35 results on '"John B. Gebhart"'
Search Results
2. Cost-effectiveness Analysis of Early Sling Loosening Versus Delayed Sling Lysis in the Management of Voiding Dysfunction After Midurethral Sling Placement
- Author
-
Darlene Vargas Maldonado, Kevin M. Wymer, John B. Gebhart, Annetta M. Madsen, John A. Occhino, Emanuel C. Trabuco, and Brian J. Linder
- Subjects
Urology ,Obstetrics and Gynecology ,Surgery - Published
- 2022
3. PD44-07 EVALUATING THE LONG-TERM IMPACT OF IMPLEMENTING STANDARDIZED POSTOPERATIVE OPIOID PRESCRIBING GUIDELINES FOLLOWING PELVIC ORGAN PROLAPSE SURGERY
- Author
-
Elizabeth J. Olive, Amy E. Glasgow, Elizabeth B. Habermann, John B. Gebhart, John A. Occhino, Emanuel C. Trabuco, and Brian J. Linder
- Subjects
Urology - Published
- 2022
4. National Patterns of Filled Prescriptions and Third-Line Treatment Utilization for Privately Insured Women With Overactive Bladder
- Author
-
Elizabeth B. Habermann, John B. Gebhart, Daniel S. Elliott, Brian J. Linder, Lindsey R. Sangaralingham, and Holly K. Van Houten
- Subjects
Adult ,medicine.medical_specialty ,Urinary urgency ,Adolescent ,Databases, Factual ,Urology ,030232 urology & nephrology ,Electric Stimulation Therapy ,Urinary incontinence ,Cholinergic Antagonists ,Health Services Accessibility ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,Humans ,Medicine ,Treatment Failure ,Botulinum Toxins, Type A ,Practice Patterns, Physicians' ,Medical prescription ,Percutaneous tibial nerve stimulation ,Referral and Consultation ,Aged ,Retrospective Studies ,Aged, 80 and over ,Insurance, Health ,030219 obstetrics & reproductive medicine ,Urinary Bladder, Overactive ,business.industry ,Obstetrics and Gynecology ,Interstitial cystitis ,Middle Aged ,medicine.disease ,United States ,Discontinuation ,Logistic Models ,Neuromuscular Agents ,Overactive bladder ,Female ,Surgery ,medicine.symptom ,business ,Follow-Up Studies - Abstract
OBJECTIVE The aim of this study was to evaluate national patterns of care for women with overactive bladder (OAB) in an administrative data set and identify potential areas for improvement. METHODS We performed an analysis using the OptumLabs Data Warehouse, which contains deidentified administrative claims data from a large national US health insurance plan. The study included women, older than 18 years, with a new OAB diagnosis from January 1, 2007, to June 30, 2017. We excluded those with an underlying neurologic etiology, with interstitial cystitis/painful bladder syndrome, were pregnant, or did not have continuous enrollment for 12 months before and after OAB diagnosis. Trends in management were assessed via the Cochran-Armitage test. Time to discontinuation among medications was compared using t test. RESULTS Of 1.4 million women in the database during the study time frame, 60,246 (4%) were included in the study. Median age was 61 years [interquartile range (IQR), 50-73], and median follow-up was 2.6 years (IQR, 1.6-4.2). Overall, 37% were treated with anticholinergics, 5% with beta-3 agonists, 7% with topical estrogen, and 2% with pelvic floor physical therapy; 26% saw a specialist; and 2% underwent third-line therapy. Median time to cessation of prescription filling was longer for beta-3 agonists versus anticholinergics [median, 4.1 months (IQR, 1-15) vs 3.6 months (IQR, 1-10); P < 0.0001]. Use of third-line therapies significantly increased over the study time frame, from 1.1% to 2.2% (P < 0.0001). CONCLUSIONS Most of the patients do not continue filling prescriptions for OAB medications, and a minority of patients were referred for specialty evaluation. Although third-line therapy use is increasing, it is used in a small proportion of women with OAB. Given these patterns, there may be underutilization of specialist referral and other OAB therapies.
- Published
- 2021
5. Urinary Tract Infection After Hysterectomy for Benign Gynecologic Conditions or Pelvic Reconstructive Surgery
- Author
-
Jennifer J. Schmitt, Daniel A. Carranza Leon, Chetna Arora, John B. Gebhart, Sherif A. El-Nashar, Ruchira Singh, and John A. Occhino
- Subjects
Adult ,Reconstructive surgery ,medicine.medical_specialty ,medicine.medical_treatment ,Urinary system ,Hysterectomy ,Logistic regression ,Pelvic Organ Prolapse ,Pelvis ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Humans ,Medicine ,030212 general & internal medicine ,Aged ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Retrospective cohort study ,General Medicine ,Odds ratio ,Middle Aged ,Plastic Surgery Procedures ,Urinary Retention ,Surgery ,Postmenopause ,Urinary Tract Infections ,Female ,Hormone therapy ,business ,Genital Diseases, Female ,Cohort study - Abstract
Objective To report rates and identify risk factors for urinary tract infection (UTI) after hysterectomy for benign conditions or combined with pelvic reconstructive surgery. Methods This is a cohort study that included women who underwent hysterectomy either for benign gynecologic conditions or hysterectomy combined with pelvic reconstructive surgery from January 1, 2012, through June 30, 2014, at a single institution. The primary outcome was UTI within 8 weeks of surgery. Logistic regression modeling was used to develop a model for predicting UTI after surgery. Results Of 1,156 women included in the study, 136 (11.8%, 95% CI 10.0-13.8) developed UTI within 8 weeks. Women who underwent hysterectomy for a benign gynecologic condition that was not combined with pelvic reconstructive surgery had an overall UTI rate of 7.3% (95% CI 5.6-9.3) vs 21.7% (95% CI 17.6-26.4) after hysterectomy combined with pelvic reconstructive surgery. After adjusting for hormone therapy use, the following were independent variables associated with postoperative UTI: premenopausal status with an adjusted odds ratio (OR) of 1.80 (95% CI 1.11-2.99), anterior vaginal wall prolapse with an adjusted OR of 4.39 (95% CI 2.77-6.97), and postvoid residual greater than 150 mL with an adjusted OR of 2.38 (95% CI 1.12-4.36). Using this model, postoperative UTI rates ranged from 4.3% to 59.4% with high postvoid residual and presence of anterior prolapse having the strongest association. Conclusion There are wide variations in the rate of UTI after hysterectomy for begin disease including pelvic reconstructive surgery. These variations can be explained with a model based on available preoperative data.
- Published
- 2018
6. Two-Year Results of Burch Compared With Midurethral Sling With Sacrocolpopexy
- Author
-
Amy L. Weaver, John B. Gebhart, Christopher J. Klingele, John A. Occhino, Roberta E. Blandon, Emanuel C. Trabuco, Brian J. Linder, and Michaela E. McGree
- Subjects
medicine.medical_specialty ,Stress incontinence ,Time Factors ,Sling (implant) ,Urinary Incontinence, Stress ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,Urinary incontinence ,Risk Assessment ,Severity of Illness Index ,Article ,law.invention ,Urethropexy ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Urethra ,Randomized controlled trial ,law ,medicine ,Humans ,Single-Blind Method ,Fisher's exact test ,Aged ,Suburethral Slings ,030219 obstetrics & reproductive medicine ,Urinary continence ,business.industry ,Absolute risk reduction ,Obstetrics and Gynecology ,Urinary Incontinence, Urge ,Middle Aged ,Surgical Mesh ,medicine.disease ,Urodynamics ,Treatment Outcome ,Colposcopy ,Patient Satisfaction ,Quality of Life ,symbols ,Urologic Surgical Procedures ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Objective To evaluate 1- and 2-year urinary continence rates after Burch retropubic urethropexy compared with a retropubic midurethral sling for women with urinary incontinence undergoing sacrocolpopexy. Methods We conducted a planned secondary analysis of a multicenter, randomized, single-blind trial comparing Burch with a sling that enrolled participants from June 2009 to August 2013. Objective outcome measures of continence were assessed at 1- and 2-year follow-up through office visits and validated questionnaires. Overall continence was defined as a negative stress test, no retreatment for stress incontinence, and no self-reported urinary incontinence (International Consultation on Incontinence Questionnaire, Short Form, score, 0). Stress-specific continence was defined as fulfillment of the first two criteria and no self-reported stress-related incontinence. Primary outcomes were assessed with intention-to-treat and within-protocol analyses. Comparisons between groups were evaluated using χ or Fisher exact test. Results The two groups were similar in all measured baseline features. Outcome assessments at 2 years were available for 48 of 57 patients (84%) in the sling group and 45 of 56 patients (80%) in the Burch group. With intention-to-treat analysis, the sling group had significantly higher rates of overall continence than the Burch group (49% [28/57] vs 29% [16/56]; 95% CI for absolute risk difference 3.0-38.1; P=.03) at 1- but not 2-year follow-up (47% [27/57] vs 32% [18/56]; 95% CI for absolute risk difference -2.6 to 33.1; P=.10). The sling group had significantly higher rates of stress-specific continence than the Burch group at 1-year (70% [40/57] vs 46% [26/56]; 95% CI for absolute risk difference 6.1-41.4; P=.01) and 2-year (70% [40/57] vs 45% [25/56]; 95% CI for absolute risk difference 7.9-43.2; P=.006) follow-up. No difference was detected in prolapse recurrence, voiding dysfunction, antimuscarinic medication use, urgency incontinence, or patient satisfaction. Conclusion Among women with baseline urinary incontinence undergoing sacrocolpopexy, the retropubic midurethral sling resulted in higher stress-specific continence rates than Burch retropubic urethropexy at 1- and 2-year follow-up.
- Published
- 2018
7. Determining Optimal Route of Hysterectomy for Benign Indications
- Author
-
Amy L. Weaver, Sean C. Dowdy, John A. Occhino, John B. Gebhart, Daniel A. Carranza Leon, Jamie N. Bakkum-Gamez, Kalyan S. Pasupathy, and Jennifer J. Schmitt
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Clinical Decision-Making ,Operative Time ,Decision tree ,Hysterectomy ,Patient Readmission ,Article ,03 medical and health sciences ,0302 clinical medicine ,Robotic Surgical Procedures ,Hysterectomy, Vaginal ,medicine ,Humans ,Surgical Wound Infection ,Robotic surgery ,030212 general & internal medicine ,Hospital Costs ,Clinical decision ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,General surgery ,Decision Trees ,Uterus ,Obstetrics and Gynecology ,Retrospective cohort study ,Organ Size ,Middle Aged ,Surgery ,body regions ,Tree (data structure) ,Urinary Tract Infections ,Cohort ,Female ,business ,Genital Diseases, Female ,Algorithms - Abstract
To evaluate practice change after initiation of a robotic surgery program using a clinical algorithm to determine the optimal surgical approach to benign hysterectomy.A retrospective postrobot cohort of benign hysterectomies (2009-2013) was identified and the expected surgical route was determined from an algorithm using vaginal access and uterine size as decision tree branches. We excluded the laparoscopic hysterectomy route. A prerobot cohort (2004-2005) was used to evaluate a practice change after the addition of robotic technology (2007). Costs were estimated.Cohorts were similar in regard to uterine size, vaginal parity, and prior laparotomy history. In the prerobot cohort (n=473), 320 hysterectomies (67.7%) were performed vaginally and 153 (32.3%) through laparotomy with 15.1% (46/305) performed abdominally when the algorithm specified vaginal hysterectomy. In the postrobot cohort (n=1,198), 672 hysterectomies (56.1%) were vaginal; 390 (32.6%) robot-assisted; and 136 (11.4%) abdominal. Of 743 procedures, 38 (5.1%) involved laparotomy and 154 (20.7%) involved robotic technique when a vaginal approach was expected. Robotic hysterectomies had longer operations (141 compared with 59 minutes, P.001) and higher rates of surgical site infection (4.7% compared with 0.2%, P.001) and urinary tract infection (8.1% compared with 4.1%, P=.05) but no difference in major complications (P=.27) or readmissions (P=.27) compared with vaginal hysterectomy. Algorithm conformance would have saved an estimated $800,000 in hospital costs over 5 years.When a decision tree algorithm indicated vaginal hysterectomy as the route of choice, vaginal hysterectomy was associated with shorter operative times, lower infection rate, and lower cost. Vaginal hysterectomy should be the route of choice when feasible.
- Published
- 2017
8. Prospective Implementation and Evaluation of a Decision-Tree Algorithm for Route of Hysterectomy
- Author
-
John B. Gebhart, Jamie N. Bakkum-Gamez, Amy L. Weaver, John A. Occhino, Michaela E. McGree, Sean C. Dowdy, Mary V. Baker, Jennifer J. Schmitt, and Kalyan S. Pasupathy
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Hysterectomy ,Decision Support Techniques ,Predictive Value of Tests ,Laparotomy ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Abdominal hysterectomy ,Vaginal route ,business.industry ,Decision Trees ,Obstetrics and Gynecology ,General Medicine ,Surgery ,Gynecology ,Predictive value of tests ,Hysterectomy vaginal ,Examination Under Anesthesia ,Female ,business ,Algorithms - Abstract
Objective To evaluate the rate of vaginal hysterectomy and outcomes after initiation of a prospective decision-tree algorithm to determine the optimal surgical route of hysterectomy. Methods A prospective algorithm to determine optimal route of hysterectomy was developed, which uses the following factors: history of laparotomy, uterine size, and vaginal access. The algorithm was implemented at our institution from November 24, 2015, to December 31, 2017, for patients requiring hysterectomy for benign indications. Expected route of hysterectomy was assigned by the algorithm and was compared with the actual route performed to identify compliance compared with deviation. Surgical outcomes were analyzed. Results Of 365 patients who met inclusion criteria, 202 (55.3%) were expected to have a total vaginal hysterectomy, 57 (15.6%) were expected to have an examination under anesthesia followed by total vaginal hysterectomy, 52 (14.2%) were expected to have an examination under anesthesia followed by robotic-assisted total laparoscopic hysterectomy, and 54 (14.8%) were expected to have an abdominal or robotic-laparoscopic route of hysterectomy. Forty-six procedures (12.6%) deviated from the algorithm to a more invasive route (44 robotic, two abdominal). Seven patients had total vaginal hysterectomy when robotic-assisted total laparoscopic hysterectomy or abdominal hysterectomy was expected by the algorithm. Overall, 71% of patients were expected to have a vaginal route of hysterectomy per the algorithm, of whom 81.5% had a total vaginal hysterectomy performed; more than 99% of the total vaginal hysterectomies attempted were successfully completed. Conclusion Vaginal surgery is feasible, carries a low complication rate with excellent outcomes, and should have a place in gynecologic surgery. National use of this prospective algorithm may increase the rate of total vaginal hysterectomy and decrease health care costs.
- Published
- 2020
9. MP02-09 ASSESSING THE IMPACT OF PROCEDURE-SPECIFIC OPIOID PRESCRIBING RECOMMENDATIONS ON OPIOID STEWARDSHIP FOLLOWING PELVIC ORGAN PROLAPSE SURGERY
- Author
-
John B. Gebhart, Emanuel Trabuco, John Occhino, Brian J. Linder, and Christopher J. Klingele
- Subjects
medicine.medical_specialty ,Pelvic organ ,Opioid ,Prescription opioid ,business.industry ,Urology ,Prolapse surgery ,medicine ,Stewardship ,Intensive care medicine ,business ,Opioid prescribing ,medicine.drug - Abstract
INTRODUCTION AND OBJECTIVES:There is increasing concern regarding the volume of opioid medications prescribed postoperatively, and the rate of prescription opioid related adverse-events. However, d...
- Published
- 2019
10. Burch Retropubic Urethropexy Compared With Midurethral Sling With Concurrent Sacrocolpopexy
- Author
-
Emanuel C. Trabuco, Michaela E. McGree, Amy L. Weaver, Maureen A. Lemens, John A. Occhino, John B. Gebhart, Roberta E. Blandon, and Christopher J. Klingele
- Subjects
medicine.medical_specialty ,Sling (implant) ,Urinary Incontinence, Stress ,medicine.medical_treatment ,Urinary incontinence ,Article ,Pelvic Organ Prolapse ,law.invention ,Urethropexy ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,030212 general & internal medicine ,Suburethral Slings ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Odds ratio ,Middle Aged ,Confidence interval ,Surgery ,Treatment Outcome ,Concomitant ,Urologic Surgical Procedures ,Female ,medicine.symptom ,Complication ,business - Abstract
OBJECTIVE To compare efficacy and safety of retropubic Burch urethropexy and a midurethral sling in women with stress urinary incontinence (SUI) undergoing concomitant pelvic floor repair with sacrocolpopexy. METHODS Women were randomly assigned to Burch retropubic urethropexy (n=56) or retropubic midurethral sling (n=57) through dynamic allocation balancing age, body mass index, history of prior incontinence surgery, intrinsic sphincter deficiency, preoperative incontinence diagnosis, and prolapse stage. Overall and stress-specific continence primary outcomes were ascertained with validated questionnaires and a blinded cough stress test. RESULTS Enrollment was June 1, 2009, through August 31, 2013. At 6 months, no difference was found in overall (29 midurethral sling [51%] compared with 23 Burch [41%]; P=.30) (odds ratio [OR] 1.49, 95% confidence interval [CI] 0.71-3.13) or stress-specific continence rates (42 midurethral sling [74%] compared with 32 Burch [57%]; P=.06) (OR 2.10, 95% CI 0.95-4.64) between groups. However, the midurethral sling group reported greater satisfaction (78% compared with 57%; P=.04) and were more likely to report successful surgery for SUI (71% compared with 50%; P=.04) and to resolve pre-existing urgency incontinence (72% compared with 41%; P=.03). No difference was found in patient global impression of severity or symptom improvement, complication rates, or mesh exposures. CONCLUSION There was no difference in overall or stress-specific continence rates between midurethral sling and Burch urethropexy groups at 6 months. However, the midurethral sling group reported better patient-centered secondary outcomes.
- Published
- 2016
11. Surgical Management of the Constricted or Obliterated Vagina
- Author
-
Jennifer J. Schmitt and John B. Gebhart
- Subjects
medicine.medical_specialty ,Colon ,Vaginal Diseases ,Constriction, Pathologic ,Preoperative care ,Patient Care Planning ,Surgical Flaps ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Gynecologic Surgical Procedures ,0302 clinical medicine ,Abdominal flaps ,Vaginal disease ,Preoperative Care ,Humans ,Medicine ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Skin Transplantation ,Plastic Surgery Procedures ,Skin transplantation ,Surgery ,medicine.anatomical_structure ,Vagina ,Female ,Vulvar Diseases ,business ,Medical therapy ,Surgical interventions - Abstract
Management of the constricted or obliterated vagina demands an understanding and recognition of the potential etiologies leading to this presentation. A thorough and comprehensive medical and surgical review is required to arrive at an accurate diagnosis, which then will guide medical or surgical intervention. It is paramount to recognize when underlying medical conditions are contributing to these conditions and to begin medical therapy; failure to do so will often yield suboptimal results. When these conditions arise after surgical interventions, compensatory surgical techniques that correct upper and lower vaginal strictures or obliteration include incision through the stricture, vaginal advancement, Z-plasty, skin grafts, perineal flaps, and abdominal flaps and grafts. Postoperative surveillance and dilation are critical to optimize long-term success.
- Published
- 2016
12. Factors Influencing Selection of Vaginal, Open Abdominal, or Robotic Surgery to Treat Apical Vaginal Vault Prolapse
- Author
-
Kristin M. Fruth, Mallika Anand, Amy L. Weaver, and John B. Gebhart
- Subjects
medicine.medical_specialty ,Urology ,Clinical Decision-Making ,030232 urology & nephrology ,Hysterectomy ,Severity of Illness Index ,Article ,Pelvic Organ Prolapse ,Statistics, Nonparametric ,03 medical and health sciences ,0302 clinical medicine ,Robotic Surgical Procedures ,medicine ,Humans ,Robotic surgery ,Selection Bias ,Aged ,Retrospective Studies ,Analysis of Variance ,030219 obstetrics & reproductive medicine ,business.industry ,Medical record ,Age Factors ,Chronic pain ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Baseline characteristics ,Vagina ,Female ,business ,Vaginal Vault Prolapse ,American society of anesthesiologists ,Abdominal surgery - Abstract
OBJECTIVES This study aimed to determine factors influencing the selection of Mayo-McCall culdoplasty (MMC), open abdominal sacrocolpopexy (ASC), or robotic sacrocolpopexy (RSC) for posthysterectomy vaginal vault prolapse. METHODS We retrospectively searched for the records of patients undergoing posthysterectomy apical vaginal prolapse surgery between January 1, 2000, and June 30, 2012, at our institution. Baseline characteristics and explicit selection factors were abstracted from the electronic medical records. Factors were compared between groups using χ tests for categorical variables, analysis of variance for continuous variables, and Kruskal-Wallis tests for ordinal variables. RESULTS Among the 512 patients identified who met inclusion criteria, the MMC group (n = 174) had more patients who were older, had American Society of Anesthesiologists class 3+ or greater, had anterior vaginal prolapse grade 3+, desired to avoid abdominal surgery, and did not desire a functional vagina. Patients in the ASC (n = 237) and RSC (n = 101) groups had more failed prolapse surgeries, suspected abdominopelvic pathologic processes, and chronic pain. Advanced prolapse was more frequently cited as an explicit selection factor for ASC than for either MMC or RSC. CONCLUSIONS The most common factors that influenced the type of apical vaginal vault prolapse surgery overlapped with characteristics that differed at baseline. In general, MMC was chosen for advanced anterior vaginal prolapse and baseline characteristics that increased surgical risks, ASC for advanced apical prolapse, and ASC or RSC for recurrent prolapse, suspected abdominal pathology, and patients with chronic pain or lifestyles including heavy lifting. Thus, efforts should be made to attempt to control for selection bias when comparing these procedures.
- Published
- 2016
13. Female Urethral Diverticulum
- Author
-
John B. Gebhart, Sherif A. El-Nashar, Shunaha Kim-Fine, Ruchira Singh, Melissa M. Bacon, John A. Occhino, and Christopher J. Klingele
- Subjects
Adult ,Reoperation ,medicine.medical_specialty ,Urology ,Urinary system ,030232 urology & nephrology ,Urinary incontinence ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Risk Factors ,Dysuria ,Urethral Diseases ,medicine ,Urethral diverticulum ,Humans ,Young adult ,Survival analysis ,Aged ,Hematuria ,Aged, 80 and over ,Suburethral Slings ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,Confidence interval ,Surgery ,Diverticulum ,Dyspareunia ,Treatment Outcome ,Urinary Incontinence ,Urinary Tract Infections ,Female ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
INTRODUCTION AND HYPOTHESIS To report on clinical presentation, diagnosis, and outcomes after treatment of female urethral diverticulum (UD). METHODS Using a record linkage system, women with a new diagnosis of UD at Mayo Clinic from January 1, 1980, through December 31, 2011, were identified. The presenting symptoms, clinical characteristics, diagnosis, and management of women presenting with UD were recorded. Outcomes after surgery were assessed using survival analysis. All statistical analyses were 2-sided and P values less than 0.05 were considered significant. Statistical analysis was done using SAS version 9.2 and JMP version 9.0 (SAS Institute Inc.). RESULTS A total of 164 cases were identified. Median age at diagnosis was 46 years (range, 21-83). The most common presenting symptom was recurrent urinary tract infection (98, 59.8%), followed by urinary incontinence (81, 49.4%), dysuria (62, 37.8%), dyspareunia (37, 22.6%), and hematuria (15, 9.1%). Examination revealed vaginal mass in 55 (33.5%) of the women. A significant trend was noted toward an increase in use of both magnetic resonance imaging and computed tomography (P < 0.001) along with a progressive decrease in use of urethrogram (P < 0.001) for diagnosis of UD over the years. Among 114 women who underwent surgical treatment for UD, 14(12.3%) women presented with recurrent UD and the 5-year recurrence rate after surgery for UD was 23.4% (95% confidence interval, 13.9-37.0) and a reoperation rate of 17.0% (95% confidence interval, 8.8-30.2) at 5 years. CONCLUSIONS Female UD is a rare and unique condition. Clinical presentation is usually nonspecific, and magnetic resonance imaging is commonly used for confirming the diagnosis. Recurrence is not uncommon, and repeat surgical intervention might be needed.
- Published
- 2016
14. Comparison of Short Term Outcomes of Sacral Nerve Stimulation and Intradetrusor Injection of OnabotulinumtoxinA (Botox) in Women With Refractory Overactive Bladder
- Author
-
Emanuel C. Trabuco, Ruchira Singh, John A. Occhino, Christopher J. Klingele, Sherif A. El Nashar, and John B. Gebhart
- Subjects
medicine.medical_specialty ,Urology ,Urinary system ,Acetylcholine Release Inhibitors ,Electric Stimulation Therapy ,Urinary incontinence ,Humans ,Medicine ,Treatment Failure ,Botulinum Toxins, Type A ,Aged ,Retrospective Studies ,Urinary bladder ,Sacrococcygeal Region ,Urinary Bladder, Overactive ,business.industry ,Obstetrics and Gynecology ,Muscle, Smooth ,Retrospective cohort study ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,medicine.anatomical_structure ,Overactive bladder ,Female ,medicine.symptom ,business ,Complication - Abstract
Objectives The aim of the study was to compare the short-term outcomes of sacral nerve stimulation (SNS) and intradetrusor injection of OnabotulinumtoxinA (Botox) for overactive bladder (OAB) symptoms refractory to behavioral modifications and pharmacologic therapy. Methods This is a retrospective cohort study evaluating the outcomes of SNS and Botox procedures that were performed for refractory OAB symptoms at a tertiary care referral center. The primary outcome was "failure" of treatment that was defined as less than 50% improvement from the baseline symptoms at 6 months. Results Sixty-five SNS and 63 Botox procedures met the inclusion criteria. Women undergoing Botox were more likely to report failure 6 months after the intervention as compared with those undergoing SNS (20 [31.8%] vs 7 [10.8%], P = 0.003; unadjusted odds ratio = 3.85, confidence interval = 1.5-9.93; adjusted odds ratio = 4.47, confidence interval = 1.69-14.4). However, there was no difference in the proportion of women who were started on antimuscarinic medications for persistent urgency urinary incontinence after both procedures (12 [18.5%] women in SNS group and 17 [27%] women in the Botox group, P = 0.249). The most common complication of the SNS procedure was wound related (8 [12.3%]), whereas the most common complication of the Botox procedure was urinary tract infection (31 [49.2%]). Conclusions The SNS resulted in lower failure rates at 6 months when performed for refractory OAB symptoms as compared with the Botox procedure. However, further studies are needed to evaluate the long-term cost-effectiveness of both procedures.
- Published
- 2015
15. Vaginal Hysterectomy: Historical Footnote or Viable Route?
- Author
-
Jennifer J. Schmitt, Sean C. Dowdy, John A. Occhino, Kalyan S. Pasupathy, Amy L. Weaver, Michaela E. McGree, John B. Gebhart, Mary V. Baker, and Jamie N. Bakkum-Gamez
- Subjects
medicine.medical_specialty ,business.industry ,General surgery ,Hysterectomy vaginal ,MEDLINE ,Obstetrics and Gynecology ,Medicine ,business - Published
- 2020
16. MP63-08 CAN URODYNAMIC PARAMETERS PREDICT SLING REVISION FOR VOIDING DYSFUNCTION IN WOMEN UNDERGOING SYNTHETIC MIDURETHRAL SLING PLACEMENT?
- Author
-
Deborah Lightner, John B. Gebhart, Brian J. Linder, Christopher J. Klingele, John Occhino, Daniel Elliott, and Emanuel Trabuco
- Subjects
medicine.medical_specialty ,Sling (implant) ,business.industry ,Urology ,medicine ,business ,Surgery - Published
- 2017
17. PD02-05 DEFINING THE PREVALENCE OF ASYMPTOMATIC MICROSCOPIC HEMATURIA AMONG WOMEN WITH PELVIC ORGAN PROLAPSE: IMPLICATIONS FOR RECOMMENDING SUBSEQUENT DIAGNOSTIC EVALUATION
- Author
-
Stephen A. Boorjian, Emanuel Trabuco, John Occhino, John B. Gebhart, and Brian J. Linder
- Subjects
Gynecology ,medicine.medical_specialty ,Pelvic organ ,Asymptomatic microscopic hematuria ,business.industry ,Urology ,medicine ,Radiology ,Diagnostic evaluation ,business - Published
- 2017
18. Effect of Additional Reconstructive Surgery on Perioperative and Postoperative Morbidity in Women Undergoing Vaginal Hysterectomy
- Author
-
L. Joseph Melton, Amy L. Weaver, John B. Gebhart, and Christine A. Heisler
- Subjects
Adult ,medicine.medical_specialty ,Reconstructive surgery ,medicine.medical_treatment ,Patient demographics ,Pelvic Organ Prolapse ,Postoperative Complications ,Risk Factors ,Hysterectomy, Vaginal ,Odds Ratio ,medicine ,Humans ,Aged ,Retrospective Studies ,Suburethral Slings ,Hysterectomy ,business.industry ,Obstetrics and Gynecology ,Retrospective cohort study ,Odds ratio ,Perioperative ,Length of Stay ,Middle Aged ,Surgery ,medicine.anatomical_structure ,Hysterectomy vaginal ,Vagina ,Female ,business ,Follow-Up Studies - Abstract
To estimate the risk of perioperative and postoperative morbidity among women undergoing vaginal hysterectomy with and without reconstructive pelvic surgery.We collected patient demographics, baseline medical status, perioperative and postoperative findings, and surgical procedures for women aged 18 years or older who had vaginal hysterectomy for a benign indication at Mayo Clinic, Rochester, Minnesota, between January 2004 and December 2005. The main outcome measure was any complication, defined by intensive care unit (ICU) admission, reoperation, readmission, or medical intervention within 9 weeks after surgery.Of 736 patients who met the study criteria, 712 had complete follow-up information. Overall, more women undergoing vaginal hysterectomy with reconstructive pelvic surgery had complications than did those without reconstructive pelvic surgery (147 of 336 [43.8%] compared with 77 of 376 [20.5%], odds ratio [OR] 3.0, 95% confidence interval [CI] 2.2-4.2, P.001). This association was significant (OR 3.0, 95% CI 1.5-6.2, P=.003) even after adjusting for factors that were significantly different between groups (age, surgical indication, and change in hemoglobin). Specifically, urinary tract infection, pulmonary edema, and unplanned ICU admissions were more common among those undergoing reconstructive pelvic surgery. Disregarding urinary tract infections, the overall complication rate was still higher among the women with concomitant reconstructive pelvic surgery (22.9% compared with 16.5%, OR 1.5, 95% CI 1.04-2.2, P=.03).Women having vaginal hysterectomy with additional reconstructive pelvic surgery were more likely to have a perioperative complication than were women undergoing vaginal hysterectomy alone.II.
- Published
- 2009
19. Risk Factors for Pelvic Floor Repair After Hysterectomy
- Author
-
Adil E. Bharucha, Cathy D. Schleck, L. Joseph Melton, John B. Gebhart, Alan R. Zinsmeister, and Roberta E. Blandon
- Subjects
medicine.medical_specialty ,Time Factors ,Minnesota ,medicine.medical_treatment ,Hysterectomy ,Risk Assessment ,Article ,Pulmonary Disease, Chronic Obstructive ,Rochester Epidemiology Project ,Risk Factors ,Uterine Prolapse ,medicine ,Humans ,Risk factor ,Pelvic floor ,Leiomyoma ,business.industry ,Rectocele ,Obstetrics and Gynecology ,Uterine prolapse ,Pelvic Floor ,Middle Aged ,medicine.disease ,Surgery ,Perineum ,body regions ,medicine.anatomical_structure ,Case-Control Studies ,Uterine Neoplasms ,Female ,Risk assessment ,business ,Pelvic floor repair ,Cystocele - Abstract
Having demonstrated that prior history of prolapse was a risk factor for pelvic floor repair procedures after hysterectomy, the objective of this study was to assess medical risk factors for pelvic floor repair after hysterectomy.Using the Rochester Epidemiology Project database of 8,220 Olmsted County, Minnesota, women who had hysterectomy for benign indications from 1965-2002, we conducted a nested case-control study in 144 pairs, comparing women who underwent pelvic floor repair after hysterectomy (case group) with women matched for known risk factors (ie, age, pelvic floor disorders at baseline, year and type of hysterectomy, and pelvic floor repair during hysterectomy) (control group).The median duration between hysterectomy and pelvic floor repair was 13 years. Chronic pulmonary disease (odds ratio [OR] 14.3, 95% confidence interval [CI] 1.2-178), but not obstetric history, obesity, indication for hysterectomy, or chronic constipation, was associated with an increased risk of pelvic floor repair after hysterectomy. Between the hysterectomy and subsequent pelvic floor repair, overall pelvic organ prolapse severity changed by one grade or less in 54 case patients (38%, group A) but increased by two or more grades in 72 case patients (50%, group B). In group A, but not group B, uterine prolapse (OR 25, 95% CI 2.1-300) and chronic pulmonary disease (OR 22, 95% CI 1.5-328) at baseline remained risk factors for pelvic floor repair after hysterectomy.In this matched case-control study, chronic pulmonary disease was the only risk factor for pelvic floor repair after hysterectomy for benign indications, underscoring the need to address pulmonary status before surgery.
- Published
- 2009
20. Urinary Tract Infection in the Adult Female
- Author
-
Christine A. Heisler and John B. Gebhart
- Subjects
medicine.medical_specialty ,Adult female ,business.industry ,Urology ,Internal medicine ,Urinary system ,medicine ,Obstetrics and Gynecology ,Surgery ,business ,Pathophysiology - Published
- 2008
21. Global Endometrial Ablation for Menorrhagia in Women With Bleeding Disorders
- Author
-
Sherif A. El-Nashar, Sunni A. Barnes, Abimbola O. Famuyide, William A. Cliby, Matthew R. Hopkins, John B. Gebhart, Rajiv K. Pruthi, and Simone S. Feitoza
- Subjects
Adult ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Hysterectomy ,law.invention ,Cohort Studies ,Endometrium ,symbols.namesake ,Randomized controlled trial ,Recurrence ,law ,Coagulopathy ,Humans ,Medicine ,Menorrhagia ,Fisher's exact test ,Retrospective Studies ,Laser Coagulation ,business.industry ,Obstetrics and Gynecology ,Retrospective cohort study ,Blood Coagulation Disorders ,Middle Aged ,Ablation ,medicine.disease ,Surgery ,Treatment Outcome ,Catheter Ablation ,Endometrial ablation ,symbols ,Female ,business ,Cohort study - Abstract
Objective To evaluate the efficacy of global endometrial ablation in women with bleeding disorders who presented with menorrhagia. Methods A records-linkage system was used to construct a retrospective cohort of 41 women with bleeding disorders (coagulopathy) and a reference group of 111 randomly selected women without bleeding disorders from a pool of 943 women who underwent global endometrial ablation (with thermal balloon ablation technology or bipolar radiofrequency ablation technology) for menorrhagia at Mayo Clinic (Rochester, Minnesota) from January 1995 through December 2005. Demographic data, type of global endometrial ablation therapy and reablation, and hysterectomy data were extracted from the database. Results There was no significant difference in baseline age, parity, body mass index, uterine size, type of global endometrial ablation therapy, or duration of follow-up between the groups. Two women (5%) in the coagulopathy group had hysterectomy or reablation, compared with 8 (7%) in the reference group (Fisher exact test, P=.728). A Kaplan-Meier plot showed no difference in the time to treatment failure between the groups (log-rank test, P=.534). Procedural-related complications were generally minor and infrequent (9 of 152 [6%]). Complications were equally distributed in the coagulopathy (4 of 41) and reference groups (6 of 111) (Fisher exact test, P=.267). Conclusion Global endometrial ablation is an effective treatment choice for women with coagulopathy presenting with menorrhagia.
- Published
- 2007
22. PD50-10 ASSESSING THE LEARNING CURVE OF ROBOTIC SACROCOLPOPEXY
- Author
-
Mallika Anand, Amy L. Weaver, Brian Linder, Christopher J. Klingele, Joshua L. Woelk, John A. Occhino, John B. Gebhart, and Emanuel C. Trabuco
- Subjects
business.industry ,Learning curve ,Urology ,Medicine ,Artificial intelligence ,business - Published
- 2015
23. Congenital Anomalies of the Female Urogenital Tract
- Author
-
Andrew J. Croak and John B. Gebhart
- Subjects
Gynecology ,medicine.medical_specialty ,Genitourinary system ,business.industry ,Urology ,medicine ,Obstetrics and Gynecology ,Surgery ,business - Published
- 2005
24. Communication Preferences Amongst Clinical Faculty at a Large, Tertiary Care Facility [5F]
- Author
-
Jennifer J. Schmitt, Ruchira Singh, John A. Occhino, Brian Linder, and John B. Gebhart
- Subjects
medicine.medical_specialty ,business.industry ,Family medicine ,medicine ,Obstetrics and Gynecology ,business ,Tertiary care - Published
- 2016
25. Cost Differences Among Robotic, Vaginal, and Abdominal Hysterectomy
- Author
-
Bijan J. Borah, Joshua L. Woelk, Herbert C. Heien, John B. Gebhart, and Emanuel C. Trabuco
- Subjects
medicine.medical_specialty ,Hysterectomy ,business.industry ,Extramural ,medicine.medical_treatment ,technology, industry, and agriculture ,MEDLINE ,Obstetrics and Gynecology ,General Medicine ,Surgery ,body regions ,surgical procedures, operative ,Salpingectomy ,Hysterectomy vaginal ,Medicine ,business ,human activities ,Abdominal hysterectomy - Abstract
OBJECTIVE:To compare the costs of vaginal and abdominal hysterectomy with robotically assisted hysterectomy.METHODS:We identified all cases of robotically assisted hysterectomy, with or without bilateral salpingo-oophorectomy, treated at the Mayo Clinic (Rochester, Minnesota) from January 1, 2007, t
- Published
- 2014
26. Risk for Oophorectomy After Hysterectomy
- Author
-
Elizabeth R. Casiano, Emanuel C. Trabuco, Adil E. Bharucha, Amy L. Weaver, Cathy D. Schleck, L. Joseph Melton, and John B. Gebhart
- Subjects
Obstetrics and Gynecology ,General Medicine - Published
- 2014
27. Midurethral Slings for the Treatment of Stress Urinary Incontinence
- Author
-
Emanuel C. Trabuco, D. Carranza, Christopher J. Klingele, Sherif A. El-Nashar, and John B. Gebhart
- Subjects
Midurethral Slings ,medicine.medical_specialty ,Long term follow up ,business.industry ,medicine ,Obstetrics and Gynecology ,Urinary incontinence ,medicine.symptom ,business ,Surgery - Published
- 2014
28. The Learning Curve of Robotic Hysterectomy
- Author
-
Joshua L. Woelk, Emanuel C. Trabuco, John B. Gebhart, Amy L. Weaver, Bobbie S. Gostout, and Elizabeth R. Casiano
- Subjects
Robotic hysterectomy ,medicine.medical_specialty ,business.industry ,Learning curve ,Treatment outcome ,Medicine ,Operative time ,Obstetrics and Gynecology ,General Medicine ,business ,Complication ,Abdominal hysterectomy ,Surgery - Abstract
Objective To evaluate the learning curve of robotic hysterectomy using objective, patient-centered outcomes and analytic methods proposed in the literature. Methods All cases of robotic hysterectomy performed at Mayo Clinic, Rochester, Minnesota, from January 1, 2007, through December 31, 2009, were collected. Experience was analyzed in 6-month periods. Operative time, complications, and length of stay longer than 1 day were compared between periods for significant change. For learning curve analysis, standard and risk-adjusted cumulative summation charting was used for the two most experienced robotic surgeons (A and B). Outcomes of interest were intraoperative complications and intraoperative or postoperative complications within 6 weeks. Proficiency was defined as the point at which each surgeon's curve crossed H0 based on complication rates of abdominal hysterectomy. Cumulative summation parameters were p0=5.7% and p1=11.4% for outcome 1 and p0=36.0% and p1=50% for outcome 2. Results In 325 cases, operative time decreased significantly from 3.5 to 2.7 hours during the 3-year period. The proportion of patients with length of stay longer than 1 day decreased significantly from 49.2% to 14.7%. Complications did not decrease significantly. The average number of procedures to cross H0 was 91 for outcome 1 and 44 for outcome 2. Observed cumulative summation curves of surgeons A and B differed from the average number of attempts calculated from p0 and p1. Conclusions Operative time and length of stay decrease with 36 months of experience with robotic hysterectomy, whereas complications may not. Cumulative summation analysis provides an objective, individualized tool to evaluate surgical proficiency and suggests this occurs after performing approximately 91 procedures. Level of evidence III.
- Published
- 2013
29. Paper 28: Prevalence of Voiding Dysfunction in Patients with Obstructed Defecation
- Author
-
Christopher J. Klingele, John B. Gebhart, A E. Bharucha, and D J. Lightner
- Subjects
business.industry ,Urology ,Anesthesia ,medicine ,Obstetrics and Gynecology ,Surgery ,In patient ,Obstructed defecation ,medicine.symptom ,business - Published
- 2004
30. Video 3
- Author
-
John B. Gebhart, Elizabeth R. Casiano, Christopher J. Klingele, and John A. Occhino
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Obstetrics and Gynecology ,Medicine ,Surgery ,Medical physics ,business - Published
- 2010
31. Assessment of inhibin and p53 in ovarian granulosa cell tumors
- Author
-
Tim Lesnick, Gary L. Keeney, John B. Gebhart, Karl C. Podratz, and Patrick C. Roche
- Subjects
Ovarian Granulosa Cell ,business.industry ,Cancer research ,Obstetrics and Gynecology ,Medicine ,business - Published
- 1999
32. NON-ORAL POSTER 72: Procedures for Pelvic Floor Repair in Olmsted County, Minnesota, 1965 ??? 2002: A Population-Based Study
- Author
-
E O. Babalola, Christopher J. Klingele, and John B. Gebhart
- Subjects
Population based study ,medicine.medical_specialty ,business.industry ,Urology ,General surgery ,medicine ,Obstetrics and Gynecology ,Surgery ,Pelvic floor repair ,business - Published
- 2006
33. NON-ORAL POSTER 71: Epidemiology of Hysterectomy in Olmsted County, Minnesota, 1965 ??? 2002: A Population-Based Study
- Author
-
E. O. Babalola, John B. Gebhart, L J. Melton, A. E. Bharucha, and A R. Zinsmeister
- Subjects
Population based study ,medicine.medical_specialty ,Hysterectomy ,business.industry ,Urology ,Family medicine ,medicine.medical_treatment ,Epidemiology ,medicine ,Obstetrics and Gynecology ,Surgery ,business - Published
- 2006
34. Non-Oral Poster 73: Matrix Metalloproteinase Activity in the Connective Tissue of Women with Pelvic Organ Prolapse
- Author
-
K C. Podratz, Y Liu, M S. Stack, John B. Gebhart, C S. Dimarco, and S Ghosh
- Subjects
Pelvic organ ,medicine.anatomical_structure ,business.industry ,Urology ,medicine ,Obstetrics and Gynecology ,Connective tissue ,Surgery ,Anatomy ,Matrix metalloproteinase ,business - Published
- 2004
35. Tips and Tricks 4: Management of Vesicouterine Fistulas: A Report of 8 Cases
- Author
-
C S. Dimarco, D S. Dimarco, Christopher J. Klingele, Andrew J. Croak, R A. Lee, and John B. Gebhart
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,General surgery ,medicine ,Obstetrics and Gynecology ,Surgery ,business - Published
- 2004
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.