2 results on '"Laura Betancor"'
Number of results to display per page
Search Results
2. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings
- Author
-
Alison E. Mather, José A. Chabalgoity, Myron M. Levine, Robert A. Kingsley, Tom J. Humphrey, Jan Jacobs, Octavie Lunguya, Melita A. Gordon, Gemma C. Langridge, Robert S. Onsare, Timothy J. Dallman, Theresa Feltwell, Dean Everett, Milagritos D. Tapia, Nicholas A. Feasey, James Hadfield, Lizeth Lacharme-Lora, Martin Aslett, François-Xavier Weill, Calman A. MacLennan, Robert S. Heyderman, Chisomo L. Msefula, Christopher M. Parry, Prerak T. Desai, Paul Wigley, J.S. Cheesbrough, Simon Le Hello, Gordon Dougan, Lars Barquist, Julian Parkhill, Satheesh Nair, Neil French, Karen H. Keddy, Samuel Kariuki, Katie L. Hopkins, Michael McClelland, Josefina Campos, Tristan A Cogan, Kristin Bornstein, Laura Betancor, Maria Fookes, Simon R. Harris, Xiangyu Deng, Nicholas R. Thomson, Samba O. Sow, Sharon M. Tennant, Anthony M. Smith, Liverpool School of Tropical Medicine (LSTM), The Wellcome Trust Sanger Institute [Cambridge], University of Liverpool, University of the Witwatersrand [Johannesburg] (WITS), National Institute for Communicable Diseases [Johannesburg] (NICD), Public Health England [London], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institute of Tropical Medicine [Antwerp] (ITM), Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella (CNR-ESS), Institut Pasteur [Paris] (IP), Plymouth University, University of California [Irvine] (UC Irvine), University of California (UC), London School of Hygiene and Tropical Medicine (LSHTM), Nagasaki University, Administración Nacional de Laboratorios e Institutos de Salud ‘Carlos Malbran' (ANLIS), Institut National de Recherche Biomédicale [Kinshasa] (INRB), University of Kinshasa (UNIKIN), University of Bristol [Bristol], University of Maryland School of Medicine, University of Maryland System, Centre pour le Développement des Vaccins [Mali], Institute of Food Research [Norwich], Biotechnology and Biological Sciences Research Council (BBSRC), University College of London [London] (UCL), The authors from the Institut Pasteur were funded by the Institut Pasteur, by the Institut de Veille Sanitaire, and by the French government ‘Investissement d’Avenir’ program (Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence, grant ANR-10-LABX-62-IBEID). J.J. was supported by the antibiotic resistance surveillance project in the Democratic Republic of the Congo, funded by Project 2.01 of the Third Framework Agreement between the Belgian Directorate General of Development Cooperation and the Institute of Tropical Medicine (Antwerp, Belgium). S.K. was supported by NIH grant R01 AI099525-02. A.E.M. was supported by Wellcome Trust grant 098051 while at the Wellcome Trust Sanger Institute and by Biotechnology and Biological Sciences Research Council grant BB/M014088/1 at the University of Cambridge., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris], University of California [Irvine] (UCI), University of California, Parkhill, Julian [0000-0002-7069-5958], Dougan, Gordon [0000-0003-0022-965X], and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Serotype ,Salmonella ,bacteraemia ,[SDV]Life Sciences [q-bio] ,Adaptation, Biological ,medicine.disease_cause ,wc_269 ,Medical and Health Sciences ,Clade ,Genetics ,Enterocolitis ,Genome ,Research Support, Non-U.S. Gov't ,Bacterial ,Genomics ,Biological Sciences ,global ,3. Good health ,qw_51 ,Salmonella Infections ,Income ,Female ,Host adaptation ,medicine.symptom ,gastroenteritis ,Microbial genetics ,Sequence Analysis ,Plasmids ,Salmonella enteritidis ,Biology ,Article ,03 medical and health sciences ,wi_140 ,Research Support, N.I.H., Extramural ,Journal Article ,medicine ,Animals ,Humans ,Adaptation ,Epidemics ,Prophage ,Africa South of the Sahara ,Poultry Diseases ,qw_138 ,multidrug resistant ,DNA ,Sequence Analysis, DNA ,Biological ,030104 developmental biology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Bacterial infection ,Chickens ,Genome, Bacterial ,Developmental Biology - Abstract
International audience; An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.