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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探究 1 型糖尿病（T1DM）患者胰岛自身抗体与甲状腺抗体的相关性。方法 选取 T1DM 患者 55 例 为观察组及同期健康体检人群60例为对照组。两组禁食10 h以上，于次日清晨抽取空腹静脉血 5 mL，采用化学发 光免疫分析法检测胰岛细胞抗体（ICA）；采用化学发光法检测胰岛素抗体（IAA）、谷氨酸脱羧酶抗体（GADA）；采用 化学发光免疫夹心分析法检测甲状腺功能指标FT3、FT4、TSH、甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗 体（TGAb）。比较两组甲状腺功能异常情况，胰岛自身抗体 ICA、IAA、GADA 及甲状腺自身抗体 TPOAb、TGAb阳性 率，分析 T1DM 患者胰岛自身抗体与甲状腺抗体的相关性。结果 观察组甲状腺功能异常发生率高于对照组 （23. 64% vs 6. 67%，P<0. 05）；观察组IAA、GADA任一抗体阳性率高于对照组（40. 00 % vs 1. 67%），TGAb阳性率高 于对照组（18. 18% vs 3. 33%），TPOAb 阳性率高于对照组（21. 82% vs 9. 09%），差异均有统计学意义（P 均<0. 05）。 观察组 IAA、GADA 阳性患者 TGAb、TPOAb 阳性率高于相应阴性患者（P 均<0. 05）。结论 T1DM 患者甲状腺功能 异常及甲状腺抗体阳性率高于健康人群，GADA、IAA阳性T1DM患者伴发自身免疫性疾病的风险更高。 [ABSTRACT FROM AUTHOR]

Objective To investigate the repair effect of bone marrow mesenchymal stem cells (BMSCs) on pulmonary vascular endothelial injury in rats with chronic obstructive pulmonary disease (COPD) -obstructive sleep apnea (OSA) overlap syndrome and to explore its possible mechanism. Methods BMSCs were isolated from femur and tibial bone marrow of SPF-grade female SD rats, and then were cultured and identified. Sixteen female SD rats with SPF grade were selected to prepare the RAT models of COPD-OSA overlap syndrome by smoking combined with intermittent hypoxia. The rats were randomly divided into the observation group and control group, with 8 rats in each group. The rats in the observation group were injected with 2 × 106 BMSCs per time, once a week, for 4 times in total, and the rats in the control group were injected with normal saline of the same volume. One week after treatment, the rats in the two groups were sacrificed, the lung tissues were taken for paraffin section for HE staining and MASSON staining to observe the pathological changes of the lung tissues and pulmonary arteriole, and the apoptosis of vascular endothelial cells in the lung tissues was observed by the triple qualitative method of DAPI-CD34-TUNEL,the expression levels of endothelin 1 (ET-1), endothelial nitric oxide synthase (e NOS), vascular endothelial growth factor (VEGF) and stromal cell derived factor 1 (SDF-1) were detected by ELISA. Results Compared with the control group, the pathological changes of the lung tissues in the observation group were milder, such as emphysema, interstitial lymphocyte infiltration, neutrophil infiltration, bronchial wall lymphocyte hyperplasia, bronchiolar wall smooth muscle hyperplasia and goblet cell hyperplasia; the changes of pulmonary arterioles myosization, outer membrane collagen fiber deposition, abnormal vascular wall structure, perivascular inflammation, and pulmonary interstitial thickening were relatively mild. The apoptosis rates of pulmonary vascular endothelial cells in the observation group and the control group were 2. 3552% ± 0. 3923% and 1. 3339% ± 0. 1553%,respectively,with statistically significant difference (both P ＜ 0. 01). The content of ET-1 and VEGF in lung tissue homogenization of the observation group was lower than that of the control group, and the content of e NOS was higher than that of the control group, with statistically significant difference (all P ＜ 0. 05); the SDF-1α content in lung tissue homogenization in the observation group was lower than that in the control group, but no statistically significant difference was found between these two groups (P ＞ 0. 05). Conclusions BMSCs can improve the vascular endothelial injury and dysfunction in pulmonary tissues of rats with COPD-OSA overlap syndrome, reduce the apoptosis of pulmonary vascular endothelial cells, and improve the remodeling of pulmonary tissues and small pulmonary vessels to some extent. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察左西孟旦治疗急性冠脉综合征经皮冠状动脉介入治疗（PCI）手术后无复流伴发心衰的临床效 果。方法 选取急性冠脉综合征PCI手术后病变血管无复流伴发心衰患者298例，随机分为观察组和对照组各149 例。两组均冠脉内推注盐酸硝普钠 200 µg+盐酸替罗非班 10 µg/kg，观察组同时微泵静脉滴注左西孟旦 0. 2 µg/（kg·min），持续滴注24 h。记录两组治疗后2周TIMI血流分级、TMPG心肌灌注分级及治疗1年后不良心血管事件 （MACE）发生率，比较其治疗前及治疗后2周血清N末端氨基末端脑钠肽前体（NT-proBNP）水平、心脏超声检查相关 指标［左心室射血分数（LVEF）、心脏指数（CI）、每搏输出量（SV）］。结果 两组TIMI血流分级及TMPG心肌灌注分 级情况比较 P均>0. 05。与治疗前比较，两组治疗后 2周血清 NT-proBNP水平均降低，LVEF、CI、SV均升高，且观察 组变化更明显（P 均<0. 05）。观察组发生再发心绞痛 5 例、再发心肌梗死 3 例、心源性死亡 0 例、心衰再入院 4 例， MACE 发生率为 8. 05%（12/149），对照组分别为 9、5、1、8 例及 15. 44%（23/149），两组 MACE 发生率比较 P<0. 05。 结论 左西孟旦对急性冠脉综合征PCI手术后病变血管无复流且伴发心衰患者的血流灌注影响不大，但能有效改 善患者的心功能，安全性较高。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：观察中波紫外线局部照射治疗大鼠腹部皮瓣缺血再灌注损伤的效果，并探讨其机制。方法 将30只大鼠随机分为280 nm组、320 nm组和对照组，均建立大鼠腹部皮瓣缺血再灌注损伤的动物模型，280 nm组、320 nm组模型建立后即行280、320 nm人工紫外线照射1次，以后2次／d，每次4 min，持续7 d；对照组皮瓣制备后，不做任何处理。各组大鼠均于术后7d用坐标贴纸法测定皮瓣成活面积，计算皮瓣成活率；取各组大鼠皮瓣组织制作切片行免疫组织化学染色并测算VEGF阳性表达面积所百分比；用TUNEL法检测各组大鼠皮瓣细胞凋亡率。结果280 nm组、320 nm组、对照组大鼠皮瓣术后7 d 的成活率分别为62．38％±8．64％、54．49％±4．48％、39．61％±4．22％，皮瓣VEGF阳性表达面积所占百分比分别为91．39％±9．29％、70．46％±4．02％、34．97％±3．08％，细胞凋亡率分别为53．06％±5．64％、64．72％±3．73％、32．82％±1．72％。以上指标280 nm组、320 nm组和对照组相比，P均＜0．05；280 nm组、320 nm组相比，P＜0．05。结论中波紫外线局部照射治疗大鼠皮瓣缺血再灌注损伤效果满意，机制可能与其提高皮瓣组织VEGF表达有关。但中波紫外线局部照射会导致皮瓣细胞凋亡率升高，紫外线波长较短者细胞凋亡程度较轻。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察连续性血液净化(CBP)联合参麦注射液治疗多器官功能障碍综合征(MODS)的临床效果。方法 将30例MODS患者随机分为观察组和对照组各15例,两组均进行CBP,观察组另予静脉滴注参麦注射液,疗程均为7 d。观察两组治疗前后APACHEⅡ评分及外周血T淋巴细胞亚群、免疫球蛋白、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、单核细胞数量及人类白细胞抗原-DR位点(HLA-DR)。结果 两组治疗后APACHEⅡ评分均低于治疗前(P均<0.05),CD+3、CD+4、CD+4/CD+8T淋巴细胞及Ig A、Ig G、Ig M、单核细胞计数、单核细胞HLA-DR均高于治疗前(P均<0.05)。两组治疗后CD+8T淋巴细胞及CRP、SAA均低于治疗前(P均<0.05),观察组较对照组降低更明显(P均<0.05)。结论 CBP联合参麦注射液可有效改善MODS患者的免疫功能及炎症状态,并且其改善程度优于单纯CBP。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：探讨米力农对老年心力衰竭的辅助治疗作用。方法选择老年心力衰竭患者104例，随机分为观察组和对照组各52例。两组均给予心力衰竭常规治疗，观察组在常规治疗的基础上给予米力农10 mg＋5％葡萄糖注射液250 mL以0．4～0．6μg／（kg· min）泵注给药，1次／d，连续应用3 d。分别于治疗前及治疗后30天采用ELISA法检测两组血浆基质金属蛋白酶9（MMP-9）、B型钠尿肽（BNP）及血清TNF-α和IL-6；行心脏超声检查，记录左心室射血分数（LVEF）、左心室舒张末期内径（LVESD）。结果与治疗前比较，两组治疗后血浆MMP-9、BNP及血清TNF-α、IL-6水平均下降，LVEF升高、LVESD减小（P均＜0．05）；观察组较对照组变化更明显（P均＜0．05）。结论在老年心力衰竭患者治疗中辅助应用米力农可改善心室结构，提高心室射血分数，降低体内炎症反应。 [ABSTRACT FROM AUTHOR]