1. Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats
- Author
-
S. Romandini, Luigi Cervo, and Rosario Samanin
- Subjects
Male ,medicine.medical_specialty ,Interpeduncular nucleus ,Serotonin ,5,7-Dihydroxytryptamine ,(+)-Naloxone ,chemistry.chemical_compound ,Internal medicine ,medicine ,Tegmentum ,Reaction Time ,Animals ,Humans ,Injections, Intraventricular ,Pharmacology ,Behavior, Animal ,Morphine ,Naloxone ,Brain ,Rats ,Substance Withdrawal Syndrome ,Endocrinology ,chemistry ,Forebrain ,Brainstem ,Morphine Dependence ,medicine.drug ,Research Article - Abstract
A withdrawal syndrome was precipitated by naloxone in morphine-dependent rats injected with 5,7-dihydroxytryptamine (5,7-DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 5,7-DHT, which markedly depleted 5-hydroxytryptamine (5-HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats with no significant effect on other withdrawal signs. The effect of morphine 10 mg kg-1 on responses on the hot plate was unchanged in 5,7-DHT-treated rats. The findings suggest that 5-HT in the forebrain is selectively involved in the jumping of morphine-abstinent rats.
- Published
- 1983