bjective: To study the effect of minimally invasive drilling and drainage on the short-term curative effect of patients with hypertensive cerebral hemorrhage, intracranial infection and hematoma re-enlargement. Methods: 81 patients with hypertensive intracerebral hemorrhage from March 2017 to February 2019 were selected. According to the random number table, they were divided into observation group (n=42) and control group (n=39). The control group was treated with conventional craniotomy and hematoma removal, and the observation group was treated with minimally invasive drilling and drainage. Observe the therapeutic effects of the two groups, the amount of hematoma, myelin basic protein (MBP), central nervous system specific protein S100 levels, NIHSS, GCS scores, and adverse reactions. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group [92.86% (39/42) vs 69.23% (27/39)] (P<0.05); hematoma volume, MBP, and S100 levels were significantly lower Control group [(9.32±2.70) m L vs (15.51±3.01) m L, (3.65±0.52) μg/L vs (4.20±0.71) μg/L, (0.98±0.26) μg/L vs (1.39±0.35) )Μg/L] (P<0.05); NIHSS score was significantly lower than the control group [(3.90±2.71) points vs (6.34±1.42) points (P<0.05); GCS score was significantly higher than the control group [(14.84±3.52) ) Points vs (10.69±3.98) points] (P<0.05); the total incidence of adverse reactions was significantly lower than that of the control group [9.52% (4/42) vs 38.46% (15/39)] (P<0.05). Conclusion: The short-term curative effect of minimally invasive drilling and drainage in the treatment of patients with hypertensive cerebral hemorrhage is significant. The hematoma is completely removed, which can effectively improve the brain nerve defect, reduce intracranial infection, and promote the recovery of the prognosis. [ABSTRACT FROM AUTHOR]