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Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion.
- Source :
- Oncology Letters; Oct2016, Vol. 12 Issue 4, p2351-2356, 6p
- Publication Year :
- 2016
-
Abstract
- Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of =4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYCLOOXYGENASE 2
CERVICAL cancer
CARCINOGENESIS
IMMUNOHISTOCHEMISTRY
STROMAL cells
Subjects
Details
- Language :
- English
- ISSN :
- 17921074
- Volume :
- 12
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Oncology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 117840887
- Full Text :
- https://doi.org/10.3892/ol.2016.4925