1. Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion.
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HOELLEN, FRIEDERIKE, WALDMANN, ANNIKA, BANZ-JANSEN, CONSTANZE, RODY, ACHIM, HEIDE, MARIA, KÖSTER, FRANK, RIBBAT-IDEL, JULIKA, THORNS, CHRISTOPH, GEBHARD, MAXIMILIAN, OBERLÄNDER, MARTINA, HABERMANN, JENS K., and THILL, MARC
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CYCLOOXYGENASE 2 ,CERVICAL cancer ,CARCINOGENESIS ,IMMUNOHISTOCHEMISTRY ,STROMAL cells - Abstract
Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of =4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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