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Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats
- Publication Year :
- 1983
- Publisher :
- Nature Publishing Group, 1983.
-
Abstract
- A withdrawal syndrome was precipitated by naloxone in morphine-dependent rats injected with 5,7-dihydroxytryptamine (5,7-DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 5,7-DHT, which markedly depleted 5-hydroxytryptamine (5-HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats with no significant effect on other withdrawal signs. The effect of morphine 10 mg kg-1 on responses on the hot plate was unchanged in 5,7-DHT-treated rats. The findings suggest that 5-HT in the forebrain is selectively involved in the jumping of morphine-abstinent rats.
- Subjects :
- Male
medicine.medical_specialty
Interpeduncular nucleus
Serotonin
5,7-Dihydroxytryptamine
(+)-Naloxone
chemistry.chemical_compound
Internal medicine
medicine
Tegmentum
Reaction Time
Animals
Humans
Injections, Intraventricular
Pharmacology
Behavior, Animal
Morphine
Naloxone
Brain
Rats
Substance Withdrawal Syndrome
Endocrinology
chemistry
Forebrain
Brainstem
Morphine Dependence
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a67c5f371c8d0943b93378d9ddc5c9fa