1. Association Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms with Serum Concentrations of Glucose and Phosphate, and Vascular Calcification in Renal Transplant Recipients
- Author
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Valerie N Babinsky, Fadil M Hannan, Sonia C Youhanna, Céline Maréchal, Michel Jadoul, Olivier Devuyst, Rajesh V Thakker, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Valenti, Giovanna, and University of Zurich
- Subjects
Blood Glucose ,Male ,lcsh:Medicine ,610 Medicine & health ,1100 General Agricultural and Biological Sciences ,Phosphates ,10052 Institute of Physiology ,Gene Frequency ,1300 General Biochemistry, Genetics and Molecular Biology ,Humans ,Genetic Predisposition to Disease ,lcsh:Science ,Promoter Regions, Genetic ,Vascular Calcification ,Genetic Association Studies ,1000 Multidisciplinary ,lcsh:R ,Middle Aged ,Kidney Transplantation ,10076 Center for Integrative Human Physiology ,570 Life sciences ,biology ,lcsh:Q ,Calcium ,Female ,Receptors, Calcium-Sensing ,Research Article - Abstract
BACKGROUND: Cardiovascular disease is the major cause of death in renal transplant recipients (RTRs) and linked to arterial calcification. The calcium-sensing receptor (CaSR), a G-protein coupled receptor, plays a pivotal role in extracellular calcium homeostasis and is expressed in the intimal and medial layers of the arterial wall. We investigated whether common CASR gene variants are predictors for aortic and coronary artery calcification or influence risk factors such as serum calcium, phosphate and glucose concentrations in RTRs. METHODS: Two hundred and eighty four RTRs were investigated for associations between three CASR promoter region single nucleotide polymorphisms (SNPs) (rs115759455, rs7652589, rs1501899), three non-synonymous CASR coding region SNPs (A986S, R990G, Q1011E), and aortic and coronary artery calcium mass scores, cardiovascular outcomes and calcification risk factors that included serum phosphate, calcium, total cholesterol and glucose concentrations. RESULTS: Multivariate analysis revealed that RTRs homozygous for the minor allele (SS) of the A986S SNP, when compared to those homozygous for the major allele (AA), had raised serum glucose concentrations (8.7±5.4 vs. 5.7±2.1 mmol/L, P
- Published
- 2015