering is still a feature of overall society. This paper attempts to look at the phenomenon from the angle of collectives, of resistance building through civic organisations such as Addiopizzo. For this investigation a computational model is presented to analyse the effect of team-reasoning on levels of resistance in systemic extortion rackets. An agent-based model is presented that implements the interaction of different kinds of decision-making of extortion victims with law enforcement deterrence. The results show that established extortion rackets are hard to undermine unless bottom-up civic engagement and law enforcement go hand in hand.

Interior point methods provide an attractive class of approaches for solving linear, quadratic and nonlinear programming problems, due to their excellent efficiency and wide applicability. In this paper, we consider PDE-constrained optimization problems with bound constraints on the state and control variables, and their representation on the discrete level as quadratic programming problems. To tackle complex problems and achieve high accuracy in the solution, one is required to solve matrix systems of huge scale resulting from Newton iteration, and hence fast and robust methods for these systems arerequired. We present preconditioned iterative techniques for solving a number of these problems using Krylov subspace methods, considering in what circumstances one may predict rapid convergence of the solvers in theory, as well as the solutions observed from practical computations.

Shear wave elastography is a versatile technique that is being applied to many organs. However, in tissues that exhibit anisotropic material properties, special care must be taken to estimate shear wave propagation accurately and efficiently. A two-dimensional simulation method is implemented to simulate the shear wave propagation in the plane of symmetry in transversely isotropic viscoelastic media. The method uses a mapped Chebyshev pseudo-spectral method to calculate the spatial derivatives and an Adams-Bashforth-Moulton integrator with variable step sizes for time marching. The boundaries of the two-dimensional domain are surrounded by perfectly matched layers (PML) to approximate an infinite domain and minimize reflection errors. In an earlier work, we proposed a solution for estimating the apparent shear wave elasticity and viscosity of the spatial group velocity as a function of rotation angle through a low frequency approximation by a Taylor expansion. With the solver implemented in MATLAB, the simulated results in this paper match well with the theory. Compared to the finite element method (FEM) simulations we used before, the pseudo-spectral solver consumes less memory and is faster and achieves better accuracy.

Several fields of research are characterized by the coexistence of two different peer review modes to select quality contributions for scientific venues, namely double blind (DBR) and single blind (SBR) peer review. In the first, the identities of both authors and reviewers are not known to each other, whereas in the latter the authors’ identities are visible since the start of the review process. The need to adopt either one of these modes has been object of scholarly debate, which has mostly focused on issues of fairness. Past work reported that SBR is potentially associated with biases related to the gender, nationality, and language of the authors, as well as the prestige and type of their institutions. Nevertheless, evidence is lacking on whether revealing the identities of the authors favors reputed authors and hinder newcomers, a bias with potentially important consequences in terms of knowledge production. Accordingly, we investigate whether and to what extent SBR, compared to a DBR, relates to a higher ration of reputed scholars, at the expense of newcomers. This relation is pivotal for science, as past research provided evidence that newcomers support renovation and advances in a research field by introducing new and heterodox ideas and approaches, whereas inbreeding have serious detrimental effects on innovation and creativity. Our study explores the mentioned issues in the field of computer science, by exploiting a database that encompasses 21,535 research papers authored by 47,201 individuals and published in 71 among the 80 most impactful computer science conferences in 2014 and 2015. We found evidence that—other characteristics of the conferences taken in consideration—SBR indeed relates to a lower ration of contributions from newcomers to the venue and particularly newcomers that are otherwise experienced of publishing in other computer science conferences, suggesting the possible existence of ingroup–outgroup behaviors that may harm knowledge advancement in the long run.

This is an experimental paper in which we introduce the possibility to analyze and to synthesize 3D medical images by using multivariate Gabor frames with Gaussian windows. Our purpose is to apply a space-variant filter-like operation in the space-frequency domain to correct medical images corrupted by different types of acquisitions errors. The Gabor frames are constructed with Gaussian windows sampled on non-separable lattices for a better packing of the space-frequency plane. An implementable solution for 3D-Gabor frames with non-separable lattice is given and numerical tests on simulated data are presented. Austrian Science Fund (FWF) P27516

The ability to forecast sea ice (both extent and thickness) and weather conditions are the major factors when it comes to safe marine transportation in the Arctic Ocean. This paper presents findings focusing on sea ice and weather prediction in the Arctic Ocean for navigation purposes, in particular along the Northeast Passage. Based on comparison with the observed sea ice concentrations for validation, the best performing Earth system models from the Intergovernmental Panel on Climate Change (IPCC) program (CMIP5—Coupled Model Intercomparison Project phase 5) were selected to provide ranges of potential future sea ice conditions. Our results showed that, despite a general tendency toward less sea ice cover in summer, internal variability will still be large and shipping along the Northeast Passage might still be hampered by sea ice blocking narrow passages. This will make sea ice forecasts on shorter time and space scales and Arctic weather prediction even more important. Electronic supplementary material The online version of this article (doi:10.1007/s13280-017-0951-5) contains supplementary material, which is available to authorized users.

The paper reports high temperature resistance of ferritic steels in fireside corrosion regime in terms of temperature and deposits aggressiveness. Four candidate power plant steels: 15Mo3, T22, T23 and T91 were exposed under simulated air-fired combustion environment for 1000 h. The tests were conducted at 600, 650 and 700 °C according to deposit-recoat test method. Post-exposed samples were examined via dimensional metrology (the main route to quantify metal loss), and mass change data were recorded to perform the study of kinetic behavior at elevated temperatures. Microstructural investigations using ESEM-EDX were performed in order to investigate corrosion degradation and thickness of the scales. The ranking of the steels from most to the least damage was 15Mo3 > T22 > T23 > T91 in all three temperatures. The highest rate of corrosion in all temperatures occurred under the screening deposit.

This paper should be read as addendum to Dieckmann et al. (J Theor Biol 241:370-389, 2006) and Parvinen et al. (J Math Biol 67: 509-533, 2013). Our goal is, using little more than high-school calculus, to (1) exhibit the form of the canonical equation of adaptive dynamics for classical life history problems, where the examples in Dieckmann et al. (J Theor Biol 241:370-389, 2006) and Parvinen et al. (J Math Biol 67: 509-533, 2013) are chosen such that they avoid a number of the problems that one gets in this most relevant of applications, (2) derive the fitness gradient occurring in the CE from simple fitness return arguments, (3) show explicitly that setting said fitness gradient equal to zero results in the classical marginal value principle from evolutionary ecology, (4) show that the latter in turn is equivalent to Pontryagin's maximum principle, a well known equivalence that however in the literature is given either ex cathedra or is proven with more advanced tools, (5) connect the classical optimisation arguments of life history theory a little better to real biology (Mendelian populations with separate sexes subject to an environmental feedback loop), (6) make a minor improvement to the form of the CE for the examples in Dieckmann et al. and Parvinen et al.

PurposeThe Strengths and Difficulties Questionnaire (SDQ) is a behavioural screening tool for children. The SDQ is increasingly used as the primary outcome measure in population health interventions involving children, but it is not preference based; therefore, its role in allocative economic evaluation is limited. The Child Health Utility 9D (CHU9D) is a generic preference-based health-related quality of-life measure. This study investigates the applicability of the SDQ outcome measure for use in economic evaluations and examines its relationship with the CHU9D by testing previously published mapping algorithms. The aim of the paper is to explore the feasibility of using the SDQ within economic evaluations of school-based population health interventions. MethodsData were available from children participating in a cluster randomised controlled trial of the school-based roots of empathy programme in Northern Ireland. Utility was calculated using the original and alternative CHU9D tariffs along with two SDQ mapping algorithms. t tests were performed for pairwise differences in utility values from the preference-based tariffs and mapping algorithms.ResultsMean (standard deviation) SDQ total difficulties and prosocial scores were 12 (3.2) and 8.3 (2.1). Utility values obtained from the original tariff, alternative tariff, and mapping algorithms using five and three SDQ subscales were 0.84 (0.11), 0.80 (0.13), 0.84 (0.05), and 0.83 (0.04), respectively. Each method for calculating utility produced statistically significantly different values except the original tariff and five SDQ subscale algorithm.ConclusionInitial evidence suggests the SDQ and CHU9D are related in some of their measurement properties. The mapping algorithm using five SDQ subscales was found to be optimal in predicting mean child health utility. Future research valuing changes in the SDQ scores would contribute to this research.

In this paper we investigate how age affects the self-reported level of life satisfaction among the elderly in Europe. By using a vignette approach, we find evidence that age influences life satisfaction through two counterbalancing channels. On the one hand, controlling for the effects of all other variables, the own perceived level of life satisfaction increases with age. On the other hand, given the same true level of life satisfaction, older respondents are more likely to rank themselves as "dissatisfied" with their life than younger individuals. Detrimental health conditions and physical limitations play a crucial role in explaining scale biases in the reporting style of older individuals.

A deflationary perspective on theories of cultural evolution, in particular dual-inheritance theory, has recently been proposed by Lewens. On this ‘pop-culture’ analysis, dual-inheritance theorists apply population thinking to cultural phenomena, without claiming that cultural items evolve by natural selection. This paper argues against this pop-culture analysis of dual-inheritance theory. First, it focuses on recent dual-inheritance models of specific patterns of cultural change. These models exemplify population thinking without a commitment to natural selection of cultural items. There are grounds, however, for doubting the added explanatory value of the models in their disciplinary context—and thus grounds for engaging in other potentially explanatory projects based on dual-inheritance theory. One such project is suggested by advocates of the theory. Some of the motivational narratives that they offer can be interpreted as setting up an adaptationist project with regard to cumulative change in cultural items. We develop this interpretation here. On it, dual-inheritance theory features two interrelated selection processes, one on the level of genetically inherited learning mechanisms, another on the level of the cultural items transmitted through these mechanisms. This interpretation identifies a need for further modelling efforts, but also offers scope for enhancing the explanatory power of dual-inheritance theory.

The Hohokam, an irrigation-based society in the American South West, used the river valleys of the Salt and Gila Rivers between 500 and 1500 AD to grow their crops. Such irrigated crops are linking human agency, water sources and the general natural environment. In order to grow crops, water available through rain and river flows needs to be diverted to land where the plants are grown. With a focus on the Gila River, this paper uses the potential harvest of maize (a main Hohokam crop) as a proxy for evaluating the influence of natural water availability and climatic changes on irrigation options for maize. Available climate variables derived from tree-ring proxies are downscaled. These downscaled data are used as input for a crop growth model for the entire sequence of Hohokam occupation along the Gila River. The results of the crop model are used to discuss the potential influence of climatic variability on Hohokam irrigation and society. The results will show that climatic change alone cannot be used as an explanation for developments in Hohokam irrigation. Societal development resulting in growing population and extensive irrigation systems increasing pressure on water sources over time would have been a key factor to include to understand Hohokam society between 500 and 1500 AD.

The main aim of Lupyan’s paper (this volume) is to claim that perception is cognitively penetrated and that this is consistent with the idea of perception as predictive coding. In these remarks I will focus on what Lupyan says about whether perception is cognitively penetrated, and set aside his remarks about epistemology. I have argued (2012) that perception can be cognitively penetrated and so I am sympathetic to Lupyan’s overall aim of showing that perception is cognitively penetrable. However, I will be critical of some of Lupyan’s reasoning in arguing for this position. I will also call for clarification of that reasoning. First, I will discuss what is meant by cognitive penetration and, in light of this, the sort of evidence that can be used to establish its existence. Second, I will question whether Lupyan establishes that all cases of cross-modal effects are cases of cognitive penetration. In doing so, I will suggest a form of cognitive penetration that has heretofore not been posited, and give an example of how one might test for its existence. Third, I will question whether Lupyan puts forward convincing evidence that categorical knowledge and language affect perception in a way that conclusively shows that cognitive penetration occurs. Fourth, I will closely examine Lupyan’s reply to the argument against cognitive penetration from illusion. I show that his reply is not adequate and that he misses a more straightforward reply that one could give. Fifth, I briefly concur with the remarks that Lupyan makes about the role of attention with respect to cognitive penetration. And finally, sixth, I spell out exactly what I think the relationship is between the thesis that predictive coding is the correct model of perception and the thesis that there is cognitive penetration.

As befits an emerging field of enquiry, there is on-going discussion about the scope, role and future of the medical humanities. One relatively recent contribution to this debate proposes a differentiation of the field into two distinct terrains, ‘medical humanities’ and ‘health humanities,’ and calls for a supersession of the former by the latter. In this paper, we revisit the conceptual underpinnings for a distinction between ‘the medical’ and ‘health’ by looking at the history of an analogous debate between ‘medical geography’ and ‘the geographies of health’ that has, over the last few years, witnessed a re-blurring of the distinction. Highlighting the value of this debate within the social sciences for the future development of the medical humanities, we call for scholars to take seriously the challenges of critical and cultural theory, community-based arts and health, and the counter-cultural creative practices and strategies of activist movements in order to meet the new research challenges and fulfill the radical potential of a critical medical humanities.

Identification of active components in a variety of chemical products used directly by consumers is described at both trace and bulk levels using mass spectrometry. The combination of external ambient ionization with a portable mass spectrometer capable of tandem mass spectrometry provides high chemical specificity and sensitivity as well as allowing on-site monitoring. These experiments were done using a custom-built portable ion trap mass spectrometer in combination with the ambient ionization methods of paper spray, leaf spray, and low temperature plasma ionization. Bactericides, garden chemicals, air fresheners, and other products were examined. Herbicide applied to suburban lawns was detected in situ on single leaves 5 d after application.

Signed graphs, i.e., undirected graphs with edges labelled with a plus or minus sign, are commonly used to model relationships in social networks. Recently, Kermarrec and Thraves (2011) initiated the study of the problem of appropriately visualising the network: They asked whether any signed graph can be embedded into the metric space \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}${{\mathbb {R}}}^{l}$\end{document}ℝl in such a manner that every vertex is closer to all its friends (neighbours via positive edges) than to all its enemies (neighbours via negative edges). Interestingly, embeddability into \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}${{\mathbb {R}}}^{1}$\end{document}ℝ1 can be expressed as a purely combinatorial problem. In this paper we pursue a deeper study of this case, answering several questions posed by Kermarrec and Thraves. First, we refine the approach of Kermarrec and Thraves for the case of complete signed graphs by showing that the problem is closely related to the recognition of proper interval graphs. Second, we prove that the general case, whose polynomial-time tractability remained open, is in fact NP-complete. Finally, we provide lower and upper bounds for the time complexity of the general case: we prove that the existence of a subexponential time (in the number of vertices and edges of the input signed graph) algorithm would violate the Exponential Time Hypothesis, whereas a simple dynamic programming approach gives a running time single-exponential in the number of vertices.

In this paper, we propose a new method for stitching multiple fluoroscopic images taken by a C-arm instrument. We employ an X-ray radiolucent ruler with numbered graduations while acquiring the images, and the image stitching is based on detecting and matching ruler parts in the images to the corresponding parts of a virtual ruler. To achieve this goal, we first detect the regular spaced graduations on the ruler and the numbers. After graduation labeling, for each image, we have the location and the associated number for every graduation on the ruler. Then, we initialize the panoramic X-ray image with the virtual ruler, and we “paste” each image by aligning the detected ruler part on the original image, to the corresponding part of the virtual ruler on the panoramic image. Our method is based on ruler matching but without the requirement of matching similar feature points in pairwise images, and thus, we do not necessarily require overlap between the images. We tested our method on eight different datasets of X-ray images, including long bones and a complete spine. Qualitative and quantitative experiments show that our method achieves good results.

Children approach counterfactual questions about stories with a reasoning strategy that falls short of adults’ Counterfactual Reasoning (CFR). It was dubbed “Basic Conditional Reasoning” (BCR) in Rafetseder et al. (Child Dev 81(1):376–389, 2010). In this paper we provide a characterisation of the differences between BCR and CFR using a distinction between permanent and nonpermanent features of stories and Lewis/Stalnaker counterfactual logic. The critical difference pertains to how consistency between a story and a conditional antecedent incompatible with a nonpermanent feature of the story is achieved. Basic conditional reasoners simply drop all nonpermanent features of the story. Counterfactual reasoners preserve as much of the story as possible while accommodating the antecedent.

The push towards low-power and wearable sleep systems requires using minimum number of recording channels to enhance battery life, keep processing load small and be more comfortable for the user. Since most sleep stages can be identified using EEG traces, enormous power savings could be achieved by using a single channel of EEG. However, detection of REM sleep from one channel EEG is challenging due to its electroencephalographic similarities with N1 and Wake stages. In this paper we investigate a novel feature in sleep EEG that demonstrates high discriminatory ability for detecting REM phases. We then use this feature, that is based on spectral edge frequency (SEF) in the 8–16 Hz frequency band, together with the absolute power and the relative power of the signal, to develop a simple REM detection algorithm. We evaluate the performance of this proposed algorithm with overnight single channel EEG recordings of 5 training and 15 independent test subjects. Our algorithm achieved sensitivity of 83%, specificity of 89% and selectivity of 61% on a test database consisting of 2221 REM epochs. It also achieved sensitivity and selectivity of 81 and 75% on PhysioNet Sleep-EDF database consisting of 8 subjects. These results demonstrate that SEF can be a useful feature for automatic detection of REM stages of sleep from a single channel EEG. Electronic supplementary material The online version of this article (doi:10.1007/s10439-014-1085-6) contains supplementary material, which is available to authorized users.

Survey data are often used for comparison purposes, such as comparisons across nations or comparisons over time. To be effective, this would require equivalent questions and equivalent responses options to the questions. Yet there is a lot of variation in the response scales used, which, for example, differ in the number of response options used and the labeling of these options. This is the case in happiness research, and as a result most of the research data in this field is incomparable. Several methods have been proposed to transform ratings on verbal response scales to a common numerical scale, typically ranging from 0 to 10. In this paper we give an overview of the progress made in those Scale Homogenization methods over time. We describe two early methods: Linear Stretch and the Semantic Judgement of Fixed Word Value Method. Next we discuss the Semantic Judgement of Word Value in Context Method in more detail. Based on these discussions we propose a new Reference Distribution Method. We apply the Semantic Judgement of Word Value in Context and the Reference Distribution Methods to data on happiness in The Netherlands for the years 1989–2009. We show that the Reference Distribution Method produces comparable time series on different questions and that it allows discontinuities in data to be corrected. http://dx.doi.org/10.1007/s11205-013-0335-6 http://link.springer.com/article/10.1007%2Fs11205-013-0335-6

Schimke immuno-osseous dysplasia (SIOD) is a rare, severe, autosomal recessive disorder that results in spondyloepiphyseal dysplasia, renal dysfunction, immunodeficiency, facial dysmorphism and growth failure. Little is known about oral features associated with SIOD. Some of the dental anomalies encountered are specific to SIOD and have only been reported in individuals with SIOD. This paper describes the clinical and radiographic dental manifestations of SIOD in two Caucasian brothers. Both lived to be about 10 years old. After a variety of symptoms were reported, a diagnosis of SIOD was finally made when the brothers were, respectively, 5 and 8 years old. At that time, dental anomalies, such as dyschromia, bulbous crowns, short and thin roots, had not been taken into account to establish the diagnosis. However, knowledge of the dental features characteristic of this disease could have helped make the diagnosis. Although both were caries- and periodontal disease-free, special attention was focused on prevention, including dietary counselling, plaque control, oral hygiene instructions and the use of fluoridated toothpaste. The two patients were followed every 6 months, for over 2 years (until their death), by both a private dentist and a university hospital dentist, which helped them maintain good oral health. Oral hygiene was assessed at each appointment and fissure sealants were placed by the private practitioner on their first permanent molars. This report describes dental anomalies specific to SIOD that could facilitate diagnosis. Clinicians and dentists should work in collaboration to diagnose and treat children with SIOD. These patients require regular and specific dental management because of their fragile health and their characteristic dental anomalies. Ideally, preventive visits should be scheduled every 6 months in addition to curative visits as needed.

11 pags.; 4 figs.; 6 tabs., Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible lung condition typically related to emphysema. It hinders air from passing through airpaths and causes that alveolar sacs lose their elastic quality. Findings of COPD may be manifested in a variety of computed tomography (CT) studies. Nevertheless, visual assessment of CT images is time-consuming and depends on trained observers. Hence, a reliable computer-aided diagnosis system would be useful to reduce time and inter-evaluator variability. In this paper, we propose a new emphysema classification framework based on complex Gabor filters and local binary patterns. This approach simultaneously encodes global characteristics and local information to describe emphysema morphology in CT images. Kernel Fisher analysis was used to reduce dimensionality and to find the most discriminant nonlinear boundaries among classes. Finally, classification was performed using the k-nearest neighbor classifier. The results have shown the effectiveness of our approach for quantifying lesions due to emphysema and that the combination of descriptors yields to a better classification performance. © 2014 International Federation for Medical and Biological Engineering., This work has been partially sponsored by the grants UNAM PAPIIT IN113611, IG100814, and TEC2010-20307 from the Spanish Ministry of Economy.

Salmon aquaculture has emerged as a successful economic industry generating high economic revenues to invest in the development of Chiloe region, Southern Chile. However, salmon aquaculture also consumes a substantial amount of ecosystem services, and the direct and indirect impacts on human wellbeing are still unknown and unexplored. This paper identifies the synergies and trade-offs caused by the salmon industry on a range of ecosystem services. The results show that large economic benefits due to the increase of provisioning ecosystem services are also causing a reduction on regulating and cultural services. Despite the improvement on average income and poverty levels experienced in communities closely associated with the sector, this progress is not large enough and social welfare did not improve substantially over the last decade. The rest of human wellbeing constituents in Chiloe region have not changed significantly compared to the development in the rest of the country.

In terms of intervening in embodied experience, medical treatment is wonder-ful in its ambition and its metaphysical presumption; yet wonder’s role in clinical medicine has received little philosophical attention. In this paper I propose the value, to doctors and others in routine clinical life, of an openness to wonder and to the sense of wonder. Key to this is the identity of the central ethical challenges for most clinicians, being not the high-tech drama of popular conceptions of medical ethics but rather the routine of patients’ undramatic but unremitting demands for the clinician’s time and respectful attention. Wonder (conceived as an intense and transfiguring attentiveness) offers: an alternative and ubiquitous ethical source in place of the more familiar respect for rational autonomy; a source of renewal galvanising diagnostic imagination; and a timely recalling of the embodied agency of both patient and clinician.

Xenograft models of human diffuse large B cell lymphoma (DLBCL) are widely used to test new drugs against this neoplasia. Most of them, however, are subcutaneous xenografts that do not show a disseminated disease as it is found in the human neoplasia. In this paper, we aimed to develop a disseminated xenograft model of DLBCL by performing a subcutaneous passage of DLBCL cells before their intravenous injection in mice. WSU-DLCL-2 (WSU) cells were injected into both flanks of NOD/SCID mice. The subcutaneous tumours were disaggregated and a cell suspension (WSU-SC) was obtained. Two groups of 10 NOD/SCID mice were intravenously injected with WSU-SC or WSU cells. All mice injected with WSU-SC cells developed lymphoma in 32-47 days and showed lymph node and bone marrow infiltration. WSU-SC cells showed a significantly higher engraftment rate and faster dissemination than WSU cells after intravenous injection in mice. When molecularly compared, WSU-SC cells showed higher expression levels of FAK, p130Cas and phosphorylated AKT than WSU cells. The subcutaneous passage enhanced the engraftment and the metastatic capacity of WSU cells, allowing the generation of a rapid and disseminated DLBCL xenograft model. The aggressive behaviour of WSU-SC cells was associated with increased p130Cas and FAK expression and AKT activation. © 2012 Springer Science+Business Media B.V.

Frontotemporal lobar degeneration (FTLD) is clinically pathologically and genetically heterogeneous. Three major proteins are implicated in its pathogenesis. About half of cases are characterized by depositions of the microtubule associated protein tau (FTLD tau). In most of the remaining cases deposits of the transactive response (TAR) DNA binding protein with Mw of 43 kDa known as TDP 43 (FTLD TDP) are seen. Lastly about 5 10 of cases are characterized by abnormal accumulations of a third protein fused in sarcoma (FTLD FUS). Depending on the protein concerned the signature accumulations can take the form of inclusion bodies (neuronal cytoplasmic inclusions and neuronal intranuclear inclusions) or dystrophic neurites in the cerebral cortex hippocampus and subcortex. In some instances glial cells are also affected by inclusion body formation. In motor neurone disease (MND) TDP 43 or FUS inclusions can present within motor neurons of the brain stem and spinal cord. This present paper attempts to critically examine the role of such proteins in the pathogenesis of FTLD and MND as to whether they might exert a direct pathogenetic effect (gain of function) or simply act as relatively innocent witnesses to a more fundamental loss of function effect. We conclude that although there is strong evidence for both gain and loss of function effects in respect of each of the proteins concerned in reality it is likely that each is a single face of either side of the coin and that both will play separate though complementary roles in driving the damage which ultimately leads to the downfall of neurons and clinical expression of disease. © 2012 Springer Verlag.