1. Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children.
- Author
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Karron, Ruth A, Herbert, Kristi, Wanionek, Kimberli, Schmidt, Alexander C, Schaap-Nutt, Anne, Collins, Peter L, and Buchholz, Ursula J
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INFLUENZA prevention , *INFLUENZA vaccines , *RNA virus infections , *IMMUNIZATION , *VACCINES , *VACCINE effectiveness , *RANDOMIZED controlled trials , *INTRANASAL administration , *PARAMYXOVIRUSES , *VIRAL antibodies , *RNA viruses , *STATISTICAL sampling , *EVALUATION , *CHILDREN , *ADULTS - Abstract
We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
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