1. Effect of gestational age at birth on neonatal outcomes in gastroschisis☆
- Author
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Carnaghan, Helen, Baud, David, Lapidus-Krol, Eveline, Ryan, Greg, Shah, Prakesh S., Pierro, Agostino, and Eaton, Simon
- Subjects
Male ,Postnatal Care ,Time Factors ,Enteral feeding ,Gestational Age ,Statistics, Nonparametric ,Enteral Nutrition ,Pregnancy ,Prenatal Diagnosis ,Sepsis ,Preterm delivery ,Humans ,Pediatrics, Perinatology, and Child Health ,Infant Nutritional Physiological Phenomena ,Proportional Hazards Models ,Retrospective Studies ,Gastroschisis ,Postnatal outcome ,Delivery, Obstetric/methods ,Enteral Nutrition/statistics & numerical data ,Female ,Gastroschisis/physiopathology ,Gastroschisis/therapy ,Incidence ,Infant ,Infant, Newborn ,Length of Stay/statistics & numerical data ,Sepsis/epidemiology ,Neonatal outcome ,Length of Stay ,Delivery, Obstetric ,LOS, Length of hospital stay ,GA, Gestational age ,CAPS Paper ,Surgery ,ENT, Time to full enteral feeds ,PN, Parenteral nutrition - Abstract
Introduction Induced birth of fetuses with gastroschisis from 34 weeks gestational age (GA) has been proposed to reduce bowel damage. We aimed to determine the effect of birth timing on time to full enteral feeds (ENT), length of hospital stay (LOS), and sepsis. Methods A retrospective analysis (2000–2014) of gastroschisis born at ≥ 34 weeks GA was performed. Associations between birth timing and outcomes were analyzed by Mann–Whitney test, Cox regression, and Fisher's exact test. Results 217 patients were analyzed. Although there was no difference in ENT between those born at 34–36 + 6 weeks GA (median 28 range [6–639] days) compared with ≥ 37 weeks GA (27 [8–349] days) when analyzed by Mann–Whitney test (p = 0.5), Cox regression analysis revealed that lower birth GA significantly prolonged ENT (p = 0.001). LOS was significantly longer in those born at 34–36 + 6 weeks GA (42 [8–346] days) compared with ≥ 37 weeks GA 34 [11–349] days by both Mann–Whitney (p = 0.02) and Cox regression analysis (p
- Published
- 2016