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Improved quality of life among seasonal allergic rhinitis patients treated with olopatadine HCl nasal spray 0.4% and olopatadine HCl nasal spray 0.6% compared with vehicle placebo
- Source :
- Allergy and Asthma Proceedings. 27:202-207
- Publication Year :
- 2006
- Publisher :
- Oceanside Publications Inc., 2006.
-
Abstract
- Seasonal allergic rhinitis (SAR) exerts a significant adverse impact on health-related quality of life (QoL) and productivity of those who suffer from it. Unfortunately, some therapies for SAR also have a negative impact. Therefore, it is important to scrutinize the influence of new SAR therapies on patients' QoL and ability to function. The purpose of this study was to evaluate the effect of a new nasal antihistamine, olopatadine, on QoL in SAR patients. In a multicenter, randomized, double-blind SAR study comparing olopatadine 0.6 and 0.4% to placebo nasal spray, patients completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at baseline and after 2 weeks of treatment. The RQLQ is a validated questionnaire that addresses overall QoL and 7 domains of impairment associated with rhinoconjunctivitis (activities, sleep, non--nose/eye allergy symptoms, practical problems, nasal symptoms, eye symptoms, and emotional impairment). The overall RQLQ mean changes from baseline with olopatadine 0.6% (-1.1 +/- 1.4) and 0.4% (-1.1 +/- 1.3) nasal sprays were superior (p < 0.05) to placebo (-0.8 +/- 1.2). Olopatadine spray 0.6% was superior to placebo in six of the seven RQLQ domains and olopatadine 0.4% was superior to placebo in five RQLQ domains (p < 0.05). The correlation between the olopatadine 0.6% mean total symptom scores and mean RQLQ score was r = 0.66 (p < 0.0001), indicating that the enhancement in QoL derived from olopatadine therapy was significantly associated with symptom reduction. Olopatadine nasal spray is an effective antiallergy medication that significantly improves the QoL of patients suffering from SAR.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Placebo
Severity of Illness Index
law.invention
Double-Blind Method
Randomized controlled trial
Quality of life
law
Internal medicine
Anti-Allergic Agents
Humans
Immunology and Allergy
Medicine
Child
Olopatadine Hydrochloride
Administration, Intranasal
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
business.industry
Rhinitis, Allergic, Seasonal
General Medicine
Middle Aged
Olopatadine
Nasal spray
Anesthesia
Quality of Life
Female
Nasal administration
Antihistamine
business
Dibenzoxepins
medicine.drug
Subjects
Details
- ISSN :
- 10885412
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Allergy and Asthma Proceedings
- Accession number :
- edsair.doi.dedup.....58557ef8aab8ce7d5494045788184c6d