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Start Over Author "Zhong, Z." Topic apoptosis Publisher sage publications inc.

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1 results on '"Zhong, Z."'

1. Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats.

Author

ZHONG, Z., QULIAN, G., YUAN, Z., WANGYUAN, Z., and ZHIHUA, S.

Subjects
*ANESTHESIA, *ANESTHETICS, *PHARMACODYNAMICS, *RAT physiology, *APOPTOSIS, *NEUROTOXICOLOGY
Abstract

The article focuses on a study which investigated the possible neurotoxicity of multiple doses of intrathecal ropivacaine in rats. Study authors injected ropivacaine in the rats via an implanted intrathecal catheter at 90-minute intervals. They evaluated apoptosis in the spinal cord using in situ TUNEL assay. They concluded that ropivacaine can induce neurotoxicity and apoptosis in a dose-dependent manner.

Published
2009

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