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Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy.
- Source :
- Chemical Communications; 5/18/2017, Vol. 53 Issue 40, p5557-5560, 4p
- Publication Year :
- 2017
-
Abstract
- A new H<subscript>2</subscript>O<subscript>2</subscript>-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H<subscript>2</subscript>O<subscript>2</subscript>-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- MESOPOROUS silica
THERAPEUTIC use of carbon monoxide
NANOMEDICINE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 40
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 123077068
- Full Text :
- https://doi.org/10.1039/c7cc01576c