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Nano-drug carriers have been widely used in chemotherapy to improve the efficacy of chemotherapeutic drugs. Polymer nano-carriers have greater potential for the enrichment of chemotherapeutic drugs at the target tumor site and controlled release. Herein, a series of amphiphilic copolymers (ITT) was synthesized via melt polymerization with a ROS-cleavable thioketal cross-linker, imidazole groups, and polyethylene glycol-conjugated triphenylphosphonium (PEG-TPP) segments; the actual proportions of the imidazole groups to the PEG-TPP segments were 5.2 : 1, 2.6 : 1, and 1.8 : 1, respectively. The amphiphilic copolymers could self-assemble into cationic micelles with hydrophobic imidazole groups as the core and hydrophilic PEG-TPP segments as the shell in deionized water. The cationic micelles with an average particle size of 124.6–187.3 nm showed a drug loading content (DLC) of 5.65–6.10%. In vitro release studies revealed the pH/ROS dual-responsiveness of the DOX-loaded ITT micelles, and the release behavior of DOX from the micelles strongly depended on the content of imidazole groups in the ITT micelles. Typically, the release of the encapsulated DOX was 27.2%, 30.0%, and 34.1% from DOX-loaded ITT-1 micelles in PBS (pH 6.5) containing 0, 100, and 500 μM H2O2, respectively. The release of the encapsulated DOX was 20.3%, 27.2%, and 42.5% from DOX-loaded ITT-1 micelles in PBS (pH 7.4), PBS (pH 6.5), and PBS (pH 5.0), respectively. The DOX-loaded micelles effectively inhibited the growth of 4T1 cells through being internalized into the 4T1 cells and releasing DOX into the mitochondria, with a cell viability of less than 65% when the DOX concentration was 2.5 μg mL−1. This work presents a novel mitochondria-targeting and pH/ROS-responsive polymer nanocarrier for potential chemotherapy applications. [ABSTRACT FROM AUTHOR]

For the hybrid organic–inorganic perovskites with the general formula of A2MIIX4 (A = methylammonium; MII = Mn, Cu and Co; X = Cl), the arrangement of metal ions and organic ligands leads to a delicate balance of space, spin and charge, which results in diverse properties. In this paper, we reported a group of hybrid organic–inorganic perovskite single crystals of (CH3NH3)2MnCl4, (CH3NH3)2CuCl4 and (CH3NH3)2CoCl4 grown by a simple solution evaporation method. Magnetic measurements show that all the single crystals display magnetic ordering at low temperature. Our results reveal a novel group of hybrid organic–inorganic magnetic perovskites. [ABSTRACT FROM AUTHOR]

A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy. [ABSTRACT FROM AUTHOR]

A new H 2 O 2 -responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H 2 O 2 -triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.