Single nucleotide polymorphism in the low-density lipoprotein receptor is associated with a threefold risk of stroke.

Background More than 600 different, but rare, mutations in the low-density lipoprotein (LDL) receptor have been identified as the cause of familial hypercholesterolaemia. In contrast, only a single common amino acid-changing polymorphism (A370T) has been reported in this gene. The association of this polymorphism with variations in lipid levels is at present unclear. [ABSTRACT FROM PUBLISHER]