1. Fluticasone furoate nasal spray is more effective than fexofenadine for nighttime symptoms of seasonal allergy
- Author
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Niran J. Amar, William T Toler, Joseph D Diaz, Bruce G Martin, Edward E. Philpot, Anand A. Dalal, Charles P. Andrews, Barbara A. Prillaman, Robert L. Jacobs, Dale Mohar, Jonathan A. Bernstein, Mark Vandewalker, Harold B. Kaiser, and Laurie A. Lee
- Subjects
Adult ,Male ,Sleep Wake Disorders ,Pulmonary and Respiratory Medicine ,medicine.medical_treatment ,Histamine Antagonists ,Administration, Oral ,Placebo ,Fluticasone propionate ,Double-Blind Method ,medicine ,Humans ,Immunology and Allergy ,Administration, Intranasal ,Sleep disorder ,Fexofenadine ,business.industry ,Rhinitis, Allergic, Seasonal ,General Medicine ,Middle Aged ,medicine.disease ,Androstadienes ,Treatment Outcome ,Nasal spray ,Anesthesia ,Peak Nasal Inspiratory Flow ,Quality of Life ,Female ,Nasal administration ,Antihistamine ,Terfenadine ,Nasal Obstruction ,business ,medicine.drug - Abstract
Nasal symptoms of allergic rhinitis are an important cause of sleep disturbance. Reduction of nasal symptoms, particularly nasal obstruction, has been linked to improvements in self-reported sleep quality. The enhanced-affinity intranasal corticosteroid fluticasone furoate and the oral antihistamine fexofenadine were compared with respect to nighttime symptoms of seasonal allergic rhinitis. In two randomized, double-blind, double-dummy, parallel-group studies, patients received fluticasone furoate nasal spray (FFNS),110 microg (study 1, n = 312; study 2, n = 224); fexofenadine, 180 mg (study 1, n = 311; study 2, n = 227); or placebo (study 1, n = 313; study 2, n = 229) once daily for 2 weeks. Fluticasone furoate was more effective (p < 0.001) than fexofenadine and placebo in both studies with respect to the mean changes from baseline over the treatment period in the nighttime symptoms score, nighttime reflective total nasal symptom score, predose instantaneous nasal symptom score, and morning peak nasal inspiratory flow. Fluticasone furoate was more effective than placebo (p
- Published
- 2009