Back to Search
Start Over
Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings
- Source :
- Nature genetics, vol 48, iss 10, Nature Genetics, Feasey, N A, Hadfield, J, Keddy, K H, Dallman, T J, Jacobs, J, Deng, X, Wigley, P, Barquist Barquist, L, Langridge, G C, Feltwell, T, Mather, A E, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, C A, Onsare, R S, Weill, F-X, Le Hello, S, McClelland, M, Desai, P, Parry, C M, Cheesbrough, J, French, N, Campos, J, Chabalgoity, J A, Betancor, L, Hopkins, K L, Nair, S, Lunguya, O, Cogan, T A, Tapia, M D, Sow, S O, Tennant, S M, Bornstein, K, Levine, M M, Everett, D B, Kingsley, R A, Parkhill, J, Dougan, G, Gordon, M A & Thomson, N R 2016, ' Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings ', Nature Genetics, vol. 48, no. 10, pp. 1211-1217 . https://doi.org/10.1038/ng.3644, Nature genetics, Nature Genetics, 2016, 48 (10), pp.1211-7. ⟨10.1038/ng.3644⟩, Feasey, N A, Hadfield, J, Keddy, K H, Dallman, T J, Jacobs, J, Deng, X, Wigley, P, Barquist, L, Langridge, G C, Feltwell, T, Harris, S R, Mather, A E, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, C A, Onsare, R S, Weill, F-X, Le Hello, S, Smith, A M, McClelland, M, Desai, P, Parry, C M, Cheesbrough, J, French, N, Campos, J, Chabalgoity, J A, Betancor, L, Hopkins, K L, Nair, S, Humphrey, T J, Lunguya, O, Cogan, T A, Tapia, M D, Sow, S O, Tennant, S M, Bornstein, K, Levine, M M, Lacharme-Lora, L, Everett, D B, Kingsley, R A, Parkhill, J, Heyderman, R S, Dougan, G, Gordon, M A & Thomson, N R 2016, ' Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings ', Nature Genetics, vol. 48, no. 10, pp. 1211-1217 . https://doi.org/10.1038/ng.3644, Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1211-7. ⟨10.1038/ng.3644⟩, Feasey, NA; Hadfield, J; Keddy, KH; Dallman, TJ; Jacobs, J; Deng, X; et al.(2016). Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. NATURE GENETICS, 48(10), 1211-1217. doi: 10.1038/ng.3644. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/94r1q0g5
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- International audience; An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
- Subjects :
- 0301 basic medicine
Serotype
Salmonella
bacteraemia
[SDV]Life Sciences [q-bio]
Adaptation, Biological
medicine.disease_cause
wc_269
Medical and Health Sciences
Clade
Genetics
Enterocolitis
Genome
Research Support, Non-U.S. Gov't
Bacterial
Genomics
Biological Sciences
global
3. Good health
qw_51
Salmonella Infections
Income
Female
Host adaptation
medicine.symptom
gastroenteritis
Microbial genetics
Sequence Analysis
Plasmids
Salmonella enteritidis
Biology
Article
03 medical and health sciences
wi_140
Research Support, N.I.H., Extramural
Journal Article
medicine
Animals
Humans
Adaptation
Epidemics
Prophage
Africa South of the Sahara
Poultry Diseases
qw_138
multidrug resistant
DNA
Sequence Analysis, DNA
Biological
030104 developmental biology
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Bacterial infection
Chickens
Genome, Bacterial
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- Nature genetics, vol 48, iss 10, Nature Genetics, Feasey, N A, Hadfield, J, Keddy, K H, Dallman, T J, Jacobs, J, Deng, X, Wigley, P, Barquist Barquist, L, Langridge, G C, Feltwell, T, Mather, A E, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, C A, Onsare, R S, Weill, F-X, Le Hello, S, McClelland, M, Desai, P, Parry, C M, Cheesbrough, J, French, N, Campos, J, Chabalgoity, J A, Betancor, L, Hopkins, K L, Nair, S, Lunguya, O, Cogan, T A, Tapia, M D, Sow, S O, Tennant, S M, Bornstein, K, Levine, M M, Everett, D B, Kingsley, R A, Parkhill, J, Dougan, G, Gordon, M A & Thomson, N R 2016, ' Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings ', Nature Genetics, vol. 48, no. 10, pp. 1211-1217 . https://doi.org/10.1038/ng.3644, Nature genetics, Nature Genetics, 2016, 48 (10), pp.1211-7. ⟨10.1038/ng.3644⟩, Feasey, N A, Hadfield, J, Keddy, K H, Dallman, T J, Jacobs, J, Deng, X, Wigley, P, Barquist, L, Langridge, G C, Feltwell, T, Harris, S R, Mather, A E, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, C A, Onsare, R S, Weill, F-X, Le Hello, S, Smith, A M, McClelland, M, Desai, P, Parry, C M, Cheesbrough, J, French, N, Campos, J, Chabalgoity, J A, Betancor, L, Hopkins, K L, Nair, S, Humphrey, T J, Lunguya, O, Cogan, T A, Tapia, M D, Sow, S O, Tennant, S M, Bornstein, K, Levine, M M, Lacharme-Lora, L, Everett, D B, Kingsley, R A, Parkhill, J, Heyderman, R S, Dougan, G, Gordon, M A & Thomson, N R 2016, ' Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings ', Nature Genetics, vol. 48, no. 10, pp. 1211-1217 . https://doi.org/10.1038/ng.3644, Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1211-7. ⟨10.1038/ng.3644⟩, Feasey, NA; Hadfield, J; Keddy, KH; Dallman, TJ; Jacobs, J; Deng, X; et al.(2016). Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. NATURE GENETICS, 48(10), 1211-1217. doi: 10.1038/ng.3644. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/94r1q0g5
- Accession number :
- edsair.doi.dedup.....674d6ac71c0c59ba23b219bf64c0f1db
- Full Text :
- https://doi.org/10.1038/ng.3644