1. Polygenic risk scores for cardiovascular risk prediction: moving towards implementation into clinical practice?
- Author
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Christoffersen, Mette, Stender, Stefan, and Tybjærg-Hansen, Anne
- Subjects
GENETIC risk score ,DISEASE risk factors ,CARDIOVASCULAR diseases risk factors ,CARDIOVASCULAR diseases ,MEDICAL genetics ,SEX factors in disease - Abstract
This article discusses the potential implementation of polygenic risk scores (PRSs) into clinical practice for cardiovascular disease risk prediction. PRSs combine multiple genetic variants to assess an individual's genetic risk for a particular disease. The study examined the integration of a PRS into guideline-recommended prediction of cardiovascular disease risk using data from the UK Biobank. The results showed that the addition of PRSs to clinical risk factors led to significant risk reclassification, particularly for individuals originally classified as intermediate risk. This suggests that PRSs could be useful in identifying individuals who would benefit from intensified preventive treatment. However, challenges remain in terms of interpreting and communicating PRS results to clinicians and patients. Further research is needed to investigate the impact of low genetic risk and to include other ethnic groups in the study. Overall, this study contributes to the ongoing discussion on the clinical utility of PRSs and brings us closer to their implementation in daily clinical practice. [Extracted from the article]
- Published
- 2024
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