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Objective: Investigate the expression and potential clinical significance of FK506-binding protein 38 (FKBP38) in breast cancer tissue. Methods: The expression of FKBP38 in 100 cases of normal breast tissue, 300 cases of invasive ductal carcinoma tissue (IDC) and 59 cases of invasive lobular carcinoma tissue (ILC) were detected by immunohistochemistry, and analyzed the relationship between the expression level of FKBP38 protein and clinicopathological parameters of breast cancer. Results: Immunohistochemical results showed that comparing with normal breast tissue, the expression levels of FKBP38 in invasive ductal carcinoma and invasive lobular carcinoma tissue significantly decreased, with a statistical difference (P<0.0001). Further analysis showed that in invasive ductal carcinoma, the expression level of FKBP38 protein was negatively correlated with the pathological grade and clinical stage, and there was a statistical difference, while the expression of FKBP38 protein was negatively correlated with the expression of PR protein. In addition, the current study demonstrated that the expression level of FKBP38 protein in triple-negative breast cancer (TNBC) was much higher than that in non-triple-negative breast cancer, and the expression of FKBP38 in TNBC was negatively correlated with the primary tumor stages. Conclusions: The expression level of FKBP38 protein significantly decreases in breast cancer patients, and it is related to the pathological grade and clinical stage of breast cancer. It is suggested that FKBP38 protein can be used as a potential target for the diagnosis and treatment of breast cancer, but the involving mechanism still needs further exploration. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between quantitative parameters of ultrasound elastic imaging and clinical stage and pathological molecular classification of benign and malignant breast tumors. Methods: 85 patients with breast mass admitted to our hospital from January 2020 to December 2022 were selected to undergo ultrasound elastic imaging examination. The pathological examination results of 85 patients with breast mass were analyzed, elastic imaging parameters of benign and malignant tumors were compared, and ROC curves were drawn for elastic strain rate, diameter change rate, area ratio and the three combined. The elastic imaging parameters of different clinical stages of breast cancer patients and the elastic imaging parameters of pathological molecular classification of breast cancer patients were analyzed. Results: Among 85 patients with breast mass, 35 cases were benign and 50 cases were malignant.The elastic strain rate, mass diameter, diameter change rate, mass area and area ratio in the malignant group were significantly lower than those in the benign group (P<0.05). The area ratio ROC curve AUC was 0.580, with 1.73 as the critical value, the diagnostic sensitivity and specificity of breast malignant tumor were 73.5% and 38.5%. The ROC curve of diameter change rate was 0.630 with 0.28 as the critical value. The diagnostic sensitivity was 75.5% and the specificity was 47.5%. The ROC curve of elastic strain rate was 0.790, with 15.2 cm2 as the critical value, the diagnostic sensitivity was 64.5%, and the specificity was 83.5%. The ROC curve was drawn with the three factors combined, and the AUC was 0.920, the diagnostic sensitivity was 82.5%, and the specificity was 92.5%. There were significant differences in the elastic strain rate, mass diameter, diameter change rate, mass area and area ratio in patients with breast malignant tumor at TNM stage Ⅰ, Ⅱ, Ⅲ and Ⅳ (P<0.05). Among them, the elastic strain rate, mass diameter, diameter change rate, mass area and area ratio of stage Ⅳ were significantly higher than those of stage Ⅲ, Ⅱ and Ⅰ, stage Ⅲ was significantly higher than those of stage Ⅱ and Ⅰ, and stage Ⅱ was significantly higher than those of stage Ⅰ. The differences of elastic strain rate, mass diameter, rate of diameter change, mass area and area ratio in Luminal A, Liminal B, Her2 overexpression and basal-like patients with breast malignant tumor were statistically significant (P<0.05). The elastic strain rate, mass diameter, rate of diameter change, mass area and area ratio of the Liminal B type are significantly higher than those of Luminal A, Her2 overexpression and basal-like type, and the overexpression of Her2 is significantly higher than those of Luminal A and basal-like type (all P<0.05). There was no statistical significance between Luminal A type and basal-like type (P>0.05). Conclusion: Ultrasound elastic imaging can be used for the diagnosis of benign and malignant breast tumors, and the quantitative parameters of ultrasound elastic imaging can be used to judge the clinical stage of malignant breast tumors, the Liminal type B, the Her2 overexpression type. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between serum eosinophil (EOS) expression level and pathology of inverted papilloma in nasal cavity and sinuses (SNIP). Methods: 63 cases of patients with SNIP admitted to our hospital from January 2016 to January 2020 were selected as the research objects. According to the EOS level of all patients, they were divided into low EOS group, medium EOS group and high EOS group. The clinicopathological characteristics of the three groups were compared, and the correlation between EOS expression level and SNIP pathology was analyzed. After surgical treatment, 63 patients were divided into poor prognosis group and good prognosis group. The clinical related indexes of the two groups were compared, and the prognostic value of EOS expression level in SNIP was analyzed. Results: There was significant difference in clinical stage and pathological diagnosis among the three groups (P<0.05); According to the expression level of EOS, there were more than 300 eosinophils at high level/μL. Medium level: 100-300/μL. Low level:<100/μL. Spearman correlation analysis showed that there was no significant correlation between the expression level of the gender, age, lesion location and EOS (P>0.05), but negative correlation between the expression level of the clinical stage and pathological diagnosis and EOS (P<0.05); There was no significant difference in PLT between the two groups (P>0.05). The levels of L and EOS in the two groups were significantly higher than those in the poor prognosis group, and the levels of N, PLR and NLR in the two groups were lower than those in the poor prognosis group (P<0.05); Logistic regression analysis showed that NLR and EOS were independent prognostic factors of SNIP (P<0.05). Conclusion: The clinical stage and SNIP are negatively correlated with the expression level of EOS, and the application of NLR and EOS can predict the recurrence of SNIP. Therefore, the expression level of EOS can be considered to determine the diagnosis and treatment effect of SNIP. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between serum P53, Matrix metalloproteinase-7(MMP-7) antibody expression and the pathological type, stage of esophageal cancer. Methods: A total of 80 patients with esophageal cancer,who were diagnosed and treated in Huai’an Second People’s Hospital from October 2019 to April 2020, were chosen as esophageal cancer group; 50 healthy people with physical examination were chosen as control group during the same period. The expression of serum P53 and MMP-7 antibody was detected in the two groups. The clinicopathological data of the patients were investigated and were performed a correlation analysis. Results: The serum P53 and MMP-7 antibody titers and positive rates of the esophageal cancer group were significantly higher than those of the control group, and the differences were statistically significant(P<0.05). In the esophageal cancer group, the differences in P53, MMP-7 antibody titers and positive expression rates among the patients with different clinical stages, tissue differentiation, lymph node metastasis, tumor size were statistically significant(P<0.05). Spearman rank correlation test analysis showed that the expression of P53 and MMP-7 antibodies were correlated with the clinical stage, and were not correlated with the clinical pathological type(P<0.05). Cox multivariate analysis showed that clinical stage, tissue differentiation, lymph node metastasis, and tumor size were the main factors affected the expression of serum P53 and MMP-7 antibodies(P<0.05). P53 and MMP-7 antibody indexes were analyzed by ROC curve. The area under the P53 curve was 0.804, with a sensitivity of 90.0% and a specificity of 60.0%. The area under the MMP-7 curve was 0.835, with a sensitivity of 97.2% and a specificity of 62.5%. Conclusion: Serum P53 and MMP-7 are highly expressed in the patients with esophageal cancer, which are correlated with the clinical stage of the patients, but not correlated with the clinical pathological type. The clinical stage, tissue differentiation, lymph node metastasis, and tumor size are the main factors affected the expression of serum P53 and MMP-7 antibodies, and both have high diagnostic sensitivity. [ABSTRACT FROM AUTHOR]

Objective: To explore the expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and their correlation with the histological type and clinical stage of non-small cell lung cancer. Methods: A total of 96 cases of patients with NSCLC diagnosed as non-small cell lung cancer admitted in our hospital from January 2014 to January 2017 were selected as the experimental group, 30 cases of patients with benign lung disease were selected as the control group. The expressions of MMP-2 and MMP-9 in lung cancer tissues were detected by immunohistochemical method. The relationship between MMP-2, MMP-9 expressions and histological type and clinical stage of non-small cell lung cancer patients were analyzed. Results: The expression of MMP-2 and MMP-9 in non-small cell lung cancer tissue were significantly higher than those in the lung benign lesion tissue(P<0.05). The expression of MMP-2 and MMP-9 in non-small cell lung cancer squamous cell carcinoma was significantly higher than those in the adenocarcinoma and adenosquamous carcinoma (P <0.05), while there was no significant difference between squamous cell carcinoma and adenosquamous carcinoma (P>0.05). The expression of MMP-2 and MMP-9 in lung cancer tissue were significantly increased with the increase of non-small cell lung cancer stage (P<0.05). Conclusion: The expression of MMP-2 and MMP-9 in non-small cell lung cancer tissues was significantly up-regulated, which was the highest in squamous cell carcinoma, they may contribute to the prognostic prediction and evaluation of histological type and clinical stage. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship of squamous cell carcinoma associated antigen (SCC) and load of high-risk human papillomavirus (HR-HPV) with the clinical stages of Uighur patients with cervical squamous cell carcinoma. Methods: We collected 130 cases of cervical squamous cell carcinoma samples from Uighur patients. According to FIGO clinical stages, there were 60 cases of early cervical squamous cell carcinoma (including E31, II A<4 cm) and 70 cases of middle and advanced squamous cervical carcinoma (including II B, III, IV A). 50 cases of cervicitis were taken as the control. Chemical luminescence method was used to detect SCC and HC-EI method for detection of HR-HPV load. Results: The serum levels of SCC in cervical squamous cell carcinoma group were significantly higher than in chronic cervicitis group, and the difference was statistically significant (P<0.05). In middle-advanced cervical squamous cell carcinoma group, the serum levels of SCC were also significantly higher than in early cervical squamous cell carcinoma group, and the difference was statistically significant (P<0.05). The HR-HPV load was significantly higher in cervical squamous cell carcinoma group than in chronic cervicitis group, with statistical differences (P<0.05). In middle-advanced cervical squamous cell carcinoma group, the HR-HPV load was significantly higher than in early cervical squamous cell carcinoma group, and the difference was also statistically significant (P<0.05). The load of HR-HPV in early stage of cervical squamous cell carcinoma was mainly distributed in 10.00 ~ 99.99 and 100.00% accounting for 98.3%. While that of the middle-advanced cervical squamous cell carcinoma was mainly distributed in 100.00% accounting for 85.7%. Conclusion: SCC and HR-HPV load values were positively correlated with the clinical stages of cervical squamous cell carcinoma of Uighur patients. The combined detection of the SCC and HR-HPV load may have more clinical significance in the diagnosis of cervical squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

Objective: To study the expressions of CD 147 in prostate cancer ancl its relationship with the clinicopathological characteristics of tumor. Methods: 61 cases with prostate cancer who were treated in our hospital from October 2013 to October 2015 were selected as the research objects, and another 49 cases with benign prostatic hyperplasia were selected as the control group. Then the expressions of CD 147 in the tissues of prostate cancer, the adjacent tumor and the benign prostatic hyperplasia by immunohistochemistry. Results: The positive expression of CD 147 in the prostate cancer was 95.08%. which was higher than 32.79% in the adjacent tumor tissues and 16.32% in the benign prostatic hyperplasia tissues, and the difference was statistically significant (P<0.05): The positive expression of CD147 in the adjacent tumor tissues was 32.79% which was higher than 16.32% in the benign prostatic hyperplasia tissues, and the difference was statistically significant (P<0.05). There was positive relationship between the CD 147 expression and the Gleason classification, the clinical tumor stage and the lymphatic and distant metastasis of tumor (P<0.05). Conclusion: CD 147 in prostate cancer tissues showed positive expression and Gleason ≥5. clinical stage at T3~4. lymph node metastasis of N1 and distant metastasis of Ml were the the risk factors of positive expressions of CD 147 in prostate cancel' tissues. [ABSTRACT FROM AUTHOR]