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Association Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms with Serum Concentrations of Glucose and Phosphate, and Vascular Calcification in Renal Transplant Recipients
- Source :
- PLoS One, Vol. 10, no. 3, p. e0119459 [1-14] (2015), PLOS ONE, PLoS ONE, PLoS ONE, Vol 10, Iss 3, p e0119459 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science, 2015.
-
Abstract
- BACKGROUND: Cardiovascular disease is the major cause of death in renal transplant recipients (RTRs) and linked to arterial calcification. The calcium-sensing receptor (CaSR), a G-protein coupled receptor, plays a pivotal role in extracellular calcium homeostasis and is expressed in the intimal and medial layers of the arterial wall. We investigated whether common CASR gene variants are predictors for aortic and coronary artery calcification or influence risk factors such as serum calcium, phosphate and glucose concentrations in RTRs. METHODS: Two hundred and eighty four RTRs were investigated for associations between three CASR promoter region single nucleotide polymorphisms (SNPs) (rs115759455, rs7652589, rs1501899), three non-synonymous CASR coding region SNPs (A986S, R990G, Q1011E), and aortic and coronary artery calcium mass scores, cardiovascular outcomes and calcification risk factors that included serum phosphate, calcium, total cholesterol and glucose concentrations. RESULTS: Multivariate analysis revealed that RTRs homozygous for the minor allele (SS) of the A986S SNP, when compared to those homozygous for the major allele (AA), had raised serum glucose concentrations (8.7±5.4 vs. 5.7±2.1 mmol/L, P
- Subjects :
- Blood Glucose
Male
lcsh:Medicine
610 Medicine & health
1100 General Agricultural and Biological Sciences
Phosphates
10052 Institute of Physiology
Gene Frequency
1300 General Biochemistry, Genetics and Molecular Biology
Humans
Genetic Predisposition to Disease
lcsh:Science
Promoter Regions, Genetic
Vascular Calcification
Genetic Association Studies
1000 Multidisciplinary
lcsh:R
Middle Aged
Kidney Transplantation
10076 Center for Integrative Human Physiology
570 Life sciences
biology
lcsh:Q
Calcium
Female
Receptors, Calcium-Sensing
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS One, Vol. 10, no. 3, p. e0119459 [1-14] (2015), PLOS ONE, PLoS ONE, PLoS ONE, Vol 10, Iss 3, p e0119459 (2015)
- Accession number :
- edsair.pmid.dedup....8019882674af5b91b963a755b8ed4b4b