Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children.

Authors :: Karron, Ruth A
Herbert, Kristi
Wanionek, Kimberli
Schmidt, Alexander C
Schaap-Nutt, Anne
Collins, Peter L
Buchholz, Ursula J
Source :: Journal of the Pediatric Infectious Diseases Society. Mar2023, Vol. 12 Issue 3, p173-176. 4p.
Publication Year :: 2023
Abstract: We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children. [ABSTRACT FROM AUTHOR]

Subjects :: *INFLUENZA prevention
*INFLUENZA vaccines
*RNA virus infections
*IMMUNIZATION
*VACCINES
*VACCINE effectiveness
*RANDOMIZED controlled trials
*INTRANASAL administration
*PARAMYXOVIRUSES
*VIRAL antibodies
*RNA viruses
*STATISTICAL sampling
*EVALUATION
*CHILDREN
*ADULTS

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