[Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats].

Authors :: Ostrov VF
Slashcheva GA
Zharmukhamedova TIu
Garbuz DG
Evgen'ev MB
Murashev AN
Source :: Bioorganicheskaia khimiia [Bioorg Khim] 2010 May-Jun; Vol. 36 (3), pp. 337-42.
Publication Year :: 2010
Abstract: The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

Subjects :: Animals
Cattle
Dose-Response Relationship, Drug
Escherichia coli
HSP70 Heat-Shock Proteins therapeutic use
Humans
Lipopolysaccharides pharmacology
Male
Rats
Recombinant Proteins pharmacology
Recombinant Proteins therapeutic use
Shock, Septic drug therapy
Shock, Septic mortality
HSP70 Heat-Shock Proteins pharmacology
Shock, Septic blood

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