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Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats.
- Source :
-
Anaesthesia & Intensive Care . Nov2009, Vol. 37 Issue 6, p929-936. 8p. 2 Black and White Photographs, 3 Charts, 3 Graphs. - Publication Year :
- 2009
-
Abstract
- The article focuses on a study which investigated the possible neurotoxicity of multiple doses of intrathecal ropivacaine in rats. Study authors injected ropivacaine in the rats via an implanted intrathecal catheter at 90-minute intervals. They evaluated apoptosis in the spinal cord using in situ TUNEL assay. They concluded that ropivacaine can induce neurotoxicity and apoptosis in a dose-dependent manner.
Details
- Language :
- English
- ISSN :
- 0310057X
- Volume :
- 37
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Anaesthesia & Intensive Care
- Publication Type :
- Academic Journal
- Accession number :
- 47144721