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An introduction is presented in which the editor discusses various papers within the issue on topics including fiscal union in Europe, monetary policy delivery by channels of bank lending in Europe, and restructuring of Greek debt.

How does mobile broadband internet affect approval of government? Using Gallup World Poll surveys of 840,537 individuals from 2,232 subnational regions in 116 countries from 2008 to 2017 and the global expansion of 3G mobile networks, we show that on average, an increase in mobile broadband internet access reduces government approval. This effect is present only when the internet is not censored, and it is stronger when the traditional media are censored. 3G helps expose actual corruption in government: revelations of the Panama Papers and other corruption incidents translate into higher perceptions of corruption in regions covered by 3G networks. Voter disillusionment had electoral implications. In Europe, 3G expansion led to lower vote shares for incumbent parties and higher vote shares for the antiestablishment populist opposition. Vote shares for nonpopulist opposition parties were unaffected by 3G expansion. [ABSTRACT FROM AUTHOR]

Magnetic minerals form or alter in the presence of hydrocarbons, making them a potential magnetic proxy for identifying hydrocarbon migration pathways. In this paper, we test this idea by magnetically measuring core samples from the Tay Fan in the Western Central Graben in the Central North Sea. In a companion paper, 3-D petroleum systems modelling has been carried out to forward model migration pathways within the Tay Fan. Rock magnetic experiments identified a range of magnetite, maghemite, iron sulphides, siderite, goethite and titanohematite, some of which are part of the background signal, and some due to the presence of hydrocarbons. Typical concentrations of the magnetic minerals were ∼10–200 ppm. Importantly, we have identified an increasing presence of authigenic iron sulphides (likely pyrite and greigite) along the identified lateral hydrocarbon migration pathway (east to west). This is likely caused by biodegradation resulting in the precipitation of iron sulphides, however, though less likely, it could alternatively be caused by mature oil generation, which subsequently travelled with the migrating oil to the traps in the west. These observations suggest mineral magnetic techniques could be a rapid alternative method for identifying the severity of biodegradation or oil maturity in core sample, which can then be used to calibrate petroleum systems models. [ABSTRACT FROM AUTHOR]

In recent years, public policymakers in Europe have become increasingly aware of the need to support Europe's failing semiconductor industry. This is an emerging policy area, and this paper examines the current state of the industry in Europe and assesses its potential future. It contends that the competitiveness of the industry will be related to its innovative capacity, especially its capability to engage in processes of open innovation. The industry in Europe is largely located in a number of discrete regional clusters, and the analysis focuses on data collected from a series of interviews with lead representatives of these clusters. The analysis indicates that the challenges facing the industry stem from the structure of the industry in Europe and the structure of the wider European technology industry. It is concluded that policies, such as the introduction of the European Chips Act, are likely to have a limited, or even negative, impact on the types of open innovation–led growth that will improve long-term competitiveness. [ABSTRACT FROM AUTHOR]

This study aims to review the open science (OS) policy documents, identify their subject areas, and distinguish the topics of OS support policies in seven European countries, providing a platform for practical cooperation between countries in science popularization. With a qualitative–inductive approach, all pertinent policy documents in OS were collected through documentary study, and thematic analysis was conducted to identify OS policies for each country. Finally, forty-six policy documents extracted up to December 2020 were thematically analyzed through a qualitative–inductive case study. All selected countries had developed OS policies, and these supportive policies were generally related to the three dimensions of 'open input, open process, and open output'. In 'open input', recommendations for the performance of research data repositories, as well as management criteria, are considered. Most countries adopted 'open output' protectionist policies. Multiple policies in the 'open process' indicate the need for an appropriate OS platform. [ABSTRACT FROM AUTHOR]

Despite the increasing proportion of female medical and nursing students, there is still a significant under-representation of women working as healthcare providers in interventional cardiology, with very few of them reaching senior leadership, academic positions, or acting principal investigators, as well as actively involved in company advisory boards. In this position paper, we will describe the current status of women working in interventional cardiology across Europe. We will also provide an overview of the most relevant determinants of the under-representation of women at each stage of the interventional cardiology career path and offer practical suggestions for overcoming these challenges. [ABSTRACT FROM AUTHOR]

Background Early reports on the pandemic nature of coronavirus disease 2019 (COVID-19) directed the nephrology community to develop infection prevention and control (IPC) guidance. We aimed to make an inventory of strategies that dialysis centres followed to prevent infection with COVID-19 in the first pandemic wave. Methods We analyzed IPC measures taken by hemodialysis centres treating patients presenting with COVID-19 between 1 March 2020 and 31 July 2020 and that completed the European Renal Association COVID-19 Database centre questionnaire. Additionally, we made an inventory of guidelines published in European countries to prevent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in dialysis centres. Results Data from 73 dialysis units located in and bordering Europe were analyzed. All participating centres implemented IPC measures to mitigate the impact of SARS-CoV-2 during the first pandemic wave. Measures mentioned most often included triage with questions before entering the dialysis ward, measuring body temperature, hand disinfection, masking for all patients and staff, and personal protective equipment for staff members. These measures were also recommended in most of the 14 guidelines that were identified in the inventory of national guidelines and were also scored as being among the most important measures by the authors of this paper. Heterogeneity existed between centres and national guidelines regarding the minimal distance between dialysis chairs and recommendations regarding isolation and cohorting. Conclusions Although variation existed, measures to prevent transmission of SARS-CoV-2 were relatively similar across centres and national guidelines. Further research is needed to assess causal relationships between measures taken and spread of SARS-CoV-2. [ABSTRACT FROM AUTHOR]

The GECEM Project Database stands out as a new Digital Humanities solution to accurately order and analyse the new historical Big Data gathered in Chinese and European historical archives. Traditional challenges such as capture, storage, analysis, data curation, searching, sharing, transfer, visualization, querying, updating, and information privacy are being tackled and solved within the design of this new multi-relational database. The implementation of this database has as its main innovative elements the capability of coding and cross-referring historical data in Chinese and Western languages. Thus, we present a new database as a digital solution to solve the long-lasting problem in historical research: the maximization and optimization of data collection when analysing historical sources and how to make use of a large amount of registers and information when developing case studies and work hypotheses for historical research. In this paper, we present a solution for data collection and analysis of probate inventories and trade records which is a relevant source when determining changes in patterns of consumption and global trade through the introduction of Chinese goods into Europe and vice versa during the early modern period. [ABSTRACT FROM AUTHOR]

Nothing puzzles sociologists of religion more than the reasons and the patterns behind religious change. In the literature on secularization processes, it is broadly accepted that ongoing modernization has undermined many of the pillars of institutional religions, leading to widespread religious decline. While a considerable body of research investigates the "why(s)" of this decline, the main focus of this paper is on the "how." Drawing on CARPE, a harmonized dataset concerning church attendance with almost 2 million observations spanning over 40 years in 39 European countries, this article disentangles the contributions of period change and cohort replacement to the general religious decline. It shows that this decline reflects a real population dynamic based on generational replacement. It is not historical events or developments affecting everyone that undermine religion: new and less religious cohorts are replacing old and more religious ones. Like many other population dynamics, this process is described by an S-shaped curve and applies—with different speeds and levels—to almost all the European countries considered herein. These findings suggest that the effects of the processes of modernization on the mechanisms of religious socialization should be scrutinized more carefully when studying the reasons behind religious decline. [ABSTRACT FROM AUTHOR]

We study the allocation of interest rate risk within the European banking sector using novel data. Banks' exposure to interest rate risk is small on aggregate, but heterogeneous in the cross-section. Contrary to conventional wisdom, net worth is increasing in interest rates for approximately half of the institutions in our sample. Cross-sectional variation in banks' exposures is driven by cross-country differences in loan-rate fixation conventions for mortgages. Banks use derivatives to partially hedge on-balance-sheet exposures. Residual exposures imply that changes in interest rates have redistributive effects within the banking sector. Received October 31, 2017; editorial decision August 30, 2018 by Editor Philip Strahan. Authors have furnished an Internet Appendix , which is available on the Oxford University Press Web site next to the link to the final published paper online. [ABSTRACT FROM AUTHOR]

Research performed in Europe has driven cardiovascular device innovation. This includes, but is not limited to, percutaneous coronary intervention, cardiac imaging, transcatheter heart valve implantation, and device therapy of cardiac arrhythmias and heart failure. An important part of future medical progress involves the evolution of medical technology and the ongoing development of artificial intelligence and machine learning. There is a need to foster an environment conducive to medical technology development and validation so that Europe can continue to play a major role in device innovation while providing high standards of safety. This paper summarizes viewpoints on the topic of device innovation in cardiovascular medicine at the European Society of Cardiology Cardiovascular Round Table, a strategic forum for high-level dialogue to discuss issues related to the future of cardiovascular health in Europe. Devices are developed and improved through an iterative process throughout their lifecycle. Early feasibility studies demonstrate proof of concept and help to optimize the design of a device. If successful, this should ideally be followed by randomized clinical trials comparing novel devices vs. accepted standards of care when available and the collection of post-market real-world evidence through registries. Unfortunately, standardized procedures for feasibility studies across various device categories have not yet been implemented in Europe. Cardiovascular imaging can be used to diagnose and characterize patients for interventions to improve procedural results and to monitor devices long term after implantation. Randomized clinical trials often use cardiac imaging-based inclusion criteria, while less frequently trials randomize patients to compare the diagnostic or prognostic value of different modalities. Applications using machine learning are increasingly important, but specific regulatory standards and pathways remain in development in both Europe and the USA. Standards are also needed for smart devices and digital technologies that support device-driven biomonitoring. Changes in device regulation introduced by the European Union aim to improve clinical evidence, transparency, and safety, but they may impact the speed of innovation, access, and availability. Device development programmes including dialogue on unmet needs and advice on study designs must be driven by a community of physicians, trialists, patients, regulators, payers, and industry to ensure that patients have access to innovative care. [ABSTRACT FROM AUTHOR]

Although firmly established as a global norm, the Women, Peace and Security Agenda (WPS) has been largely driven by the global North attempting to solve insecurities in the global South. Postcolonial feminist research shows that this western-centrism and colonial legacies continue to dominate both WPS practices and knowledge production. This article focuses on WPS in central Europe, a previously ignored 'non-region' that remains outside the North–South divide. Combining postcolonial and decolonial approaches with feminist institutionalism, we interrogate what WPS becomes in the Czech, Polish and Slovakian contexts characterized by illiberal populist and anti-gender governance and politics. Building on interviews with key stakeholders, on document analysis and our own encounters, we argue that the three countries understand WPS as key to their western belongingness and reliability as international partners. As a result, they replicate rather than challenge 'western' WPS thinking. The resulting National Action Plans are centred around women's participation and security problems 'out there'. This lack of localization enables them to stay immune to the anti-gender alliances, but limits the engagement of feminist civil society. Amidst Russian imperial aggression, central Europe's WPS agendas serve as mere paper tigers and are failing to address the multitude of domestic and regional gendered insecurities. [ABSTRACT FROM AUTHOR]

Set in nineteenth century Europe, InSEXts tells the story of Lady Bertram and Mariah, two women in a romantic relationship who can transform into insects in order to defend their nascent family. In the second arc of the series , The Necropolis, Lady Bertram, and Mariah are joined by Phoebe (a Black, transgender artist) whose friends are being transformed into art by members of the patriarchal art community, who value women only as silent and beautiful Muses. Allying with 'Medusa', a misidentified Javanese goddess who has been forcibly brought to Europe, Lady Bertram and Mariah thus enter a narrative replete with Greek and Roman mythology. In this paper, the author sets out to demonstrate that, through the receptions of Pygmalion and Medusa , InSEXts : The Necropolis effectively reflects Cixous' 'Laugh of the Medusa', replicating the empowerment of female creativity which Cixous suggests. By mirroring these Ovidian intertexts and becoming 'writing women' themselves, comics creators Bennett and Kristantina allow their own characters to re-write and subvert traditional narratives, to tell their own stories that represent elements of Ovidian narrative to respond to and embody the kind of female creativity advocated by Cixous. [ABSTRACT FROM AUTHOR]

This paper analyses the distortions that banks' cross-border activities, such as foreign assets, deposits and equity, can introduce into regulatory interventions. We find that while each individual dimension of cross-border activities distorts the incentives of a domestic regulator, a balanced amount of cross-border activities does not necessarily cause inefficiencies, as the various distortions can offset each other. Empirical analysis using bank-level data from the recent crisis provides support to our theoretical findings. Specifically, banks with a higher share of foreign deposits and assets and a lower foreign equity share were intervened at a more fragile state, reflecting the distorted incentives of national regulators. We discuss several implications for the supervision of cross-border banks in Europe. - Thorsten Beck, Radomir Todorov and Wolf Wagner [ABSTRACT FROM AUTHOR]

This paper asks what insights the literature provides on divergence versus convergence of innovation paths in Europe and Asia. It contrasts the abundant literature on determinants of innovation paths with the scarcity of studies that are explicitly comparative across countries or continents. Implicit conclusions however emerge from several lines of work including evolutionary perspectives which stress differences in national conditions, and other perspectives which stress latecomer and globalisation effects. This paper distils and draws together the main conclusions on why innovation paths can be expected to diverge or converge. Its contribution lies in spelling out and bringing together implicit and explicit insights from a wide range of literatures. It also provides an analytical backdrop for some of the other papers in this special issue of Science and Public Policy which provide comparative empirical analyses of low carbon innovation paths. [ABSTRACT FROM AUTHOR]

Economic crises carry a substantial impact on population health and health systems, but little is known on how these transmit to health workers (HWs). Addressing such a gap is timely as HWs are pivotal resources, particularly during pandemics or the ensuing recessions. Drawing from the empirical literature, we aimed to provide a framework for understanding the impact of recessions on HWs and their reactions. We use a systematic review and best-fit framework synthesis approach to identify the relevant qualitative, quantitative and mixed-methods evidence, and refine an a priori, theory-based conceptual framework. Eight relevant databases were searched, and four reviewers employed to independently review full texts, extract data and appraise the quality of the evidence retrieved. A total of 57 peer-reviewed publications were included, referring to six economic recessions. The 2010-15 Great Recession in Europe was the subject of most (52%) of the papers. Our consolidated framework suggests that recessions transmit to HWs through three channels: (1) an increase in the demand for services; (2) the impacts of austerity measures; and (3) changes in the health labour market. Some of the evidence appeared specific to the context of crises; demand for health services and employment increased during economic recessions in North America and Oceania, but stagnated or declined in Europe in connection with the austerity measures adopted. Burn-out, lay-offs, migration and multiple jobholding were the reactions observed in Europe, but job opportunities never dwindled for physicians during recessions in North America, with nurses re-entering labour markets during such crises. Loss of motivation, absenteeism and abuse of health systems were documented during recessions in low-income countries. Although the impacts of recessions may vary across economic events, health systems, labour markets and policy responses, our review and framework provide an evidence base for policies to mitigate the effects on HWs. [ABSTRACT FROM AUTHOR]

This paper introduces a special section of Science and Public Policy on science in society in Europe. Based on extensive data collected for the Monitoring Policy and Research Activities on Science in Society in Europe (MASIS) project, contributions to this special section explore pertinent issues related to the location, role and responsibility of science across EU member states and associated countries. By developing analytical typologies and classifying countries, the collection of papers provides a novel and detailed picture of Europe. It reveals considerable variation regarding the interactions of science and society at the national level, and it offers a platform for international learning. The identification of patterns and trends concerning the place of science in society may also feed into emerging European discussions about 'responsible research and innovation'. [ABSTRACT FROM AUTHOR]

The European patent system was designed around a paradigm of human inventorship. This paper will analyse in depth and from a de lege ferenda perspective the rather general arguments against and in favour of a possible designation of artificial intelligence (AI) systems as inventors. For the sake of a more concrete discussion, it will also outline a potential reform of the European patent system to implement AI inventorship and allocate the right to the European patent for such inventions by default to the machine's operator. In the process, it will highlight the major specific issues associated with a reform that acknowledges AI inventorship and touch upon possible alternative approaches to addressing the growing autonomy of machines within the R&D process. The study must not be understood as a call for a reform to recognise AI systems as inventors but rather as a manner of laying the foundations for a more concrete, critical and fruitful discussion on non-human inventorship and its alternatives. The analysis will show that the more general, highly conceptional reservations advanced in the current discussion against AI inventorship are somewhat unfounded, e.g. the alleged break with the functions of the current patent system or the alleged need to endow AI with legal personality. More convincing arguments against a reform that allows for the designation of AI systems as inventor might instead relate to the specific difficulties associated with such reform. [ABSTRACT FROM AUTHOR]

Background Schizophrenia is a chronic disease associated with significant and long-lasting effects on health, and it is also a social and financial burden, not only for patients but also for families, other caregivers, and the wider society. It is essential to conduct the assessment of indirect costs, to understand all the effects of the disease on society. Our aim is to gain a better understanding of the indirect costs of schizophrenia in Europe. Methods We conducted a comprehensive systematic literature review covering EMBASE, Medline, and PsycINFO as well as reviewing Health Technology Assessment databases from different countries. We used a qualitative research synthesis for presenting information, as most of the studies were methodologically diverse, a quantitative analysis would have been impractical. Results Indirect cost adjusted to inflation ranged vastly between studies included in the review from 119 Euros to 62, 034 Euros annually. The average proportion of indirect costs of total costs was 44%. Studies highlighted important cost drivers as age, gender, and disease severity, explaining the variation in costs between treatment and patient groups. Conclusions Regardless of the methodological heterogeneity of the reviewed studies, there was an agreement about the significance of indirect costs of schizophrenia on the society. Considering the relatively high prevalence of schizophrenia in Europe, a need for more cost of illness studies especially from Central Eastern and Southern Europe is suggested. [ABSTRACT FROM AUTHOR]

Summary: In international football (soccer), two‐legged knockout ties, with each team playing at home in one leg and the final outcome decided on aggregate, are common. Many players, managers and followers seem to believe in ‘second‐leg home advantage’, i.e. that it is beneficial to play at home on the second leg. A more complex effect than the well‐documented usual home advantage, it is more difficult to identify, and previous statistical studies have not proved conclusive about its actuality. As opposed to previous research, the paper addresses the question from a purely non‐parametric perspective, which is not based on any particular model specification which could orientate the analysis in one or the other direction. Along the way, the paper reviews the well‐known shortcomings of the Wald confidence interval for a proportion, suggests new non‐parametric confidence intervals for conditional probability functions, revisits the problems of bias and bandwidth selection when building confidence intervals in non‐parametric regression and provides a novel bootstrap‐based solution to them. Finally, the new intervals are used when analysing game outcome data for the UEFA (Union of European Football Associations) Champions and Europa Leagues from 2009–2010 to 2014–2015. A slight second‐leg home advantage is evidenced. [ABSTRACT FROM AUTHOR]

The existing literature that estimates the incidence of arrears relies on either household survey data or administrative data derived from the lender's records of their borrowers. But estimates based on these different sources will give different estimates of arrears. Moreover, the estimates are not useful for policy analysis or for a bank's lending decision, since they ignore the fact that some households do not borrow. The paper discusses the selection issues that are involved in using either source of data and is the first paper to bound the estimate of the household's underlying propensity to repay. To demonstrate the methodology, it uses data from the European Union Survey of Income and Living Conditions survey for 2008 to estimate the factors that affect repayment among Eurozone households. [ABSTRACT FROM AUTHOR]

Civil society organizations (CSOs) are a cornerstone of democracy in Europe. Nonetheless, "civil society" and "political society" should not be equated as membership-based organizations are not necessarily politically engaged. This paper theorizes and empirically examines which membership-based CSOs engage in interest representation through sustained advocacy activity. We propose an incentive-theoretical framework on CSO investments in advocacy activities—a collective, non-exclusive incentive from which also non-members can profit—by organizations fundamentally dependent on member support. Theorizing how CSOs' own structural characteristics, resource dependencies, and government demand for CSO input affect how CSOs reconcile selective and collective incentive provision, we test our hypotheses using new data from four recent surveys conducted in four European democracies. In line with our framework, CSOs organizing individual citizens rather than corporate actors and those pursuing member interests are less likely to engage in advocacy, while CSO professionalization and state funding access enhance CSOs' propensities to do so. Furthermore, the analysis shows that the former structural CSO characteristics are similarly relevant for CSO advocacy across distinct country settings, while the role of resource variables is mediated by institutional context revealing an important source of inequality in democratic interest representation. [ABSTRACT FROM AUTHOR]

Scientists who work on bioinspired systems may see the potential for products resulting from their research, but are often unaware of the various steps or issues related to commercialization or product development. Commercialization topics lie outside the usual training of a basic biologist, and therefore much of their exposure to these topics is adventitious, such as from casual conversations at meetings. Thus, the information gleaned may be somewhat piecemeal. In this paper, I briefly summarize some of what I have learned over the last 10 years about commercialization from a variety of different sources, related to a bioinspired project in which I am involved. My collaborators and I have invented and patented a technology to entrap insect pests by a purely physical mechanism (a "physical insecticide" that does not involve a chemical insecticide). This bioinspired technology is based on a historical control method, in which leaves from bean plants were used to capture bed bugs for hundreds of years in parts of eastern Europe. Sharp recurved microstructures (nonglandular trichomes) on the leaf surfaces irreversibly impale the tarsi (feet) of the bed bugs as they walk over the surfaces, trapping them in place. Pest professionals have identified bed bugs as the most difficult pest to control; there is a clear need for new methods of control for this pest. There are societal benefits and consumer demand for products that are sustainable, without regulatory constraints, and that minimize insecticide exposure for humans. But how would these products be developed from this starting point of a bioinspired invention? I will briefly share some of our experiences in the early and ongoing product development of entrapping surfaces, with the hope that this might interest or aid others who are considering entrepreneurial activities. Unfamiliar topics such as intellectual property, customer segmentation, value propositions, business models, conflict of interest, and conflict of commitment may require some attention from prospective entrepreneurs. This brief and introductory overview is intended for those academic scientists with little to no experience or knowledge in the area of commercialization. [ABSTRACT FROM AUTHOR]

On 19 April 2012, the Court of Justice (the Court) dismissed an appeal by Tomra Group (Tomra) against the General Court's judgment which upheld the decision of the Commission fining Tomra for abuse of dominant position. [ABSTRACT FROM AUTHOR]

Background During the coronavirus disease 2019 (COVID-19) pandemic, all European countries were hit, but mortality rates were heterogenous. The aim of the current paper was to identify factors responsible for this heterogeneity. Methods Data concerning 40 countries were gathered, concerning demographics, vulnerability factors and characteristics of the national response. These variables were tested against the rate of deaths per million in each country. The statistical analysis included Person correlation coefficient and Forward Stepwise Linear Regression Analysis (FSLRA). Results The FSLRA results suggested that 'days since first national death for the implementation of ban of all public events' was the only variable significantly contributing to the final model, explaining 44% of observed variability. Discussion The current study suggests that the crucial factor for the different death rates because of COVID-19 outbreak was the fast implementation of public events ban. This does not necessarily mean that the other measures were useless, especially since most countries implemented all of them as a 'package'. However, it does imply that this is a possibility and focused research is needed to clarify it, and is in accord with a model of spreading where only a few superspreaders infect large numbers through prolonged exposure. [ABSTRACT FROM AUTHOR]

Recent antitrust scholarship has claimed that parallel investments by institutional investors in competing firms may harm competition. Proponents of this theory, dubbed 'common ownership', posit that harm may arise even with small shareholdings, particularly in oligopolistic markets.  Although the debate has been focused on the U.S. the European Commission recently invoked common ownership as an 'element of context' in two merger decisions. This article examines common ownership through a European lens. A threshold issue will be whether levels of common ownership in Europe are comparable to those in the U.S.; the available evidence suggests they are not.  We note a number of misconceptions about the asset management industry, putting in doubt core elements of the common ownership hypothesis. We review the academic debate in which the theory has been vigorously contested on both methodological and theoretical grounds. We review the battle between empirical studies claiming to demonstrate and to disprove common ownership effects. The article considers whether the theory is sufficiently robust to provide a basis for enforcement, and (if so) whether current European Union competition law tools could be used to that end. The European Commission's invocation of common ownership is subjected to critical evaluation. We conclude that it is premature to draw any conclusions as to the reality of alleged common ownership concerns or to base enforcement efforts on them. Until a better understanding of the underlying facts and a broad academic consensus emerge, reform prescriptions that have been advanced are a solution in search of a problem—to say nothing of the conflicts that would arise with other rules governing asset management. [ABSTRACT FROM AUTHOR]

The European brewing industry has experienced considerable development related to the changes of beer production volume. These trends are generalised by Vernon's concept of product life-cycle that is already anchored in the economic geography. The differences of its growth, maturity and decline stages are important to study transnational corporations' (TNC) strategies within the combination of different stages of all European markets. Therefore, the aim of this paper is to verify how the TNCs' behaviour in individual countries depends on the stages of their beer markets. In the beer life-cycle perspective, Europe can be divided into several regions with a similar stage of development. Expected behaviour of brewing TNCs in the dependence of the countries' stage in the beer life-cycle have been proved in the large extent. Some interesting differences were, however, also found. The paper finally pointed on the rising beer life-cycle of microbreweries, which could replace the life-cycle of traditional breweries. [ABSTRACT FROM AUTHOR]

The paper considers whether water privatization 30 years ago has delivered the promised superior performance to nationalization, which remains the dominant model in Europe. The paper sets out the arguments at privatization, in particular in relation to efficiency, the managerial incentives, the role of private-sector balance sheets in facilitating investment, and the impacts on the cost of capital. Alternative explanations of relative performance, notably the regulation model adopted, are highlighted, and the paper concludes by outlining an alternative model of water regulation which better marries up public responsibilities and private incentives. [ABSTRACT FROM AUTHOR]

A response by Christian Strupp to a letter to the editor about his articles on beryllium toxicity is presented.

This paper investigates the effects of Resale Price Maintenance (RPM) agreements in Europe by studying a legally permitted form of RPM in the book market. In particular, we study the effects of such agreements on prices and sales, finding that countries which have Fixed Book Prices policies witness higher book sales, relative to countries without such a policy, with no noticeable effect on the average price of books. We suggest that the mechanism for these findings is that FBP policies promote non-price competition and a diverse network of retailers, increasing quantity, whereas a change in bargaining power reduces double marginalisation, offsetting upward pricing pressure from RPM. While these results are limited to the book sector and are based on a limited number of countries changing policy, they nonetheless highlight that RPM agreements have the ability to confer positive competition effects and absolute prohibition of such agreements may not always be warranted. [ABSTRACT FROM AUTHOR]

Analysis of phylogenetic trees has become an essential tool in epidemiology. Likelihood-based methods fit models to phylogenies to draw inferences about the phylodynamics and history of viral transmission. However, these methods are often computationally expensive, which limits the complexity and realism of phylodynamic models and makes them ill-suited for informing policy decisions in real-time during rapidly developing outbreaks. Likelihood-free methods using deep learning are pushing the boundaries of inference beyond these constraints. In this paper, we extend, compare, and contrast a recently developed deep learning method for likelihood-free inference from trees. We trained multiple deep neural networks using phylogenies from simulated outbreaks that spread among 5 locations and found they achieve close to the same levels of accuracy as Bayesian inference under the true simulation model. We compared robustness to model misspecification of a trained neural network to that of a Bayesian method. We found that both models had comparable performance, converging on similar biases. We also implemented a method of uncertainty quantification called conformalized quantile regression that we demonstrate has similar patterns of sensitivity to model misspecification as Bayesian highest posterior density (HPD) and greatly overlap with HPDs, but have lower precision (more conservative). Finally, we trained and tested a neural network against phylogeographic data from a recent study of the SARS-Cov-2 pandemic in Europe and obtained similar estimates of region-specific epidemiological parameters and the location of the common ancestor in Europe. Along with being as accurate and robust as likelihood-based methods, our trained neural networks are on average over 3 orders of magnitude faster after training. Our results support the notion that neural networks can be trained with simulated data to accurately mimic the good and bad statistical properties of the likelihood functions of generative phylogenetic models. [ABSTRACT FROM AUTHOR]

This paper introduces a normative, expert-informed, time-dependent index of Social Inclusion for European administrative regions in five countries, using longitudinal data from Eurostat. Our contribution is twofold: first, our indicator is based on a non-additive aggregation operator (the Choquet Integral), which allows us to model many preferences' structures and to overcome the limitations embedded in other approaches. Second, we elicit the parameters of the aggregation operator from an expert panel of Italian policymakers in Social Policy, and Economics scholars. Our results highlight that Mediterranean countries exhibit lower Inclusion levels than Northern/Central countries, and that this disparity has grown in the last decade. Our results complement and partially challenge existing evidence from data-driven aggregation methods. [ABSTRACT FROM AUTHOR]

Introduction and Objective This paper provides an overview of the DUQuE (Deepening our Understanding of Quality Improvement in Europe) project, the first study across multiple countries of the European Union (EU) to assess relationships between quality management and patient outcomes at EU level. The paper describes the conceptual framework and methods applied, highlighting the novel features of this study. Design DUQuE was designed as a multi-level cross-sectional study with data collection at hospital, pathway, professional and patient level in eight countries. Setting and Participants We aimed to collect data for the assessment of hospital-wide constructs from up to 30 randomly selected hospitals in each country, and additional data at pathway and patient level in 12 of these 30. Main outcome measures A comprehensive conceptual framework was developed to account for the multiple levels that influence hospital performance and patient outcomes. We assessed hospital-specific constructs (organizational culture and professional involvement), clinical pathway constructs (the organization of care processes for acute myocardial infarction, stroke, hip fracture and deliveries), patient-specific processes and outcomes (clinical effectiveness, patient safety and patient experience) and external constructs that could modify hospital quality (external assessment and perceived external pressure). Results Data was gathered from 188 hospitals in 7 participating countries. The overall participation and response rate were between 75% and 100% for the assessed measures. Conclusions This is the first study assessing relation between quality management and patient outcomes at EU level. The study involved a large number of respondents and achieved high response rates. This work will serve to develop guidance in how to assess quality management and makes recommendations on the best ways to improve quality in healthcare for hospital stakeholders, payers, researchers, and policy makers throughout the EU. [ABSTRACT FROM AUTHOR]

Background: Within the European Union (EU), substantial efforts are being made to achieve economic and social cohesion, and the reduction of health inequalities between EU regions is integral to this process. This paper is the first to examine how self-reported conditions and non-communicable diseases (NCDs) vary spatially between and within countries. Methods: Using 2014 European Social Survey (ESS) data from 20 countries, this paper examines how regional inequalities in self-reported conditions and NCDs vary for men and women in 174 regions (levels 1 and 2 Nomenclature of Statistical Territorial Units, 'NUTS'). We document absolute and relative inequalities across Europe in the prevalence of eight conditions: general health, overweight/obesity, mental health, heart or circulation problems, high blood pressure, back, neck, muscular or joint pain, diabetes and cancer. Results: There is considerable inequality in self-reported conditions and NCDs between the regions of Europe, with rates highest in the regions of continental Europe, some Scandinavian regions and parts of the UK and lowest around regions bordering the Alps, in Ireland and France. However, for mental health and cancer, rates are highest in regions of Eastern European and lowest in some Nordic regions, Ireland and isolated regions in continental Europe. There are also widespread and consistent absolute and relative regional inequalities in all conditions within countries. These are largest in France, Germany and the UK, and smallest in Denmark, Sweden and Norway. There were higher inequalities amongst women. Conclusion: Using newly available harmonized morbidity data from across Europe, this paper shows that there are considerable regional inequalities within and between European countries in the distribution of self-reported conditions and NCDs. [ABSTRACT FROM AUTHOR]

Background: It has been suggested that cross-national variation in educational inequalities in health outcomes (e.g. NCDs) is due to cross-national variation in risky health behaviour. In this paper we aim to use highly recent data (2014) to examine educational inequalities in risky health behaviour in 21 European countries from all regions of the continent to map cross-national variation in the extent to which educational level is associated with risky health behaviour. We focus on four dimensions of risky health behaviour: smoking, alcohol use, lack of physical activity and lack of fruit and vegetable consumption. Methods: We make use of recent data from the 7th wave of the European Social Survey (2014), which contains a special rotating module on the social determinants of health. We performed logistic regression analyses to examine the associations between educational level and the risky health behaviour indicators. Educational level was measured through a three-category version of the harmonized International Standard Classification of Education (ISCED). Results: Our findings show substantial and mostly significant inequalities in risky health behaviour between educational groups in most of the 21 European countries examined in this paper. The risk of being a daily smoker is higher as respondents' level of education is lower (Low education (L): OR = 4.24 (95% CI: 3.83^.68); Middle education (M): OR = 2.91 (95% CI: 2.65-3.19)). Respondents have a lower risk of consuming alcohol frequently if they have a low level of education (L: OR = 0.59 (95% CI: 0.54-0.64); M: OR = 0.70 (95% CI: 0.65-0.76)), but a higher risk of binge drinking frequently (L: OR = 1.29 (95% CI: 1.16-1.44); M: OR = 1.15 (95% CI: 1.04-1.27)). People are more likely to be physically active at least 3 days in the past week when they have a higher level of education (M: OR = 1.42 (95% CI: 1.34-1.50); H: OR = 1.67 (95% CI: 1.55-1.80)). Finally, people are more likely to consume fruit and vegetables at least daily if they have a higher level of education (fruit: M: OR = 1.09 (95% CI: 1.03-1.16); H: OR = 1.77 (95% CI: 1.63-1.92); vegetables: M: OR = 1.34 (95% CI: 1.26-1.42); H: OR = 2.35 (95% CI: 2.16-2.55)). However, we also found considerable cross-national variation in the associations between education and risky health behaviour. Conclusions: Our results yield a complex picture: the lowest educational groups are more likely to smoke and less likely to engage in physical activity and to eat fruit and vegetables, but the highest educational groups are at greater risk of frequent alcohol consumption. Additionally, inequalities in risky health behaviour do not appear to be systematically weakest in the South or strongest in the North and West of Europe. [ABSTRACT FROM AUTHOR]

Background Previous research has suggested an ethnic association of Heck's disease with a prominent genetic and familial inheritance pattern, but no systematic review has been reported, which has collected all the evidence in one paper. The aim was estimation of the updated age estimates and gender predilection of this disease and also questioning its proposed link to ethnic and geographical factors. Methods Heck's disease from 1966 until present are tabulated, including various descriptive characteristics. After removal of duplicates and adhering to all the inclusion criteria, we shortlisted 95 case reports. The quality assessment of all included studies has been done following STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) guidelines. Results We found an age range of 3–92 years (mean: 23.1 years) with a male to female ratio of 3:4. Geographical distribution revealed one of the main findings of this study, which was an increased incidence of Heck's disease in the European region. Conclusions As already observed and established, there is a much greater prevalence of this disease in the indigenous populations of the world and more research should be encouraged to understand the correct transmission and pattern of spread of this disease. [ABSTRACT FROM AUTHOR]

Ulipristal acetate (UPA) is a medical treatment for uterine fibroids and was authorized for surgical pre-treatment in 2012 after the conduct of the PEARL I and II randomized controlled trials and for intermittent treatment after the observational PEARL III and IV trials. However, UPA came into disrepute due to its temporary suspension in 2017 and 2020 because of an apparent association with liver injury. This clinical opinion paper aims to review the process of marketing authorization and implementation of UPA, in order to provide all involved stakeholders with recommendations for the introduction of future drugs. Before marketing authorization, the European Medicines Agency (EMA) states that Phase III registration trials should evaluate relevant outcomes in a representative population, while comparing to gold-standard treatment. This review shows that the representativeness of the study populations in all PEARL trials was limited, surgical outcomes were not evaluated and intermittent treatment was assessed without comparative groups. Implementation into clinical practice was extensive, with 900 000 prescribed treatment cycles in 5 years in Europe and Canada combined. Extremely high costs are involved in developing and evaluating pre-marketing studies in new drugs, influencing trial design and relevance of chosen outcomes, thereby impeding clinical applicability. It is vitally important that the marketing implementation after authorization is regulated in such way that necessary evidence is generated before widespread prescription of a new drug. All stakeholders, from pharmaceutical companies to authorizing bodies, governmental funding bodies and medical professionals should be aware of their role and take responsibility for their part in this process. [ABSTRACT FROM AUTHOR]

Background To address social inequalities in adolescent substance use and consequent disparities in health, it is important to identify the mechanisms of the association between substance use and academic performance. We study the role of health literacy (HL) in the association between academic performance and weekly smoking, monthly alcohol use and cannabis ever-use among adolescents in Europe. Methods SILNE-R school survey data, which was collected in 2016–17 with paper-and-pencil-method from Hanover (GE), Amersfoort (NL) and Tampere (FI), were used (N  = 5088, age 13–19). Health Literacy for School-aged Children instrument was used to assess students' HL. Logistic regression analyzed the association of substance use with academic performance and HL, separately and in the same model. Linear and multinomial logistic regression analyzed the association between academic performance and HL. Results Poor academic performance compared with high was associated with smoking [odds ratio (OR) 3.94, 95% confidence interval (CI) 2.83–5.49], alcohol use (OR: 2.94, 95% CI: 2.34–3.68) and cannabis use (OR: 2.56, 95% CI: 1.89–3.48). Poor HL was also associated with each substance use (with ORs of 2.32, 1.85 and 1.29). HL was positively associated with academic performance (β = 1.04, 95% CI: 0.89–1.20). The associations between academic performance and substance use were only slightly attenuated after controlling for HL. Conclusions Academic performance and HL were both determinants of substance use, confirming their role in tackling the disparities in substance use. However, HL did not demonstrably mediate the association between academic performance and substance use. A wider set of factors needs to be tackled to address emerging social inequalities in adolescent substance use. [ABSTRACT FROM AUTHOR]

The article discusses the highlights of the conference titled "Devian Imaging: Lesbian/Gay/Queer--Film," held on May 23, 1998 at the University of Warwick in England. It was organized by José Arroyo, Julianne Pidduck and Richard Dyer. The event featured a diverse selection of papers from a various European cinemas and television. Also discussed are concerns on differet manifestations, the extent of image appropriation by different groups across different sets of boundaries.

This paper exploits enlargement of the European Union as a natural experiment to provide evidence for cluttering of the trade mark register in Europe. Enlargement increased regulatory uncertainty for pharmaceutical firms because the number of medical regulators that had to approve invented names for pharmaceutical products increased sharply at the time. The effects of this regulatory shock on pharmaceutical firms’ trade mark application strategies are studied using Difference-in-Differences and bias adjusted matching estimators. It is shown that enlargement had a significant and quantitatively important effect on pharmaceutical firms’ incentives to clutter trade mark registers with trade marks they are unlikely to use. [ABSTRACT FROM PUBLISHER]

We study a newly created panel data set of relative prices for a large number of consumer goods among 31 European countries over a 15-year period. The data set includes eurozone members both before and after the inception of the euro, floating exchange rate countries of Western Europe, and emerging market economies of Eastern and Southern Europe. We find that there is a substantial and continuing deviation from purchasing power parity (PPP) at all levels of aggregation, both for traded and non-traded goods, even among eurozone members. Real exchange rates (RER) exhibit two clear properties in the sample (a) they are closely tied to gross domestic product (GDP) per capita relative to the European average, at all levels of aggregation and for both cross country time series variation; (b) they are highly positively correlated with variation in the relative price of non-traded goods. We then construct a simple two-sector endowment economy model of real exchange rate determination which exhibits these two properties, calibrated to match the data. Simulating the model using the historical relative GDP per capita for each country, we find that for most countries, there is a close fit between the actual and simulated real exchange rate. In terms of policy relevance, the model can offer suggestions of the degree to which real exchange rates in Europe (both in and out of the eurozone) have been overvalued (by approximately 15% in Greece and Portugal and 6% in Italy and Spain). -Martin Berka and Michael B. Devereux [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editor discusses various papers related to the economic crisis, effects of fiscal policy and recapitalization of banks and the duration of housing slumps in the Europe.

Background Parents' reluctance to vaccinate their children undermines the effectiveness of vaccination programmes in Western Europe. There is anecdotal evidence suggesting a connection between the rise of political populism and vaccine hesitancy. Methods This paper analyses national-level data to examine the link between political populism and vaccine hesitancy in Western Europe. Political populism is operationalised as the percentage of people in a country who voted for populist parties in the 2014 European Parliament elections. Vaccine hesitancy is operationalised as the percentage of people in a country who believe that vaccines are not important, safe and effective according to data from the Vaccine Confidence Project (2015). Results There is a highly significant positive association between the percentage of people in a country who voted for populist parties and who believe that vaccines are not important (R = 0.7923, P = 0.007) and effective (R = 0.7222, P = 0.0035). The percentage of people who think vaccines are unsafe just misses being significant at the 5% level (R = 0.5027, P = 0.0669). Conclusions Vaccine hesitancy and political populism are driven by similar dynamics: a profound distrust in elites and experts. It is necessary for public health scholars and actors to work to build trust with parents that are reluctant to vaccinate their children, but there are limits to this strategy. The more general popular distrust of elites and experts which informs vaccine hesitancy will be difficult to resolve unless its underlying causes—the political disenfranchisement and economic marginalisation of large parts of the Western European population—are also addressed. [ABSTRACT FROM AUTHOR]

Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems. [ABSTRACT FROM AUTHOR]

Objectives This paper explores how to measure successful aging in a manner consistent with the preferences of older persons about what matters in their lives. Method To overcome the fact that existing objective and subjective measures of successful aging may not reflect the preferences of older persons about what matters in their lives, a new preference-based measure of successful aging is proposed. To implement the measure, the preferences of older persons are estimated using a statistical life satisfaction model, which is estimated with data from 11 European countries from the Survey of Health, Ageing and Retirement in Europe (SHARE). Results The proposed measure is found to yield different results compared to objective and subjective measures in terms of how successful aging has evolved between 2007 and 2013 and how countries are ranked for successful aging. Successful aging measured by a subjective measure is highest in 2011 compared to 2007 and 2013, for instance, whereas the ranking is reversed for the objective- and preference-based measures. Discussion The findings highlight the relevance of the degree of importance we attribute to the preferences of older persons in the measurement of successful aging, methodologically as well as empirically. [ABSTRACT FROM AUTHOR]

This paper studies the macroeconomic performance of the EU-12 member countries over 1990–2002 from the point of view of the subjective well-being (life satisfaction) of the citizens. The paper uses data for over 50,000 individuals and controls for personal characteristics (especially income and employment status). Life satisfaction is found to be negatively associated with the unemployment rate and inflation, but positively associated with the growth rate. In contrast to earlier findings, the weights placed on inflation and unemployment are of a similar magnitude. The life satisfaction regression is used to determine the weights to be attached to growth, employment, and price stability in a macroeconomic performance index. It is found that the overall macroeconomic performance ranking of the countries is robust across alternative specifications of the index. [ABSTRACT FROM AUTHOR]

Background: measures of physical capability may be predictive of subsequent health, but existing published studies have not been systematically reviewed. We hypothesised that weaker grip strength, slower walking speed and chair rising and shorter standing balance time, in community-dwelling populations, would be associated with higher subsequent risk of fracture, cognitive outcomes, cardiovascular disease, hospitalisation and institutionalisation.Methods: studies were identified through systematic searches of the electronic databases MEDLINE and EMBASE (to May 2009). Reference lists of eligible papers were also manually searched.Results: twenty-four papers had examined the associations between at least one physical capability measure and one of the outcomes. As the physical capability measures and outcomes had been assessed and categorised in different ways in different studies, and there were differences in the potential confounding factors taken into account, this made it impossible to pool results. There were more studies examining fractures than other outcomes, and grip strength and walking speed were the most commonly examined capability measures. Most studies found that weaker grip strength and slower walking speed were associated with increased risk of future fractures and cognitive decline, but residual confounding may explain results in some studies. Associations between physical capability levels and the other specified outcomes have not been tested widely.Conclusions: there is some evidence to suggest that objective measures of physical capability may be predictors of subsequent health in older community-dwelling populations. Most hypothesised associations have not been studied sufficiently to draw definitive conclusions suggesting the need for further research. [ABSTRACT FROM AUTHOR]

AstraZeneca's European patent EP 0907364 relating to a sustained release formulation of the antipsychotic drug quetiapine was held invalid in the UK, this being the opposite outcome to parallel litigation before the District Court of the Hague. [ABSTRACT FROM PUBLISHER]

This paper examines whether multinational banks have a stabilizing or a destabilizing role during times of financial distress. With a focus on Europe, it looks at how these banks' foreign affiliates have been faring during the recent financial crisis. It finds that retail and corporate lending of these foreign affiliates has been stable and even increasing between 2007 and 2009. This pattern is related to the functioning of the internal capital market through which these banks funnel funds across their units. The internal capital market has been an effective tool to support foreign affiliates in distress and to isolate their lending from the local availability of financial resources, notwithstanding the systemic nature of the recent crisis. This effect has been particularly large within the EU integrated financial market and for the EMU countries, thus showing complementarity between economic integration and multinational banks' internal capital markets. In light of these findings, this paper supports the call for an integration of the European supervisory and regulatory framework overseeing multinational banks. The analysis is based on an analytical framework which derives the main conditions under which the internal capital market can perform this support function under idiosyncratic and systemic stresses. The empirical evidence uses both aggregate evidence on foreign claims worldwide, and firm-level evidence on the behaviour of banking groups' affiliates, compared to stand-alone national banks. - Giorgio Barba Navaretti, Giacomo Calzolari, Alberto Franco Pozzolo and Micol Levi [ABSTRACT FROM AUTHOR]

The primary purpose of this paper is to provide a review of the papers within the economics literature that have examined the questions of immigrant welfare use and the responsiveness of immigrants to the incentives created by welfare systems. While our focus is largely on papers looking at the European case, we also draw on studies from the United States, in particular on issues where the European literature is thin. One set of papers asks whether immigrants who are more likely to use welfare are attracted to more generous welfare states. The results from these papers are not clear-cut. Another set of papers asks if immigrants use welfare more intensively than natives and if they assimilate out of or into welfare participation. In most cases, the unadjusted data show higher use of welfare by immigrants, although for some countries, for example Germany, this can be explained by differences in immigrants' characteristics. Yet another set of papers finds that the rate of welfare use by existing migrants can influence the welfare use of newly arrived co-nationals. We illustrate some of these issues by looking at immigrant welfare use in Ireland and the UK. Immigrants in the UK appear to use welfare more intensively than natives, but the opposite appears to be the case in Ireland. [ABSTRACT FROM AUTHOR]