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A study conducted at the University of Toronto examined the incidence of postoperative C5 palsy after anterior or posterior decompression for degenerative cervical myelopathy. The research found that the odds of postoperative C5 palsy were significantly higher after posterior decompression compared to anterior decompression. This information may be valuable for surgical decision-making in cases where both treatment options are being considered. The study was peer-reviewed and published in the journal Spine. [Extracted from the article]

A recent study conducted at Thomas Jefferson University evaluated the use of a bioresorbable polymer scaffold in patients with thoracic complete spinal cord injury (SCI). The study, known as INSPIRE 2.0, was a randomized controlled trial that compared the implantation of the scaffold to standard-of-care spine surgery. The results showed that the scaffold did not produce significant clinical benefit in improving neurological outcomes for patients with SCI. The study, funded by InVivo Therapeutics Corporation, highlighted the safety of surgical intervention in spinal cord injuries. [Extracted from the article]

The article discusses the feasibility of using brain-computer interfaces (BCIs) during nighttime for individuals with severe motor and speech impairments, specifically focusing on a person with amyotrophic lateral sclerosis (ALS). The study found that neural signal features used for BCI control were significantly higher at night compared to daytime, and a nightmode decoder was developed to allow the user to call a caregiver with minimal unintended activations. The research highlights the importance of adjusting BCI decoders to sleep-related signal changes for reliable nighttime use, emphasizing the need for 24/7 BCI functionality for individuals with advanced ALS. [Extracted from the article]

The article discusses the role of astrocytic Kir4.1 channels in spasticity after spinal cord injury, highlighting the potential for new therapeutic targets. While past research has focused on neuronal factors, this study explores the impact of astrocytes in reducing spasticity. The findings suggest that enhancing Kir4.1 function could help alleviate spasticity in spinal cord injury mice, offering insights into neurological diseases associated with neuronal hyperexcitability. This preprint has not yet undergone peer review, and more information can be found at biorxiv.org/content/10.1101/2024.10.11.617793v1. [Extracted from the article]

The article discusses a study on using a minimally invasive Brain-Computer Interface (BCI) with epidural electrodes to restore hand functions in tetraplegia patients with complete spinal cord injuries. The system enabled real-time control of hand movements and rehabilitation of hand functions at home. The study showed significant improvement in hand grasping and daily tasks performance over a 9-month period, indicating potential for neurological recovery in impaired spinal cord connections. The preprint has not been peer-reviewed, and more information can be found at medrxiv.org/content/10.1101/2024.09.05.24313041v3. [Extracted from the article]

A recent study from Harbin Medical University in China explores the potential of targeting astrocyte polarization as a therapeutic approach for spinal cord injuries (SCI). The research highlights the importance of understanding the different states of astrocytes after SCI, particularly the neurotoxic 'A1' phenotype and the neuroprotective 'A2' phenotype. The study suggests that interventions focusing on astrocyte polarization could lead to improved motor-sensory function and quality of life for SCI patients in the future. For more information, the full article can be accessed for free at the Frontiers in Cellular Neuroscience website. [Extracted from the article]

A recent study published in the Journal of Spinal Cord Medicine examined healthcare utilization among community-living individuals with spinal cord injury (SCI) in the United States. The research found that rates of healthcare utilization among people with SCI are below recommended levels and vary across demographic, socioeconomic, and injury-related subgroups. The study highlights the need for further research to address barriers to accessing healthcare services for individuals living with SCI. The research was supported by the Craig H. Neilsen Foundation and the United States Department of Health & Human Services. [Extracted from the article]

A recent report from Dongguan Children's Hospital highlights the unique characteristics of spinal cord injuries in children, which account for about 5% of all cases. Motor vehicle accidents are the primary cause of these injuries, and early diagnosis through MRI imaging is crucial to prevent long-term complications. The study emphasizes the importance of a family-centered rehabilitation model to help children with spinal cord injuries reintegrate into society and achieve a normal life. [Extracted from the article]

A study conducted at Capital Medical University in Beijing, China, focused on the occurrence of pathological spontaneous activity (PSA) in different thoracic paraspinal muscles (TPMs) in patients with Amyotrophic Lateral Sclerosis (ALS). The research found that PSA was correlated with pulmonary function and clinical disability, with positive sharp wave (PSW) potentials more frequently observed than fibrillation (fib) in certain segments. The study concluded that PSA in TPM could serve as a practical indicator for comprehensive disease evaluation, regardless of the site of onset. The findings suggest potential implications for the involvement of pulmonary ventilation function (PVF) in ALS. [Extracted from the article]

A study conducted by investigators from Wakayama Medical University in Japan focused on the clinical and radiographic characteristics of increased signal intensity (ISI) of the spinal cord at the vertebral body level in patients with cervical myelopathy. The research found that ISI at the vertebral body level may be related to cord compression or stretching at the flexion position, impacting the anterior components of the vertebrae. The study concluded that this mechanism differs from the conventionally held pincer-mechanism concept. The findings were published in the Journal of Orthopaedic Science and have been peer-reviewed. [Extracted from the article]

Researchers at the University of Michigan conducted a study on older adults with spinal cord injury (SCI) to explore factors predicting comorbidities and secondary conditions. The study utilized survey methods and found that age, basic mobility, primary health care payer, and parking limitations were common predictors of comorbidities and secondary conditions. The research highlighted the importance of demographic and injury factors, physical functioning, satisfaction with social roles, access to home environment adaptations, and health resources in predicting these conditions among older adults with SCI. [Extracted from the article]

Researchers at the University of Sydney conducted a study on amyotrophic lateral sclerosis (ALS) focusing on cortical interneuron circuits. The study utilized transcranial magnetic stimulation (TMS) and advanced EEG to examine GABA-ergic dysfunction in ALS patients. The findings suggested dysfunction of GABA-ergic circuits in the motor cortex, correlating with clinical disability and disease duration in ALS patients. This research provides insights into the pathogenic features of ALS and the role of cortical interneurons in the disease. [Extracted from the article]

A study conducted at the Federal University Minas Gerais in Belo Horizonte, Brazil, explored memory deficits in individuals with sporadic and Type 8 Amyotrophic Lateral Sclerosis (ALS) related to emotional stimuli. The research found that both groups of ALS patients showed decreased recognition of positive emotional information compared to negative stimuli, a phenomenon not observed in healthy controls. This study sheds light on the impact of ALS on emotional memory processing and highlights the need for further research in this area. [Extracted from the article]

Researchers at the National Hospital Paraplejicos in Toledo, Spain conducted a study on the Health and Life domain priorities of youth with pediatric-onset spinal cord injury (SCI) and their parents/caregivers in Spain. The study involved 60 participants, including youth with pediatric-onset SCI and their parents/caregivers, and identified top priorities such as 'parenthood expectations,' 'leg/foot movement,' and 'bladder function.' The research aims to aid rehabilitation professionals in implementing comprehensive SCI management programs for the pediatric population. The study was published in the Journal of Spinal Cord Medicine and was supported by the Alicia Koplowitz Foundation. [Extracted from the article]

A recent study explored the connection between specific bacterial taxa and a metabolite called DHPS in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. The research suggests that DHPS, which is linked to gut dysbiosis, may play a role in the onset and progression of these neurodegenerative diseases. The findings highlight a potential link between gut microbiome dysregulation and central nervous system conditions, shedding light on new pathways for understanding these complex disorders. [Extracted from the article]

The article discusses a study on the effects of treadmill step training on corticospinal tract plasticity after incomplete spinal cord injury. The research highlights the importance of understanding the topographical changes within the corticospinal tract and their correlation with behavioral outcomes. The study utilized a mouse model to quantify CST plasticity and found that treadmill training enhanced CST rewiring, especially in highly motivated animals, leading to improved locomotor recovery and synaptic density in the ventral horn. The results suggest that both task-specific training and motivation play a role in promoting functional recovery after spinal cord injury. [Extracted from the article]

A recent study conducted at NITTE (Deemed to be University) in Karnataka, India, explored the sex disparity in the canal-to-body ratio of the cervical spine as an indicator of the prevalence of cervical myelopathy. The research found that females had a larger canal-to-body ratio compared to males, suggesting potential gender-related differences in the development of cervical myelopathy. This study highlights the importance of considering sex as a contributing factor to myelopathy and the potential diagnostic value of the canal-to-body ratio in identifying canal stenosis. [Extracted from the article]

A study conducted by researchers at St. Marianna University School of Medicine in Japan focused on the diagnostic accuracy of cerebrospinal fluid (CSF) anti-human T-cell leukemia virus type I (HTLV-1) antibody testing for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM). The study found that measuring anti-HTLV-1 antibody levels in CSF using various test kits, along with clinical findings, can aid in the accurate diagnosis of HAM. The research was supported by the Health And Labour Sciences Research Grant on Rare And Intractable Diseases from the Ministry of Health, Labour And Welfare of Japan. For more information, readers can refer to the journal article "Diagnostic Value of Anti-HTLV-1-Antibody Quantification in Cerebrospinal Fluid for HTLV-1-Associated Myelopathy" published in Viruses. [Extracted from the article]

A recent study conducted at the Graduate School of Medicine in Osaka, Japan, focused on the impact of degeneration of the cervical multifidus muscles on the physical activity-related quality of life after laminoplasty for degenerative cervical myelopathy (DCM). The research found that increased degeneration of the multifidus muscle at the C7 level negatively affected postoperative quality of life. These findings may assist spine surgeons in predicting the physical activity-related quality of life in patients with DCM following laminoplasty. The study was published in Clinical Spine Surgery and has been peer-reviewed. [Extracted from the article]

The article discusses a study on targeting resident astrocytes to alleviate neuropathic pain after spinal cord injury. Researchers selectively eliminated resident astrocytes in the lumbar enlargement of mice, which resulted in reduced pain symptoms and activation of microglia. The study found that the type I interferons signal was significantly activated after astrocyte elimination, suggesting that targeting this signal could be an effective strategy for treating neuropathic pain after spinal cord injury. The preprint has not been peer-reviewed, and more information can be found on biorxiv.org. [Extracted from the article]

A recent study conducted by researchers at National Taiwan Ocean University focused on identifying DNA methylation biomarkers for Amyotrophic Lateral Sclerosis (ALS) by analyzing comorbidities and gene functions. By utilizing electronic medical records and word2vec analysis, the researchers identified potential biomarkers such as SOD3, CACNA1H, and ERBB4 for early ALS detection through blood samples. This study highlights the importance of early screening and prophylactic treatment for high-risk ALS patients, offering a promising approach to improving diagnostics and care for individuals with ALS. [Extracted from the article]

A clinical trial, NCT06635759, is being conducted to compare the effectiveness of low-load endurance exercise and stretching exercise on the upper trapezius muscle in patients with chronic neck-shoulder pain. The study aims to assess pain, pressure pain, muscle stiffness, and muscle endurance before and after a 5-week training period. Secondary outcomes include the Neck Disability Index and Disabilities of Shoulder, Arm and Hand Questionnaire. The findings will inform clinical management and physiotherapists about effective exercise prescriptions for individuals with neck-shoulder pain. [Extracted from the article]

The article from Women's Health Weekly highlights recent research findings from Memorial Sloan Kettering Cancer Center. One study focused on predicting response to hormone therapy combined with CDK4/6 inhibitors in estrogen receptor-positive breast cancer patients, while another study showed improved disease control and quality of life in metastatic castration-resistant prostate cancer patients using 177Lu-PSMA-617 therapy. Additionally, advancements in radiation treatment, including insights into optimal dosing for spinal metastasis and the effectiveness of proton therapy in recurrent head and neck cancers, were presented at the American Society for Radiation Oncology Annual Meeting. The research aims to provide better treatment options and outcomes for patients with various types of cancer. [Extracted from the article]

A recent study conducted in a large for-profit United States health care system focused on nontraumatic spinal cord injuries (NTSCI). The research analyzed data from 2807 inpatients with NTSCI between 2014 and 2020, highlighting demographic, clinical characteristics, hospital course, and outcomes. Findings indicated that factors such as increased Charlson Comorbidity Index, ICU stay, and hospital-acquired pulmonary complications were associated with poorer outcomes after acute care hospitalization for NTSCI patients. The study concluded that NTSCI cases in the sample were predominantly incomplete cervical central SCIs. [Extracted from the article]

A recent study conducted by researchers at the University of Vigo in Spain explored the use of immersive virtual reality (IVR) as a tool for multisensory stimulation in a 76-year-old woman with amyotrophic lateral sclerosis (ALS). The study involved IVR stimulation sessions three times a week for 12 weeks and found that the program was feasible, safe, and easy to execute. The participant reported improvements in mental health, quality of life, and maintained functional capacity, indicating the potential benefits of implementing physical-cognitive stimulation programs with IVR for individuals with ALS. [Extracted from the article]

Researchers from Taiyuan University of Technology conducted a scoping review on managing bladder infections and preventing urinary tract infections (UTIs) in athletes with spinal cord injuries (SCI). The study identified evidence-based protocols for safe bladder management, highlighting the effectiveness of weekly oral cyclic antibiotics and coated catheters in preventing UTIs. The research also emphasized the importance of patient education and the use of suprapubic and coated intermittent catheters for safe bladder management in SCI patients. The findings suggest that cranberry supplements and low-dose antibiotic prophylaxis may not be reliable methods for preventing UTIs in this population. [Extracted from the article]

A recent report from King Abdulaziz University in Jeddah, Saudi Arabia, discusses research findings on amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. The study highlights the challenges in developing diagnostic and prognostic tools for ALS due to its heterogeneous nature. Biofluid biomarkers are explored as potential indicators of disease progression and response to therapy, with neurofilaments emerging as superior biomarkers of neurodegeneration. The research emphasizes the importance of quantitative biofluid biomarkers in understanding ALS pathophysiology. [Extracted from the article]

Researchers at Thomas Jefferson University Hospital conducted a study on the safety and feasibility of the Reynolds Innovative Spinal Electrical Stimulation (RISES) system for spinal cord injury rehabilitation. The study involved four participants with spinal cord injuries who underwent a clinical trial with activity-based training using transcutaneous spinal cord stimulation. Results showed no serious adverse events, with no significant differences in vital signs or pain between open-loop and closed-loop stimulation. The study concluded that RISES demonstrated safety and feasibility, with future work focusing on clinical efficacy. [Extracted from the article]

A recent study conducted by investigators at RTI International focused on the remote-use applications of the Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R) clinical outcome assessment tool. The research aimed to identify existing remote-use ALSFRS-R tools, assess feasibility and comparability of administration modes, and highlight barriers and facilitators for developing a standardized remote-use ALSFRS-R tool. The study emphasized the importance of engaging individuals living with amyotrophic lateral sclerosis, care partners, and providers in future research to create a standardized remote-use tool. This research was supported by the US Food & Drug Administration and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at Sapporo Medical University in Japan explored the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells in patients with chronic severe spinal cord injury. The study, funded by the Japanese Ministry of Education, Culture, Sports, Science, and Technology, found that the infusion was safe and resulted in significant functional improvements and increased quality of life in patients. While the initial case series was not blinded, the researchers concluded that further large-scale studies are needed to fully evaluate the therapeutic potential of this approach. [Extracted from the article]

A patent application titled "N-Acylhydrazone Compounds Capable Of Inhibiting Nav1.7 And/Or Nav1.8" was filed by inventors from Brazil and made available online in October 2024. The application focuses on developing compounds that target sodium channels involved in pain transmission, particularly for neuropathic pain-related conditions. The compounds aim to provide alternative treatments with reduced adverse effects, offering potential therapeutic benefits for pain-related diseases. [Extracted from the article]

The article discusses a potential therapeutic strategy for Amyotrophic Lateral Sclerosis type 4 (ALS4), a motor neuron disease caused by mutations in the SETX gene. Researchers designed siRNAs to target the mutated allele of SETX, effectively reducing mutant protein levels without affecting the wild-type protein. This approach shows promise in selectively silencing the mutant allele and restoring normal cellular function in ALS4 patients. The study highlights the potential of allele-specific siRNA as a therapeutic approach for ALS4, although the research has not yet undergone peer review. [Extracted from the article]

A study conducted at the University of Health Sciences in Istanbul, Turkey, focused on investigating the prevalence and predictors of polypharmacy among individuals living with traumatic spinal cord injury (TSCI). The research found that over half of the patients with chronic TSCI had polypharmacy, with predictors including complete injury, advancing age, and longer injury duration. This study sheds light on the complex medical needs of individuals with TSCI and highlights the importance of understanding and addressing polypharmacy in this population. [Extracted from the article]

A study conducted at the University of Lubeck compared two radiotherapy regimens for patients with malignant spinal cord compression and favorable survival prognoses. The study found that a three-week regimen of 15 x 2.633 Gy had similar outcomes to a four-week regimen of 20 x 2.0 Gy, with potential advantages in motor function improvement and reduced treatment time. The research, funded by the European Regional Development Fund, provides valuable insights into treatment options for patients with spinal cord compression. [Extracted from the article]

Researchers at Nagoya University Graduate School of Medicine conducted a study on dysphagia in older patients with cervical spinal cord injury (SCI). The study, involving 707 patients, found that low nutritional status before injury was a significant risk factor for dysphagia in elderly patients with cervical SCI. Factors such as male sex, dementia, fracture, complete paralysis, anterior surgery, and tracheostomy were also identified as risk factors for dysphagia in this population. The study highlights the importance of nutritional status in the recovery of feeding function in elderly patients with cervical SCI. [Extracted from the article]

A recent study conducted at the University of Texas MD Anderson Cancer Center in Houston, Texas, focused on the effectiveness of spinal laser interstitial thermal therapy (sLITT) in treating thoracic metastatic epidural spinal cord compression. The study included 129 patients who received sLITT to 144 vertebral segments, with a majority being radiotherapy-naïve and having radioresistant histologies. Results showed that sLITT with radiotherapy was an effective minimally invasive treatment approach, with one-year freedom from local failure (FFLF) and overall survival (OS) rates of 80% and 78%, respectively. The study concluded that early treatment response could serve as a prognostic imaging biomarker. [Extracted from the article]

The article discusses a study on the effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) encapsulated in a fibrin matrix on cytokine levels in a rat model of spinal cord injury. The study found that the combination treatment significantly influenced pro- and anti-inflammatory cytokine levels, with a dose-dependent effect. These findings suggest the potential of extracellular vesicles to modulate inflammatory responses and promote regeneration in chronic spinal cord injury. The preprint has not been peer-reviewed and more information can be found on biorxiv.org. [Extracted from the article]

Researchers from the Chinese Academy of Sciences have conducted a study on using bioengineered induced pluripotent stem cell-derived exosomes loaded with miRNA to enhance spinal cord repair. The study aimed to develop exosomes capable of targeting and supporting neurons to accelerate recovery from spinal cord injury. Results showed that the engineered exosomes loaded with miRNA promoted spinal cord injury recovery with negligible systemic toxicity, indicating potential for clinical applications. This research provides valuable insights into cutting-edge therapeutic approaches for improving spinal cord injury recovery. [Extracted from the article]

The article from Stem Cell Week discusses research conducted at Qilu Hospital of Shandong University on spinal cord injury and the potential of mesenchymal stem cell transplantation as a therapeutic approach. The study focuses on the regulation of imbalanced microenvironment post-SCI, specifically addressing inflammation, neurotrophy, and axonal regeneration. The research provides a comprehensive perspective on the clinical translation of MSC transplantation for SCI, highlighting its application, limitations, and future prospects. For more information, readers can access the full article in Stem Cell Research & Therapy. [Extracted from the article]

Researchers at Lanzhou University in the People's Republic of China have developed a neurophilic peptide-reinforced dual-fiber-network bioactive hydrogel for spinal cord injury repair. The hydrogel exhibits neuro-affinity, self-healing ability, biodegradability, and biocompatibility, promoting targeted spinal cord injury repair and regeneration. In vitro and in vivo studies have shown promising results, indicating that this hydrogel system has great potential for clinical applications in treating spinal cord injuries. The research has been peer-reviewed and published in the Chemical Engineering Journal. [Extracted from the article]

Researchers have submitted a patent application for S-enantiomerically enriched compositions of beta blockers to treat Amyotrophic Lateral Sclerosis (ALS). The patent application focuses on using oxprenolol, a non-selective beta blocker, to potentially delay the progression of ALS and improve quality of life for individuals with the disease. The application highlights the potential benefits of administering enantiomerically enriched compositions of beta blockers, specifically S-oxprenolol, to individuals with ALS. [Extracted from the article]

Researchers from Xiangya Hospital in Hunan, China, conducted a study on the effects of spinal cord injury (SCI) on metabolic disruptions and neural tissue remodeling. They found that decreased expression of monocarboxylate transporter 1 (MCT1) in endothelial cells post-SCI disrupts lactate transport to neurons, hindering axonal regeneration. By administering an adeno-associated virus to restore MCT1 expression in endothelial cells, they observed enhanced axonal regeneration and improved functional recovery in SCI mice. The study highlights a potential therapeutic pathway for treating SCI by targeting lactate transport mechanisms. [Extracted from the article]

The article discusses a study that aims to develop non-invasive AI tools to detect and quantify emotional responsiveness in patients with Amyotrophic Lateral Sclerosis (ALS). By analyzing pulse and speech data, the study found that financial concerns triggered the strongest emotional response in ALS patients, while discussions about breathing, mobility, and feeding tube increased anxiety. The use of AI and affective computing in evaluating emotional responses in ALS patients could enhance patient-provider communication, telemedicine effectiveness, and clinical trial outcome measures, potentially benefiting other neurological disorders as well. [Extracted from the article]

A patent application has been submitted for methods of treating spinal cord injuries using alternating electric fields. The application aims to increase N-cadherin expression, promote migration of neural stem progenitor cells, and enhance axon regeneration and neuronal protection in subjects with spinal cord injuries. The methods outlined in the patent application offer potential advancements in the treatment of spinal cord injuries, addressing the challenges associated with cell migration and neural tissue repair. [Extracted from the article]

Researchers at the University of California have conducted a study on Friedreich's ataxia, an autosomal recessive disorder that affects mitochondrial function and can lead to cardiomyopathy. The study found significant sex differences in a mouse model of the disease, with males exhibiting a worse cardiac phenotype, lower survival rates, and deficiencies in kidney and reproductive organs. These differences were attributed to a decline in testosterone levels and alterations in protein expression related to cholesterol transfer and calcium signaling in the heart. The research sheds light on sexual dimorphism in Friedreich's ataxia and its impact on cardiac function. [Extracted from the article]

A recent study conducted at Yangzhou University in Jiangsu, China, focused on developing a novel micellar thermosensitive hydrogel containing minocycline to enhance its therapeutic efficacy in spinal cord injury (SCI) treatment. The gel demonstrated favorable properties and extended minocycline release without cytotoxic effects. In animal models, the gel promoted neuronal regeneration and showed promising results in reducing damage in the spinal cord. This research lays a foundation for further exploration of the gel's application in SCI and other neurodegenerative diseases. [Extracted from the article]

The patent application titled "Biomarkers For Amyotrophic Lateral Sclerosis Stratification" by inventors from Arizona State University addresses the need for biomarkers to diagnose and treat ALS effectively. The method involves detecting specific biomarkers in samples to diagnose ALS or its subtypes, such as ALS-Glia, ALS-Ox, and ALS-TD, which are associated with different molecular profiles. Therapeutic agents can be administered based on the diagnosed subtype, offering personalized treatment options. This research aims to improve clinical outcomes by addressing the heterogeneity of ALS and providing insights into disease progression and prognosis. [Extracted from the article]

A recent study conducted at Hubei University of Science and Technology focused on identifying immune-related hub genes in spinal cord injury (SCI). The researchers utilized various analyses to pinpoint three key genes (ABHD5, EDNRB, EDN3) associated with SCI progression or repair through immunomodulation. The study also highlighted potential targeted drugs and their diagnostic potential for SCI. This research sheds light on the importance of immune regulation in understanding and treating spinal cord injuries. [Extracted from the article]

A recent study conducted by researchers at James Cook University in Townsville, Australia, focused on evaluating the effects of functional electrical stimulation (FES) cycling on muscle spasticity in individuals with spinal cord injury (SCI). The systematic review included 16 studies with a total of 203 participants, aged 7 to 80 years old. While some studies reported a reduction in spasticity following FES cycling, the overall evidence on the effectiveness of this intervention remains inconclusive. Further research with larger sample sizes is needed to confirm these findings and determine the optimal parameters for reducing spasticity. [Extracted from the article]

A recent study from the University of Oxford explores the role of mitochondrial dysfunction in amyotrophic lateral sclerosis (ALS) and its impact on axonal transport in motor neurons. The research highlights how mutations in TDP-43 lead to deficiencies in mitochondrial functions, affecting axonal transport, which can be partially rescued by overexpression of dynactin-1. This study sheds light on the complex determinants of ALS, including genetic and non-genetic factors, and offers insights into potential therapeutic interventions. [Extracted from the article]