44 results on '"La Torre, M."'
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2. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: The COVIDSurg mortality score.
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Bravo L., Nepogodiev D., Glasbey J.C., Li E., Simoes J.F.F., Kamarajah S.K., Picciochi M., Abbott T.E.F., Ademuyiwa A.O., Arnaud A.P., Agarwal A., Brar A., Elhadi M., Mazingi D., Cardoso V.R., Lawday S., Sayyed R., Omar O.M., de la Madina A.R., Slater L., Venn M.L., Gkoutos G., Bhangu A., Karwath A., Siaw-Acheampong K., Argus L., Chaudhry D., Dawson B.E., Gujjuri R.R., Jones C.S., Khatri C., Keatley J.M., Mann H., Marson E.J., Mclean K.A., Taylor E.H., Tiwari A., Trout I.M., Wilkin R.J.W., Dajti I., Gjata A., Boccalatte L., Modolo M.M., Cox D., Pockney P., Townend P., Aigner F., Kronberger I., Hossain K., VanRamshorst G., Lawani I., Ataide G., Baiocchi G., Buarque I., Gohar M., Slavchev M., Martin J., Olivos M., Calvache J., Rivera C.J.P., Hadzibegovic A.D., Kopjar T., Mihanovic J., Klat J., Novysedlak R., Christensen P., El-Hussuna A., Batista S., Lincango E., Emile S.H., Mengesha M.G., Hailu S., Tamiru H., Kauppila J., Laukkarinen J., Albertsmeiers M., Lederhuber H., Loffler M., Tabiri S., Metallidis S., Tsoulfas G., Lorena M.A., Grecinos G., Mersich T., Wettstein D., Ghosh D., Kembuan G., Brouk P., Khosravi M., Mozafari M., Adil A., Mohan H.M., Zmora O., Fiore M., Gallo G., Pata F., Pellino G., Satoi S., Ayasra F., Chaar M., Fakhradiyev I.R., Jamal M., Gulla A., Roslani A., Martinez L., De La Medina A.R., Outani O., Jonker P., Kruijff S., Noltes M., Steinkamp P., van der Plas W., Osinaike B., Seyiolajide J., Williams E., Pejkova S., Augestad K.M., Soreide K., Al Balushi Z., Qureshi A., Daraghmeh M.A.M., Abukhalaf S., Cukier M., Gomez H., Shu S., Vasquez X., Parreno-Sacdalan M.D., Major P., Azevedo J., Cunha M., Santos I., Zarour A., Bonci E.-A., Negoi I., Efetov S., Litvin A., Ntirenganya F., Al Ameer E., Radenkovic D., Xiang F.K.H., Hoe C.M., Yong J.N.C., Moore R., Nhlabathi N., Colino R.B., Bravo A.M., Minaya-Bravo A., Jayarajah U., Wickramasinghe D., Elmujtaba M., Jebril W., Rutegard M., Sund M., Isik A., Leventoglu S., Benson R., Caruna E., Chakrabortee S., Demetriades A., Desai A., Drake T.D., Edwards J.G., Evans J.P., Ford S., Fotopoulou C., Griffiths E., Hutchinson P., Jenkinson M.D., Khan T., Knight S., Kolias A., Leung E., McKay S., Norman L., Ots R., Raghavan V., Roberts K., Schache A., Shaw R., Shaw K., Smart N., Stewart G., Sundar S., Vimalchandran D., Wright N., Alshryda S., Alser O., Breen K., Ganly I., Kaafarani H., Kendall B., Mashbari H., Al Naggar H., Valenzuela J.I., Boccalatte L.A., Gemelli N.A., Smith D.E., Dudi-Venkata N.N., Kroon H.M., Sammour T., Roberts M., Mitchell D., Lah K., Pearce A., Morton A., Dawson A.C., Drane A., Sharpin C., Nataraja R.M., Pacilli M., Cox D.R.A., Muralidharan V., Riddiough G.E., Clarke E.M., Jamel W., Qin K.R., Cope D., Egoroff N., Lott N., Putnis S., De Robles S., Ang Z., Mitteregger M., Uranitsch S., Stiegler M., Seitinger G., Lumenta D.B., Nischwitz S.P., Richtig E., Pau M., Srekl-Filzmaier P., Eibinger N., Michelitsch B., Fediuk M., Papinutti A., Seidel G., Kahn J., Cohnert T.U., Messner F., Ofner D., Presl J., Varga M., Weitzendorfer M., Emmanuel K., Binder A.D., Zimmermann M., Holawe S., Nkenke E., Grimm C., Kranawetter M., Rahman Mitul A., Islam N., Karim S., Komen N., Ang E., De Praetere H., Tollens T., Schols G., Smets C., Haenen L., Quintens J., Van Belle K., Van Ramshorst G.H., Pattyn P., Desender L., Martens T., Van de Putte D., Lerut P., Grimonprez A., Janssen M., De Smul G., Wallaert P., Van den Eynde J., Oosterlinck W., Van den Eynde R., Sermon A., Boeckxstaens A., Cordonnier A., De Coster J., Jaekers J., Politis C., Miserez M., Duchateau N., De Gheldere C., Flamey N., Christiano A., Guidi B., Minussi A.L., Castro S., Okoba W., Maldonado F.H.R., Oliveira P., Baldasso T., Santos L., Gomes G.M.A., Buarque I.L., Pol-Fachin L., Bezerra T.S., Barros A.V., da Silva A.M.R., Leite A.L.S., Silvestre D.W.A., Ferro C.C., Araujo M.S., Lopes L.M., Damasceno P.D., Araujo D.H.S., Laporte G., Salem M.C., Guimaraes-Filho M.A.C., Nacif L., Flumignan R.L.G., Nakano L.C.U., Kuramoto D.A.B., Aidar A.L.S., Pereda M.R., Correia R.M., Santos B.C., Carvalho A.A., Amorim J.E., Guedes Neto H.J., Areias L.L., Sousa A.F., Flumignan C.D.Q., Lustre W.G., Moreno D.H., Barros N., Baptista-Silva J.C.C., Matos L.L., Kowaski L.P., Kulcsar M.A.V., Nunes K.S., Teixeira M.F., Nunes R.L., Ijichi T.R., Kim N.J., Marreiro A., Muller B., Barakat Awada J., Kowalski L.P., Vartanian J.G., Makdissi F.B., Aguiar S., Marques N., Carvalho G.B., Marques T.M.D.M., Abdallah E.A., Zurstrassen C.E., Gross J.L., Zequi S.C., Goncalves B.T., Santos S.S., Duprat J.P., Coimbra F.J.F., Cicco R., Takeda F., Cecconello I., Ribeiro U., Gatti A., Oliva R., Nardi C., Atanasov B., Belev N., Dell A., Bigam D., Dajani K., Al Riyami S., Cheng D., Yang H., Fayad A., Carrier F.M., Amzallag E., Desroches J., Ruel M., Caminsky N.G., Boutros M., Moon J., Wong E.G., Vanounou T., Pelletier J., Wong S., Girsowicz E., Bayne J., Obrand D., Gill H., Steinmetz O., MacKenzie K., Lukaszewski M., Jamjoum G., Richebe P., Verdonck O., Discepola S., Godin N., Idrissi M., Briatico D., Sharma S., Talwar G., Bailey K., Lecluyse V., Cote G., Demyttenaere S., Garfinkle R., Kouyoumdjian A., Dumitra S., Khwaja K., Luo L., Berry G., Liberman A.S., Schmid S., Spicer J., Al Farsi M., Abou-Khalil J., Couture E., Mohammadi S., Tremblay H., Gagne N., Bergeron A., Turgeon A.F., Costerousse O., Bellemare D., Babin C., Blier C., Wood M.L., Persad A., Groot G., Pham H., D'Aragon F., Carbonneau E., Bouchard M., Masse M., Pesant F., Heroux J., Karanicolas P., Hallet J., Nadler A., Nathens A., Ko M., Mayson K., Kidane B., Srinathan S., Escudero M.I., Reyes J.T., Ramirez Nieto P., Sepulveda R., Bolbaran A., Molero A., Ruiz I., Reyes G.P., Salas R., Suazo C., Munoz R., Grasset E., Inzunza M., Besser N., Irarrazaval M.J., Jarry C., Bellolio F., Romero Manqui C.A., Ruiz Esquide M., Fuentes T., Campos J., Perez Rivera C.J., Cabrera P.A., Pinilla R.E., Guevara O., Jimenez Ramirez L.J., Velasquez Cuasquen B.G., Herrera Mora D.R., Bonilla A., Diaz S., Manrique E., Facundo H., Velez Bernal J.L., Angel J., Garcia M., Guzman L., Lehmann C., Cervera S., Trujillo Sanchez L.M., Guevara R., Valbuena D., Suarez L., Jimenez G., Velandia A., Vargas J., Espinosa J., Rey S., Mendoza Quevedo J., Calvache J.A., Orozco-Chamorro C.M., Sanchez-Gomez T.A., Rojas-Tejada D.A., Bakmaz B., Rakvin I., Sulen N., Andabaka T., Luksic I., Mamic M., Martinek L., Skrovina M., Zatecky J., Peteja M., Kristensen H.O., Mekhael M., Westh L., Smith H., Haugstvedt A.F., Jonsson M.L., Crespo A., Rodriguez-Abreu J., Tactuk N., Diaz-Delgado P.J., Rivas R., Sarmiento-Bobadilla J.A., Ashoush F., Samir Abdelaal A., Qatora M.S., Elsayed Hewalla M.E., Metwalli M., Atta R., Abdelmajeed A., Abosamak N.E., Sabry A., Shehata S., Sallam I., Amira G., Sherief M., Sherif A., Salem H., Hamdy R., Aboulkassem H., Ghaly G., Sherif G., Morsi A., Abdelrahman A., Omnia A., Tawheed A., El Kassas M., Omar W., Abdelsamed A., Seleim A., Azzam A.Y., ElFiky M., Nabil A., Ibraheem M., ElDeeb M., Fawzy M., Hamed H., Emile S., Elfallal A., Elfeki H., Shalaby M., Sakr A., Alrahawy M., Atif H., Soltan H., Sayed A.K., Salah A., Atiya A., Wassim K., Abbas A.M., Abd Elazeem H.A.S., Abd-Elkariem A.Y., Abd-Elkarem M.M., Alaa S., Ali A.K., Ashraf M., Ayman A., Azizeldine M.G., Elkhayat H., Emad Mashhour A., Gaber M., Hamza H.M., Hawal I., Hetta H.F., Elghazaly S.M., Mohammed M.M., Monib F.A., Nageh M.A., Saad A., Saad M.M., Shahine M., Yousof E.A., Youssef A., Esmail E., Khalaf M., Eldaly A., Ghoneim A., Hawila A., Badr H., Elhalaby I., Abdel-Bari M., Elbahnasawy M., Hamada M.K., Morsy M.S., Hammad M., Essa M., Fayed M.T., Elzoghby M., Rady M., Hamad O., Salman S., Sarsik S., Abd-Elsalam S., Gamal Badr S., El-Masry Y., Moahmmed M.M.H., Wolde A., Mengesha M., Nida S., Workneh M., Ahmed M.Y., Fisseha T., Kassa D., Zeleke H., Admasu A., Laeke T., Tirsit A., Gessesse M., Addissie A., Bekele D., Kauppila J.H., Sarjanoja E., Testelin S., Dakpe S., Devauchelle B., Bettoni J., Lavagen N., Schmitt F., Lemee J.M., Boucher S., Breheret R., Kun-Darbois J.D., Kahn A., Gueutier A., Bigot P., Borraccino B., Lakkis Z., Doussot A., Heyd B., Manfredelli S., Mathieu P., Paquette B., Turco C., Barrabe A., Louvrier A., Moszkowicz D., Giovinazzo D., Bretagnol F., Police A., Charre L., Volpin E., Braham H., El Arbi N., Villefranque V., Bendjemar L., Girard E., Abba J., Trilling B., Chebaro A., Lecolle K., Truant S., El Amrani M., Zerbib P., Pruvot F.R., Mathieu D., Surmei E., Mattei L., Christou N., Ballouhey Q., Ferrero P., Coste Mazeau P., Tricard J., Barrat B., Taibi A., Usseglio J., Laloze J., Salle H., Fourcade L., Duchalais E., Regenet N., Rigaud J., Waast D., Denis W., Malard O., Buffenoir K., Espitalier F., Ferron C., Varenne Y., Crenn V., De Vergie S., Cristini J., Samarut E., Tzedakis S., Bouche P.A., Gaujoux S., Kantor E., Gossot D., Seguin-Givelet A., Fuks D., Grigoroiu M., Sanchez Salas R., Cathelineau X., Macek P., Barbe Y., Rozet F., Barret E., Mombet A., Cathala N., Brian E., Zadegan F., Conso C., Blanc T., Broch A., Sarnacki S., Ali L., Bonnard A., Peycelon M., Hervieux E., Clermidi P., Maisonneuve E., Aubry E., Thomin A., Langlais T., Passot G., Glehen O., Cotte E., Lifante J.C., De Simone B., Chouillard E., Violas P., Bergeat D., Merdrignac A., Scalabre A., Perotto L.O., Le Roy B., Haddad E., Vermersch S., Ezanno A.C., Barbier O., Vigouroux F., Malgras B., Aime A., Seeliger B., Mutter D., Philouze G., Pessaux P., Germain A., Chanty H., Ayav A., Kassir R., Von Theobald P., Sauvat F., O'Connor J., Mayombo Idiata M., O'Connor Z., Tchoba S., Modabber A., Winnand P., Holzle F., Sommer B., Shiban E., Wolf S., Anthuber M., Sommer F., Kaemmerer D., Schreiber T., Kamphues C., Lauscher J.C., Schineis C., Loch F.N., Beyer K., Nasser S., Sehouli J., Hohn P., Braumann C., Reinkemeier F., Uhl W., Weitz J., Bork U., Welsch T., Praetorius C., Korn S., Distler M., Fluegen G., Knoefel W.T., Vay C., Golcher H., Grutzmann R., Binder J., Meister P., Gallinat A., Paul A., Schnitzbauer A.A., Thoenissen P., El Youzouri H., Schreckenbach T., Nguyen T.A., Eberbach H., Bayer J., Erdle B., Sandkamp R., Nitschke C., Izbicki J., Uzunoglu F.G., Koenig D., Gosau M., Bottcher A., Heuer A., Klatte T.O., Priemel M., Betz C.S., Burg S., Mockelmann N., Busch C.J., Bewarder J., Zeller N., Smeets R., Thole S., Vollkommer T., Speth U., Stangenberg M., Hakami I., Boeker C., Mall J., Schardey H.M., von Ahnen T., von Ahnen M., Brunner U., Tapking C., Kneser U., Hirche C., Jung M., Kowalewski K.F., Kienle P., Reissfelder C., Seyfried S., Herrle F., Hardt J., Galata C., Birgin E., Rahbari N., Vassos N., Stoleriu M.G., Hatz R., Albertsmeier M., Borner N., Lampert C., Werner J., Kuehlmann B., Prantl L., Brunner S.M., Schlitt H.J., Brennfleck F., Pfister K., Oikonomou K., Reinhard T., Nowak K., Ronellenfitsch U., Kleeff J., Delank K.S., Michalski C.W., Szabo G., Widyaningsih R., Stavrou G.A., Bschorer R., Mielke J., Peschel T., Konigsrainer A., Quante M., Loffler M.W., Yurttas C., Doerner J., Seiberth R., Bouchagier K., Klimopoulos S., Paspaliari D., Stylianidis G., Syllaios A., Baili E., Schizas D., Liakakos T., Charalabopoulos A., Zografos C., Spartalis E., Manatakis D.K., Tasis N., Antonopoulou M.I., Xenaki S., Xynos E., Chrysos E., Athanasakis E., Tsiaousis J., Lostoridis E., Tourountzi P., Tzovaras G., Tepetes K., Zacharoulis D., Baloyiannis I., Perivoliotis K., Hajiioannou J., Korais C., Gkrinia E., Skoulakis C.E., Saratziotis A., Koukoura O., Symeonidis D., Diamantis A., Christou C.D., Tooulias A., Papadopoulos V., Anthoulakis C., Grimbizis G., Zouzoulas D., Tsolakidis D., Tatsis D., Christidis P., Loutzidou L., Ioannidis O., Astreidis I., Antoniou A., Antoniadis K., Vachtsevanos K., Paraskevopoulos K., Kalaitsidou I., Alexoudi V., Stavroglou A., Mantevas A., Michailidou D., Grivas T., Deligiannidis D., Politis S., Barrios Duarte A., Portilla A.L., Lowey M.J., Recinos G., Lopez Muralles I., Siguantay M.A., Estrada E.E., Aguilera-Arevalo M.L., Cojulun J.M., Echeverria-Davila G., Marin C., Icaza de Marin G.C., Kok S.Y., Joeng H.K.M., Chan L.L., Lim D., Novak Z., Echim T., Susztak N., Banky B., Pajan H., Islam A.A., Rahim F., Safari H., Brouki Milan P., Tizmaghz A., Rezaei Tavirani M., Ahmed A., Hussein R., Fleming C., O'Brien S., Kayyal M.Y., Daly A., Killeen S., Corrigan M., De Marchi J., Hill A., Farrell T., Davis N.F., Kearney D., Nelson T., Maguire P.J., Barry C., Farrell R., Smith L.A., Mehigan B.J., McCormick P., Larkin J.O., Fahey B.A., Rogers A., Donlon N., O'Sullivan H., Nugent T., Reynolds J.V., Donohue C., Shokuhi P., Ravi N., Fitzgerald C., Lennon P., Timon C., Kinsella J., Smith J., Boyle T., Alazawi D., Connolly E., Butt W., Croghan S.M., Manecksha R.P., Fearon N., Winter D., Heneghan H., Maguire D., Gallagher T., Conlon K., Kennedy N., Martin S., Kennelly R., Hanly A., Ng K.C., Fagan J., Geary E., Cullinane C., Carrington E., Geraghty J., McDermott E., Pritchard R., McPartland D., Boland M., Stafford A., Geoghegan J., Elliott J.A., Ridgway P.F., Gillis A.E., Bass G.A., Neary P.C., O'Riordan J.M., Kavanagh D.O., Reynolds I.S., Joyce D.P., Boyle E., Egan B., Whelan M., Elkady R., Tierney S., Connelly T.M., Earley H., Umair M., O'Connell C., Thomas A.Z., Rice D., Madden A., Bashir Y., Creavin B., Cullivan O., Owens P., Canas-Martinez A., Murphy C., Pickett L., Murphy B., Mastrosimone A., Beddy D., Arumugasamy M., Allen M., Aremu M., McCarthy C., O'Connor C., O'Connor D.B., Kent E., Malone F., Geary M., McKevitt K.L., Lowery A.J., Ryan E.J., Aherne T.M., Fowler A., Hassanin A., Hogan A.M., Collins C.G., Finnegan L., Carroll P.A., Kerin M.J., Walsh S.R., Nally D., Peirce C., Coffey J.C., Cunningham R.M., Tormey S., Hardy N.P., Neary P.M., Muallem-Kalmovich L., Kugler N., Lavy R., Horesh N., Vergari R., Mochet S., Barmasse R., Usai A., Morelli L., Picciariello A., Papagni V., Altomare D.F., Colledan M., Zambelli M.F., Tornese S., Camillo A., Rausa E., Bianco F., Lucianetti A., Prucher G.M., Baietti A.M., Ruggiero F., Maremonti P., Neri F., Ricci S., Biasini M., Zarabini A.G., Belvedere A., Bernante P., Bertoglio P., Boussedra S., Brunocilla E., Cipriani R., Cisternino G., De Crescenzo E., De Iaco P., Della Gatta A.N., Dondi G., Frio F., Jovine E., Mineo Bianchi F., Neri J., Parlanti D., Perrone A.M., Pezzuto A.P., Pignatti M., Pilu G., Pinto V., Poggioli G., Ravaioli M., Rottoli M., Schiavina R., Serenari M., Serra M., Solli P., Taffurelli M., Tanzanu M., Tesei M., Violante T., Zanotti S., Tonini V., Sartarelli L., Cervellera M., Gori A., Armatura G., Scotton G., Patauner S., Frena A., Podda M., Pisanu A., Esposito G., Frongia F., Abate E., Laface L., Casati M., Schiavo M., Casiraghi T., Sammarco G., Vescio G., Fulginiti S., Scorcia V., Giannaccare G., Carnevali A., Giuffrida M.C., Marano A., Palagi S., Di Maria Grimaldi S., Testa V., Peluso C., Borghi F., Simonato A., Puppo A., D'Agruma M., Chiarpenello R., Pellegrino L., Maione F., Cianflocca D., Pruiti Ciarello V., Giraudo G., Gelarda E., Dalmasso E., Abrate A., Daniele A., Ciriello V., Rosato F., Garnero A., Leotta L., Giacometti M., Zonta S., Lomiento D., Taglietti L., Dester S., Compagnoni B., Viotti F., Cazzaniga R., Del Giudice R., Mazzotti F., Pasini F., Ugolini G., Fabbri N., Feo C.V., Righini E., Gennari S., Chiozza M., Anania G., Urbani A., Koleva Radica M., Carcoforo P., Portinari M., Sibilla M., Anastasi A., Bartalucci B., Bellacci A., Canonico G., Capezzuoli L., Di Martino C., Ipponi P., Linari C., Montelatici M., Nelli T., Spagni G., Tirloni L., Vitali A., Agostini C., Alemanno G., Bartolini I., Bergamini C., Bruscino A., Checcucci C., De Vincenti R., Di Bella A., Fambrini M., Fortuna L., Maltinti G., Muiesan P., Petraglia F., Prosperi P., Ringressi M.N., Risaliti M., Sorbi F., Taddei A., Lizzi V., Vovola F., Arminio A., Cotoia A., Sarni A.L., Familiari P., D'Andrea G., Picotti V., Bambina F., Fontana T., Barra F., Ferrero S., Gustavino C., Kratochwila C., Ferraiolo A., Costantini S., Batistotti P., Aprile A., Almondo C., Ball L., Robba C., Scabini S., Pertile D., Massobrio A., Soriero D., D'Ugo S., Depalma N., Spampinato M.G., Lippa L., Gambacciani C., Santonocito O.S., Aquila F., Pieri F., Ballabio M., Bisagni P., Longhi M., Armao T., Madonini M., Gagliano A., Pizzini P., Costanzi A., Confalonieri M., Monteleone M., Colletti G., Frattaruolo C., Mari G., Spinelli A., Mercante G., Spriano G., Gaino F., Ferreli F., De Virgilio A., Rossi V., Carvello M.M., Di Candido F., Kurihara H., Marrano E., Torzilli G., Castoro C., Carrano F.M., Martinelli F., Macchi A., Pasquali S., Cioffi S.P.B., Baia M., Abatini C., Sarre C., Mosca A., Biasoni D., Gronchi A., Citterio D., Mazzaferro V., Cadenelli P., Gennaro M., Capizzi V., Guaglio M., Sorrentino L., Bogani G., Sarpietro G., Giannini L., Comini L.V., Rolli L., Folli S., Raspagliesi F., Piazza C., Cosimelli M., Salvioni R., Antonelli B., Baldari L., Boni L., Cassinotti E., Pignataro L., Rossi G., Torretta S., Beltramini G.A., Gianni A., Tagliabue M., De Berardinis R., Pietrobon G., Chu F., Cenciarelli S., Adamoli L., Ansarin M., Fumagalli Romario U., Mastrilli F., Mariani N.M., Nicastro V., Cellerino P., Colombo F., Frontali A., Bondurri A., Guerci C., Maffioli A., Ferrario L., Candiani M., Bonavina G., Ottolina J., Valsecchi L., Mortini P., Gagliardi F., Piloni M., Medone M., Negri G., Bandiera A., De Nardi P., Sileri P., Carlucci M., Pelaggi D., Rosati R., Vignali A., Parise P., Elmore U., Tamini N., Nespoli L.C., Rennis M., Pitoni L., Chiappetta M.F., Vico E., Fruscio R., Grassi T., Sasia D., Migliore M., Gattolin A., Rimonda R., Travaglio E., Olearo E., Tufo A., Marra E., Maida P., Marte G., Tammaro P., Incollingo P., Izzo F., Belli A., Patrone R., Albino V., Leongito M., Granata V., Piccirillo M., Palaia R., Francone E., Gentilli S., Nikaj H., Fiorini A., Norcini C., Chessa A., Marino M.V., Mirabella A., Vaccarella G., Musini L., Ampollini L., Bergonzani M., Varazzani A., Bellanti L., Domenichini M., Cabrini E., Fornasari A., Freyrie A., Dejana D.O., D'Angelo G., Bertoli G., Di Lella F., Bocchialini G., Falcioni M., Lanfranco D., Poli T., Giuffrida M., Annicchiarico A., Perrone G., Catena F., Raffaele A., De Manzoni Garberini A., Baldini E., Conti L., Ribolla M., Capelli P., Isolani S.M., Maniscalco P., Cauteruccio M., Ciatti C., Puma Pagliarello C., Gattoni S., Galleano R., Malerba M., Ciciliot M., Farnesi F., Calabro M., Pipitone Federico N.S., Lunghi E.G., Muratore A., Di Franco G., Palmeri M., Tartaglia D., Coccolini F., Chiarugi M., Simoncini T., Gadducci A., Caretto M., Giannini A., Perutelli A., Domenici L., Garibaldi S., Capanna R., Andreani L., Furbetta N., Guadagni S., Bianchini M., Gianardi D., Pinotti E., Montuori M., Carissimi F., Baronio G., Zizzo M., Castro Ruiz C., Annessi V., Montella M.T., Falco G., Mele S., Ferrari G., Mastrofilippo V., Mandato V.D., Aguzzoli L., Corbellini C., Baldi C., Sampietro G.M., Palini G.M., Zanini N., Garulli G., Barone R., Murgese A., Mungo S., Grasso M., Marafante C., Birolo S.L., Moggia E., Caccetta M., Masciandaro A., Deirino A., Garino M., Perinotti R., Maiello F., Gordini L., Lombardi C.P., Marzi F., Marra A.A., Ratto C., Di Muro M., Litta F., De Simone V., Cozza V., Rosa F., Agnes A., Parello A., Alfieri S., Sganga G., Lapolla P., Mingoli A., De Toma G., Fiori E., La Torre F., Sapienza P., Brachini G., Cirillo B., Iannone I., Zambon M., Chiappini A., Meneghini S., Fonsi G.B., Cicerchia P.M., Bruzzaniti P., Santoro A., Frati A., Marruzzo G., Ribuffo D., Sagnotta A., Marino Cosentino L., Mancini S., Lisi G., Spoletini D., Bellato V., Campanelli M., Sica G., Siragusa L., Bonavina L., Asti E., Bernardi D., Lovece A., Perra T., Porcu A., Fancellu A., Feo C.F., Scanu A.M., Tuminello F., Franceschi A., Langone A., Fleres F., Spolini A., Bordoni P., Franzini M., Clarizia G., Grechi A., Longhini A., Guaitoli E., Manca G., Grossi U., Novello S., Zanus G., Romano M., Rossi S., Pirozzolo G., Recordare A., Paiella S., Turri G., Rattizzato S., Campagnaro T., Guglielmi A., Pedrazzani C., Ruzzenente A., Poletto E., Conci S., Casetti L., Fontana M., Salvia R., Malleo G., Esposito A., Landoni L., De Pastena M., Bassi C., Tuveri M., Nobile S., Marchegiani G., Bortolasi L., Ferrara F., La Torre M., Sambugaro E., Malavolta M., Moretto G., Impellizzeri H., Inama M., Barugola G., Ascari F., Ruffo G., Granieri S., Cotsoglou C., Berselli M., Desio M., Marchionini V., Cocozza E., Di Saverio S., Ietto G., Iovino D., Carcano G., Qasem A., Ayasra Y., Al-Masri M., Abou Chaar M.K., Al-Najjar H., Ghandour K., Alawneh F., Abdel Jalil R., Abdel Al S., Elayyan M., Ghanem R., Lataifeh I., Alsaraireh O., Abu Za'nouneh F.J., Fahmawee T., Ibrahim A., Obeidat K., Lee K.J., Shin S.J., Chung H., Albader I., Alabbad J., Albader M.A.S., Bouhuwaish A., Taher A.S., Omar M.S.M., Abdulwahed E., Biala M., Morgom M., Elhadi A., Alarabi A., Msherghi A., Elhajdawe F., Alsoufi A., Salamah A., Salama H., Bulugma M., Almabrouk H., Venskutonis D., Dainius E., Kubiliute E., Bradulskis S., Parseliunas A., Kutkevicius J., Subocius A., Cheong Y.J., Masood M.S., Ngo C.W., Saravanan R., Abdul Maei N., Hayati F., Amin Sahid N., Yanowsky Reyes G., Orozco Perez J., Damian R., Santana Ortiz R., Colunga Tinajero C.A., Cordera F., Gomez-Pedraza A., Maffuz-Aziz A., Posada J.A., De la Rosa Abaroa M.A., Alvarez M.R., Arrangoiz R., Hernandez R., Bozada Gutierrez K., Trejo-Avila M., Valenzuela-Salazar C., Herrera-Esquivel J., Moreno-Portillo M., Pinto-Angulo V.M., Sosa-Duran E.E., Ziad-Aboharp H., Jimenez Villanueva X., Soule Martinez C.E., Lupian-Angulo A.I., Martinez Zarate J.J., Reyes Rodriguez E., Montalvo Dominguez G., Becerra Garcia F.C., Melchor-Ruan J., Vilar-Compte D., Romero-Banuelos E., Herrera-Gomez A., Meneses-Garcia A., Isla-Ortiz D., Salcedo-Hernandez R.A., Hernandez-Nava J.M., Morales-Castelan J.E., Posadas-Trujillo O.E., Buerba G.A., Alfaro-Goldaracena A., Pena Gomez-Portugal E., Lopez-Pena G., Hinojosa C.A., Mercado M.A., Ramos-De la Medina A., Duran I., Gonzalez D.S., Martinez M.J., Nayen Sainz de la Fuente A., Miguelena L., Hernandez Miguelena L., Louraoui S.M., El Azhari A., Rghioui M., Khya E., Ghannam A., Souadka A., El Ahmadi B., Belkhadir Z.H., Majbar M.A., Benkabbou A., Mohsine R., Oudrhiri M.Y., Bechri H., Arkha Y., El Ouahabi A., Frima H., Bachiri S., Groen L.C., Verhagen T., ter Brugge F.M., Scheijmans J.C.G., Boermeester M.A., Hompes R., Meima-Van Praag E.M., Sharabiany S., Borgstein A.B.J., Gisbertz S.S., van Berge Henegouwen M.I., Gans S., Van Duijvendijk P., Herklots T., De Hoop T., De Graaff M.R., Sloothaak D., Bolstervan Eenennaam M., Baaij J., Klinkenbijl J.H.G., Van Eekeren R., Spillenaar Bilgen E.J., Van der Burg S.W., Harlaar N.J., Jonker F.H.W., Vermaas M., Voigt K.R., Nellensteijn D., Bensi E.A.B., Posma-Bouman L., Van Sambeek M., Holscher M., Van den den Broek W.T., Kruijff S.H., De Vries J.P.P.M., Steinkamp P.J., Jonker P.K.C., Van der Plas W.Y., Bierman W., Janssen Y., Franken J., Oosterling S., Boerma E.G., Schweitzer D., Keulen M.H.F., Ketting S., Wegdam J.A., de Vries Reilingh T.S., Schipper E., Teeuwen P.H.E., Hendriks E.R., Van Geloven A.A.W., Emous M., Poelstra R., Teunissen M., Gerritsen S.L., Boerma D., De Reuver P.R., Thunnissen F., Vermeulen B.A.M., Groen A., Van Ginhoven T.M., Vietor C.L., van der Oest M.J.W., Vriens P.W.H.E., Houwen T., Heisterkamp J., van Petersen A.S., van der Meij W., Stevens C.T., Pronk A., Bakker W.J., Richir M.C., Vriens M.R., Filipe M.D., Uittenbogaart M., Leclercq W.K.G., Sijmons J.M.L., Vancoillie P.J., Konsten J., Van Heinsbergen M., Dekker N.A.M., den Boer F.C., Akinmade A., Adeyeye A., Enoch E., Fayose S., Okunlola A.I., Adeniyi A.A., Adeyemo O.T., Adebara I.O., Bakare A., Babalola O.F., Abiyere O.H., Banjo O.O., Olori S., Akaba O.G., Agida E.T., Abdullahi I.H., Egbuchulem I.K., Olulana D., Lawal T.A., Ogundoyin O., Oyelakin O.A., Nwaorgu O.G., Sule S.O., Makwe C.C., Afolabi B.B., Seyi-Olajide J.O., Bode C.O., Atoyebi O., Elebute O.A., Okunowo A.A., Williams O.M., Eke N.G., Oshodi O.A., Faboya O.M., Adeniran A.S., Omisanjo O.A., Oshodi Y.A., Ogunyemi A.A., Atobatele K.M., Aremu I., Olasehinde O., Abdur-Rahman L., Bello J., Popoola A., Sayomi T.O., Raji H.O., Adeleke N., Lawal B., Habeeb O., Agodirin O., Tolani M.A., Sholadoye T.T., Nwabuoku S.E., Abubakar M., Risteski T., Cvetanovska Naunova V., Jovcheski L., Lazova E., Agledahl I., Breuer R.G., Massoud J., Waqar S.H., Rashid I., Ayubi A., Bhatti A.B.H., Younis M.U., Ghouri A., Ayub B., Sayyed R.H., Saleem A., Turk K., Alvi A., Abassy J., Khan S., Arshad M., Ahmed K., Siddiqui T., Pirzada A., Kerawala A.A., Jamal A., Rai L., Nafees Ahmed R., Memon A.S., Qureshi A.U., Ayyaz M., Umar M., Butt U., Kashif M., Khan W.H., Waris Farooka M., Wasim T., Talat N., Tahir W., Naseem J., Akbar A., Afroze S., Sultan A., Ali H.B., Janjua M.H., Janjua A., Asghar S., Farooq M.S., Sarwar M.Z., Naqi S.A., Gondal K.M., Bukhari S.I., Tariq M., Javed S., Yaqoob E., Mahmood U., Raja Shabbir K., Abukhalaf S.A., Amro A., Cabada Lee J.M., Aguilar A., Rodriguez E., Castillo K., Rodriguez-Zentner H., Arrue E., Isaacs Beron R., Rodriguez Gonzalez A., Panduro-Correa V., Cornelio D.K., Otiniano Alvarado C.E., Caballero Sarabia V.D., Vasquez-Ojeda X.P., Lizzetti-Mendoza G., Niquen-Jimenez M., Shu-Yip S.B., Leon Palacios J.L., Borda-Luque G., Zegarra S.A., Huaman Egoavil E., Suazo Carmelo C., Castro de la Mata R., Rivas D., Targarona J., Trujillo Y., Olivera Villanueva M., Lahoud-Velaochaga A., Cabillas K., Castaneda W., Colina Casas J., Betalleluz Pallardel J., Camacho Zacarias F., Velez Segura E., Cruz Condori D.L., Huaman E., Ugarte Oscco R., Vergel Cabrera C., Carpio Colmenares Y.T., Garcia Barrionuevo L.A., Cardenas Ruiz de Castilla D., Mansilla Doria P., Li Valencia M.R., Salazar A., Sarmiento A., Diaz C., Morales E., Ore E., Zegarra H., Siccha J., Guardia M., Sandoval M., Mendiola G.C., Mimbela M., Diaz-Ruiz R., Zeta L.A., Cordova-Calle E., Nunez H.M., Ortiz-Argomedo M.R., Caballero-Alvarado J., Salazar-Tantalean A., Espinoza-Llerena R., Aliaga-Ramos M., Asodisen O., Jabagat E., Tedoy C.M., Ramos R.A., Lopez M.P.J., Violago K.L.E., Aram R., Carlos Santos P., Filarca R.F., Carlos A., Santos P., Filarca R.L., Domingo E.J., Khu K.J.O., Lapitan M.C., Sacdalan M.D.P., Kho M.J.N., Baticulon R.E., Bravo S.L.R., Cueto M.A.C., Ramos C.L., Fuentes J.R., Sadian H., Gumarao A., Barraquio A., Cruz E.M., Gonzales A.D., Reyes J.A.S., Salud J.A., Tancinco E.G., Rivera R.D., Lim J.A., Barcelon J.C., Chiu J.A., Carballo M.I., Gawron I., Jach R., Borges F., Matos Costa P., Henriques S., Rodrigues S.C., Goncalves N., Curvas J.M., Cabeleira A., Branco C., Serralheiro P., Alves R., Teles T., Lazaro A., Canhoto C., Simoes J., Costa M., Almeida A.C., Nogueira O., Oliveira A., Athayde Nemesio R., Silva M., Lopes C., Amaral M.J., Valente da Costa A., Andrade R., Martins R., Guimaraes A., Guerreiro P., Ruivo A., Camacho C., Duque M., Santos E., Breda D., Oliveira J.M., De Oliveira Lopez A.L., Garrido S., Colino M., De Barros J., Correia S., Rodrigues M., Cardoso P., Teixeira J., Soares A.P., Morais H., Pereira R., Revez T., Manso M.I., Domingues J.C., Henriques P., Ribeiro R., Ribeiro V.I., Cardoso N., Sousa S., Martins dos Santos G., Carvalho L., Osorio C., Antunes J., Lourenco S., Balau P., Godinho M., Pereira A., Silva N., Kam da Silva Andrade A., Pereira Rodrigues A., Borges N., Correia J., Vieira I., Ribeiro T., Catarino J., Correia R., Pais F., Carreira Garcia R., Bento R., Cardoso J., Luis M., Henriques J., Patena Forte J., Maciel J., Pinheiro Santos J., Silva T.P., Branquinho A., Caiado A., Miranda P., Garrido R., Peralta Ferreira M., Ascensao J., Costeira B., Cunha C., Rio Rodrigues L., Sousa Fernandes M., Azevedo P., Ribeiro J., Lourenco I., Gomes H., Mendinhos G., Nobre Pinto A., Ribeiro A., Gil C.G., Lima-Da-Silva C., Pereira C., Tavares F., Ferraz I., Almeida J.I., Marialva J., Lopes L., Costa M.J.M.A., Nunes-Coelho M., Teixeira M.J., Machado N., Alfonso J.P., Saraiva P., Silva R.L., Santos R., Almeida-Reis R., Correia-De-Sa T., Fernandes V., Almeida-Pinto J., Goncalves J.P., Santos-Sousa H., Cavaleiro S., Leite-Moreira A.M., Pereira-Neves A., Faria C.S., Monteiro J.M., Nogueiro J., Sampaio-Alves M., Magalhaes Maia M., Vieira P., Pina-Vaz T., Jacome F., Devezas V., Almeida A., Silveira H., Vaz S., Castanheira Rodrigues S., Costa Santos D., Grilo J.V., Abreu da Silva A., Claro M., Deus A.C., Branquinho R., Santos P.M.D.D., Patricio B., Vieira Paiva Lopes A.C., Mendes J.M., Carvalho M.F., Oliveira C.M., Tojal A., Pinto J., Abutaka A., Abdelkareem M., Ali S.M., Al Tarakji M., Alfkey R., Mukhtar K., Wani I.R., Singh R., Bouchiba N., Mahdi H., Abdelaziem Mustafa S., Al Ansari A., Drasovean R., Caziuc A., Galliamov E., Agapov M., Kakotkin V., Semina E., Kubyshkin V., Kamalov A., Efetov S.K., Kochetkov V.S., Garmanova T., Tsarkov P., Tulina I., Rodimov S., Markaryan D., Kazachenko E., Yanishev A., Abelevich A., Bazaev A., Kokobelyan A., Zarubenko P., Zakharenko A., Novikova A., Kim G., Shmatov D., Stoliarov M., Kamenskikh M., Nambi G., Almulhim A.S., Madkhali T., Alzouhir A., Alissa A., Alameer E., Badedi M., Alnami A.Q., Darraj H., Alkhuzaie A., Khadwardi F., Abualjadayel M., Tashkandi W., Farsi A., Malibary N., Trabulsi N., Farsi S., Said Bayazeed A., Nasser M., Siddiqui M.S., Al Awwad S., Alshahrani M., Alsharif F., Fahmi M.W., Gudal A., Alasmari A., Alqahtani S., Majrashi S., Mashat A., Al Raddadi R., Alharbi A., Nasser Y., Hamayel H., Alhojaili A., Aljohani R., Sogair O., Alfarhan O., Alzahrani A., Alzomaili B., Azab M.A., Alotaibi M., Maashi A., Zowgar A., Alsakkaf M., Alnemary M., Khayat S., Felmban S., Almhmadi A., Alqannas M., Cortes Guiral D., Alyami M., Elawad A., Alhefdhi A., Alresaini F., Kurdi W., Tulbah M., Aldakheel M., Alsahan N., Koussayer S., Elsheikh H., Al-Qattan M., Alshanafey S., Rafique A., Mahabbat N., Saeed B., Al-Kharashi E., Alsowaina K., Arab N., Aljaber F., Al Hasan I., Alghamdi A., Badahdah F., Alghuliga A., Abdulfattah F., Alanazi F., Albaqami F., Alsuhaibani A., AlFakhri A., Alqasem S., Alajaji N., Nouh T., Bin Nasser A., Alowais J., Alburakan A., Alamri O., Albdah A., Alawi K., Alshalhoub M., ElSanhoury K., Almofarreh A., Ibrahim S., Elshafie H., Osman I., Guzman T., Mutair H., Siddiqui A., Chowdhury S., Alghamdi R., Almutrafi S., Alfaifi J., D'Souza J., Alshitwi A., Alkreedees N., Alramadhan M., Alshehri M., Alobaysi S., Alshahrani A., Alshehri A., Alrashed M., Altahan T., Alsabahi T., Alhossaini R., Sbaih M., Alalawi Y., Alnwijy K., Al Ayed A., Ghedan S., Alharthi R., Awad S., Sharara M., Abdelrhman S., Althobaiti W., Srbinovic L., Perovic M., Mikovic Z., Nikolic B., Vasiljevic M., Pazin V., Mandic Markovic V., Dimitrijevic D., Zecevic N., Gregoric P., Micic D., Loncar Z., Doklestic K., Ivancevic N., Djukic V., Stojakov D., Ilic R., Savic P., Pijanovic N., Milanovic M., Radosavljevic M., Dejanovic T., Kostic M., Paskas J., Bojic S., Stevanovic P., Djuric M., Kadija M., Tulic G., Glisovic Jovanovic I., Lieske B., Kayombo E., Kruger I., De Kock M., Malan A., Ferreira C., Du Preez H., Mulder W., Noel C., Le Grange S., Lusawana O., Kies C., Steyn E., Janson J., Buitendag J.J.P., Chu K., Mihalik M., Nel R., Naidoo S., Kloppers C., Nel D., Jonas E., Pickard H., Bernon M., Almgla N., Rayamajhi S., Mugla W., Carapinha C., Hyman G.Y., Fourtounas M., Sanchez Mozo A., Aguado Lopez H., Zarate Pinedo A., Jimenez Toscano M., Alonso de la Fuente N., Mancebo G., Cecchini L., Munarriz M., Cazador Labat M., Lopez Campillo A., Martorell P., Espinosa C.A., Caja Vivancos P., Villalabeitia Ateca I., Prieto Calvo M., Marin H., Martin Playa P., Gainza A., Aragon Achig E.J., Rodriguez Fraga A., Melchor Corcostegui I., Mallabiabarrena Ormaechea G., Garcia Gutierrez J.J., Barbier L., Pesantez Peralta M.A., Jimenez Jimenez M., Municio Martin J.A., Gomez Suarez J., Garcia Opere G., Pascua Gomez L.A., Onate Aguirre M., Fernandez-Colorado A., De la Rosa-Estadella M., Gasulla-Rodriguez A., Serrano-Martin M., Peig-Font A., Junca-Marti S., Juarez-Pomes M., Garrido-Ondono S., Blasco-Torres L., Molina-Corbacho M., Maldonado-Sotoca Y., Gasset-Teixidor A., Blasco-Moreu J., Gomez Fernandez L., Cayetano Paniagua L., Izquierdo O., Ventura D., Castellanos J., Ballester Vazquez E., Sanchez Lopez A., Balague Ponz C., Targarona Soler E.M., Sanchez Cabus S., Molina Santos V., Gonzalez Lopez J.A., Medrano Caviedes R., Moral Duarte A., Espin-Basany E., Blanco-Colino R., Turrado-Rodriguez V., Lacy A.M., de Lacy F.B., Morales X., Carreras-Castaner A., Torner P., Jornet-Gibert M., Balaguer-Castro M., Renau-Cerrillo M., Camacho-Carrasco P., Vives-Barq... [Ovid has truncated this field to avoid Excel character limitations], Bravo L., Nepogodiev D., Glasbey J.C., Li E., Simoes J.F.F., Kamarajah S.K., Picciochi M., Abbott T.E.F., Ademuyiwa A.O., Arnaud A.P., Agarwal A., Brar A., Elhadi M., Mazingi D., Cardoso V.R., Lawday S., Sayyed R., Omar O.M., de la Madina A.R., Slater L., Venn M.L., Gkoutos G., Bhangu A., Karwath A., Siaw-Acheampong K., Argus L., Chaudhry D., Dawson B.E., Gujjuri R.R., Jones C.S., Khatri C., Keatley J.M., Mann H., Marson E.J., Mclean K.A., Taylor E.H., Tiwari A., Trout I.M., Wilkin R.J.W., Dajti I., Gjata A., Boccalatte L., Modolo M.M., Cox D., Pockney P., Townend P., Aigner F., Kronberger I., Hossain K., VanRamshorst G., Lawani I., Ataide G., Baiocchi G., Buarque I., Gohar M., Slavchev M., Martin J., Olivos M., Calvache J., Rivera C.J.P., Hadzibegovic A.D., Kopjar T., Mihanovic J., Klat J., Novysedlak R., Christensen P., El-Hussuna A., Batista S., Lincango E., Emile S.H., Mengesha M.G., Hailu S., Tamiru H., Kauppila J., Laukkarinen J., Albertsmeiers M., Lederhuber H., Loffler M., Tabiri S., Metallidis S., Tsoulfas G., Lorena M.A., Grecinos G., Mersich T., Wettstein D., Ghosh D., Kembuan G., Brouk P., Khosravi M., Mozafari M., Adil A., Mohan H.M., Zmora O., Fiore M., Gallo G., Pata F., Pellino G., Satoi S., Ayasra F., Chaar M., Fakhradiyev I.R., Jamal M., Gulla A., Roslani A., Martinez L., De La Medina A.R., Outani O., Jonker P., Kruijff S., Noltes M., Steinkamp P., van der Plas W., Osinaike B., Seyiolajide J., Williams E., Pejkova S., Augestad K.M., Soreide K., Al Balushi Z., Qureshi A., Daraghmeh M.A.M., Abukhalaf S., Cukier M., Gomez H., Shu S., Vasquez X., Parreno-Sacdalan M.D., Major P., Azevedo J., Cunha M., Santos I., Zarour A., Bonci E.-A., Negoi I., Efetov S., Litvin A., Ntirenganya F., Al Ameer E., Radenkovic D., Xiang F.K.H., Hoe C.M., Yong J.N.C., Moore R., Nhlabathi N., Colino R.B., Bravo A.M., Minaya-Bravo A., Jayarajah U., Wickramasinghe D., Elmujtaba M., Jebril W., Rutegard M., Sund 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[Ovid has truncated this field to avoid Excel character limitations]
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- 2021
3. What cardiologists should know about sleep
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Pengo, Martino Francesco, Javaheri, Sogol, Sanchez-de-la-Torre, Manuel, Schwarz, Esther Irene, Pengo, M, Javaheri, S, Sanchez-De-La-Torre, M, Schwarz, E, and University of Zurich
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Cardiologists ,Cardiovascular Diseases ,Cardiovascular Disease ,Humans ,610 Medicine & health ,Cardiologist ,10178 Clinic for Pneumology ,Cardiology and Cardiovascular Medicine ,Sleep ,2705 Cardiology and Cardiovascular Medicine ,Human - Published
- 2022
4. Polysomnographic characterization of circadian blood pressure patterns in patients with obstructive sleep apnea.
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Pinilla L, Benítez ID, Gracia-Lavedan E, Torres G, Minguez O, Aguilà M, Targa A, Dalmases M, Mediano O, Masa JF, Masdeu MJ, Barbé F, and Sánchez-de-la-Torre M
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- Humans, Blood Pressure physiology, Prospective Studies, Sleep, Blood Pressure Monitoring, Ambulatory, Sleep Apnea, Obstructive
- Abstract
We characterized the polysomnography (PSG) parameters associated with alterations in the circadian blood pressure (BP) pattern aiming to identify the main contributors to explain the nondipper profile in obstructive sleep apnea (OSA). This is an observational prospective-multicenter study that included participants referred to the sleep unit for suspected OSA. Following a PSG study, subjects with an apnea-hypopnea index (AHI) ≥5 events/hr were included. Two groups were established based on the 24-hr ambulatory blood pressure monitoring dipping ratio (DR; night/day BP ratio): dippers (DR ≤ 0.9) and nondippers (DR > 0.9). The cohort consisted of 299 patients: 131 (43.8%) dippers and 168 (56.2%) nondippers. A significant increase in the risk of presenting a nondipper BP pattern was found along with AHI gain [odds ratio (OR) (95% CI) = 1.71 (1.28 to 2.28)]. The best AHI cutoff for predicting nondipper status was 25.2 events/hr, increasing the OR (95% CI) to 3.50 (2.02 to 6.07). The hypopnea index [OR (95% CI) = 1.70 (1.27 to 2.26)], TSat90 [OR (95% CI) = 1.41 (1.06 to 1.87)], and respiratory arousal index [OR (95% CI) = 1.74 (1.30 to 2.34)] were individually associated with the risk of a nondipping pattern. Multivariate variable selection processes identified the respiratory arousal index as the most relevant risk factor for the nondipper profile, beyond classical clinical risk factors and usual PSG metrics., (© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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5. What cardiologists should know about sleep.
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Pengo MF, Javaheri S, Sanchez-de-la-Torre M, and Schwarz EI
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- Humans, Sleep, Cardiologists, Cardiovascular Diseases
- Abstract
Competing Interests: Conflict of interest: none declared.
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- 2022
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6. Sleep profile predicts the cognitive decline of mild-moderate Alzheimer's disease patients.
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Targa ADS, Benítez ID, Dakterzada F, Carnes A, Pujol M, Jorge C, Minguez O, Dalmases M, Sánchez-de-la-Torre M, Barbé F, and Piñol-Ripoll G
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- Amyloid beta-Peptides, Biomarkers, Humans, Neuropsychological Tests, Prospective Studies, Sleep, tau Proteins, Alzheimer Disease complications, Alzheimer Disease epidemiology, Cognitive Dysfunction epidemiology, Cognitive Dysfunction etiology
- Abstract
Study Objectives: To investigate the association between sleep and cognitive decline of patients with mild-moderate Alzheimer's disease., Methods: Observational, prospective study, including consecutive patients diagnosed with mild-moderate Alzheimer's disease. Cerebrospinal fluid was collected for amyloid-beta, total-tau, and phospho-tau levels determination. Also, overnight polysomnography was performed, followed by neuropsychological evaluations at baseline and after 12 months of follow-up. Principal component analysis revealed two profiles of patients in terms of sleep: one with a propensity to deepen the sleep (deep sleepers) and the other with a propensity to spend most of the time in the lighter sleep stage (light sleepers)., Results: The cohort included 125 patients with a median [IQR] of 75.0 [72.0;80.0] years. Deep and light sleepers did not present differences in relation to the cerebrospinal fluid pathological markers and to the cognitive function at the baseline. However, there was a significant difference of -1.51 (95% CI: -2.43 to -0.59) in the Mini-mental state examination after 12 months of follow-up. Accordingly, sleep depth and cognitive decline presented a dose-response relationship (p-for-trend = 0.02). Similar outcomes were observed in relation to the processing speed (Stroop words test, p-value = 0.016) and to the executive function (Verbal fluency test, p-value = 0.023)., Conclusions: Considering the increased cognitive decline presented by light sleepers, the sleep profile may have a predictive role in relation to the cognitive function of patients with mild-moderate Alzheimer's disease. The modifiable nature of sleep sets this behavior as a possible useful intervention to prevent a marked cognitive decline., Clinical Trial Information: Role of Hypoxia Ans Sleep Fragmentation in Alzheimer's Disease. and Sleep Fragmentation. Completed. NCT02814045., (© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2021
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7. The effect of chronic intermittent hypoxia in cardiovascular gene expression is modulated by age in a mice model of sleep apnea.
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Castro-Grattoni AL, Suarez-Giron M, Benitez I, Tecchia L, Torres M, Almendros I, Farre R, Targa A, Montserrat JM, Dalmases M, Barbé F, Gozal D, and Sánchez-de-la-Torre M
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- Animals, Disease Models, Animal, Gene Expression, Hypoxia genetics, Mice, Mice, Inbred C57BL, Sirtuins, Sleep Apnea Syndromes
- Abstract
Study Objectives: Chronic intermittent hypoxia (CIH) is a major determinant in obstructive sleep apnea cardiovascular morbidity and this effect is influenced by age. The objective of the present study was to assess the differential molecular mechanisms at gene-level expression involved in the cardiovascular remodeling induced by CIH according to chronological age., Methods: Two- and 18-month-old mice (N = 8 each) were subjected to CIH or normoxia for 8 weeks. Total messenger RNA (mRNA) was extracted from left ventricle myocardium and aortic arch, and gene expression of 46 intermediaries of aging, oxidative stress, and inflammation was measured by quantitative real-time polymerase chain reaction., Results: Cardiac gene expression of Nrf2 (2.05-fold increase, p < 0.001), Sod2 (1.9-fold increase, p = 0.035), Igf1r (1.4-fold increase, p = 0.028), Mtor (1.8-fold increase, p = 0.06), Foxo3 (1.5-fold increase, p = 0.020), Sirt4, Sirt6, and Sirt7 (1.3-fold increase, p = 0.012; 1.1-fold change, p = 0.031; 1.3-fold change, p = 0.029) was increased after CIH in young mice, but not in old mice. In aortic tissue, endothelial isoform of nitric oxide synthase was reduced in young mice (p < 0.001), Nrf2 was reduced in 80% (p < 0.001) in young mice and 45% (p = 0.07) in old mice, as its downstream antioxidant target Sod2 (82% reduced, p < 0.001). IL33., Conclusions: CIH effect in gene expression is organ-dependent, and is modulated by age. CIH increased transcriptional expression of genes involved in cardioprotection and cell survival in young, but not in old mice. In aortic tissue, CIH reduced gene expression related to an antioxidant response in both young and old mice, suggesting vascular oxidative stress and a proaging process., (© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2021
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8. Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias.
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McEvoy RD, Sánchez-de-la-Torre M, Peker Y, Anderson CS, Redline S, and Barbe F
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- Continuous Positive Airway Pressure, Humans, Randomized Controlled Trials as Topic, Cardiovascular Diseases epidemiology, Sleep Apnea, Obstructive therapy
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- 2021
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9. Exploring the underlying prothrombotic mechanisms promoted by intermittent hypoxia: a potential therapeutic target?
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Sánchez-de-la-Torre M and Barbé F
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- Angiopoietin-2, Humans, Hypoxia, Sleep Apnea, Obstructive, von Willebrand Factor
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- 2021
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10. Predictors of pacemaker implantation after transcatheter aortic valve implantation according to kind of prosthesis and risk profile: a systematic review and contemporary meta-analysis.
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Bruno F, D'Ascenzo F, Vaira MP, Elia E, Omedè P, Kodali S, Barbanti M, Rodès-Cabau J, Husser O, Sossalla S, Van Mieghem NM, Bax J, Hildick-Smith D, Munoz-Garcia A, Pollari F, Fischlein T, Budano C, Montefusco A, Gallone G, De Filippo O, Rinaldi M, la Torre M, Salizzoni S, Atzeni F, Pocar M, Conrotto F, and De Ferrari GM
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- Bundle-Branch Block epidemiology, Bundle-Branch Block etiology, Bundle-Branch Block therapy, Humans, Aortic Valve Stenosis epidemiology, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Pacemaker, Artificial, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Aims: Permanent pacemaker implantation (PPI) may be required after transcatheter aortic valve implantation (TAVI). Evidence on PPI prediction has largely been gathered from high-risk patients receiving first-generation valve implants. We undertook a meta-analysis of the existing literature to examine the incidence and predictors of PPI after TAVI according to generation of valve, valve type, and surgical risk., Methods and Results: We made a systematic literature search for studies with ≥100 patients reporting the incidence and adjusted predictors of PPI after TAVI. Subgroup analyses examined these features according to generation of valve, specific valve type, and surgical risk. We obtained data from 43 studies, encompassing 29 113 patients. Permanent pacemaker implantation rates ranged from 6.7% to 39.2% in individual studies with a pooled incidence of 19% (95% CI 16-21). Independent predictors for PPI were age [odds ratio (OR) 1.05, 95% confidence interval (CI) 1.01-1.09], left bundle branch block (LBBB) (OR 1.45, 95% CI 1.12-1.77), right bundle branch block (RBBB) (OR 4.15, 95% CI 3.23-4.88), implantation depth (OR 1.18, 95% CI 1.11-1.26), and self-expanding valve prosthesis (OR 2.99, 95% CI 1.39-4.59). Among subgroups analysed according to valve type, valve generation and surgical risk, independent predictors were RBBB, self-expanding valve type, first-degree atrioventricular block, and implantation depth., Conclusions: The principle independent predictors for PPI following TAVI are age, RBBB, LBBB, self-expanding valve type, and valve implantation depth. These characteristics should be taken into account in pre-procedural assessment to reduce PPI rates. PROSPERO ID CRD42020164043., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
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11. Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer's disease.
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Targa A, Dakterzada F, Benítez I, López R, Pujol M, Dalmases M, Arias A, Sánchez-de-la-Torre M, Zetterberg H, Blennow K, Pamplona R, Jové M, Barbé F, and Piñol-Ripoll G
- Subjects
- Amyloid beta-Peptides, Biomarkers, Humans, Intermediate Filaments, Sleep, tau Proteins, Alzheimer Disease, Cognitive Dysfunction
- Abstract
Study Objectives: The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy participants. Our objective was to investigate the association between sleep and several biomarkers that reflect distinct aspects of AD physiopathology., Methods: The cohort included 104 individuals with mild-moderate AD. The participants were submitted to one-night polysomnography, and cerebrospinal fluid was collected in the following morning to measure the selected biomarkers associated with amyloid deposition, tau pathology, neurodegeneration, axonal damage, synaptic integrity, neuroinflammation, and oxidative damage., Results: There was a positive correlation between neurofilament light (NF-L) and the time spent in stage 1 of non-rapid eyes movement (NREM) (N1) sleep and a negative correlation between this marker and the time spent in stage 3 of NREM (N3) sleep. Accordingly, we observed that deep sleep was associated with lower levels of NF-L, whereas light sleep increased the probability of having higher levels of this marker. Furthermore, chitinase-3-like-1 (YKL-40) was negatively correlated with sleep efficiency, the time spent in stage 2 of NREM (N2) sleep, and the time spent in N3 sleep. Conversely, there was a positive correlation between N3 sleep and the oxidative protein damage markers N-ε-(carboxyethyl)lysine and N-ε-(malondialdehyde)lysine., Conclusions: There were significant correlations between sleep parameters and AD biomarkers related to axonal damage and neuroinflammation, such as NF-L and YKL-40. A lack of deep sleep was associated with higher levels of NF-L. This highlights a potential role for NF-L as a biomarker of sleep disruption in patients with mild-moderate AD in addition to its role in predicting neurodegeneration and cognitive decline., (© Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.)
- Published
- 2021
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12. Delayed benign surgery during the COVID-19 pandemic: the other side of the coin.
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La Torre M, Pata F, and Gallo G
- Subjects
- Aged, COVID-19, Coronavirus Infections complications, Coronavirus Infections transmission, Hemorrhoids complications, Humans, Male, Pneumonia, Viral complications, Pneumonia, Viral transmission, SARS-CoV-2, Betacoronavirus, Coronavirus Infections epidemiology, Disease Transmission, Infectious prevention & control, Hemorrhoids surgery, Pandemics, Pneumonia, Viral epidemiology, Surgical Procedures, Operative standards, Time-to-Treatment standards
- Published
- 2020
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13. The role of sleep disorders breathing treatment as a modifiable condition for cardiovascular risk associated hypertension.
- Author
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Mediano O, Sánchez-de-la-Torre M, and García-Río F
- Subjects
- Blood Pressure, Humans, Prognosis, Risk Factors, Cardiovascular Diseases, Hypertension, Sleep Wake Disorders
- Published
- 2019
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14. Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos.
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Cokus SJ, De La Torre M, Medina EF, Rasmussen JP, Ramirez-Gutierrez J, Sagasti A, and Wang F
- Subjects
- Animals, Gene Expression Profiling, Gene Expression Regulation, Developmental, Phenotype, Embryonic Development genetics, Epithelium embryology, Organogenesis genetics, Transcriptome, Zebrafish embryology, Zebrafish genetics
- Abstract
Epithelial cells are the building blocks of many organs, including skin. The vertebrate skin initially consists of two epithelial layers, the outer periderm and inner basal cell layers, which have distinct properties, functions, and fates. The embryonic periderm ultimately disappears during development, whereas basal cells proliferate to form the mature, stratified epidermis. Although much is known about mechanisms of homeostasis in mature skin, relatively little is known about the two cell types in pre-stratification skin. To define the similarities and distinctions between periderm and basal skin epithelial cells, we purified them from zebrafish at early development stages and deeply profiled their gene expression. These analyses identified groups of genes whose tissue enrichment changed at each stage, defining gene flow dynamics of maturing vertebrate epithelia. At each of 52 and 72 hr post-fertilization (hpf), more than 60% of genes enriched in skin cells were similarly expressed in both layers, indicating that they were common epithelial genes, but many others were enriched in one layer or the other. Both expected and novel genes were enriched in periderm and basal cell layers. Genes encoding extracellular matrix, junctional, cytoskeletal, and signaling proteins were prominent among those distinguishing the two epithelial cell types. In situ hybridization and BAC transgenes confirmed our expression data and provided new tools to study zebrafish skin. Collectively, these data provide a resource for studying common and distinguishing features of maturing epithelia., (Copyright © 2019 Cokus et al.)
- Published
- 2019
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15. Mid-term survival outcome of single-port video-assisted thoracoscopic anatomical lung resection: a two-centre experience.
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Wu CF, Fernandez R, de la Torre M, Delgado M, Fieira E, Wu CY, Hsieh MJ, Paradela M, Liu YH, and Gonzalez-Rivas D
- Subjects
- Aged, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Spain, Taiwan, Treatment Outcome, Pneumonectomy adverse effects, Pneumonectomy methods, Pneumonectomy mortality, Pneumonectomy statistics & numerical data, Thoracic Surgery, Video-Assisted adverse effects, Thoracic Surgery, Video-Assisted methods, Thoracic Surgery, Video-Assisted mortality, Thoracic Surgery, Video-Assisted statistics & numerical data
- Abstract
Objectives: Single-port video-assisted thoracoscopic surgery (SPVATS) anatomical resection has been shown to be a feasible technique for lung cancer patients. Whether SPVATS has equivalent or better oncological outcomes for lung cancer patients remains controversial. The purpose of this study was to evaluate the perioperative and mid-term survival outcomes of SPVATS in 2 different medical centres., Methods: We retrospectively reviewed patients who underwent SPVATS anatomical resections between January 2014 and February 2017 in Coruña University Hospital's Minimally Invasive Thoracic Surgery Unit (Spain) and Chang Gung Memorial Hospital (Taiwan). Survival outcomes were assessed by pathological stage according to the American Joint Committee on Cancer (AJCC) 7th and 8th classifications., Results: In total, 307 patients were enrolled in this study. Mean drainage days and postoperative hospital stay were 3.90 ± 2.98 and 5.03 ± 3.34 days. The overall 30-day mortality, 90-day morbidity and mortality rate were 0.7%, 20.1% and 0.7%, respectively. The 2-year disease-free survival and 2-year overall survival of the cohort were 80.6% and 93.4% for 1A, 68.8% and 84.6% for 1B, 51.0% and 66.7% for 2A, 21.6% and 61.1% for 2B, 47.6% and 58.5% for 3A, respectively, following the AJCC 7th classification. By the AJCC 8th classification, these were 92.3% and 100% for 1A1, 73.7% and 91.4% for 1A2, 75.2% and 93.4% for 1A3, 62.1% and 85.9% for 1B, 55.6% and 72.7% for 2A, 47.1% and 64.2% for 2B and 42.1% and 60.3% for 3A., Conclusions: Our preliminary results revealed that SPVATS anatomical resection achieves acceptable 2-year survival outcomes for early-stage lung cancer and is consistent with AJCC 8th staging system 2-year survival data. For advanced stage non-small-cell lung cancer patients, further evaluation is warranted.
- Published
- 2018
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16. Comparison of the efficiency of bacterial and fungal laccases in delignification and detoxification of steam-pretreated lignocellulosic biomass for bioethanol production.
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De La Torre M, Martín-Sampedro R, Fillat Ú, Eugenio ME, Blánquez A, Hernández M, Arias ME, and Ibarra D
- Subjects
- Fermentation, Glucose chemistry, Hydrogen-Ion Concentration, Lignin chemistry, Saccharomyces cerevisiae metabolism, Triticum chemistry, Triticum microbiology, Xylose chemistry, Biomass, Laccase metabolism, Steam, Streptomyces enzymology, Trametes enzymology
- Abstract
This study evaluates the potential of a bacterial laccase from Streptomyces ipomoeae (SilA) for delignification and detoxification of steam-exploded wheat straw, in comparison with a commercial fungal laccase from Trametes villosa. When alkali extraction followed by SilA laccase treatment was applied to the water insoluble solids fraction, a slight reduction in lignin content was detected, and after a saccharification step, an increase in both glucose and xylose production (16 and 6%, respectively) was observed. These effects were not produced with T. villosa laccase. Concerning to the fermentation process, the treatment of the steam-exploded whole slurry with both laccases produced a decrease in the phenol content by up to 35 and 71% with bacterial and fungal laccases, respectively. The phenols reduction resulted in an improved performance of Saccharomyces cerevisiae during a simultaneous saccharification and fermentation (SSF) process, improving ethanol production rate. This enhancement was more marked with a presaccharification step prior to the SSF process.
- Published
- 2017
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17. Cell Death Biomarkers and Obstructive Sleep Apnea: Implications in the Acute Coronary Syndrome.
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Bauça JM, Yañez A, Fueyo L, de la Peña M, Pierola J, Sánchez-de-la-Torre A, Mediano O, Cabriada-Nuño V, Masdeu MJ, Teran-Santos J, Duran-Cantolla J, Masa JF, Abad J, Sanchez-de-la-Torre M, Barbé F, and Barceló A
- Subjects
- Case-Control Studies, Cell Death, DNA blood, Female, Humans, Male, Middle Aged, Myocardial Infarction blood, Myocardial Infarction pathology, Nucleosomes metabolism, Polysomnography, Randomized Controlled Trials as Topic, Risk Assessment, Risk Factors, Acute Coronary Syndrome blood, Acute Coronary Syndrome pathology, Biomarkers blood, Sleep Apnea, Obstructive blood, Sleep Apnea, Obstructive pathology
- Abstract
Study Objectives: Nucleosomes and cell-free double-stranded DNA (dsDNA) have been suggested as promising biomarkers in cell death-related diseases, such as acute coronary syndrome (ACS). Currently, the impact of obstructive sleep apnea (OSA) in patients with ACS is unclear. Our aim was to evaluate the relationship between OSA, dsDNA, and nucleosomes and to assess their potential implication in the development of ACS., Methods: Up to 549 patients were included in the study and divided into four groups (145 ACS; 290 ACS + OSA; 62 OSA; 52 controls). All patients underwent a sleep study, and serum concentrations of dsDNA and nucleosomes were measured., Results: Nucleosome and dsDNA levels were higher in patients with OSA than in controls (nucleosomes: 1.47 ± 0.88 arbitary units [AU] vs. 1.00 ± 0.33 AU; p < .001, dsDNA: 315.6 ± 78.0 ng/mL vs. 282.6 ± 55.4 ng/mL; p = .007). In addition, both biomarker levels were higher in patients with ACS than in non-ACS, independently of the presence of OSA., Conclusions: Both nucleosomes and dsDNA are increased in patients with OSA and might be related with the high cardiovascular risk seen in these patients. The extensive cell lysis during a myocardial infarction seems to be the major contributor to the high biomarker levels, and OSA does not seem to be implicated in such elevation when this acute event occurs., Clinical Trial Registration: NCT01335087 (clinicaltrials.gov)., (© Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.)
- Published
- 2017
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18. Early and mid-term outcomes of 1904 patients undergoing transcatheter balloon-expandable valve implantation in Italy: results from the Italian Transcatheter Balloon-Expandable Valve Implantation Registry (ITER).
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Salizzoni S, D'Onofrio A, Agrifoglio M, Colombo A, Chieffo A, Cioni M, Besola L, Regesta T, Rapetto F, Tarantini G, Napodano M, Gabbieri D, Saia F, Tamburino C, Ribichini F, Cugola D, Aiello M, Sanna F, Iadanza A, Pompei E, Stefàno P, Cappai A, Minati A, Cassese M, Martinelli GL, Agostinelli A, Fiorilli R, Casilli F, Reale M, Bedogni F, Petronio AS, Mozzillo RA, Bonmassari R, Briguori C, Liso A, Sardella G, Bruschi G, Fiorina C, Filippini C, Moretti C, D'Amico M, La Torre M, Conrotto F, Di Bartolomeo R, Gerosa G, and Rinaldi M
- Subjects
- Aged, Aged, 80 and over, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Echocardiography, Female, Humans, Italy, Male, Registries, Transcatheter Aortic Valve Replacement adverse effects, Transcatheter Aortic Valve Replacement methods, Transcatheter Aortic Valve Replacement mortality, Treatment Outcome, Bioprosthesis, Heart Valve Prosthesis, Transcatheter Aortic Valve Replacement instrumentation
- Abstract
Objectives: The aim of this multicentre study is to report the clinical experiences of all patients undergoing transcatheter aortic valve implantation (TAVI) with a balloon-expandable device in Italy., Methods: The Italian Transcatheter balloon-Expandable valve Registry (ITER) is a real-world registry that includes patients who have undergone TAVI with the Sapien (Edwards Lifesciences, Irvine, CA, USA) bioprosthesis in Italy since it became available in clinical practice. From 2007 to 2012, 1904 patients were enrolled to undergo TAVI in 33 Italian centres. Outcomes were classified according to the updated Valve Academic Research Consortium (VARC-2) definitions. A multivariable analysis was performed to identify independent predictors of all-cause mortality., Results: Mean age was 81.7 (SD:6.2) years, and 1147 (60.2%) patients were female. Mean Logistic EuroSCORE was 21.1% (SD:13.7). Transfemoral, transapical, transaortic and transaxillary TAVI was performed in 1252 (65.8%), 630 (33.1%), 18 (0.9%) and 4 (0.2%) patients, respectively. Operative mortality was 7.2% (137 patients). The VARC-2 outcomes were as follows: device success, 88.1%; disabling stroke, 1.0%; life-threatening and major bleeding 9.8 and 10.5%, respectively; major vascular complication, 9.7%; acute kidney injury, 8.2%; acute myocardial infarction ≤72 h, 1.5%. Perioperative pacemaker implantation was necessary in 116 (6.1%) patients. At discharge, the mean transprosthetic gradient was 10.7 (SD:4.5) mmHg. Incidence of postoperative mild, moderate or severe paravalvular leak was, respectively, 32.1, 5.0 and 0.4%. A total of 444/1767 (25.1%) deaths after hospital discharge were reported: of these, 168 (37.8%) were classified as cardiac death. Preoperative independent predictors of all-cause mortality were male gender (HR: 1.395; 95% CI:1.052-1.849); overweight, BMI 25-30 kg/m
2 (HR: 0.775; 95% CI: 0.616-0.974); serum creatinine level (every 1 mg/dl increase; HR: 1.314; 95% CI:1.167-1.480); haemoglobin level (every 1 g/dl increase; HR: 0.905; 95% CI:0.833-0.984); critical preoperative state (HR: 2.282; 95% CI: 1.384-3.761); neurological dysfunction (HR: 1.552; 95% CI:1.060-2.272); atrial fibrillation (HR: 1.556; 95% CI:1.213-1.995); pacemaker rhythm (HR: 1.948; 95% CI:1.310-2.896); NYHA Class III or IV (HR: 1.800; 95% CI:1.205-2.689 or HR: 2.331; 95% CI:1.392-3.903, respectively)., Conclusions: TAVI with a balloon-expandable device in the 'real world' shows good mid-term outcomes in terms of survival, technical success, valve-related adverse events and haemodynamic performance., (© The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)- Published
- 2016
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19. Non-intubated video-assisted thoracoscopic lung resections: the future of thoracic surgery?
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Gonzalez-Rivas D, Bonome C, Fieira E, Aymerich H, Fernandez R, Delgado M, Mendez L, and de la Torre M
- Subjects
- Humans, Intubation, Intratracheal, Patient Positioning, Pulmonary Ventilation, Pneumonectomy methods, Pneumonectomy trends, Thoracic Surgery, Video-Assisted methods, Thoracic Surgery, Video-Assisted trends
- Abstract
Thanks to the experience gained through the improvement of video-assisted thoracoscopic surgery (VATS) technique, and the enhancement of surgical instruments and high-definition cameras, most pulmonary resections can now be performed by minimally invasive surgery. The future of the thoracic surgery should be associated with a combination of surgical and anaesthetic evolution and improvements to reduce the trauma to the patient. Traditionally, intubated general anaesthesia with one-lung ventilation was considered necessary for thoracoscopic major pulmonary resections. However, thanks to the advances in minimally invasive techniques, the non-intubated thoracoscopic approach has been adapted even for use with major lung resections. An adequate analgesia obtained from regional anaesthesia techniques allows VATS to be performed in sedated patients and the potential adverse effects related to general anaesthesia and selective ventilation can be avoided. The non-intubated procedures try to minimize the adverse effects of tracheal intubation and general anaesthesia, such as intubation-related airway trauma, ventilation-induced lung injury, residual neuromuscular blockade, and postoperative nausea and vomiting. Anaesthesiologists should be acquainted with the procedure to be performed. Furthermore, patients may also benefit from the efficient contraction of the dependent hemidiaphragm and preserved hypoxic pulmonary vasoconstriction during surgically induced pneumothorax in spontaneous ventilation. However, the surgical team must be aware of the potential problems and have the judgement to convert regional anaesthesia to intubated general anaesthesia in enforced circumstances. The non-intubated anaesthesia combined with the uniportal approach represents another step forward in the minimally invasive strategies of treatment, and can be reliably offered in the near future to an increasing number of patients. Therefore, educating and training programmes in VATS with non-intubated patients may be needed. Surgical techniques and various regional anaesthesia techniques as well as indications, contraindications, criteria to conversion of sedation to general anaesthesia in non-intubated patients are reviewed and discussed., (© The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2016
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20. Intraoperative bleeding control by uniportal video-assisted thoracoscopic surgery†.
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Gonzalez-Rivas D, Stupnik T, Fernandez R, de la Torre M, Velasco C, Yang Y, Lee W, and Jiang G
- Subjects
- Conversion to Open Surgery, Hemostasis, Endoscopic instrumentation, Hemostasis, Surgical instrumentation, Humans, Blood Loss, Surgical prevention & control, Hemostasis, Endoscopic methods, Hemostasis, Surgical methods, Pneumonectomy methods, Thoracic Surgery, Video-Assisted methods
- Abstract
Owing to advances in video-assisted thoracic surgery (VATS), the majority of pulmonary resections can currently be performed by VATS in a safe manner with a low level of morbidity and mortality. The majority of the complications that occur during VATS can be minimized with correct preoperative planning of the case as well as careful pulmonary dissection. Coordination of the whole surgical team is essential when confronting an emergency such as major bleeding. This is particularly important during the VATS learning curve, where the occurrence of intraoperative complications, particularly significant bleeding, usually ends in a conversion to open surgery. However, conversion should not be considered as a failure of the VATS approach, but as a resource to maintain the patient's safety. The correct assessment of any bleeding is of paramount importance during major thoracoscopic procedures. Inadequate management of the source of bleeding may result in major vessel injury and massive bleeding. If bleeding occurs, a sponge stick should be readily available to apply pressure immediately to control the haemorrhage. It is always important to remain calm and not to panic. With the bleeding temporarily controlled, a decision must be made promptly as to whether a thoracotomy is needed or if the bleeding can be solved through the VATS approach. This will depend primarily on the surgeon's experience. The operative vision provided with high-definition cameras, specially designed or adapted instruments and the new sealants are factors that facilitate the surgeon's control. After experience has been acquired with conventional or uniportal VATS, the rate of complications diminishes and the majority of bleeding events are controlled without the need for conversion to thoracotomy., (© The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2016
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21. Single-port thoracoscopic lobectomy in a nonintubated patient: the least invasive procedure for major lung resection?
- Author
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Gonzalez-Rivas D, Fernandez R, de la Torre M, Rodriguez JL, Fontan L, and Molina F
- Subjects
- Anesthesia methods, Carcinoid Tumor diagnosis, Frozen Sections, Humans, Hypnotics and Sedatives administration & dosage, Length of Stay, Lung Neoplasms diagnosis, Lymph Node Excision, Male, Middle Aged, Operative Time, Patient Positioning, Positron-Emission Tomography, Solitary Pulmonary Nodule diagnosis, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Carcinoid Tumor surgery, Lung Neoplasms surgery, Pneumonectomy methods, Solitary Pulmonary Nodule surgery, Thoracic Surgery, Video-Assisted methods
- Abstract
Objectives: General anaesthesia with single-lung ventilation was always considered a condition for thoracoscopic major pulmonary resections. However, nonintubated thoracoscopic lobectomy has been reported recently by using conventional video-assisted thoracoscopic surgery (VATS), epidural anaesthesia and vagus blockade. Here, we present a technique that reduces the surgical access trauma even more: single-incision VATS approach with no need for epidural or vagus blockade in a nonintubated patient., Methods: A 46-year old male smoker was admitted to our department for surgery. A computed tomography scan revealed a 1.5-cm nodule in the right middle lobe. A positron emission tomography scan demonstrated uptake (5.4 SUV) with no lymph node involvement. The patient was proposed for nonintubated uniportal VATS surgery. The patient received intramuscular midazolam and atropine 30 min before anaesthesia. No epidural catheter was placed. A laryngeal mask was used to control the airway and for oxygen inhalation. Sevoflurane gas and continued perfusion of remifentanil were administered for sedation. The patient was positioned in a left lateral decubitus position. The skin and the fifth intercostal space were infiltrated with levobupivacaine., Results: A VATS approach through a single 2.5-cm incision was made at the level of the fifth intercostal space on the right side. No intrathoracic vagus blockade was necessary. A wedge resection of a 1.5-cm tumour on the middle lobe was performed. The frozen section confirmed a carcinoid tumour and so a middle lobectomy and a lymph node dissection were completed. The total surgical time was 80 min. The chest tube was removed within the next 16 h and the patient was discharged home 36 h after the operation., Conclusions: Single-port video-assisted thoracoscopic lobectomy in nonintubated patients seems to be feasible and safe, and probably represents the least invasive approach to lobectomy. Further studies are necessary to evaluate the results with a series of patients., (© The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2014
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22. Advanced heart failure in critical patients (INTERMACS 1 and 2 levels): ventricular assist devices or emergency transplantation?
- Author
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Attisani M, Centofanti P, La Torre M, Boffini M, Ricci D, Ribezzo M, Baronetto A, and Rinaldi M
- Subjects
- Adult, Critical Illness, Emergencies, Female, Heart Failure diagnosis, Heart Failure mortality, Heart Failure physiopathology, Heart Failure surgery, Hemodynamics, Humans, Italy, Kaplan-Meier Estimate, Male, Middle Aged, Patient Selection, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Ventricular Function, Left, Heart Failure therapy, Heart Transplantation adverse effects, Heart Transplantation mortality, Heart-Assist Devices adverse effects, Waiting Lists mortality
- Abstract
Objective: For patients in advanced heart failure, emergency transplantation or ventricular assist devices (VADs) are possible strategies. The aim of this single-centre, retrospective study was to evaluate early and long-term results for these two strategies., Methods: From 2005 to 2011, we analysed 49 INTERMACS level 1 and 2 patients, who were divided into the following two groups: group A comprised 26 patients on the waiting list for heart transplantation with urgent conditions; and group B comprised 23 patients who underwent VAD implantation as a bridge to candidacy., Results: In group A, 25 patients underwent transplantation. In group B, 19 patients were supported with left VAD and four with biventricular VAD. Of these 23 patients, 13 underwent transplantation (mean time 279 ± 196 days). The 30 day mortality was 42.3 and 4.3% in group A and B, respectively. Survival at 6 and 12 months was significantly better in group B than in group A (87 vs 53%, P = 0.018 at 6 months; and 77 vs 48%, P = 0.045 at 12 months)., Conclusion: Improved outcomes may justify the use of mechanical assistance devices as a bridge to candidacy or bridge to transplantation in INTERMACS 1 and 2 patients in order to avoid high-risk transplants. Evaluation of long-term multicentre outcomes is needed to assess future strategies.
- Published
- 2012
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23. Single-port video-assisted thoracoscopic left upper lobectomy.
- Author
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Gonzalez-Rivas D, de la Torre M, Fernandez R, and Mosquera VX
- Subjects
- Aged, Humans, Male, Treatment Outcome, Lung Neoplasms surgery, Pneumonectomy methods, Thoracic Surgery, Video-Assisted
- Abstract
Video-assisted thoracic surgery (VATS) anatomic lobectomy for lung cancer was initially described in 1993. Since then, many thoracic surgery departments have progressively adopted this technique, although the approach description may vary greatly among them. Most of surgeons use three incisions but the lobectomy can be performed by only one port, especially when it is performed by surgeons experienced in double-port technique. Lower lobes are the easiest cases to perform. To the best of our knowledge this is the first report of a single-port upper lobectomy with no rib spreading.
- Published
- 2011
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24. Video-assisted thoracic surgery lobectomy: 3-year initial experience with 200 cases.
- Author
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Gonzalez D, de la Torre M, Paradela M, Fernandez R, Delgado M, Garcia J, Fieira E, and Mendez L
- Subjects
- Adult, Aged, Aged, 80 and over, Clinical Competence, Epidemiologic Methods, Female, Humans, Intraoperative Period, Length of Stay statistics & numerical data, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Pneumonectomy adverse effects, Pneumonectomy standards, Pneumonectomy statistics & numerical data, Thoracic Surgery, Video-Assisted adverse effects, Thoracic Surgery, Video-Assisted standards, Thoracic Surgery, Video-Assisted statistics & numerical data, Treatment Outcome, Lung Neoplasms surgery, Pneumonectomy methods, Thoracic Surgery, Video-Assisted methods
- Abstract
Objective: To analyse the evolution of the video-assisted thoracoscopic (VATS) approach for lobectomy and results during the first 3 years of program., Methods: From 1(st) July-2007 to 31(th) July-2010 we carried out 200 lobectomies by VATS. In February 2009 we started performing VATS lobectomies with only 2 incisions .We have analyzed both annual and overall outcomes regarding type of approach, conversion rate, surgical time, lymphadenectomy and overall survival., Results: Distribution of the cases per year were as follows: first-year 32, second-year 65, third-year 103. Overall conversion rate was 14,5% (first-year 25%, second-year 20%, third-year 7.8%; p = 0.017). Surgical approach was: 4 ports (1 case), 3 ports (99 cases, 100% in first-year), 2 ports (99 cases, 80% in third-year), single-port (1 case, third-year) Mean surgical time in successful VATS was 193.8 min (210.8 first-year, 207.9 second-year, 181.1 third-year; p = 0.011), mean number of lymph nodes were 11.9 (9.3 first-year, 10.1 second-year, 13.9 third-year; p = 0.003) and mean explored stations was 4.2 (3.6 first-year, 3.8 second-year, 4.5 third-year; p < 0.001). Globally median chest tube duration was 3 days. Median length of stay was 4 days. The disease-free survival at 30 months was 85% for Stage I patients and 62% for non-stage I patients., Conclusions: As we gain more experience over time, with more cases performed each year and less invasive approaches, results improve in terms of less surgical time and more extended lymphadenectomies. Furthermore, we have observed a clear evolution in our surgical approach to a less invasive 2-port approach. In selected cases we have implemented the single-port lobectomy., (Copyright © 2011 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.)
- Published
- 2011
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25. Rapid and sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in a patient with nephrotic syndrome secondary to systemic juvenile idiopathic arthritis-related amyloidosis.
- Author
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De La Torre M, Arboleya L, Pozo S, Pinto J, and Velasco J
- Abstract
AA amyloidosis, or secondary amyloidosis, is a rare but serious complication of chronic inflammatory diseases. Chronic inflammatory arthritis is the commonest cause of AA amyloidosis and, when the latter appears, treatment can be frustrating. Deposition of fibrils, derived from circulating acute-phase reactant serum amyloid A protein (SAA), in the kidneys can lead to proteinuria and progressive loss of renal function. We describe the case of a 14-year-old female with systemic juvenile idiopathic arthritis who developed nephrotic syndrome secondary to AA amyloidosis; while she was unresponsive to all measures, including anti-tumour necrosis factor therapy, treatment with tocilizumab, an anti-human interleukin-6 receptor antibody, immediately normalized the SAA and reversed the nephrotic syndrome. We discuss this new therapeutic approach.
- Published
- 2011
- Full Text
- View/download PDF
26. Multiple splenic infarctions due to septic embolization in a patient supported with Berlin Heart-EXCOR biventricular assist device.
- Author
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Attisani M, Centofanti P, La Torre M, and Rinaldi M
- Subjects
- Adult, Anti-Bacterial Agents therapeutic use, Debridement, Embolism therapy, Heart Transplantation, Humans, Male, Prosthesis Design, Prosthesis-Related Infections therapy, Sepsis therapy, Splenectomy, Splenic Infarction diagnostic imaging, Splenic Infarction therapy, Tomography, X-Ray Computed, Treatment Outcome, Cardiomyopathies therapy, Embolism microbiology, Heart-Assist Devices adverse effects, Methicillin-Resistant Staphylococcus aureus isolation & purification, Prosthesis-Related Infections microbiology, Sepsis microbiology, Splenic Infarction microbiology
- Abstract
Patients awaiting cardiac transplantation often require ventricular assist devices (VADs) due to instable circulatory condition. Device-related infections remain the 'Achilles heel' of mechanical circulatory support and wound complications after VAD placement are a formidable challenge to surgeons. Up to 25% of deaths in VAD patients are due to systemic sepsis, which occurs in 11-26% of patients and bacteria that are common pathogens including Staphylococcus, Pseudomonas, Enterococcus, and Candida. Sepsis, infection of implanted pump components, and infections of percutaneous drivelines continue to limit survival. The Berlin Heart-EXCOR VAD is a para-corporeal pulsatile system that has been successful in patients with severe biventricular dysfunction. We report a case of a 35-year-old male suffering from a postischemic cardiomyopathy who received an EXCOR biventricular assist device as a bridge to transplant. During the assistance the patient developed concomitant methicillin-resistant Staphylococcus aureus infection of implanted pump components which was resistant to conventional therapy. The patient developed sepsis with splenic infarctions due to septic embolization which was successfully treated with a heart transplant. In some extreme cases of VAD infections, such as this, the only therapeutic option is transplantation or device replacement.
- Published
- 2011
- Full Text
- View/download PDF
27. The two-incision approach for video-assisted thoracoscopic lobectomy: an initial experience.
- Author
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Borro JM, Gonzalez D, Paradela M, de la Torre M, Fernandez R, Delgado M, Garcia J, and Fieira E
- Subjects
- Adult, Aged, Aged, 80 and over, Chest Tubes, Female, Humans, Length of Stay statistics & numerical data, Male, Middle Aged, Pneumonectomy adverse effects, Pneumonectomy methods, Postoperative Care methods, Retrospective Studies, Thoracic Surgery, Video-Assisted adverse effects, Treatment Outcome, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms surgery, Thoracic Surgery, Video-Assisted methods
- Abstract
Objective: The video-assisted thoracoscopic approach (video-assisted thoracic surgery (VATS)) to lobectomy for non-small-cell lung cancer (NSCLC) is not standardised. Although three to four incisions are usually made, with the right surgical technique, the operation can be successfully carried out using only two incisions. We have analysed retrospectively, the characteristics and postoperative evolution of patients undergoing VATS lobectomies using two ports., Methods: From June 2007 to November 2009, we carried out 131 major pulmonary resections by VATS, of which 40 (February 2009 to November 2009) were realised using only two incisions: one 1-cm incision through the 7th/8th intercostal space in the mid-axillary line, and a 3-5-cm anterior utility incision in the 5th intercostal space. The patients' mean age was 60.8±11.4 years (75% male, 25% female)., Results: The conversion rate was 10% (four patients). Of the remaining 36 cases, the diagnosis in six patients was benign, and in four was metastatic disease. Of the 26 cases with NSCLC, the most frequent stage was that of interactive application (IA) (58%) and histology mostly revealed adenocarcinoma (33%). Mean duration of surgery in the 36 resections completed by VATS was 168.6±54.0 min (range 80-300 min). The median chest tube duration was 2.5 days and the median length of stay in hospital was 3 days. There was no perioperative mortality in completed VATS cases, and no patient needed to be re-operated. Those patients with chronic obstructive pulmonary disease (COPD) needed longer hospital stays (p=0.046). Similarly, extreme cases of adhesion during surgery needed more days of thoracic drainage (p=0.040) and longer hospital stays (p=0.011), as well as displaying a higher percentage of postoperative complications (p=0.008). If the group of patients is divided in two periods (February to July 2009 and August to November 2009), more extended lymphadenectomies are observed among those performed during the latter period., Conclusions: VATS lobectomy with two incisions is a safe and reliable procedure producing good postoperative results. As we obtain more experience over time, results improve, especially in the performance of more extended lymphadenectomies., (Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
28. Electromyography for assessment of pain in low back muscles.
- Author
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Candotti CT, Loss JF, Pressi AM, Castro FA, La Torre M, Melo Mde O, Araújo LD, and Pasini M
- Subjects
- Adult, Analysis of Variance, Chi-Square Distribution, Female, Humans, Linear Models, Male, Muscle Fatigue, Pain Measurement, Electromyography methods, Low Back Pain physiopathology, Muscle, Skeletal physiopathology
- Abstract
Background and Purpose: Pain is currently evaluated with "subjective" methods (eg, patient self-report). This study aimed to test whether fatigue indexes are able to accurately discriminate between subjects with and subjects without low back pain., Subjects: Sixty subjects separated into 2 groups--a group with low back pain (n=30) and a group without low back pain (n=30)--participated in this study., Methods: Electromyographic (EMG) and force data were obtained during a muscle fatigue test. The same test was repeated to monitor recovery. Linear regression analysis was used to obtain fatigue indexes., Results: Subjects with pain produced significantly lower force values than those without pain. The use of fatigue indexes and force values permitted accurate classification in 89.5% of cases., Discussion and Conclusion: The results confirm that subjects with pain show early myoelectrical manifestations of muscle fatigue and that EMG can be a useful tool in the evaluation of low back pain.
- Published
- 2008
- Full Text
- View/download PDF
29. Antibiotic prescription for community-acquired pneumonia in the intensive care unit: impact of adherence to Infectious Diseases Society of America guidelines on survival.
- Author
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Bodí M, Rodríguez A, Solé-Violán J, Gilavert MC, Garnacho J, Blanquer J, Jimenez J, de la Torre MV, Sirvent JM, Almirall J, Doblas A, Badía JR, García F, Mendia A, Jordá R, Bobillo F, Vallés J, Broch MJ, Carrasco N, Herranz MA, and Rello J
- Subjects
- Community-Acquired Infections drug therapy, Community-Acquired Infections mortality, Drug Prescriptions statistics & numerical data, Female, Humans, Intensive Care Units, Male, Middle Aged, Prognosis, Prospective Studies, Severity of Illness Index, Survival Rate, United States, Anti-Bacterial Agents therapeutic use, Guideline Adherence statistics & numerical data, Pneumonia, Bacterial drug therapy, Pneumonia, Bacterial mortality
- Abstract
Background: The purpose of our study was to analyze prognostic factors associated with mortality for patients with severe community-acquired pneumonia (CAP)., Methods: We conducted a prospective multicenter study including all patients with CAP admitted to the intensive care unit during a 15-month period in 33 Spanish hospitals. Admission data and data on the evolution of the disease were recorded. Multivariate analysis was performed using the SPSS statistical package (SPSS)., Results: A total of 529 patients with severe CAP were enrolled; the mean age (+/-SD) was 59.9+/-16.1 years, and the mean Acute Physiology and Chronic Health Evaluation (APACHE) II score (+/-SD) was 18.9+/-7.4. Overall mortality among patients in the intensive case unit was 27.9% (148 patients). The rate of adherence to Infectious Diseases Society of America (IDSA) guidelines was 57.8%. Significantly higher mortality was documented among patients with nonadherence to treatment (33.2% vs. 24.2%). Multivariate analysis identified age (odds ratio [OR], 1.7), APACHE II score (OR, 4.1), nonadherence to IDSA guidelines (OR, 1.6), and immunocompromise (OR, 1.9) as the variables present at admission to the intensive care unit that were independently associated with death in the intensive care unit. In 15 (75%) of 20 cases of Pseudomonas aeruginosa infection, the antimicrobial treatment at admission was inadequate (including 8 of 15 cases involving patients with adherence to IDSA guidelines). Chronic obstructive pulmonary disease (OR, 17.9), malignancy (OR, 11.0), previous antibiotic exposure (OR, 6.2), and radiographic findings demonstrating rapid spread of disease (OR, 3.9) were associated with P. aeruginosa pneumonia., Conclusions: Better adherence to IDSA guidelines would help to improve survival among patients with severe CAP. Pseudomonas coverage should be considered for patients with chronic obstructive pulmonary disease, malignancy, or recent antibiotic exposure.
- Published
- 2005
- Full Text
- View/download PDF
30. Type of resection and prognosis in lung cancer. Experience of a multicentre study.
- Author
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Rami-Porta R, Mateu-Navarro M, Freixinet J, de la Torre M, Torres-García AJ, Pun YW, and Armengod AC
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Bronchogenic mortality, Carcinoma, Bronchogenic pathology, Humans, Lung Neoplasms mortality, Lung Neoplasms pathology, Lymph Nodes pathology, Lymph Nodes surgery, Mediastinum pathology, Mediastinum surgery, Middle Aged, Neoplasm Staging, Prospective Studies, Survival Analysis, Thoracotomy methods, Treatment Outcome, Carcinoma, Bronchogenic surgery, Lung Neoplasms surgery
- Abstract
Objective: Analysis of prognosis of the different types of resections for lung cancer defined by the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S)., Methods: From October 1993 to September 1997, 2994 patients with bronchogenic carcinoma who underwent thoracotomy were prospectively recruited by the GCCB-S. Prior to recruitment, the GCCB-S had defined two types of non-resectional operations (diagnostic and exploratory thoracotomies) and three types of resections (complete-CR-: free resection margins, mediastinal nodal dissection, no extracapsular nodal involvement, no involvement of most distant removed nodes; relatively incomplete-RIR-: free resection margins, no mediastinal nodal dissection, unremoved nodes, involvement of most distant removed nodes, positive pleural effusion with no pleural implants; and incomplete-IR-: positive resection margins, extracapsular nodal involvement, unremoved positive nodes, positive pleural effusion with pleural implants). For survival analyses, patients with small cell carcinoma, induction therapy, postoperative mortality, unclassified operation, or lost to follow-up were excluded. The total number of evaluable patients was 2543., Results: In 1047 (97%) patients, RIR was defined because they had undergone a lesser nodal evaluation than mediastinal nodal dissection. Five-year survival and 95% confidence interval were: diagnostic thoracotomy 11% (0-30%), exploratory thoracotomy 5% (1-9%), IR 20% (14-26%), RIR 43% (39-47%), and CR 45% (41-49%). Differences between IR and CR or RIR were statistically significant (P<0.0001), but those between CR and RIR were not (P=0.18)., Conclusions: CR and RIR should be combined in a single category as complete resection, because they do not discriminate prognostic differences.
- Published
- 2005
- Full Text
- View/download PDF
31. Acute renal failure and oligohydramnios induced by magnesium dypirone (metamizol) in a pregnant woman.
- Author
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Sánchez de la Nieta MD, Rivera F, De la Torre M, Alcázar R, Caparrós G, Paz Alcaide M, Vozmediano C, and Sánchez A
- Subjects
- Adult, Female, Humans, Pregnancy, Acute Kidney Injury chemically induced, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Dipyrone adverse effects, Oligohydramnios chemically induced, Pregnancy Complications chemically induced
- Published
- 2003
- Full Text
- View/download PDF
32. Longer pre-dialysis nephrological care is associated with improved long-term survival of dialysis patients. More facts.
- Author
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Górriz JL, Sancho A, Pallardó LM, Amoedo ML, Barril G, Salgueira M, and de la Torre M
- Subjects
- Humans, Kidney Failure, Chronic mortality, Kidney Failure, Chronic physiopathology, Survival Analysis, Survivors, Time Factors, Kidney Failure, Chronic therapy, Renal Replacement Therapy methods
- Published
- 2002
- Full Text
- View/download PDF
33. The genetics of signal transduction and the effect of smoking on intrauterine growth.
- Author
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Bottini E, Gloria-Bottini F, La Torre M, and Lucarini N
- Subjects
- Analysis of Variance, Birth Weight, Case-Control Studies, Female, Fetal Growth Retardation epidemiology, Genotype, Humans, Infant, Newborn, Italy epidemiology, Pregnancy in Diabetics genetics, Fetal Growth Retardation chemically induced, Isoenzymes genetics, Pregnancy genetics, Protein Tyrosine Phosphatases genetics, Proto-Oncogene Proteins, Signal Transduction genetics, Smoking adverse effects, Smoking genetics
- Abstract
We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.
- Published
- 2001
- Full Text
- View/download PDF
34. The dialysis patient with headache and sudden hypotension: consider pituitary apoplexy.
- Author
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De la Torre M, Alcázar R, Aguirre M, and Ferreras I
- Subjects
- Acute Disease, Adenoma complications, Aged, Humans, Magnetic Resonance Imaging, Male, Pituitary Apoplexy diagnosis, Pituitary Neoplasms complications, Headache etiology, Hypotension etiology, Pituitary Apoplexy complications, Renal Dialysis
- Published
- 1998
- Full Text
- View/download PDF
35. Genitourinary tuberculosis as the cause of unexplained hypercalcaemia in a patient with pre-end-stage renal failure.
- Author
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Peces R, de la Torre M, Alcázar R, Tejada F, and Gago E
- Subjects
- Adult, Humans, Hypercalcemia blood, Kidney Failure, Chronic therapy, Male, Parathyroid Hormone blood, Renal Dialysis adverse effects, Hypercalcemia etiology, Kidney Failure, Chronic etiology, Tuberculosis, Urogenital complications
- Published
- 1998
- Full Text
- View/download PDF
36. Rapid method for detection of anti-recombinant human erythropoietin antibodies as a new form of erythropoietin resistance.
- Author
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Urra JM, de la Torre M, Alcazar R, and Peces R
- Subjects
- Humans, Recombinant Proteins, Antibodies blood, Drug Resistance, Enzyme-Linked Immunosorbent Assay, Erythropoietin immunology
- Published
- 1997
37. Symptomatic intrarenal arteriovenous fistula detected 25 years after percutaneous renal biopsy.
- Author
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Alcázar R, de la Torre M, and Peces R
- Subjects
- Adult, Arteriovenous Fistula diagnostic imaging, Female, Humans, Kidney pathology, Renal Artery diagnostic imaging, Renal Veins diagnostic imaging, Time Factors, Tomography, X-Ray Computed, Ultrasonography, Arteriovenous Fistula etiology, Biopsy, Needle adverse effects, Renal Artery injuries, Renal Veins injuries
- Published
- 1996
38. Visceral leishmaniasis and renal tuberculosis in a patient on maintenance haemodialysis.
- Author
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Peces R, de la Torre M, and Alcázar R
- Subjects
- Animals, Antibodies, Protozoan analysis, Antimony therapeutic use, Antiprotozoal Agents therapeutic use, Antitubercular Agents therapeutic use, Humans, Kidney Failure, Chronic complications, Leishmania donovani immunology, Leishmania donovani isolation & purification, Leishmaniasis, Visceral drug therapy, Macrophages parasitology, Male, Meglumine therapeutic use, Meglumine Antimoniate, Middle Aged, Organometallic Compounds therapeutic use, Remission Induction, Tuberculosis, Renal drug therapy, Kidney Failure, Chronic therapy, Leishmaniasis, Visceral complications, Renal Dialysis, Tuberculosis, Renal complications
- Published
- 1996
- Full Text
- View/download PDF
39. Acyclovir-associated encephalopathy in haemodialysis.
- Author
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Peces R, de la Torre M, and Alcázar R
- Subjects
- Adult, Brain Diseases therapy, Herpes Zoster complications, Herpes Zoster drug therapy, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Male, Skin Diseases, Viral complications, Skin Diseases, Viral drug therapy, Acyclovir adverse effects, Antiviral Agents adverse effects, Brain Diseases chemically induced, Renal Dialysis
- Published
- 1996
- Full Text
- View/download PDF
40. A mutation that decreases the efficiency of plasmid R1 replication leads to the activation of parD, a killer stability system of the plasmid.
- Author
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Ruiz-Echevarría MJ, de la Torre MA, and Díaz-Orejas R
- Subjects
- Base Sequence, Molecular Sequence Data, Mutation, Transcription, Genetic, Bacterial Proteins genetics, DNA Helicases, DNA-Binding Proteins, Plasmids, Proteins, Trans-Activators
- Abstract
The silent parD (kis/kid) stability operon of plasmid R1 is normally repressed by the co-ordinated action of the Kis and Kid proteins. In this report it is shown that a mutation in repA, the gene of the plasmid replication protein, that reduces two-fold the copy number of the plasmid, leads to the derepression of the parD system. This derepression can be prevented by a suppressor mutation in copB, a copy number control gene of plasmid R1, that increases the efficiency of replication of the repA mutant. Derepression of the wild-type parD system leads to high plasmid stability. These data show the activation of a plasmid stability operon by a mutation that reduces the efficiency of wild-type plasmid replication.
- Published
- 1995
- Full Text
- View/download PDF
41. Treatment of prerenal azotaemia associated with severe ovarian hyperstimulation syndrome.
- Author
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Peces R, Escalada P, Sánchez-Fructuoso A, and de la Torre M
- Subjects
- Adult, Albumins administration & dosage, Female, Furosemide administration & dosage, Humans, Infusions, Intravenous, Ovarian Hyperstimulation Syndrome etiology, Ovarian Hyperstimulation Syndrome therapy, Ovulation Induction adverse effects, Uremia etiology, Uremia therapy, Ovarian Hyperstimulation Syndrome complications, Uremia complications
- Published
- 1994
42. Pituitary-testicular function in cyclosporin-treated renal transplant patients.
- Author
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Peces R, de la Torre M, and Urra JM
- Subjects
- Adult, Cyclosporins therapeutic use, Follicle Stimulating Hormone blood, Humans, Luteinizing Hormone blood, Male, Middle Aged, Pituitary Gland physiopathology, Prolactin blood, Testis physiopathology, Testosterone blood, Cyclosporins pharmacology, Gonadal Steroid Hormones blood, Kidney Transplantation physiology, Pituitary Gland drug effects, Renal Dialysis, Testis drug effects
- Abstract
The aim of this study was to investigate the differences in LH, FSH, PRL and testosterone levels in 20 men on haemodialysis and 26 men following renal transplantation. Nineteen of the renal transplant recipients were receiving cyclosporin, azathioprine, and prednisone, while the seven remaining individuals received azathioprine and prednisone. A subgroup of eight patients were also studied longitudinally while undergoing maintenance haemodialysis and after transplantation. The results show that successful renal transplantation resulted in a normalization of hormone levels in either the cross-sectional or longitudinal groups, the degree of which was unaffected by treatment modality. Cyclosporin given in therapeutic doses does not alter the pituitary-testicular function in renal transplant recipients.
- Published
- 1994
43. Successful treatment of haemodialysis-related porphyria cutanea tarda with erythropoietin.
- Author
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Peces R, Enríquez de Salamanca R, Fontanellas A, Sánchez A, de la Torre M, Caparros G, Ferreras I, and Nieto J
- Subjects
- Deferoxamine therapeutic use, Female, Humans, Middle Aged, Recombinant Proteins therapeutic use, Erythropoietin therapeutic use, Porphyria Cutanea Tarda therapy, Renal Dialysis adverse effects
- Published
- 1994
44. Schönlein-Henoch glomerulonephritis complicating diabetic glomerulosclerosis.
- Author
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Peces R, Sánchez A, de la Torre M, and Blanco J
- Subjects
- Aged, Diabetic Nephropathies pathology, Glomerulonephritis, IGA pathology, Humans, Kidney Glomerulus pathology, Male, Diabetic Nephropathies complications, Glomerulonephritis, IGA complications, IgA Vasculitis complications
- Published
- 1994
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