The genetics of signal transduction and the effect of smoking on intrauterine growth.

Authors :: Bottini E
Gloria-Bottini F
La Torre M
Lucarini N
Source :: International journal of epidemiology [Int J Epidemiol] 2001 Apr; Vol. 30 (2), pp. 400-2.
Publication Year :: 2001
Abstract: We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.

Subjects :: Analysis of Variance
Birth Weight
Case-Control Studies
Female
Fetal Growth Retardation epidemiology
Genotype
Humans
Infant, Newborn
Italy epidemiology
Pregnancy in Diabetics genetics
Fetal Growth Retardation chemically induced
Isoenzymes genetics
Pregnancy genetics
Protein Tyrosine Phosphatases genetics
Proto-Oncogene Proteins
Signal Transduction genetics
Smoking adverse effects
Smoking genetics

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