Author: "Ostrov VF" / Publisher: nauka - Searchworks@Jio Institute Digital Library Search Results

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Author: Ostrov VF, Evgen'ev MB, and Murashev AN
Subjects: Animals, Disease Models, Animal, Humans, Lipopolysaccharides immunology, Male, Mice, Mice, Inbred Strains, Rats, Rats, Sprague-Dawley, Staphylococcus aureus immunology, Teichoic Acids immunology, HSP70 Heat-Shock Proteins therapeutic use, Recombinant Proteins therapeutic use, Sepsis prevention & control
Abstract: Our research with Sprague-Dawley rats demonstrates protective properties of recombinant human heat shock protein 70 kDa (exogenous rhHSP70) as a prevent therapy agent for gram-positive sepsis. In this study we investigate acute toxicity of rhHSP70 on CD-1 mice and demonstrate very low dangerous of the substance.
Published: 2011
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Author: Ostrov VF, Slashcheva GA, Zharmukhamedova TIu, Garbuz DG, Evgen'ev MB, and Murashev AN
Subjects: Animals, Cattle, Dose-Response Relationship, Drug, Escherichia coli, HSP70 Heat-Shock Proteins therapeutic use, Humans, Lipopolysaccharides pharmacology, Male, Rats, Recombinant Proteins pharmacology, Recombinant Proteins therapeutic use, Shock, Septic drug therapy, Shock, Septic mortality, HSP70 Heat-Shock Proteins pharmacology, Shock, Septic blood
Abstract: The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.
Published: 2010
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